性别： 男
籍贯： 广东
民族：汉
职称：教授 博导,硕导
职务：院长
学历：研究生
学位： 博士
电话： 020－85227039
传真：020－85227039
电子邮件： tqyhe@jnu.edu.cn
学习经历：
1995:博士学位 (生物化学) 英国 谢菲尔德大学 (University of Sheffield)
1988:硕士学位 (化学) 暨南大学 / 中山大学
1985:学士学位 (化学) 暨南大学
工作经历：
2002–2006:香港大学 助理教授 (蛋白质组学 / 生物化学)
1996–2002:美国 佛蒙特大学 (University of Vermont)
博士后 → 副研究员 → 研究助理教授 (蛋白质生物化学)
1992:英国 牛津大学 (University of Oxford) 访问学者 (生物电化学)
1988–1991:北京 石油化工研究院 助理工程师 (均相酶催化)
研究方向：
1.癌症蛋白质组学：肿瘤标记物的筛选和确证.
2.药物蛋白质组学：药物靶标发现及药物作用机制。
3.化学生物学：生物体中含铁蛋白介导的铁转运分子机制.
主要论文：
1. Xuesong Sun,Feng Ge, Chuan-Le Xiao,Xing-Feng Yin,Ruiguang Ge, Liu-Hui Zhang, Qing-Yu He*, “Phosphoproteomic analysis
reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae. ”,J Proteome Res. 2010 Jan;9(1):275-82.
2. Ka-Wing Cheng, Chi-Chun Wong, Mingfu Wang, Qing-Yu He*, Feng Chen.*, “Identification and characterization of molecular
targets of natural products by mass spectrometry. ”, Mass Spectrom Rev. 2010 Jan-Feb;29(1):126-55.
3. Guang-Rong Yan, Chuan-Le Xiao, Gui-Wei He, Xing-Feng Yin, Nan-Peng Chen,Ya Cao,Qing-Yu He.*, “Global phosphoproteomic
effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways.Proteomics.”, Proteomics. 2010 Mar;10(5):976-86.
4. Yan Ma, Jun Yu, Henry L.Y. Chan, Yang-chao Chen, Hua Wang, Ying Chen, Chu-yan Chan, Minnie Y.Y.Go, Sau-na Tsai, Sai-ming Ngai, Ka-fai To, Joanna H.M. Tong, Qing-Yu He, Joseph J.Y. Sung, Hsiang-fu Kung, Christopher H. K. Cheng,
Ming-liang He*, “Glucose-Regulated Protein 78 Is an Intracellular Antiviral Factor against Hepatitis B Virus”, Mol Cell
Proteomics. 2009 Aug 11;2582-2594.
5. Zhen Cai, Yuan Zhou, Ting Lei, Jen-Fu Chiu, Qing-Yu He*, “Mammary serine protease inhibitor inhibits epithelial growth
factor-induced epithelial-mesenchymal transition of esophageal carcinoma cells”, Cancer. 2009 Jan 1; 115(1):36-48.
6. Feng Ge and Qing-Yu He *, “Genomic and proteomic approaches for predicting toxicity and adverse drug reactions”,
Expert Opin Drug Metab Toxicol., 2009, 5(1):29-37.
7. Yang Xu, Jen-Fu Chiu, Qing-Yu He*, Feng Chen*, “Tubeimoside-1 Exerts Cytotoxicity in HeLa Cells through Mitochondrial
Dysfunction and Endoplasmic Reticulum Stress Pathways.”, J Proteome Res. 2009, 8 :1585-1593, Feb 12.
8. Feng Ge, Xin-Peng Lu, Hui-Lan Zeng, Quan-Yuan He, Sheng Xiong, Lin Jin, Qing-Yu He*, “Proteomic and Functional Analyses
Reveal a Dual Molecular Mechanism Underlying Arsenic-Induced Apoptosis in Human Multiple Myeloma Cells”, J Proteome Res.
2009 Jun 5;8(6):3006-3019.
9. Xuesong Sun, Ruiguang Ge, Zongwei Cai, Hongzhe Sun and Qing-Yu He*, “Iron depletion decreases proliferation and induces
apoptosis in a human colonic adenocarcinoma cell line, Caco2”, J Inorg Biochem. 2009 Jul;103(7):1074-81.
10. Xuesong Sun, Heather M. Baker, Ruiguang Ge, Hongzhe Sun, Qing-Yu He* and Edward N. Baker*,“Crystal Structure and
Metal Binding Properties of the Lipoprotein MtsA, Responsible for Iron Transport in Streptococcus pyogenes.”,
Biochemistry. 2009 Jul 7;48(26):6184-90.
11. Bin Li, Sai Wah Tsao, Yuk Yin Li, Xianghong Wang, Ming Tat Ling, Yong Chuan Wong, Qing-Yu He, and Annie L M Cheung*,
“Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT
signaling pathway”, Int J Cancer. 2009 Dec 1;125(11):2576-85.
12. Wei Liu, Xing-wang Zhou, Shaojun Liu, Kunhua Hu, Chong Wang, Qing-Yu He, Mingtao Li*, “Calpain-truncated CRMP-3 and -4
contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons”, Proteomics. 2009 Jul; 9(14):3712-28.
13. Ruiguang Ge, Xuesong Sun and Qingyu He, “Iron acquisition by Streptococcus species: An updated review”, Front. Biol.
China 2009, 4(4):392-401.
14. Ting Lei, Qing-Yu He*, Zhen Cai, Yuan Zhou, Yi-Li Wang, Lu-Sheng Si, and Jen-Fu Chiu, “Proteomics Analysis of Chromium
Cytotoxicity in Cultured Rat Lung Epithelial Cells”, Proteomics, 2008, 8:2420-2429.
15. Chi Chun Wong, Ka Wing Cheng, Qing-Yu He*, Feng Chen*, “Unraveling the molecular targets of natural products:
Insights from genomic and proteomic analyses”, Proteomics Clin.Appl..2008 Mar, 2(3):338-354.
16. Chi Chun Wong, Ying Wang, Jen-Fu Chiu, Qing-Yu He*, Feng Chen*, “Comparative proteomic analysis of indioside D-triggered cell death in HeLa cells.”, J Proteome Res. 2008 May 2; 7(5):2050-2058. Epub 2008 Apr 1.
17. Yeung BH, Kwan BW, He QY, Lee AS, Liu J, Wong AS, “Glucose-regulated protein 78 as a novel effector of BRCA1 for
inhibiting stress-induced apoptosis.”, Oncogene. 2008 Dec 4;27(53):6782-9. Epub 2008 Sep 8.
18. Ying Wang, Chi-Ming Che, Jen-Fu Chiu, and Qing-Yu He*, “Dioscin (Saponin)-Induced Generation of Reactive Oxygen
Species through Mitochondria Dysfunction: A Proteomic-Based Study.”, J Proteome Res. 2007, 6(12):4703-10.
19. Ruiguang Ge, Xuesong Sun, Q. Gu, Rory M. Watt, JA Tanner, BC Wong, HH Xia, Jian-Dong Huang, Qing-Yu He*, Hongzhe Sun*,
“A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori.”,J Biol Inorg Chem.
2007 12(6):831-842. May 15.
20. Ying Wang, Yim Hing Cheung, Zhiqi Yang, Jen-Fu Chiu, Chi-Ming Che*, and Qing-Yu He*, “Proteomic approach to study the
cytotoxicity of dioscin (saponin)”, (2006), Proteomics, 6(8):2422-32.
21. Pei-Hui Yang, Xuesong Sun, Jen-Fu Chiu, Hongzhe Sun*, and Qing-Yu He*, “Transferrin-Mediated Au-Nanoparticle
Cellular Uptake”, (2005), Bioconjugate Chem., 16(3):494-496. (该论文被美国National Cancer Institute 于Nanotech News 专文评介：http://nano.cancer.gov/news_center/nanotech_news_2005-06-20b.asp)
22. Qing-Yu He*, Jia Chen, Hsing-Fu Kung, Po-Wing Yuen and Jen-Fu Chiu, “Identification of tumor-associated proteins in oral
tongue squamous cell carcinoma by proteomics”, Proteomics, (2004), 4：271-278. (该论文被美国NewsRX于Vaccine Weekly专文评介:
http://www.newsrx.com/newsletters/Vaccine-Weekly/2004-04-21/0421200433353VW.html )
23. Jia Chen, Qing-Yu He*, Anthony Po-Wing Yuen and Jen-Fu Chiu, “Proteomics of Buccal Squamous Cell Carcinoma: The
Involvement of Multiple Pathways in Tumorigenesis”, Proteomics, (2004), 4 (8), 2465-2475. (该论文结果作为封面图片刊登于《Proteomics》2004年4卷1期封面)
24. Qing-Yu He*, George K.K. Lau, Yuan Zhou, Siu-Tsan Yuen, Marie C. Lin, Hsing-Fu Kung and Jen-Fu Chiu, “Serum biomarkers
of hepatitis B virus infected liver inflammation: A proteomic study”, Proteomics, 3 (5) (2003), 666-674.
承担课题：
P. I.: ****特聘教授配套基金, “疾病蛋白质组学研究”, 200万元, 2008.5-2011.4, 51208014
P. I.: 广东省自然科学基金重点项目, “化脓性链球菌的铁转运机制的研究”, 20万元, 2009.10-2012.9 , 9251063201000006
P. I.: 国家自然科学基金, “化脓性链球菌中脂蛋白MtsA的铁离子结合特性”, 30万元, 2009.1-2011.12, 20871057
P. I.: 广州市科技攻关项目, “肺癌靶向治疗及个体化预后评估体系”, 20万元, 2007.10-2009.12 , 2007E3-E026
P. I.: 广州市科技攻关项目, “基于蛋白质组学技术的抑瘤蛋白AMP-18的药物开发”，20万元，2007.10-2009.12，2007Z3-E4021
P. I.: RGC Research Grant, “Functional and structural characterization of lipoprotein MtsA in MtsABC responsible for
transport of iron and other metal ions in Streptococcus pyogenes”, 港币1,460,957, 2005-2008, HKERGC,
HKU 7512/05M HK
P.I.: RGC Research Grant, “Molecular dynamics of iron transport”, 港币1,180,340, 2002-2005, HKRGC,
HKU 7227/02M HK
P.I.: Scientist Development Grant, “Iron transport regulated by HFE”, 美元260,000, 2002-2005,
American Heart Association, 0230369N, USA.
所授课程：
生物大分子化学Chemistry of Biomolecules, Chem 204 & Biochem 320
蛋白质生物化学Protein Biochemistry
功能蛋白质研究
社会职务：
暨南大学生命科学技术学院 副院长
基因工程药物国家工程研究中心 副主任
美国生物化学与分子生物学会（American Society for Biochemistry and Molecular Biology）会员；
英国皇家化学会(Royal Society of Chemistry)资深会员(Fellow, FRSC)；
香港蛋白质组学学会（Hong Kong Proteomics Society）创会秘书长；
Journal of Integrated OMICS, Associated Editor (http://sing.ei.uvigo.es/ojs/index.php/jio/about/displayMembership/3);
JBC, MCP, JPR, Proteomics等20种国际学术期刊审稿人
荣誉与奖励：
“****” 特聘教授，2007，国家教育部
“新世纪百千万人才工程” 国家级人选, 2006, 人事部科技部等七部委
Scientist Development Grant Award, 2002-2005, American Heart Association, 美国.
Who's Who in America, 55th & 56th Edition (2001, 2002), Marquis Who’s Who, 美国
Daiwa Adrian Prize, 1996, The Daiwa Anglo-Japanese Foundation, 英国
Who's Who in the World®， 25th Silver Anniversary Edition （2007）， Marquis' Who's Who in the World，美国
简介：
1981-1988年在暨南大学学习并获化学学士和硕士学位，1992-1995年在英国谢菲尔德大学(University of Sheffield)学习并获生物化学博士学位；曾任英国牛津大学(University of Oxford)访问学者(1992)，美国佛蒙特大学(University of Vermont)博士后及研究助理教授(1996-2002)和香港大学助理教授(2002-2006)； 2006年回国内后被国家人事部、科技部等七部委评为“新世纪百千万人才工程”国家级人选；2007年入选“****”特聘教授。现任暨南大学生命与健康工程研究院院长，教授，博士生导师；兼任暨南大学生命科学技术学院副院长及基因药物国家工程研究中心副主任。
近年来一直致力于生物化学和功能蛋白质组学领域的研究工作，在生物体中含铁蛋白介导的铁转运分子机制和人类疾病相关的蛋白质组学及抗肿瘤药物的作用机理等领域进行了深入系统的研究。相关科研成果获得美国国家癌症研究院（NCI）及美国NewsRX的专文评介。在国际期刊上发表SCI论文110余篇，平均影响因子>4, 被引用>1500次（截至2009年12月）。近年来主持及参与国家自然科学基金，美国NIH和香港政府RGC基金项目12项，经费共627万元港币，211万美元。以第一发明人身份获得美国发明专利2项，参编美国著作4部。
获得英国Daiwa Adrian Prize (The Daiwa Anglo-Japanese Foundation, 1996) 及美国心脏学会奖Scientist Development Grant Award (American Heart Association, 2002)。是新加坡卫生部科研基金的常任评审人；Journal of Integrated OMICS的副编辑(Associated Editor)及20种国际化学和生物化学杂志的审稿人。 是美国ASBMB会员, 英国皇家化学会高级会员(Fellow, FRSC)，香港蛋白质组学学会创会秘书长, 中国蛋白质组学专业委员会委员。