张伟 副研究员简介

张伟，男， 1976年出生，博士学位。2000年毕业于北京大学医学部临床
医学七年制，获得本科及硕士学位。2004年至2008年就读于香港科技大学生物
化学系，获得生物化学博士学位。毕业后在香港科技大学生物化学系从事博士后
工作。2009年9月入职暨南大学，获聘为副研究员。





近五年代表性论文
1. Wan J., Zhang W., Wu L., Bai T., Zhang M., Lo KW., Chui YL., Cui Y., Tao Q., Yamamoto M., Akira S. and Wu Z. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. Mol Cell Biol. 2006; 26(2): 448-56. （共同第一作者；2009年影响因子6.057）
2. Zhang, W., Chan, H.M., Gao, Y., Poon, R. and Wu, Z. BS69 is involved in cellular senescence through the p53-p21Cip1 pathway. EMBO Reports 2007; 8: 952-8. （第一作者；2009年影响因子6.907）
3. Sun, L., Ma, K., Wang, H., Xiao, F., Gao, Y., Zhang, W., Wang, K., Gao, X., Ip, N., and Wu, Z. JAK1/STAT1/STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J. Cell Biol. 2007; 179: 129-138. （2009年影响因子9.575）
4. Yu, B., Shao, Y., Zhang, J., Dong, X. L., Liu, W. L., Yang, H., Liu, L., Li, M. H., Yue, C. F., Fang, Z. Y., Zhang, C., Hu, X. P., Chen, B. C., Wu, Q., Chen, Y. W., Zhang, W. and Wan, J. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. Br J Dermatol. 2010; 162(5):1038-43.（共同通讯作者，2009年影响因子4.26）
5. Yu B, Shao Y, Li P, Zhang J, Zhong Q, Yang H, Hu X, Chen B, Peng X, Wu Q, Chen Y, Guan M, Wan J, Zhang W. Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus. Br J Dermatol. 2010; 163(5): 935-940.（通讯作者，2009年影响因子4.26）
6. Yu, B., Shao, Y., Zhang, C., Chen, Y., Zhong, Q., Zhang, J., Yang, H., Zhang, W. and Wan, J. BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation. Exp Cell Res. 2009; 315(20): 3543-53. （共同通讯作者，2009年影响因子3.589）
7. Yu B, Wu Q, Chen Y, Li P, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Zhang W, Wan J. Polymorphisms of PXK are associated with autoantibody production, but not disease risk, of systemic lupus erythematosus in Chinese mainland population. Lupus. 2010 Sep 9.（共同通讯作者）
8. Yu B, Chen Y, Wu Q, Li P, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Wan J, Zhang W. The association between single-nucleotide polymorphisms of NCF2 and systemic lupus erythematosus in Chinese mainland population. Clin Rheumatol. 2010 Sep 15.（通讯作者）
9. Li, Z., Zhang, W., Shao, Y., Zhang, C., Wu, Q., Yang, H., Wan, X., Zhang, J., Guan, M., Wan, J. and Yu, B. High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers. Med Oncol. 2010; 27(3):998-1004（共同第一作者）
10. Zhang, C., Shao, Y., Zhang, W., Wu, Q., Yang, H., Zhong, Q., Zhang, J., Guan, M., Yu, B. and Wan, J. High-resolution melting analysis of ADAMTS9 methylation levels in gastric, colorectal, and pancreatic cancers. Cancer Genet Cytogenet. 2010; 196(1):38-44.
11. Zhang, W., Li, T., Shao, Y., Zhang, C., Wu, Q., Yang, H., Zhang, J., Guan, M., Yu, B. and Wan, J. Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis. J Cancer Res Clin Oncol. 2010; 136(8):1267-73.（第一作者）
12. Yu, B., Yang, H., Zhang, C., Wu, Q., Shao, Y., Zhang, J., Guan, M., Wan, J. and Zhang, W. High-resolution melting analysis of PCDH10 methylation levels in gastric, colorectal and pancreatic cancers. Neoplasma. 2010; 57(3): 247-52.（通讯作者）
13. Shao Y, Zhang W, Zhang C, Wu Q, Yang H, Zhang J, Guan M, Wan J, Yu B. High-resolution melting analysis of BLU methylation levels in gastric, colorectal, and pancreatic cancers. Cancer Invest. 2010; 28(6):642-8.（共同第一作者）
14. Yang, H., Zhang, C., Zhao, X., Wu, Q., Fu, X., Yu, B., Shao, Y., Guan, M., Zhang, W., Wan, J. and Huang, X. Analysis of copy number variations of BS69 in multiple types of hematological malignancies. Ann Hematol. 2010; 89(10): 959-64.
15. Fang Z, Xiong Y, Li J, Liu L, Li M, Zhang C, Zhang W, Wan J. Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression. Med Oncol. 2010 Jun 29.

近五年承担的主要教学、科研项目
1. 主持项目：JAK/STAT信号途径在肌肉损伤修复中的作用研究，广东省自然科学基金博士启动项目。
2. 参与项目：一叶萩型生物碱抑制NMDA受体活性的立体选择性研究，国家自然科学基金青年基金项目。

联系电话：
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