李熙灿 职称/职位：教授，中药学硕士研究生导师、博士研究生导师，1970年1月出生，湖南桂阳县人，汉族 。



教育、工作经历
1987/9–1991/7，湖南师范大学，化学，学士
1994/9–1997/7，华南师范大学，天然有机化学，硕士
科研与学术工作经历：
1997/8-至今，广州中医药大学中药学院，历任助教、讲师、副教授、教授

研究方向
（1）中药保健品的抗氧化机制；（2）中药抗氧化化学

科研及教学课题
①主持：国家自然科学基金面上项目“新型白术内酯促骨髓间充质干细胞向软骨分化的网络共激活机制”（**），研究周期：2016-2019。
②主持：广东省省级科技计划项目/前沿与关键技术创新/粤港联合创新领域“基于干细胞技术辨析防治骨病的中药有效成分”（2017A），研究周期：2017-2019。
③共同主持：广东省科技发展专项资金（基础与应用基础研究）团队项目“中药小分子调控iPSCs成软骨分化的网络共激活机制”（2017A），研究周期：2017-2021。
④主持：全国中医药行业高等教育“十三五”规划教材《有机化学》数字化教学改革，(GJYJS16065)，立项日期2016-2019。


承担课程
有机化学（含实验）

代表性成绩
广州中医药大学讲课比赛一等奖（2008） 广州中医药大学“学生心目中的好老师”（2008） 研究生培养：共培养博士研究生1名，硕士研究生17名。其中，国家奖学金10人次；省优秀研究生1人；科技创新奖3人。

代表性论文论著
截至2021年2月，共发表SCI论文65篇，总影响因子约160，H=23.
[1] Xican Li*. Solvent Effects and Improvements in the Deoxyribose Degradation Assay for Hydroxyl Radical-scavenging. Food Chemistry, 2013, 141, 2083-2088.
[2] Xican Li*. Improved Pyrogallol Autoxidation Method: A Reliable and Cheap Superoxide-scavenging Assay Suitable for All Antioxidants. Journal of Agricultural and Food Chemistry, 2012, 60:6418-6424.
[3] Xican Li*, #, Yaoxiang Gao#, Fei Li, Aifeng Liang, Zhiming Xu, Ye Bai, Wenqiong Mai, Lu Han, Dongfeng Chen*. Maclurin Protects against Hydroxyl Radical-induced Damages to Mesenchymal Stem Cells: Antioxidant Evaluation and Mechanistic Insight, Chemico-Biological Interactions, 2014, 219, 221-228.
[4] Xican Li*, Wengqiong Mai, Li Wang, Weijuan Han. A Hydroxyl-scavenging Assay Based on DNA Damage in vitro. Analytical Biochemistry, 2013, 438(1):29-31.
[5] Xican Li#, Gang Wei#, Xiaozhen Wang, Dong-Hui Liu*, Ru-Dong Deng, Hui Li, Jian-Hong Zhou, Yi-Wei Li, He-Ping Zeng, Dong-Feng Chen*. Targeting of the Shh Pathway by Atractylenolides promotes chondrogenic differentiation of mesenchymal stem Cells. Biological & Pharmaceutical Bulletin. 2012; 35:1328-1335.
[6] Xican Li*, #, Jing Lin#, Yaoxiang Gao, Weijuang Han, Dongfeng Chen*. Antioxidant activity and mechanism of RhizomaCimicifugae. Chemistry Central Journal. 2012; 6:140.
[7] Xican Li*, #, Qiuping Hu#, Shuxia Jiang, Fei Li, Jian Lin, Lu Han, Yuling Hong, Wenbiao Lu, Yaoxiang Gao, Dongfeng Chen. FlosChrysanthemiIndici Protects against Hydroxyl-induced Damages to DNA and MSCs via Antioxidant Mechanism: A Chemistry Study. Journal of Saudi Chemical Society, Journal of Saudi Chemical Society (2015) 19, 454–460.
[8] Xican Li*, #, Jian Lin#, Weijuang Han, Wenqiong Mai, Li Wang, Qiang Li, Dongfeng Chen*. Antioxidant Ability and Mechanism of RhizomaAtractylodesmacrocephala, Molecules. 2012; 17:13457-13472.
[9] Xican Li*, Xiaoting Wu, Ling Huang. Correlation Between Antioxidant Activities and Phenolic Contents of Radix AngelicaeSinensis (Danggui), Molecules, 2009, 14: 5349-5361.
[10] Xican Li*, Lu Han, Yunrong Li, Jing Zhang, Jiemin Chen, Wenbiao Lu, XiaojunZhao, Yingtao Lai, Dongfeng Chen, Gang Wei*. Protective Effect of Sinapine against Hydroxyl Radical-Induced Damage to Mesenchymal Stem Cells and Possible Mechanisms, Chem. Pharm. Bull. 2016, 64: 319–325.
[11] Xican Li, Dongfeng Chen*, Ying Mai, Bi Wen, Xiaozhen Wang. Concordance between antioxidant activities in vitro and chemical components of Radix Astragali (Huangqi), Natural Product Research, 2012; 26:1050-1053.
[12] Xican Li*, #, Yaoxiang Gao#, Weijuan Han, Jing Lin, Qiuping Hu, Dongfeng Chen*. Antioxidant activity and its mechanism for flower of HylocereusUndatus (Haw. ) Britt. et Rose. Acta BiologicaCracoviensia: Series Botanica 2013, 55:80-85.
[13] Xican Li*, Weijuan Han, Wengqiong Mai, Li Wang. Antioxidant Activity and Mechanism of Tetrahydroamentoflavone in vitro. Natural Product Communications, 2013, 8, 787-789.
[14] Lu Han#, Chengjie Sun#, Jian Lin, Zisheng Wu, Ye Bai, Fei Li, Xican Li*, Wenqiong Mai, Dongfeng Chen*. HerbaEcliptae Protects against Hydroxyl Radical-induced Damages to DNA and Mesenchymal Stem Cells via Antioxidant Mechanism, Journal of the Chinese Chemical Society, 2014, 61(10), 1161-1167.
[15] Xican Li*, #, Qian Fang#, Jing Lin, Zhengpeng Yuan, Lu Han, Yaoxiang Gao. Chemistry Study on Protective Effect against ?OH-induced DNA Damage and Antioxidant Mechanism of Cortex Magnoliae Officinalis, Bulletin of the Korean Chemical Society, 2014, 35:117-122.
[16] Xican Li*, #, Wenqiong Mai#, Dongfeng Chen*. Chemical study on protective effect against hydroxyl-induced DNA damage and antioxidant mechanism of myricitrin, Journal of the Chinese Chemical Society, 2014, 61: 383-391.
[17] Xican Li*, Jing Lin, Yaoxiang Gao, Ruimin Tian, Dongfeng Chen*. Nitric Oxide (NO) as Antioxidant Protects HT22 Cells and Biomolecules against Fenton’s Reagent-Induced Damages via Multiple Pathways. ChemistrySelect. 2016, 3, 585-589.
[18] Xican Li*, #, Li Wang#, Weijuan Han, Wenqiong Mai, Lu Han, Dongfeng Chen. Amentoflavone Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism, Turkish Journal of Biochemistry, 2014; 39, 30-36.
[19] Jian Lin#, Xican Li*, #, Lu Han, Fei Li, Wenbiao Lu, Ye Bai, Dongfeng Chen*. Folium Sennae Protects against Hydroxyl Radical-induced DNA Damage via Antioxidant Mechanism: An in vitro Study, Botanical studies. 2014; 55:16.
[20] Jing Lin#, Xican Li*, #, Li Chen, Weizhao Lu, Xianwen Chen, Lu Han, Dongfeng Chen*. Protective effect against hydroxyl radical-induced DNA damage and antioxidant mechanism of [6]-gingerol: A Chemical Study. Bulletin of the Korean Chemical Society, 2014, 35(6), 1633-1638.
[21] Xiaozhen Wang, Xican Li*, Dongfeng Chen. Evaluation of Antioxidant Activity of Isoferulic Acid in vitro, Natural Product Communications. 2011, 6, 1285-1288.
[22] Dong-Feng Chen*, Xican Li, Zhiwei Xu, Xiaobing Liu, Shao-Hui Du, Hui Li, Jian-Hong Zhou, He-Ping Zeng, Zi-Chun Hua. Hexadecanoic Acid from BuzhongYiqi Decoction Induces Proliferation of Bone Marrow Mesenchymal Stem Cells. Journal of Medicinal Food. 2010. 8, 13, 967- 970.
[23] 王光荣, 李熙灿, 曾和平*. (E)-N-芳基-3-[2-(8-羟基喹啉基)-乙烯基]咔唑的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究. 化学学报, 2009, 67：974-982.
[24] Ting-Ting Wang, Gong-Chang Zeng, Xi-Can Li, He-Ping Zeng*. In vitro studies on the antioxidant and protective effect of 2-substituted- 8-hydroxyquinoline derivatives against H₂O₂-Induced oxidative stress in BMSCs. Chemical Biological Drug Design, 2010, 75(2): 214–222.
[25] Xican Li*, Jingjing Liu, Jian Lin, Tingting Wang, Jieyuan Huang, Yongqiang Lin, Dongfeng Chen*. Protective Effects of Dihydromyricetin against OH-Induced Mesenchymal Stem Cells Damage and Mechanistic Chemistry, Molecules 2016, 21, 604; doi:10. 3390/molecules**.
[26] Xican Li#, Jingjing Liu#, Zhong-xiang Zhao*, Tingting Wang, Jian Lin, and Dongfeng Chen*. Effects of Natural ChalconeTannin Hybrids Protecting Mesenchymal Stem Cells against ROS-mediated Oxidative Damage and Indexes for Antioxidant Mechanisms, Chemistry Letters, 2016, 45(7), 743-745.
[27] Xican Li*, Qian Jiang, Tingting Wang, Jingjing Liu, Dongfeng Chen*. Comparison of the Antioxidant Effects of Quercitrin and Isoquercitrin: Understanding the Role of the 6″-OH Group. Molecules 2016, 21, 1246.
[28] Tingting Wang, Xican Li*, Yunrong Li, Jianrun Wu, Yuyin Huang, Gang Wei, Dongfeng Chen. Mechanistic Chemistry of Extraordinary Capacity of Salvianolic Acid B on Oxidatively-Damaged Mesenchymal Stem Cells. J. Chin. Chem. Soc. 2016, 63(11), 924-929.
[29] Jingjing Liu, Xican Li*, Jian Lin, Yunrong Li, Tingting Wang, Qian Jiang, Dongfeng Chen*. Sarcandra glabra (Caoshanhu) Protects Mesenchymal Stem Cells from Oxidative Stress: A Bioevaluation and Mechanistic Chemistry, BMC Complementary and Alternative Medicine, 2016, 16:423.
[30] Qian Jiang, Xican Li*, Yage Tian, Qiaoqi Lin, Hong Xie, Wenbiao Lu, Yuguang Chi, Dongfeng Chen*. Lyophilized aqueous extracts of Mori Fructus and Mori Ramulus protect Mesenchymal stem cells from ?OH–treated damage: bioassay and antioxidant mechanism. BMC Complementary and Alternative Medicine, 2017, 17:242.
[31]Xican Li*, Tingting Wang, Jingjing Liu, Yulong Liu, Jun Zhang, Jian Lin, Zhongxiang Zhao, Dongfeng Chen*. Effect and mechanism of wedelolactone as antioxidant-coumestan on OH-treated mesenchymal stem cells. Arabian Journal of Chemistry , 2017.
[32]Xican Li*, Yage Tian, Tingting Wang, Qiaoqi Lin, Xiaoyi Feng, Qian Jiang, Yamei Liu, Dongfeng Chen*. Role of the p-Coumaroyl Moiety in the Antioxidant and Cytoprotective Effects of Flavonoid Glycosides: Comparison of Astragalin and Tiliroside. Molecules 2017, 22, 1165; doi:10. 3390/molecules**.
[33] Xican Li*. 2-Phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO?) Radical-scavenging: A New and Simple Antioxidant. Journal of Agricultural & Food Chemistry. 2017, 65, 6288?6297.
[34]Yulu Xie#, Xican Li*, #, Jieying Xu, Qian Jiang, Hong Xie, Jianfeng He, Dongfeng Chen*. Two phenolic antioxidants in (Suoyang) enhance viability of ?OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry. Chemistry Central Journal, 2017, 11 (1) :84.
[35] Xican Li*, #, Hong Xie#, Qian Jiang, Gang Wei, Lishan Lin, Changying Li, Xingmei Ou, Lichan Yang, YuluXie, Zhen Fu, Yamei Liu, Dongfeng Chen*. The mechanism of (+) taxifolin’s protective antioxidant effect for ?OH-treated bone marrow-derived mesenchymal stem cells, Cellular & Molecular Biology Letters, 2017, 22:31.
[36]Xican Li*, #, Ke Li#, Hong Xie, YuluXie, Yueying Li, Xiaojun Zhao, Xiaohua Jiang, Dongfeng Chen*. Antioxidant and Cytoprotective Effects of the Di-O-caffeoylquinic Acid Family: The Mechanism, Structure–Activity Relationship, and Conformational Effect. Molecules 2018, 23, 222.
[37] Yage Tian#, Xican Li*, #, Hong Xie, Xiaozhen Wang, YuluXie, Chuanbing Chen, Dongfeng Chen*. Mechanism of the Antioxidant Baicalein toward Hydroxyl Radical-Treated Bone Marrow-Derived Mesenchymal Stem Cells. Molecules 2018, 23, 223.
[38] Hong Xie#, Xican Li*, #, Zhenxing Ren, WeiminQiu, Jianlan Chen, Qian Jiang, Ban Chen, Dongfeng Chen*. Antioxidant and Cytoprotective Effects of Tibetan Tea and its Phenolic Components. Molecules 2018, 23, 179.
[39] Xican Li*, #, YuluXie#, Ke Li, Aizhi Wu*, Hong Xie, Qian Guo, PenghuiXue, YerkingulMaleshibek, Wei Zhao, Jiasong Guo, Dongfeng Chen. Antioxidation and Cytoprotection of Acteoside and Its Derivatives: Comparison and Mechanistic Chemistry. Molecules 2018, 23, 498.
[40] Xican Li*, #, YuluXie#, Hong Xie, Jian Yang, Dongfeng Chen*. π -π Conjugation Enhances Oligostilbene’s Antioxidant Capacity: Evidence from α-Viniferin and Caraphenol A. Molecules, 2018, 23(3), 694.
[41]Xican Li*, #, Hong Xie#, Ruicai Zhan, Dongfeng Chen*. Effect of Double Bond Position on 2-Phenyl-benzofuran Antioxidants: A Comparative Study of Moracin C and iso-Moracin C. Molecules, 2018, 23(4), 754.
[42] Xican Li*, # , Jian Lin#, Ban Chen, Fei Li, Hong Xie, Dongfeng Chen*. Antioxidant and Cytoprotective Effects of Kukoamines A and B: Comparison and Positional Isomeric Effect. Molecules, 2018, 23(4), 973.
[43]Xican Li* , Ban Chen, Hong Xie, Yuhua He, Dewei Zhong, Dongfeng Chen*. Antioxidant Structure–Activity Relationship Analysis of Five Dihydrochalcones, Molecules, 2018, 23(5), 1162.
[44] Jian Lin, Xican Li*, Ban Chen, Gang Wei, Dongfeng Chen*. E-Configuration Improves Antioxidant and Cytoprotective Capacities of Resveratrols. Molecules, 2018, 23(7):1790.
[45]Xican Li*, Ban Chen, Xiaojun Zhao, Donfeng Chen. 2-Phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl 3-oxide Radical (PTIO?) Trapping Activity and Mechanisms of 16 Phenolic Xanthones. Molecules, 2018, 23, 1692.
[46] Fu Yuan Yang, Rui Chen, Xiaohu Zhang, Biao Huang, Lai Ling Tsang, Xican Li, Xiaohua Jiang*. Mesenchymal Stem Cells on Colitis Through PGE2-Mediated T-Cell Modulation. Cell Transplant. , 2018, 27(9): 1352-1367.
[47] Yulu Xie?, Xican Li*?, Jingyu Chen, Yuman Deng, Wenbiao Lu, Dongfeng Chen*. pH Effect and Chemical Mechanisms of Antioxidant Higenamine. Molecules, 2018, 23(9):2176.
[48] Xican Li*, Qian Jiang, Ban Chen, Xiaoling Luo, Dongfeng Chen*. Structure-activity Relationship and Prediction of Electron-transfer Potential of Xanthones Series. ChemistryOpen, 2018, 7(9): 730-736.
[49] Xican Li*?, Zhenxing Ren?, Zimei Wu, Zhen Fu, Hong Xie, Langyu Deng, Xiaohua Jiang, Dongfeng Chen*. Sanggenons C and D as Antioxidant Diels-Alder-Type Adducts Protecting Mesenchymal Stem Cells from Oxidative Stress: Evidence of the Steric Effect. Molecules, 2018, 23(10):2610.
[50] Qianru Liu?, Xican Li?*, Xiaojian Ouyang, Dongfeng Chen*. Dual Effect of Glucuronidation of a Pyrogallol-type Phytophenol Antioxidant: A Comparison between Scutellarein and Scutellarin. Molecules, 2018, 23(12):3225.
[51] Xiaojian Ouyang?, Xican Li?*, Wenbiao Lu, Xiaojun Zhao, Dongfeng Chen*. Null B-Ring Improves the Antioxidant Levels of Flavonol: A Comparative Study between Galangin and 3, 5, 7-Trihydroxychromone. Molecules, 2018, 23(12):3083.
[52] Minshi Liang?, Xican Li?*, Xiaojian Ouyang, Hong Xie, Dongfeng Chen*. Antioxidant Mechanisms of Echinatin and Licochalcone A. Molecules, 2019, 24(1):3.
[53] Xican Li* (Sole author). Comparative Study of 1, 1-Diphenyl-2-picryl-hydrazyl Radical (DPPH^?) Scavenging Capacity of the Antioxidant Xanthones Family. ChemistrySelect, 2018, 3(46):13081-13086.
[54] Rongxin Cai*, Xican Li*, Ban Chen, YuluXie, Hong Xie, Dongfeng Chen. Antioxidant Change in Biosynthesis from Naringenin Chalcone to Flavonoid Apingenin. Chemistry Select, 2019, 4(17):5155-5159.
[55]Xican Li*, Xiaojian Ouyang, Rongxin Cai, Dongfeng Chen*. 3’, 8”-Dimerization Enhances the Antioxidant Capacity of Flavonoids: Evidence from Acacetin and Isoginkgetin. 2019, Molecules.
[56] Xican Li *, ?, Xiaojian Ouyang?, Minshi Liang， Dongfeng Chen*. Comparative Analysis of Radical Adduct Formation (RAF) Products and Antioxidant Pathways between Myricetin-3-O-Galactoside and Myricetin Aglycone. Molecules, 2019, 24(15):2769.
[57] Biao Huang, Bin Wang, Wayne Yuk-Wai Lee, Kin Pong U, Kam Tong Leung, Xican Li, Zhenqing Liu, Rui Chen, Jiacheng Lin, Lai Ling Tsang, Baohua Liu, Yechun Ruan, Hsiao Chang Chan, Gang Li, Xiaohua Jiang*. KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization. iScience, 2019, 21: 375-390.
[58] Xican Li*, Tingting Wang, Jingjing Liu, Yulong Liu, Jun Zhang，Jian Lin, Zhongxiang Zhao, Dongfeng Chen*. Effect and mechanism of wedelolactone as antioxidant-coumestan on ^?OH -treated mesenchymal stem cells. Arabian Journal of Chemistry, 2020, 13(1):184-192.
[59] Li X*, Zeng J, Liu Y, Liang M, Liu Q, Li Z, Zhao X, Chen, D*. Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-Alder anti-Dimer on Erastin-Induced Ferroptosis in Bone Marrow-Derived Mesenchymal Stem Cells. Antioxidants 2020, 9(3), 205.
[60] Liu J, Li X*, Cai R, Ren Z, Zhang A, Deng F, Chen D*. Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and (S)-Butin. Molecules 2020, 25(3), 674.
[61] Ouyang Xiaojian, Li Xican*, Liu Jie, Liu Yangping, Xie Yulu, Du Zhongcun, Xie Hong, Chen Ban, Lu Wenbiao, Chen Dongfeng. Structure-activity Relationship and Mechanism of Four Monostilbenes with Respect to Ferroptosis Inhibition. RSC Advances, 2020, 10(52):31171-31179.
[62] Li Xican*, Liu Jie, Chen Ban, Chen Yingci, Dai Wanjian, Li Yuling, Zhu Meiling. Covalent Bridging of Corilagin Improves Antiferroptosis Activity: Comparison with 1, 3, 6-Tri- O-galloyl-β-d-glucopyranose. 2020, 11(11):2232-2237.
[63]Yangping Liu, Xican Li*, Yujie Hua, Wenhui Zhang, Xianxi Zhou, Jianfeng He, Dongfeng Chen*. Tannic Acid as a Natural Ferroptosis Inhibitor: Mechanisms and Beneficial Role of 3’-O-Galloylation. ChemistrySelect. doi. org/10. 1002/slct. **.
[64] Ban Chen, Xican Li, * Jie Liu, Yuling Li, Wanjian Dai, Yingci Chen, Dongfeng Chen*. Ferroptosis-Inhibitory Effect and Possible Mechanisms of Ellagitannin Geraniin. ChemistryOpen，doi. org/10. 1002/open. .
[65] Ban Chen, Xican Li*, Xiaojian Ouyang, Jie Liu, Yangping Liu, Dongfeng Chen*. Comparison of Ferroptosis-inhibitory Mechanisms between Ferrostatin-1 and Dietary Stilbenes (Piceatannol and Astringin). Molecules. 2021，26(4), 1092.