吴杰伟
学位： 博士
职称： 副研究员




教育、工作经历

2017/9-至今 广州中医药大学 中药学院 副研究员
2015/07-2017/09 中国科学院华南植物园 博士后 导师：邱声祥
2010/09-2015/07 中国科学院上海药物研究所 博士 导师：叶阳
2005/09-2009/07 广东药科大学 药学 学士 导师：申东升


研究领域及方向

植物药源分子的发现


代表性科研及教学课题

1.国家自然基金青年科学基金项目，**，LC-MS导向分离米碎花中酚酸苷和酯类化合物及其基于PI3K/Akt信号通路的抗肝纤维化活性探讨，2020/01-2022/12，20万元，在研，主持
2.中科院上海药物研究所新药研究国家重点实验室开放课题，SIMM1803KF-09，串钱柳间苯三酚类成分的分离鉴定及其抗MRSA活性机理研究，2018/04-2019/03，8 万元，已结题，主持
3.中国博士后面上项目，2015M582436，串钱柳抗MRSA活性成分的发现和机理研究， 2015/11-2017/09，5 万元，已结题，主持


承担的课程

主要承担《岭南特色中药综合开发与应用》、《中药现代化关键技术》等课程。


代表性研究论文



1. Jiewei Wu, Chunping Tang, Lan Chen, Yan Qiao, Meiyu Geng, Yang Ye*. Dicarabrones A and B, a Pair of New Epimers Dimerized from Sesquiterpene Lactones via a [3 + 2] Cycloaddition from Carpesium abrotanoides. Org. Lett. 2015, 17, 1656-1659.
2. Jiewei Wu, Chunping Tang, Sheng Yao, Lei Zhang, Changqiang Ke, Linyin Feng, Ge Lin, Yang Ye*. Anti-inflammatory inositol derivatives from the whole plant of Inula cappa, J. Nat. Prod. 2015, 78, 2332–2338.
3. Jiewei Wu, Chunping Tang, Yaoyao Cai, Changqiang Ke, Ligen Lin, Sheng Yao, Yang Ye*. Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa. Chinese Chem. Lett. 2017, 28, 927-930.
4. Jiewei Wu, Chunping Tang, Changqiang Ke, Sheng Yao, Ligen Lin, Yang Ye*. Dicarabrol A, dicarabrone C and dipulchellin A, unique sesquiterpene lactone dimers from Carpesium abrotanoides. RSC Adv. 2017, 7, 4639–4644.
5. Jialing Song#, Bailin Li#, Yao Yuan, Linghui Nie, Jia Niu, Zhifang Xu, Jiewei Wu*, Shengxiang Qiu*. Yangonindimers A-C, three new kavalactone dimers from Piper methysticum (kava). Nat. Prod. Res. 2017, 31, 2459–2466.
6. Jialing Song, Yao Yuan, Linghui Nie, Bailin Li, Xubing Qin, Yan Li, Jiewei Wu*, Shengxiang Qiu*. A new ent-kaurane diterpene derivative from the stems of Eurya chinensis R.Br. Nat. Prod. Res. 2018, 32, 182-188.
7. Yao Yuan, Jianxiang Yang, Linghui Nie, Bailin Li, Xubing Qin, Jiewei Wu*, Shengxiang Qiu*. Three new kavalactone dimers from Piper methysticum (kava). J. Asian Nat. Prod. Res. 2018, 20(9), 837-843.
8. Jialing Song, Yao Yuan, Linghui Nie, Bailin Li, Xubing Qin, Yan Li, Jiewei Wu*, Shengxiang Qiu*. Two new ent-kaurane diterpenes from the stems of Eurya chinensis. J. Asian Nat. Prod. Res. 2018, 20(10), 962-968.
9. Yao Yuan#, Jiewei Wu#, Bailin Li, Jia Niu, Haibo Tan*, Shengxiang Qiu*. Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells. Sci. Rep. 2018, 8, 992.
10. Jiewei Wu, Bailin Li, Chunping Tang, Changqiang Ke, Nanlin Zhu, Shengxiang Qiu*, Yang Ye*. Callistemonols A and B, Potent Antimicrobial Acylphloroglucinol Derivatives with Unusual Carbon Skeletons from Callistemon viminalis. J. Nat. Prod. 2019, 82(7), 1917-1922.
11. Yunong Tian, Bailin Li, Juanjuan Hu, Jindan Xie, Wenjing Xiao, Linghui Nie, Jiewei Wu*. Rosanortriterpenes A–B, two new nortriterpenes from the fruits of Rosa laevigata var. leiocapus. Nat. Prod. Res. 2019, Accepted.
12. Yunong Tian, Lu Feng, Bailin Li, Juanjuan Hu, Jindan Xie, Wenjing Xiao, Linghui Nie, Jiewei Wu*. Rosanortriterpene C, a 3,24-dinor-2,4-seco-ursane triterpene from the fruits of Rosa laevigata var. leiocapus. Chem. Pharm. Bull. 2019, 67(11), 1255-1258.
13. Jiewei Wu, Bailin Li, Wenjing Xiao, Juanjuan Hu, Jindan Xie, Jie Yuan, Lingli Wang. Longistylin A, a natural stilbene isolated from the leaves of Cajanus cajan, exhibits significant anti-MRSA activity. Int. J. Antimicrob. Agents. 2020, 55(1), 105821.