王晓玲，博士，广州医科大学“南山****”，广州医科大学生命科学学院生物技术系教授。2000年毕业于武汉大学病毒系获得硕士学位，2008年在美国纽约州立大学布法罗分校获得药理学博士学位，2008年于加利福尼亚大学旧金山分校进行干细胞方向博士后研究。2011年在洛杉矶City of Hope肿瘤研究中心进行细胞工程和基因编辑方向的研究。期间在国际核心刊物，包括Nature Biotechnology等，发表多篇第一作者文章。2014年初于美国Intrexon公司和香雪制药从事细胞治疗相关研发工作，有丰富的基因编辑和细胞治疗领域研究经验。目前研究兴趣是RNA编辑和细胞免疫治疗实体瘤的靶点和机制研究。实验室座落在广州医科大学番禹校区。希望有分子、细胞或者生物化学相关实验经验的学生加入。

招生条件：招收全日制高校本科毕业，招生专业为生物化学与分子生物学。
邮件：wangxiaoling@gzhmu.edu.cn
主要代表成果：
Xiaoling Wang, Youjun Yu，Jiing-Kuan Yee. Detection of CRISPR/Cas9-Generated Off-Target Effect by Integration-Defective Lentiviral Vector. CRISPR Guide RNA Design. Methods in Molecular Biology, 2021 vol 2162. https://doi.org/10.1007/978-1-0716-0687-2_14
Xiaoling Wang, Yebo Wang, Xiwei Wu, Jinhui Wang, Zhaojun Qiu, Tammy Chang, Ren-Jang Lin and Jiing-Kuan Yee. Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs usingintegrase-defective lentiviral vectors.Nature Biotechnology. 2015 Feb; 33(2):175-8（132）
Chinnam M,Wang X, Zhang X, Goodrich DW. Evaluating effects of hypomorphic Thoc1 alleles on embryonic development in Rb1 null mice. 2016. Mol Cell Biol 36:1621–1627.（0）
Buyuan Chen，Xinji Chen, Xiwei Wu,Xiaoling Wang, Yingjia Wang, Ting-Yu Lin, Jessica Kurata, Jun Wu, Steven Vonderfecht, Guihua Sun, He Huang，Jiing-Kuan Yee, Jianda Hu，Ren-Jang.LinDisruption of microRNA-21 by TALEN leads to diminished cell transformation and increased expression of cell–environment interaction genes.Cancer Letter, 2015, 356:506-516.（6）
Xiaoling Wang,Xinji Chen, Yingjia Wang, Buyuan Chen, Ren-Jang Lin and Jiing-Kuan Yee.Precise gene modification mediated by TALEN and single-stranded oligodeoxynucleotides in human cells. Plos one, 2014,9(4):e93575（10）
Laura Pitzonka,Xiaoling Wang, Sumana Ullas, David W. Wolff, Yanqing Wang, and David W. Goodrich.The THO ribonucleoprotein complex is required for stem cell homeostasis in the mouse small intestine.Mol Cell Biol, 2013. 33(17):3505-3514.（5）
Xiaoling wang, Ji Wang, Rob Place, Vera Huang, and Long-Cheng Li. Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation. Biochemical Journal,2012, 443:821–828（24）
Robert F Place, Ji Wang, Emily J Noonan, Rachel Meyers, Muthiah Manoharan, Klaus Charisse, Rick Duncan, Vera Huang,Xiaoling Wangand Long-Cheng LiFormulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression.Molecular Therapy Nucleic Acids(2012)1, e15; doi:10.1038/mtna.2012.5（22）
Vera Huang, Yi Qin, Ji Wang,Xiaoling wang, Rob Place, and Long-Cheng Li. RNAa is conserved in mammalian cells. Plos One, 2010, 5(1): e8848（86）
Ji Wang, Rob Place, Vera Huang,Xiaoling wang,Emily J. Noonan,Clara E. Magyar,Jiaoti Huangand Long-Cheng Li. Prognostic Value and Function of KLF4 in Prostate Cancer: RNAa and Vector-Mediated Overexpression Identify KLF4 as an Inhibitor of Tumor Cell Growth and Migration . Cancer Res, 2010 70; 10182（71）
Xiaoling Wang, Meena Chinnam, Xiaojing Zhang, Yanqing Wang and David W. Goodrich.Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse. Mol Cell Biol, 2009. 29(10): 2794-803.（20）
Xiaoling Wang, Yanping Li, Xiaojing Zhang, and David W. Goodrich.An allelic series for studying the mouse Thoc1 gene.Genesis, 2007. 44: 32-37.
Yanping Li, Athena W. Lin, Xiaojing Zhang, Yanqing Wang,Xiaoling Wang, and David W. Goodrich.Cancer Cells and Normal Cells Differ in Their Requirements for Thoc1.Cancer Res, 2007. 67(14): 6657-64.（29）
Yanping Li, Athena W. Lin, Xiaojing Zhang, Yanqing Wang,Xiaoling Wang, and David W. Goodrich.Thoc1 as a potential molecular target for cancer therapy.Medicina-Buenos Aires, 2007 67:13-19.
Xiaoling Wang, Yanjie Chang, Yanping Li, Xiaojing Zhang, and David W. Goodrich.Thoc1/Hpr1/p84 is essential for early embryonic development 1 in the mouse. Mol Cell Biol, 2006. 26(11): 4362-4367（24）
Yangping Li,Xiaoling Wang, Xiaojing Zhang, and David W. Goodrich.Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Mol Cell Biol, 2005. 25(10): 4023-33.（40）
Ming Li, Peixin Cai, Liping Nie, Minghui Huang, Xiaomei Tao, Yuzhu Li,Xiaoling Wang, Zhu Xiang, Mingchun Wang and Mengsu Yang.Detection of thalassemia using ThalaChip.Chinese Journal of Hematology, 2003 24(10): 551-552.
Shayan Wang, Peixin Cai, Ruanzhang Zhang, Fangfang Li,Xiaoling Wang, Yong Dai and Mengsu Yang.Application of microarray in screening deletion mutation of α-thalassemia.Chinese Journal of Hematology, 2002 23(11): 603-604.Xiaoling Wang, Linbai, Ye, Jingrong Gao, Jinping Xu, Hui Zeng.Expression of a human TNF-α mutant in E.coli and measurement of its ability to induce apoptosis.Wuhan University Journal of Natural Sciences, 2001 Vol.47 No.2 P.200-204.