姓名：王涛
性别：男
职称：研究员
学历：博士
电话：
传真：
电子邮件:wang_tao@gibh.ac.cn
通讯地址广州市科学城开源大道190号

简历：

2017.3- Guangzhou Institutes of Biomedicine and Health PI
2015.4-2017.3 Yale University, Yale Stem Cell Center Associated Research Scientist
2012.6-2015.4 The University of North Carolina-Chapel Hill, Postdoctoral Associate
2010.7-2012.6 Guangzhou Institutes of Biomedicine and health, Research Scientist
2006.9-2010.7 Guangzhou Institutes of Biomedicine and health, Research Scientist, Ph.D student
2002.7-2005.9 NanKai University, Master Student
1998.7-2002.9 Yangtze University, Bachelor Student

研究领域：

We are interested in ageing biology、aging related diseases and stem cell regeneration. Cell aging (Cell Senescence) cause tissue dysfunction/degeneration. Cumulative researches uncovered distinct factors that can trigger senescence, such as telomere erosion、DNA damage、mitochondrial dysfunction and epigenetic alteration. One of our aims is to search for new proteins or factors maintaining genome integrity and stability, to this end, we perform whole genome wide screening and manipulate these factors to delay senescence even aging.
Emerging reports suggested that elimination of senescent cell in mouse can delay aging or restore tissue function in some extent. We are also exploiting vulnerabilities of senescent cell to identify novel pathways to selective killing of old cell.
Organoids culture and stem cell differentiation provide powerful tools to investigate human disease mechanisms, we want to combine organoid culture and gene editing to model aging related diseases with purpose of invention of cure methods.

承担科研项目情况：

社会任职：

获奖及荣誉：

代表论著：

1.Wu, T.P., T. Wang, M.G. Seetin, Y. Lai, S. Zhu, K. Lin, Y. Liu, S.D. Byrum, S.G. Mackintosh, M. Zhong, A. Tackett, G. Wang, L.S. Hon, G. Fang, J.A. Swenberg, and A.Z. Xiao. DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature. 2016. 532:329-333.
2.Esteban, M.A. *, Wang, T. *, Qin, B. *, Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., Chen, K., Li, Y., Liu, X., Xu, J., Zhang, S., Li, F., He, W., Labuda, K., Song, Y., Peterbauer, A., Wolbank, S., Redl, H., Zhong, M., Cai, D., Zeng, L., and Pei, D. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 2010. 6(1): 71-79. (*Contributed equally)
3.Wang, T., Chen, K., Zeng, X., Yang, J., Wu, Y., Shi, X., Qin, B., Zeng, L., Esteban, M.A., Pan, G., and Pei, D. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell, 2011. 9(6): 575-587.
4.Chen, J., Liu, H., Liu, J., Qi, J., Wei, B., Yang, J., Liang, H., Chen, Y., Wu, Y., Guo, L., Zhu, J., Zhao, X., Peng, T., Zhang, Y., Chen, S., Li, X., Li, D., Wang, T., and Pei, D. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2013. 45(1): 34-42.
5.Qin, D., Gan, Y., Shao, K., Wang, H., Li, W., Wang, T., He, W., Xu, J., Zhang, Y., Kou, Z., Zeng, L., Sheng, G., Esteban, M.A., Gao, S., and Pei, D. Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factors. J Biol Chem, 2008. 283(48): 33730-33735.
6.Zhang, X., Zhang, J., Wang, T., Esteban, M.A., and Pei, D. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J Biol Chem, 2008. 283(51): 35825-35833.
7.Pan, G., Wang, T., Yao, H., and Pei, D. Somatic cell reprogramming for regenerative medicine: SCNT vs. iPS cells. Bioessays, 2012. 34(6): 472-476.