朱强性别:
男
职务:
职称:
研究员
学历:
博士通讯地址:
广州市萝岗区科学城开源大道190号B区307
电话:
邮政编码:
510530
传真:
电子邮件:
zhu_qiang@gibh.ac.cn
简历：
- 1995,9~2000,6中国科学院上海有机化学研究所,有机化学，博士；
1991,9~1995,6南京大学化学化工学院,有机化学,本科。 - 2008,5~中国科学院广州生物医药和健康研究院；
2005,9~2008,2美国XTLBiopharmaceuticalsInc.研究员;
2001,4~2005,9美国Vivoquest,Inc.研究员;
2000,8~2001,4美国科罗拉多州立大学(CSU)化学系博士后。
研究领域：
- 抗肺癌、抗TB药物分子的设计和合成
- 多组分、多反应中心、串连反应等一步形成多个碳碳键或碳杂键的高效的杂环化合物合成方法研究；异腈参与的新反应；
- 组合化学；化合物库的建立；
- 青蒿素结构改造；抗肺癌活性化合物的结构优化。
社会任职：
获奖及荣誉：
代表论著：
- HonggenWang,YongWang,ChanglanPeng,JiancunZhang,*andQiangZhu*.ADirectIntramolecularC-HAminationReactionCocatalyzedbyCopper(II)andIron(III)asPartofanEfficientRoutefortheSynthesisofPyrido[1,2-a]benzimidazolesfromN-Aryl-2-aminopyridines.J.Am.Chem.Soc.2010,132,13217–13219
- JiajiZhao,ChanglanPeng,LanyingLiu,YongWang,andQiangZhu*.Synthesisof2-Alkoxy(aroxy)-3-substitutedQuinolinesbyDABCO-PromotedCyclizationofo-AlkynylarylIsocyanides.J.Org.Chem.2010,75,7502–7504
- HonggenWang,YongWang,DongdongLiang,LanyingLiu,JiancunZhang,*andQiangZhu*.Copper-CatalyzedIntramolecularDehydrogenativeAminooxygenation:DirectAccesstoFormyl-SubstitutedAromaticN-HeterocyclesAngew.Chem.Int.Ed.2011,50,5678–5681
- LijiecPeng,HonggenWang,ChanglanPeng,KeDing,*QiangZhu*.SequentialHydration–Condensation–DoubleCyclizationofPyridine-Substituted2-Alkynylanilines:AnEfficientApproachtoQuinoline-BasedHeterocycles.Synthesis2011,No.11,1723–1732
- QiangZhu,Li-XinQiao,YikangWu,andYu-LinWu*Radical-MediatedConstructionofCyclopentanewithConcurrentFormationofaWell-DefinedQuaternaryCenterJ.Org.Chem.1999,64,2428-2432.
- QiangZhu,Kai-YiFan,Hong-WeiMa,Li-XinQiao,Yu-LinWu,*andYikangWu*Radical-MediatedDiastereoselectiveConstructionofaChiralSynthonforSynthesisofDolabellanesOrganicLetters1999,1,757-759.
- QiangZhu,LixinQiao,YikangWu,andYu-LinWu*StudiestowardtheTotalSynthesisofClavulactoneJ.Org.Chem.2001,66,2692-2699.
- QiangZhu,MichaelO.Delaney,andMarcM.Greenberg*ObservationandEliminationofN-AcetylationofOligonucleotidesPreparedUsingFast-DeprotectionPhosphoramiditesandUltra-MildDeprotectionBioorganicandMedicinalChemistryLetters,2001,11,1105-1107.
- QiangZhu*,JieWu,RezaFathi,andZhenYang*PhenyliodoniumZwitterionasanEfficientElectrophileinthePalladium-CatalyzedSuzuki-typeReaction:aNovelMethodfortheSynthesisof3-Aryl-4-hydroxycoumarinsOrganicLetters2002,4,3333-3336.
- YongWang,ChanglanPeng,LanyingLiu,JiajiZhao,LiSu,andQiangZhu*Sulfuricacidpromotedcondensationcyclizationof2-(2-(trimethylsilyl)ethynyl)anilineswitharylaldehydesinalcoholicsolvents:anefficientone-potsynthesisof4-alkoxy-2-arylquinolinesTetrahedronLetters2009,50,2261-2265.
- LanyingLiu,YongWang,HonggenWang,ChanglanPeng,JiajiZhao,andQiangZhu*Tetrabutylammoniumchloride-triggered6-endocyclizationofo-alkynylisocyanobenzenes:anefficientsynthesisof2-chloro-3-substitutedquinolinesTetrahedronLetters2009,50,6715-6719.
- HonggenWang,LanyingLiu,YongWang,ChanglanPeng,JiancunZhang*,andQiangZhu*Anefficientsynthesisof4-alkyl-2(1H)-quinazolinonesand4-alkyl-2-chloroquinazolinesfrom1-(2-alkynylphenyl)ureasTetrahedronLetters2009,50,6841-6843.
- YongWang,HongLu,QiangZhu*,ShiboJiang*,andYunLiao*Structure-baseddesign,synthesisandbiologicalevaluationofnewN-carboxyphenylpyrrolederivativesasHIVfusioninhibitorstargetinggp41Bioorganic&MedicinalChemistryLetters2010,20,189-192.
- ChanglanPeng,YongWang,LanyingLiu,HonggenWang,JiajiZhao,andQiangZhu*p-ToluenesulfonicAcidPromotedAnnulationof2-AlkynylanilineswithActivatedKetones:EfficientSynthesisof4-Alkyl-2,3-DisubstitutedQuinolinesEur.J.Org.Chem.2010,818-822.
