胡文辉性别:
男
职务:
职称:
研究员
学历:
博士通讯地址:
广州萝岗区科学城开源大道190号B座三楼
电话:
邮政编码:
510530
传真:
电子邮件:
hu_wenhui@gibh.ac.cn
简历：
2006.11—至今研究员，中国科学院广州生物医药与健康研究院。
2002.12–2006.10博士后，药物发现与化学生物学中心，美国西北大学医学院。
1999.9—2002.7博士，药物化学，中国医学科学院和北京协和医科大学药物研究所
研究领域：
本实验室针对重大疾病的新药研发，以药物分子设计与合成为核心，依靠与各科研团队的合作，包括药理、药代、毒理评价等，确立候选药物，完成新药的发现过程；同时，依托国内制药百强企业，共同开发新药，形成完整的创新药物价值链。
目前的主要研究方向包括：
1.新型抗糖尿病药物的研发。
2.抗神经炎症抑制剂的发现。
3.抗流感药物的研发
社会任职：
获奖及荣誉：
代表论著：
1、Anti-influenzadrugdiscovery
●XinZhao,ChufangLi,ShaogaoZeng,WenhuiHu*.DiscoveryofhighlypotentagentsagainstinfluenzaAvirus.EuropeanJournalofMedicinalChemistry.2011,46(1):52-57.
●WenhuiHu*,ShaogaoZeng,ChufangLi，YanlingJie,ZhiyuanLiandLingChen.IdentificationofHitsasMatrix-2InhibitorsthroughtheFocusedScreeningofaSmallPrimaryAmineLibrary.JournalofMedicinalChemistry.2010,53(9):3831-3834.
●CN200910030051.8
●CN200910031106.7
2、Anti-diabeticdrugdiscovery
●JifengDeng,LiPeng,GuichengZhang,XiaobingLan,ChufangLi,FuxinChen,YayaoZhou,ZuoxianLin,LingChen,RenkeDai,HongjiangXu,LingYang,XiquanZhang,WenhuiHu*.ThehighlypotentandselectivedipeptidylpeptidaseIVinhibitorsbearingathienopyrimidinescaffoldeffectivelytreattype2diabetes.EuropeanJournalofMedicinalChemistry.2011,46(1):71-76
●LiLiZeng,YingJieDing,GuiChengZhang,HongRuiSong,WenHuiHu*.ApracticalsynthesisoftrifluorophenylR-aminoacid:Thekeyprecursorforthenewanti-diabeticdrugsitagliptin.ChineseChemicalLetters.2009,20:1397-1399.
●CN200910024698.x
●CN201010228604.3
3、Anti-alzheimer'sdiseasedrugdiscovery
●ZhenboHuang,HaoWang,XiurongRao,GuifaZhong,WenhuiHu,GuoaingSheng.Differenteffectsofscopolamineontheretrievalofspatialmemoryandfearmemory.BehaviouralBrainResearch.2011(221):604–609.
●LauraKChico,HeatherBehanna,WenhuiHu,GuifaZhong,SaktimayeeMitraRoy,andD.MartinWatterson.MolecularpropertiesandCYP2D6substrates:centralnervoussystemtherapeuticscasestudyandpatternanalysisofasubstratedatabase.Drugmetabolismanddisposition.2009,37(11):2204-2211.
●LenkaMunoz,HantamalalaRalayRanaivo,SaktimayeeM.Roy,WenhuiHu,JeffreyM.Craft,LaurieK.McNamara,LindaJ.VanEldikandD.MartinWatterson.Anovelp38αMAPKinhibitorsuppressesbrainproinflammatorycytokineup-regulationandattenuatessynapticdysfunctionandbehavioraldeficitsinanAlzheimer'sdiseasemousemodel.JournalofNeuroinflammation.2007,4:21.
●WenhuiHu,HantamalalaRalayRanaivo,SaktimayeeM.Roy,HeatherA.Behanna,LauraK.Wing,LenkaMunoz,LingGuo,LindaJ.VanEldikandD.MartinWatterson.Developmentofanoveltherapeuticsuppressorofbrainproinflammatorycytokineup-regulationthatattenuatessynapticdysfunctionandbehavioraldeficits.Bioorganic&MedicinalChemistryLetters.2007,17(2):414-418.
●HantamalalaRalayRanaivo,JeffreyM.Craft,WenhuiHu,LingGuo,LauraK.Wing,LindaJ.VanEldikandD.MartinWatterson.Gliaasatherapeutictarget:attenuationofhumanA?inducedneuroinflammationandhippocampaldeficitsbyoraladministrationofaselectiveinhibitorofglialactivation.JournalofNeuroscience.2006,26(2):662-670
●WenhuiHu,HantamalalaRalayRanaivo,JeffreyM.Craft,LindaJ.VanEldik,andD.MartinWatterson.ValidationoftheneuroinflammationcycleasadrugdiscoverytargetusingintegrativechemicalbiologyandleadcompounddevelopmentwithanAlzheimer’sdisease-relatedmousemodel.CurrentAlzheimerResearch.2005,2,197-205.
●JeffreyM.Craft,LindaJ.VanEldik,MagdalenaZasadzki,WenhuiHuandD.MartinWatterson.AminopyridazinesattenuatehippocampusdependentbehavioraldeficitsinducedbyhumanAinamurinemodelofneuroinflammation.TheJournalofMolecularNeuroscience.2004,24:115-122.
●WO2007127448-A2;WO2007127375-A2;WO2007127474-A;WO2007130383-A2;WO2007127475-A2;WO2006050359-A2;WO2006050389-A2;US2004058977-A1;US2004029951-A1
4、Others：
●HongLi,YingxueLiu,QijunLiu,WenhuiHu,GuochunZhou.Synthesisof2-amino-5-hydroxycaprolactamderivativesmediatedbyE-selectiveolefinationandasymmetricoxidationoftheenolether.Synthesis.2010,23:4068-4074.
●WenhuiHu,ZongruGuo,XiangYi,ChangbinGuo,FengmingChuandGuifangCheng.Discoveryof2-Phenyl-3-sulfonylphenyl-indolederivativesasanewclassofselectiveCOX-2inhibitors.Bioorganic&MedicinalChemistry.2003,11(24):5539-44.
●WenhuiHu,ZongruGuo,FengmingChu,AipingBai,XiangYi,GuifangCheng,JingLi.Synthesisandbiologicalevaluationofsubstituted2-sulfonyl-phenyl-3-phenyl-indoles:anewseriesofselectiveCOX-2inhibitors.Bioorganic&MedicinalChemistry.2003,11(7),1153-1160.
●WenHuiHu,ZongRuGuo,AiPingBai,ZhiBinXu.Aconvenientsynthesisofthesubstituted2,3-diaryl-indole–thepotentselectiveCOX-2inhibitors.ChineseChemicalLetters.2002,13(4):296-298.
