陈永雄 教授/博导
学科（方向）：眼科学
所在系部：眼科研究所
办公电话：
邮 箱：yxchen1962@xmu.edu.cn
系部网址：http://eye.xmu.edu.cn



研究领域：
新生血管性眼病是眼的一种异常血管形成，是多种眼病常见的现象，严重影响患者的视力甚至导致失明。以往的研究认为眼的新生血管形成是促与抑血管内皮生长因子生成的失衡引起的血管内皮细胞出芽性增殖所致。我们通过多种转基因小鼠和鸡角膜新生血管形成模型的比较研究，发现导致角膜新生血管形成的起始因素不是血管内皮生长因子及其受体，而是角膜上皮和基质细胞代谢方面的改变。我们正在致力于揭示参与新生血管性眼病的细胞和分子机制，探索其治疗的新方法以防治失明。

学习经历：
1980~1985 福建医学院医疗系医疗专业 医学学士；
1988~1991 中山医科大学组织学与胚胎学专业 医学硕士；
1996~1999 中山医科大学内科学肾脏病专业 医学博士；

工作经历：
1985~1988 福建医学院组织学与胚胎学教研室 助教；
1991~2003 中山医科大学附属第一院肾内科 历任实习研究员、助理研究员、副研究员；
1999~2001 香港大学内科系。研究助理；
2001~2001 美国Baylor College of Medicine内科系 博士后，
2001~2002 美国Vanderbilt University 医学中心 博士后；
2002~2006 香港大学外科系 博士后；
2006~2007 英国Imperial College of Science, Technology and Medicine生物外科和生物技术系 研究员；
2007~2009 美国Rutgers, The State University of New Jersey细胞生物学和神经科学系神经科学和干细胞研究中心 研究员；
2010~至今 厦门大学医学院厦门大学眼科研究所 教授

代表性成果：
1.Chan VS#, Chan KY#, Chen Y#, Poon LL, Cheung AN, Zheng B, Chan KH, Mak W, Ngan HY, Xu X, Screaton G, Tam PK, Austyn JM, Chan LC, Yip SP, Peiris M, Khoo US, Lin CL. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat Genet. 2006, 38(1):38-46

2.Chen Y, Chan VS, Zheng B, Chan KY, Xu X, To LY, Huang F, Khoo US, Lin CL. A novel subset of putative stem/progenitor CD34+Oct4+ cells is the major target for SARS coronavirus in human lung. The Journal of Experimental Medicine. 2007, 204(11):2529-2536

3.Chen Y; Hwang SL; Chan VS; Chung NP; Wang SR; Li Z; Ma J; Lin CW; Hsieh YJ; Chang KP; Kung SS; Wu YC; Chu CW; Tai HT; Gao GF; Zheng B; Yokoyama KK; Austyn JM; Lin CL. Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells. PLoS Pathogens. 2013, 9(1):e**

4.Ma J, Zhou D, Fan M, Wang H, Huang C, Zhang Z, Wu Y, Li W, Chen Y*, Liu Z*. Keratocytes Create Stromal Spaces to Promote Corneal Neovascularization Via MMP13 Expression. Invest Ophthalmol Vis Sci. 2014, 55(10):6691-703

5.Huang C; Wang H; Pan J; Zhou D; Chen W; Li W; Chen Y; Liu Z. Benzalkonium Chloride induces Subconjunctival Fibrosis through the COX-2- modulated activation of a TGF-β1/Smad3 Signaling Pathway. Invest Ophthalmol Vis Sci. 2014, 55(12): 8111-8122

主持过的重要课题：
1. 角膜基质细胞重塑细胞外基质引导角膜新生血管形成的机制研究。国家自然科学基金（No. **）；68.4万元；2016,01-2019,12。项目负责人
2. 血管紧张素转化酶II阳性干细胞分化成角膜树突状细胞的类型和功能的研究。国家自然科学基金（No. **）；70万元；2014,01-2017,12。项目负责人
3. 干细胞治疗视网膜变性的基础与临床转化研究。国家重大研究计划项目（973项目） (No. 2013CB967502) ；51万元； 2013,01-2017,12。项目骨干
4. 血管紧张素II阳性新型肺干细胞来源和分化的研究。国家自然科学基金（No. **）；40万元；2011,01-2013,12。项目负责人

所有论文列表：
1. Wu SG, Zhang WW, He ZY, Sun JY, Chen YX*, Guo L*. Sites of metastasis and overall survival in esophageal cancer: a population-based study. Cancer Manag Res. 2017 Dec 6; 9:781-788

2. Wu SG, Zhang WW, Sun JY, Li FY, Lin HX, Chen YX*, He ZY*. Comparable Survival between Additional Radiotherapy and Local Surgery in Occult Breast Cancer after Axillary Lymph Node Dissection: A Population-based Analysis. J Cancer. 2017 Oct 17;8(18):3849-3855

3.Wu SG, Zhang WW, Sun JY, Li FY, Chen YX*, He ZY*. Postoperative radiotherapy for invasive micropapillary carcinoma of the breast: an analysis of Surveillance, Epidemiology, and End Results database. Cancer Manag Res. 2017 Oct 3;9:453-459

4. Wu SG, Li H, Tang LY, Sun JY, Zhang WW, Li FY, Chen YX*, He ZY*. The effect of distant metastases sites on survival in de novo stage-IVbreast cancer: A SEER database analysis. Tumour Biol. 2017 Jun;39(6):05082

5. Sun JY, Wu SG, Chen SY, Li FY, Lin HX, Chen YX*, He ZY*. Adjuvant radiation therapy and survival for adenoid cystic carcinoma of the breast. Breast. 2016 Dec 1,31:214-218.

6. Wang Y, Li S, Chen X, Ma B, He H, Liu T, Yu J, Zhang L, Chen Y, Liu Z, Li W. Meibomian Gland Absence Related Dry Eye in Ectodysplasin A Mutant Mice. Am J Pathol. 2016 Jan;186(1):32-42

7. Zhang L, Zou D, Li S, Wang J, Qu Y, Ou S, Jia C, Li J, He H, Liu T, Yang J, Chen Y, Liu Z, Li W. An Ultra-thin Amniotic Membrane as Carrier in Corneal Epithelium Tissue-Engineering. Sci Rep. 2016 Feb 15;6:21021

8. Wu SG, Rao MY, Zhou J, Lin Q, Wang ZJ, Chen YX*, He ZY*. Distribution of metastatic disease in the brain in relation to the hippocampus: a retrospective single-center analysis of 6064 metastases in 632 patients. Oncotarget. 2015 Dec 22;6(41):44030-6

9. Dong F,Liu CY,Yuan Y,Zhang Y,Li W, Call M,Zhang L,Chen Y,Liu Z,Kao WW. Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.Dev Biol.2015 Oct 15;406(2):147-57.

10. Wang X; Cao K; Sun X; Chen Y; Duan Z; Sun L; Guo L; Bai P; Sun D; Fan J; He X; Young W; Ren Y.Macrophages in spinal cord injury: Phenotypic and functional change from exposure to myelin debris. Glia. 2015, 63(4):635-51

11. Huang C; Wang H; Pan J; Zhou D; Chen W; Li W; Chen Y; Liu Z. Benzalkonium Chloride induces Subconjunctival Fibrosis through the COX-2- modulated activation of a TGF-β1/Smad3 Signaling Pathway. Invest Ophthalmol Vis Sci. 2014, 55(12): 8111-8122

12.. Ma J, Zhou D, Fan M, Wang H, Huang C, Zhang Z, Wu Y, Li W, Chen Y*, Liu Z*. Keratocytes Create Stromal Spaces to Promote Corneal Neovascularization Via MMP13 Expression. Invest Ophthalmol Vis Sci. 2014, 55(10):6691-703（共同通讯作者）

13. Zhang Z; Yang WZ; Zhu ZZ; Hu QQ; Chen YF; He H; Chen Y; Liu Z. Therapeutic Effects of Topical Doxycycline in a Benzalkonium Chloride-Induced Mouse Dry Eye Model. Invest Ophthalmol Vis Sci. 2014, 55(5):2963-74.

14. Chen Y; Hwang SL; Chan VS; Chung NP; Wang SR; Li Z; Ma J; Lin CW; Hsieh YJ; Chang KP; Kung SS; Wu YC; Chu CW; Tai HT; Gao GF; Zheng B; Yokoyama KK; Austyn JM; Lin CL. Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells. PLoS Pathogens. 2013, 9(1):e**

15. Wang XQ; Lo CM; Chen L; Cheung CK; Yang ZF; Chen YX; Ng MN; Yu WC; Ming X; Zhang W; Ho DW; Chan SC; Fan ST. Hematopoietic chimerism in liver transplantation patients and hematopoietic stem/ progenitor cells in adult human liver. Hepatology. 2012, 56(4):1557-66.

16. Chen W; Hu J; Zhang Z; Chen L; Xie H; Dong N; Chen Y; Liu Z.Localization and Expression of Zonula Occludins-1 in the Rabbit Corneal Epithelium following Exposure to Benzalkonium Chloride. PLoS One. 2012, 7(7):e40893.

17. Han Y; Shao Y; Lin Z; Quyang L; Wang H; Zhou Y; Chen W; Chen Y; Chen WL; Hu FR; Li W; Liu Z.Netrin-1 Simultaneously Suppresses Corneal Inflammation and Neovascularization.Invest Ophthalmol Vis Sci. 2012, 53(3):1285-95.

18. Chen W; Li Z; Hu J; Zhang Z; Chen L; Chen Y; Liu Z. Corneal alternations induced by topical application of benzalkonium chloride in rabbit. PLoS One. 2011;6(10):e26103.

19. Sun X; Wang X; Chen T; Li T; Cao K; Lu A; Chen Y; Sun D; Luo J; Fan J; Young W; Ren Y. Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system.PLoS One. 2010, 23, 5(2):e9380.

20. To YF, Sun RW, Chen Y, Chan VS, Yu WY, Tam PK, Che CM, Lin CL. Gold(III) porphyrin complex is more potent than cisplatin in inhibiting growth of nasopharyngeal carcinoma in vitro and in vivo.Int J Cancer. 2009, 124(8): 1971-9.

21. Xie Y, Chan H, Fan J, Chen Y, Young J, Li W, Miao X, Yuan Z, Wang H, Tam PK, Ren Y. Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma.Carcinogenesis. 2007, 28(10):2122-30 .

22. Chen Y, Chan VS, Zheng B, Chan KY, Xu X, To LY, Huang F, Khoo US, Lin CL. A novel subset of putative stem/progenitor CD34+Oct4+ cells is the major target for SARS coronavirus in human lung. The Journal of Experimental Medicine. 2007, 204(11):2529-2536

23. Chan VS*, Chan KY*, Chen Y*, Poon LL, Cheung AN, Zheng B, Chan KH, Mak W, Ngan HY, Xu X, Screaton G, Tam PK, Austyn JM, Chan LC, Yip SP, Peiris M, Khoo US, Lin CL. Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. Nat Genet. 2006, 38(1):38-46

24. Fan J, Chen Y, Chan HM, Tam PK, Ren Y. Removing intensity effects and identifying significant genes for Affymetrix arrays in macrophage migration inhibitory factor-suppressed neuroblastoma cells. Proc Natl Acad Sci USA. 2005，102(49):17751-6.

25. Ren Y, Chan H, Fan J, Xie Y, Chen Y, Li W, Jiang G, Liu Q, Meinhardt A, Tam PK. Inhibition of growth and metastasis in vitro and in vivo by targeting marophage migration inhibitory factor in human neuroblastoma. Oncogene. 2006, 25(25):3501-8.

26. Ren Y, Cao B, Law S, Xie Y, Lee PY, Cheung L, Chen Y, Huang X, Chan HM, Zhao P, Luk J, Vande Woude G, Wong J. Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas. Clin Cancer Res. 2005, 11(17):6190-7.

27. Zhang HY, Nanji AA, Luk JM, huang XR, Lo CM, Chen YX, Yuen ST, Lan HY, Lau GK. Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection. Liver Int. 2005, 25(3):571-9.

28. Ren Y, Tsui HT, Poon RT, Ng IO, Li Z, Chen Y, Jiang G, Lau C, Yu WC, Bacher M, Fan ST. Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma. Int J Cancer. 2003, 107(1):22-9.

29. Yu CM, Lai KW, Chen YX, Huang XR, Lan HY. Expression of macrophage migration inhibitory factor in acute ischemic myocardial injury. J Histochem Cytochem. 2003, 51(5):625-31.

30. Xiong HQ, Chen YX, Yi YJ, Tsuchiya K, Moeckel G, Cheung J, Liang D, Tham K, Xu XH, Chen XZ, Pei Y, Zhao ZJ, Wu GQ. A novel gene encoding a TIG multiple domain protein is a positional candidate for autosomal recessive polycystic kidney disease. Genomics 2002, 80(1):96-104.

31. Nanji AA, Lau GK, Tipoe GL, Yuen ST, Chen YX, Thomas P, Lan HY. Macrophage migration inhibitory factor expression in male and female ethanol-fed rats. J Interferon Cytokine Res. 2001, 21(12):1055-62

32. Huang XR, Hui CW, Chen YX, Chun B, Wong Y, Fung PC, Metz C, Cho CH, Hui WM, Bucala R, Lam SK, Lan HY. Macrophage migratio inhibitory factor is an important mediator in the pathogenesis of gastric inflammation. Gastroenterology, 2001, 121(3):619-630

33. Lin SG, Yu XY, Chen YX, Huang XR, Metz C, Bucala R, Lau CP, Lan HY. De novo statement of macrophage migration inhibitory factor in atherogenesis in rabbits. Circulation Research, 2000, 87(12):1202-83
All Publications：https://www.ncbi.nlm.nih.gov/pubmed/?term=Chen+Y