宋刚 福建省新世纪优秀人才、
厦门市重点引进人才

职称：教授/博导
学科（专业）：肿瘤学
研究方向：细胞分子生物学
邮箱：gangsongsd@xmu.edu.cn
电话：

教育背景：
1994-1998 烟台师范学院 生物学系 本科
1998-2001 福建农林大学 生物技术 硕士
2003-2006 厦门大学 细胞生物学 博士

工作经历：
2006-2008 香港中文大学癌症中心 Research Associate
2008.7-至今 厦门大学医学院 教师

主要研究领域：
肿瘤发生发展过程中的信号转导。目前涉及：1）USPs调控p53等通路；2）MSCs调控肿瘤的转移；3）抗肿瘤的天然药物的筛选与作用机理。
主要学术成果：

论文：

1
Wang WW, Zhong W, Yuan JH, Tong YP, Yan CC, Hu SP, Mao YB, Zhang B, Hu TH, Song G*. Involvement of wnt/β-catenin Signaling in the mesenchymal stem cellspromote metastatic growth and chemoresistance ofcholangiocarcinoma.Oncotarget. 2015; 6(39): 42276-89.

2
Zhou H, Xu MY, Gao Y, Deng ZG, Cao HW, Zhang WQ, Wang Q, Zhang B, Song G*, Zhan YY*, Hu TH*. Matrine Induces Caspase-Independent Program Cell Death in Hepatocellular Carcinoma through Bid-Mediated Nuclear Translocation of Apoptosis Inducing Factor. Mol Cancer.2014, 13(59)1-11.

3
Zhang JF, Cao HL, Zhang B, Cao HW, Xu XQ, Ruan H, Yi TT, Tan L, Qu R, Song G*, Wang BM*, Hu TH*. Berberine Potently Attenuates Intestinal Polyps Growth in ApcMin mice and Familial Adenomatous Polyposis Patients through Inhibition of Wnt Signaling.J Cell Mol Med.2013. 17(11):1484-93.

4
Hu C^#, Song G^#,*, ZhangB, Liu Z, Chen R, Hu TH*.Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway.J Cell Mol Med.2012, 16(1):96-106.

5
Song G*, Guo S, Wang W, Hu C, Mao Y, Zhang B, Hu T*. Intestinal metabolite compound K of ginseng saponin potently attenuating metastatic growth of hepatocellular carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway. J Agric Food Chem.2010, 58(24):12753-60.

6
Song G, Chen GG, Hu TH and Lai PBS. Bid Stands at the Crossroad of Stress-response Pathways. Current Cancer Drug Targets.2010. 10 (6): 584-92.

7
Song G,Ouyang G, Mao YB, Ming YL, Bao S, Hu TH. Osteopontin promotes metastatic growth of gastric cancer by augmenting cell survival and invasion through Akt-mediated HIF-1α up-regulation and MMP9 activation. J Cell Mol Med.2009, 13(8B):1706-18.

8
Song G, Chen GG, Yun JP and Lai PBS. Association of p53 with Bid induces cell death in response to etoposide treatment in hepatocellular carcinoma. Current Cancer Drug Targets.2009, 9(7): 871-80.

9
Song G, Cai QF, Mao YB, Ming YL, Bao S, Ouyang G.. Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1α expression through the PI3-K/Akt pathway.Cancer Sci. 2008, 10: 1901-7.

10
Song G, Chen GG, Chau DK, Miao J, Lai PBS. Bid exhibits S phase checkpoint activation and plays a pro-apoptotic role in response to etoposide-induced DNA damage in hepatocellular carcinoma cells. Apoptosis.2008, 13(5): 693-701.

主持课题：

1
国家自然科学基金,胞外基质蛋白类在MSCs调控肠炎及其恶变过程中的功能研究, 2015.01-2018.12

2
国家自然科学基金, MSCs靶向ATM/BID/NOD1/2通路对肠炎及其恶化的调控机制，2013.01-2016.12

3
厦门市科技计划项目,抗肠炎及其恶性转化的人参皂甙次级代谢产物的筛选，2014.01-2016.12

4
福建省重点项目，泛素特异性蛋白酶USP39对肿瘤细胞炎性微环境的调控，2017.04-2019.03



获奖：

1
厦门市科技进步二等奖，传统中药治疗消化道恶性肿瘤的作用机制与临床应用，2015.12