杨天赐福建省福建省科技创新领军人才

职称：教授/博导
学科（专业）：检验医学
研究方向：梅毒的免疫损伤和实验诊断
邮箱：yangtianci@xmu.edu.cn
电话：

教育背景：
1985-1989福建医科大学医学检验专业本科
1997-2000厦门大学生科院细胞生物学硕士
2003-2008厦门大学生科院生化与分子生物学博士

工作经历：
1989.07-2007.03厦门大学医院检验科 技师/主管技师/副主任技师
2007.4-至今厦门大学附属中山医院检验科 副主任技师（副教授）/主任技师（教授）

主要研究领域：
主要研究领域为梅毒的免疫损伤与实验诊断，包括梅毒的分子致病基础；梅毒的血清固定机理；神经梅毒的临床与流行病学；梅毒的诊断与试剂研发；其他梅毒临床难点热点研究。

主要学术成果：

论文：

1
Man-Li Tong, Li-Rong Lin, Li-Li Liu, Hui-Lin Zhang, Song-Jie Huang, Yu-Yan Chen, Xiao-Jing Guo, Ya Xi, Long Liu, Fu-Yi Chen, Ya-Feng Zhang, Qiao Zhang, Tian-Ci Yang(corresponding). Analysis of three algorithms for syphilis serodiagnosis and implications for clinical management. Clinical Infectious Diseases 2014;58:1115-1124.

2
Li-Li Liu, , Li-Rong Lin, , Man-Li Tong, Hui-Lin Zhang, Song-Jie Huang, Yu-Yan Chen, Xiao-Jing Guo, Ya Xia, Long Liu, Fu-Yi Chen,Ya-Feng Zhang, Qiao Zhang, Tian-Ci Yang(corresponding). Incidence and Risk Factors for the Prozone Phenomenon in Serologic Testing for Syphilis in a Large Cohort. Clinical Infectious Diseases; 2014;59:183-189.

3
Man-Li Tong, Li-Rong Lin, Gui-Li Liu, Yan-Li Zeng, Hui-Lin Zhang, Wei-Hong Zheng, Li-Li Liu , Tian-Ci Yang(corresponding).. Factors Associated with Serological Cure and the Serofast State of HIV-negtive patients with primary, secondary, latent, and tertiary syphilis.PLOS ONE. 2013; 8(7):1-7

4
Xin-Hui Qiu, Ya-Feng Zhang, Yu-Yan Chen, Qiao Zhang, Fu-Yi Chen, Long Liu, Jin-Yi Fan, Kun Gao, Xiao-Zhen Zhu Wei-Hong Zheng, Hui-Lin Zhang, Li-Rong Lin, Li-Li Liu, Man-Li Tong, Chang-Gong Zhang,Jian-Jun Niu, Tian-Ci Yang(corresponding).,Evaluation of the Boson Chemiluminescence Immunoassay as a First-Line Screening Test in the ECDC Algorithm for Syphilis Serodiagnosis in a Population with a High Prevalence of Syphilis, Journal of Clinical Microbiology 2015,53, 1-5

5
Jian-Jun, Niu,Qiao Zhang , Fu-Yi, Long Liu,Li-Li Liu, Tian-Ci Yang(corresponding).. The evaluation method for assessing a diagnostictest of HIV: Some noteworthy. Journal of Clinical Virology. 2015,65, 74-75

6
Li-Rong Lin, Hui-Lin Zhang, Song-Jie Huang, Yan-Li Zeng, Ya Xi, Xiao-Jing Guo, Gui-Li Liu, Man-Li Tong, Wei-Hong Zheng, Li-Li Liu, Tian-Ci Yang(corresponding).. Psychiatric manifestations as primary symptom of neurosyphilis among HIV-negative patients. Journal of neuropsychiatry and clinical neurosciences. 2014; 26:233–240

7
Fan Liu, Li-Rong Lin, Hui-Lin Zhang, Gui-Li Liu, Man-Li Tong, Yan-Li Zeng, Song-Jie Huang, Chun-Ling Huang, Li-Li Liu,Tian-Ci Yang(corresponding).. Laboratorial characteristics of patients with diarrhea suffering from egg white allergy. Allergologia et immunopathologia. 2014;42（3）:180-185.

8
Manli TONG, Ya XI, Xiaojing GUO, Yuyan CHEN, Yafeng ZHANG, Qiao ZHANG, Long LIU, Fuyi CHEN, Songjie HUANG, Huilin ZHANG, Weihong ZHENG, Lirong LIN, Lili LIU, Tian-Ci Yang(corresponding)..Association between Neurosyphilis and Diabetes Mellitus: Resurgence of an Old Problem. journal of diabetes. 2014;6:403-408

9
Fan Liu, Li-Li Liu, Xiao-Jing Guo, Ya Xi, Li-Rong Lin, Hui-Lin Zhang, Song-Jie Huang, Yu-Yan Chen, Ya-Feng Zhang, Qiao Zhang, Ge-Ling Huang, Man-Li Tong, Jie Jiang, Tian-Ci Yang(corresponding).. Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era. International Immunopharmacology. 2014; 20：331-336

10
Li-Li Liu, Hui-Lin Zhang , Song-Jie Huang, Long Liu, Man-Li Tong, Li-Rong Lin , Yu-Yan Chen , Ya Xi , Xiao-Jing Guo, Ya-Feng Zhang, Qiao Zhang, Wei-Hong Zheng, Fu-Yi Chen, Tian-Ci Yang(corresponding).. Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection. International Immunopharmacology. 2013;17:1120-1124

11
Yan-Li Zeng, Wen-Jie Wang, Hui-Lin Zhang, Fu-Yi Chen, Song-Jie Huang, Gui-Li Liu, Ya Xi, Xiao-Jing Guo, Tian-Ci Yang(corresponding)., Wei-Hong Zheng. Neuropsychiatric disorders secondary to neurosyphilis in elderly people: one theme not to be ignored. International Psychogeriatrics.2013;25(9):1513-1520.

12
Hui-Lin Zhang, Li-Rong Lin, Gui-Li Liu, Yan-Li Zeng, Jing-Yi Wu, Wei-Hong Zheng, Man-Li Tong, Jie Dong, Yuan-Hui Su, Li-Li Liu, Tian-Ci Yang(corresponding).. Clinical spectrum of neurosyphilis among HIV-negative patients in the modern era. Dermatology. 2013; 226(22):148-156.

13
Man-Li Tong，Li-Rong Lin, Hui-Lin Zhang, Song-Jie Huang, Gui-Li Liu, Wei-Hong Zheng, Yuan-Hui Su, Jing-Yi Wu, Jie Dong, Li-Li Liu,Tian-Ci Yang(corresponding)..Spectrum and characterization of movement disorders secondary to neurosyphilis. Parkinsonism & Related Disorders. 2013, 19:441-445

14
Man-Li Tong, Li-Li Liu, Yan-Li Zeng，Hui-Lin Zhang, Gui-Li Liu, Wei-Hong Zheng, Jie Dong , Jing-Yi Wu, Yuan-Hui Su, Li-Rong Lin，Tian-Ci Yang(corresponding). g. Laboratory Findings in Neurosyphilis Patients with Epileptic Seizures Alone as the Initial Presenting Symptom. Diagnostic Microbiology and Infectious Disease. 2013, 5:377-30

15
Li-Li Liu, Peng-Li Chao, Hui-Lin Zhang, Man-Li Tong , Gui-Li Liu, Li-Rong Lin, Yuan-Hui Su,Jing-Yi Wu, Jie Dong, Wei-Hong Zheng, Tian-Ci Yang(corresponding).. Analysis of lymphocyte subsets in HIV-negative neurosyphilis patients. Diagnostic Microbiology and Infectious Disease,75:165-168,2013

16
Tian-ci Yang，Xian-Cang Ma, Fan Liu, Li-Rong Lin, Li-Li Liu, Gui-Li Liu, Man-Li Tong, Zuo-Gen Fu, and Lei Zhou. Screening of the Salmonella Paratyphi A CMCC 50973 Strain Outer Membrane Proteins for Potential Vaccine Targets. Molecular Medicine Reports[J]. 2012,5:78-83.

17
Li-Li Liu, Li-Rong Lin, Man-Li Tong, Zuo-Gen Fu, Gui-Li Liu, Wei-Hong Zheng, Fan Liu, Dai-Wei Zhang, Zhong-Ying Zhang, Tian-Ci Yang(corresponding).. Effects of silencing cyclooxygenase-2 expression by RNA interference on the tumorigenicity of human hepatocarcinoma cell line SMMC-7721 Oncology reports；2012，27:1829-1834.

18
Li-Li Liu, Hong Yao, Xiao-Ling Zhang, Hui-Lin Zhang, Man-Li Tong, Gui-Li Liu, Li-Rong Lin, Fan-Liu, Zhong-Ying Zhang, Tian-Ci Yang(corresponding).. Characteristics of patients suffering from cow milk allergy[J].International Immunopharmacology.2012, 14:94-98.

19
Li-Li Liu,Wei-Hong Zheng,Man-Li Tong, Gui-Li Liu,Zuo-Gen Fu, Li-Rong Lin, Tian-Ci Yang(corresponding).. Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients. Journal of the Neurological Sciences. 2012,317:35-39.

20
Li-Rong Lin, Wei-Hong Zheng, Man-Li Tong, Zuo-Gen Fu, Gui-Li Liu, Jian-Guo Fu, Dai-Wei Zhang, Tian-Ci Yang(corresponding)., Li-Li Liu. Further Evaluation of the Characteristics of Treponema Pallidum-specific IgM antibody in syphilis serofast reaction patients[J]. Diagnostic microbiology and infectious disease. 2011; 71:201–207.

21
Li-Rong Lin, Man-LI Tong, Zuo-Gen Fu, Bing Dan, Chang-Gong Zhang, Tian-Ci Yang(corresponding)., Zhong-Ying Zhang. Evaluation of a colloidal gold-immunochromatography assay in the detection of Treponema Pallidm specific IgM antibody in syphilis serofast reaction patients: a serologic marker for the relapse and infection of syphilis [J].Diagnostic microbiology and infectious disease. 2011;70:10-16.

22
Fan Liu, Fang-Fang Qiao, Man-Li Tong, Li-Li Liu，Zuo-Gen Fu, Bing Dan, Li-Rong，Lin, Tian-Ci Yang(corresponding)., Zhong-Ying Zhang. Further evaluation of a novel nano-scale gene vector for in vivo transfection of siRNA[J]. Journal of Cellular Biochemistry, 2011,112, 1329-1336.

23
Li-Li Liu，Jia-Lan Lv，Peng-Li Chao，Li-Rong Lin，Zhong-Ying Zhang，Tian-Ci Yang(corresponding)..Lower prevalence of circulating invariant natural killer T (iNKT) cells in patients with acute myocardial infarction undergoing primary coronary stenting. International Immunopharmacology，2011,11, 480-484.

24
Lei Zhou，Fan Liu，Fang-fang Qiao，Man-li Tong，Zuo-gen Fu，Bing Dan，Tian-Ci Yang(corresponding)., Zhong-Ying Zhang.Optimization of Conditions for Transfection with Sofast Gene Vector. Molecular Medicine Reports，2011，4: 129-135.

25
Li-Li Liu, Li-Rong Lin，Cheng-Xiang Lu, Jian-Guo Fu, Peng-Li Chao, Hong-Wei Jin, Zhong-Ying Zhang, Tian-Ci Yang(corresponding).. Expression of inflammatory and apoptosis factors following coronary stent implantation in coronary heart disease patients[J].International Immunopharmacology.2011,11:1850-1854.

26
Li-Rong Lin，Zuo-Gen Fu，Bing Dan，Guang-Jun Jing， Man-li Tong，De-Teng Chen， Yang Yu，Chang-Gong Zhang，Tian-Ci Yang(corresponding)., Zhong-Ying Zhang. Development of a colloidal gold-immunochromatography assay to detect Immunoglobulin G Antibodies to Treponema pallidum with TpN17 and TpN47. Diagnostic Microbiology and Infectious Disease，2010，68:193-200.

27
Guang-Jun Jing， Zuo-Gen Fu， Bing Dan， Li-Rong Lin，Tian-Ci Yang(corresponding)., Song-Lin Shi. Development and evaluation of a novel nano-scale vector for siRNA. Journal of Cellular Biochemistry，2010，111(4):881-888.

28
Song-Lin Shi， Bing Dan， Li-Rong Lin，Zuo-Gen Fu，Guang-Jun Jing，Tian-Ci Yang(corresponding)., Zhong-Ying Zhang. Synthesis and characterization of a novel cationic polymer gene delivery vector. International Journal of Molecular Medicine，2010，26: 491-500.

29
Yu-Yan Chen; Ya-Feng Zhang; Xin-Hui Qiu; Qiao Zhang; Fu-Yi Chen; Long Liu; Jin-Yi Fan; Kun Gao; Xiao-Zhen Zhu; Wei-Hong Zheng; Hui-Lin Zhang; Li-Rong Lin; Li-Li Liu; Man-Li Tong; Jian-Jun Niu，Tian-Ci Yang(corresponding).,Clinical and laboratory characteristics in patients suffering from general paresis in the modern era. Journal of the Neurological Sciences, 2015,350, 79-83.

30
Yu-Yan Chen Xin-Hui Qiu Ya-Feng Zhang Qiao Zhang Jin-Yi Fan Kun Gao Xiao-Zhen Zhu,Fu-Yi Chen,Tian-Ci Yang(corresponding)., A better definition of active syphilis infection, Clinica Chimica Acta, 2015,444, 1-2.

授权专利：

1
国家发明专利：阳离子聚合物基因传递载体及其制备，8.2

2
国家发明专利：梅毒螺旋体实时荧光定量PCR多靶检测试剂盒及其制备，7.6

3
国家发明专利：梅毒特异性IgG抗体与特异性总抗体联合检测试剂条及其制备方法，1.5

4
国家发明专利：梅毒特异性总抗体胶体金免疫层析检测试剂条及其制备方法，5.X

5
国家发明专利：梅毒特异性IgM抗体与特异性总抗体联合检测试剂条及其制备方法，1.2

6
国家发明专利：梅毒特异性IgG抗体免疫印迹检测试剂条及其制备方法，5.8

7
国家发明专利：弓形虫IgM与IgG抗体联合检测试剂条及其制备方法，1.7

8
国家发明专利：梅毒螺旋体IgM 抗体生物素亲和素酶联免疫检测试剂盒及其制备方法，7.X

9
国家发明专利：梅毒螺旋体总抗体生物素亲和素酶联免疫检测试剂盒及其制备方法，1.4

10
国家发明专利：梅毒螺旋体IgG 抗体生物素亲和素酶联免疫检测试剂盒及其制备方法，7.7

主持课题：

1
国家科技部创新基金，最新一代阳离子聚合物基因转染试剂的研制，2004.01-2008.12

2
863，溶藻弧菌外膜蛋白的抗原组学与高效多价疫苗功能基因优选，2006.01-2009.12

3
厦门市科技计划项目，10)肿瘤基因治疗药物中siRNA基因传递载体构建及其应用，2009.01-2011.12

4
福建省科技计划重点项目，基因治疗中基因传递载体的构建及其在肿瘤治疗中的应用，2010.01-2012.12

5
福建省自然科学基金甲型副伤寒沙门氏菌外膜蛋白疫苗靶标的筛选，2010.01-2012.12

6
国家自然科学基金重大研究计划，炎症微环境刺激肝癌发生与发展的关键调控分子的研究，2011.01-2015.12

7
福建省社会发展科技重大项目，基于实时荧光定量PCR的梅毒螺旋体多靶检测技术建立及临床应用，2011.01-2014.12

8
国家自然科学基金，梅毒螺旋体免疫原性膜蛋白质在梅毒血清固定形成中的作用机制，2012.01-2012.12

9
国家自然科学基金，亲神经亚型梅毒螺旋体在神经梅毒发生中的作用机制，2013.01-2016.12

10
市科技计划项目，梅毒血清固定患者分子分型筛选及其在早期诊断中的应用，2013.01-2015.12

11
国家自然科学基金，M2型巨噬细胞在梅毒血清固定形成中的作用和机制，2015.01-2018.12

12
市重大疾病联合攻关项目，神经梅毒致病基因型的筛选及发病风险预测，2015.01-2017.12

获奖：

1
2012年教育部科学研究优秀成果奖二等奖，水产重要病原菌外膜蛋白的功能研究

2
2012厦门市科技进步二等奖，基因治疗中基因传递载体的构建及其应用

3
2013厦门市科技进步一等奖，梅毒系列检测技术的创建及其临床诊断研究

4
2014厦门市科技进步三等奖，冠脉支架置入术预后实验室指标的建立及临床应用

5
2014厦门市医学创新奖，梅毒系列诊断技术

6
2015厦门市医学创新奖，神经梅毒的临床与诊断系列研究