陈霁云 CHEN Jiyun, Ph.D.
助理教授
RNA加工与调控 (RNA processing and regulation)
E-mail: chenjiyun@xmu.edu.cn



简历:
2014年，北京大学基础医学专业，学士学位；
2017年，北京大学生物物理学专业，博士学位；
2017年至2020年，北京大学医学部，博士后
2020年至今，厦门大学生命科学学院，助理教授。
2014, B.Sc., Basic Medical Sciences, Peking University;
2017, Ph.D., Biophysics, Peking University;
2017-2020, Postdoctoral Fellow, Peking University Health Science Center
2020-present, School of Life Sciences, Xiamen University, Assistant Professor.




研究领域（Research Area)
RNA解旋酶介导的基因表达与调控的结构生物学研究
Structural studies of RNA helicases mediated gene expression and regulation




代表性论文(Selected Publications) * Corresponding author # co-first author
1. Wang J^#, Chen J^#, Wu G^#, Zhang H^#, Du X^#, Chen S, Zhang L, Wang K, Wu X, Gao S, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y, Li J, Yun C, Cheng H. NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes Dev. 2019 Mar 6. doi: 10.1101/gad.322602.118.
2. Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. Sci Rep. 2016 Aug 23;6:31425. doi: 10.1038/srep31425.（IF2016=4.259）
3. Liu L^#, Chen JY^#, Yang B, Wang FH, Wang YH, Yun CH. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function. Structure. 2015 Nov 3;23(11):2066-75. doi: 10.1016/j.str.2015.08.015.
4. Zhao P, Yao MY, Zhu SJ, Chen JY, Yun CH. Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045. Biochem Biophys Res Commun. 2018 Jul 20;502(3):332-337. doi: 10.1016/j.bbrc.2018.05.154.
5. Shi Y, Fan S, Wang D, Huyan T, Chen J, Chen J, Su J, Li X, Wang Z, Xie S, Yun C, Li X, Tie L. FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission. Biochim Biophys Acta. 2018 Jul;1864(7):2481-2494. doi: 10.1016/j.bbadis.2018.04.005.
6. Liu F, Wang B, Wang Q, Qi Z, Chen C, Kong LL, Chen JY, Liu X, Wang A, Hu C, Wang W, Wang H, Wu F, Ruan Y, Qi S, Liu J, Zou F, Hu Z, Wang W, Wang L, Zhang S, Yun CH, Zhai Z, Liu J, Liu Q. Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML). Oncotarget. 2016 Jun 14. doi: 10.18632/oncotarget.10037.
7. Liu L, Chen J, Yang B, Wang Y. Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins. Biochem Biophys Res Commun. 2015 Mar 6;458(2):429-34.
8. Liu L, Chen J, Yang B, Wang Y. Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions. FEBS Open Bio. 2015 Mar 5;5:155-62.