郭晨云
职称：副教授
电话：
Email：guochy78@xmu.edu.cn
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:: 个人简历
山西大学生物科学与技术学院生物化学理学学士（1996-2000）;
山西大学生物技术研究所生物化学与分子生物学理学博士（2000-2005）
中科院上海药物研究所助理研究员（2005-2008）;
美国马里兰大学化学与生物化学系博士后（2008-2010）;
厦门大学化学与化工学院化学生物化学系副教授（2010-）.

:: 工作方向
蛋白质和多肽的结构与功能研究
:: 承担的基金
1．国家自然科学基金面上项目(No.**)，人朊病毒蛋白G127V多态性保护作用的结构基础，2017/01-2020/12，在研，参与。
2．国家重点研发计划(No.2016YFA**)，核糖体蛋白翻译后修饰调控网络及新调节因子功能研究，2016/07–2021/06，在研，参与。
3.国家自然科学基金面上项目(No.**),Raf1激酶抑制蛋白RKIP与配体的复合物溶液结构和功能研究,2015/01-2016/12,已结题,主持。
4.福建省自然科学基金面上项目(No.2011J01246),用NMR技术研究腺苷酸激酶AK1在催化过程中构象和动力学的变化,2011/04–2014/06,已结题,主持。
5.国家自然科学基金青年项目(No**),RKIP磷酸化交叉调控MAPK信号通路与GPCR信号通路的分子机制和结构基础,2010/01-2012/12,已结题,主持。

:: 代表性文章
(1)Chenyun Guo^#, Yihang Xiao^#, Fangkai Bi, Weiliang Lin, Huilin Wang, Hongwei Yao, Donghai Lin*, Recombinant expression, biophysical and functional characterization of ClpS from Mycobacterium tuberculosis,Acta Biochimica et Biophysica Sinica (Shanghai), 2019, 51(11): 1158-1167.
(2)Chenyun Guo,Ting Chang, Tao Sun, Zhihua Wu, Yazhuang Dai, Hongwei Yao, Donghai Lin^*Anti-leprosy drug Clofazimine binds to human Raf1 kinase inhibitory protein and enhances ERK phosphorylation,Anti-leprosy drug Clofazimine binds to human Raf1 kinase inhibitory protein and enhances ERK phosphorylation. 2018, 50(10): 1062-1067.
(3)Shuangliang Tian, Hanyu Chen, Tao Sun, Huilin Wang, Xu Zhang, Yan Liu, Jinmei Xia,Chenyun Guo*, Donghai Lin*,Expression, purification and characterization of Esx-1 secretion-associated protein EspL from Mycobacterium tuberculosis.Protein Expression and Purification,2016, 128: 42-51.
(4) Hanyu Chen，Huilin Wang，Tao Sun，Shuangliang Tian，Donghai Lin,Chenyun Guo^*, Recombinant preparation and functional studies of EspI ATP binding domain from Mycobacterium tuberculosis,Protein Expression and Purification, 2016, 123: 51-59.
(5) Tao Sun, Zhihua Wu, Mengyao Luo, Donghai Lin,Chenyun Guo*,Pranlukast, a novel binding ligand of human Raf1 kinase inhibitory protein.Biotechnology Letters,2016, 38(8):1375-1380.
(6) Kejiang Lin, Ziyao Yu, Yuanhui Yao, Xinli Liao, Pei Huang,Chenyun Guo*,Donghai Lin*, Distinct effects of Cu2+-binding on oligomerization of human and rabbit prion proteins,Acta Biochimica et Biophysica Sinica (Shanghai),2015, 47(10):842-850.
(7)Chenyun Guo#, Cuiying Yi#, Yu Peng, Yi Wen, Donghai Lin*, Solution structure and backbone dynamics of human Raf-1 kinase inhibitor protein,Biochemical and Biophysical Research Communications,2013, 438(1): 129-132.
(8)Chenyun Guo, Raquel Godoy-Ruiz, Vitali Tugarinov*, High resolution measurement of methyl¹³C(m)-¹³C and¹H(m)-¹³C(m) residual dipolar couplings in large proteins,Journal of the American Chemical Society, 2010, 132(40):13984-139847.
(9)Chenyun Guo, Vitali Tugarinov*, Selective¹H-¹³C NMR spectroscopy of methyl groups in residually protonated samples of large proteins,Journal of Biomolecular NMR, 2010, 46(2):127-33.
(10)Chenyun Guo,Vitali Tugarinov*, Identification of HN-Methyl NOEs in large proteins using simultaneous amide-methyl TROSY-based Detection,Journal of Biomolecular NMR, 2009, 43(1): 21-30.
(11)Chenyun Guo,Hua Diao, Yandong Lian, Hongyu Yu, Hongchang Gao, Yonglian Zhang, Donghai Lin*, Recombinant expression and characterization of an epididymis-specific antimicrobial peptide BIN1b / SPAG11E,Journal of Biotechnology, 2009, 139(1): 33-37.
(12)Chenyun Guo,Chun Geng, Vitali Tugarinov*, Selective backbone labeling of proteins using 1,2-¹³C₂-pyruvate as carbon source,Journal of Biomolecular NMR, 2009, 44(3):167-173.
(13)Chenyun Guo,Daoning Zhang, Vitali Tugarinov*, A NMR experiment for simultaneous TROSY –baseddetection of amide and methyl groups in large proteins,Journal of American Chemical Society, 2008, 130(33): 10872-10873.
(14)Chenyun Guo,Zhuoyi Li, Jingming Yuan*, Preparation of an immunoadsorbent coupled with a recombinant antigen to remove anti-acetylcholine receptor antibodies in abnormal serum,Journal of Immunological Method, 2005, 303: 142-147.
(15)Chenyun Guo,Zhuoyi Li, Yawei Shi, Mingqun Xu, John G. Wise, Wolfgong E. Trommer, Jingming Yuan*, Intein-mediated fusion expression, high efficient refolding and one-step purification of gelonin toxin,Protein Expression and Purification, 2004, 37: 361-367.


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:: 学术职务