教授、博士生导师
化学生物学和分析化学方向
电话：（0592）** （办公室）

　　　（0592）** （实验室）
传真：（0592）**
电子邮箱：xmyan@xmu.edu.cn
课题组： http://xmyan.xmu.edu.cn/
个人简历：

学士（厦门大学科学仪器工程系，1990）
博士（厦门大学化学系，1996，日本名古屋大学联合培养）
博士后（美国佛罗里达大学化学系，1996-1997）
博士后、研究员（美国Los Alamos国家实验室生物科学部，1997-2005）



先后获得教育部新世纪优秀人才支持计划、国家****科学基金、福建省高校领军人才、福建省科技创新领军人才、厦门市五一劳动奖章、第十二届福建青年科技奖、科技部中青年科技创新领军人才、中国女分析化学家奖、厦门市双百计划领军型创业人才A⁺、国家“****”科技创新领军人才等奖项与称号。
研究兴趣：

纳米流式检测技术的研发及其在生命科学、生物医药、食品安全、环境监测、能源材料领域中的应用
单分子、单颗粒、单细胞测量与分析
液相芯片技术的开发及其生化分析、生物医学应用等

近期主要代表论著：
1. He, SB; Hong, XY; Zhang, MM; Wu, LN; Yan, XM*, Label-Free Detection of Bacteria in Fruit Juice by Nano-Flow Cytometry, Anal. Chem. 2020, 92, 2393-2400.
2. Lian, H; He, SB; Chen, CX; Yan, XM*, Flow Cytometric Analysis of Nanoscale Biological Particles and Organelles, Annu. Rev. Anal. Chem. 2019, 12, 389-409.
3. Tian, Y; Gong, MF; Hu, YY; Liu, HS; Zhang, WQ; Zhang MM; Hu, XX, Aubert, D; Zhu, SB; Wu, LN; Yan, XM*, Quality and Efficiency Assessment of Six Extracellular Vesicle Isolation Methods by Nano-Flow Cytometry, J. Extracell. Vesicles 2019, 9, **.
4. Wu, LN*; Zhang, MM; Song, YY; Deng, MF; He, SB; Su, LQ; Chen, Y; Wood, T. K.; Yan, XM*, Deciphering the Antitoxin-Regulated Bacterial Stress Response via Single-Cell Analysis, ACS Chem. Biol. 2019, 14, 122859-122866.
5. Chen, CX*; Gao, KM; Lian, H; Chen, C; Yan, XM*, Single-Particle Characterization of Theranostic Liposomes with Stimulus Sensing and Controlled Drug Release Properties, Biosens. Bioelectron. 2019, 131, 185-192.
6. Gao, M; Lian, H; Yu, LJ; Gong, MF; Ma, L; Zhou, YX; Yu, MX; Yan, XM*, Rolling Circle Amplification Integrated with Suspension Bead Array for Ultrasensitive Multiplex Immunodetection of Tumor Markers, Anal. Chim. Acta, 2019, 1048, 75-84.
7. Tian, Y; Ma, L; Gong, MF; Su, GQ*, Zhu, SB; Zhang, WQ; Wang, S; Li ZB; Chen CX; Li, LH; Wu, LN; Yan, XM*, Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry, ACS Nano 2018, 12, 671-680.
8. Zhang, WQ; Tian, Y; Hu, XX; He, SB; Niu, Q; Chen, CX; Zhu, SB; Yan, XM*, Light-Scattering Sizing of Single Submicron Particles by High-Sensitivity Flow Cytometry, Anal. Chem. 2018, 90, 12768-12775.
9. Wang, S; Li, LH; Jin, SH; Li, WF; Hang, W; Yan, XM*, Rapid and Quantitative Measurement of Single Quantum Dots in a Sheath Flow Cuvette, Anal. Chem. 2017, 89, 9857-9867.
10. Wu, LN; Wang, X; Zhang, JQ; Luan, T; Bouveret, E.; Yan, XM*, Flow Cytometric Single-Cell Analysis Enables Quantitative in vivo Detection of Protein-Protein Interactions via Relative Reporter Protein Expression Measurement, Anal. Chem. 2017, 89, 2782-2789.
11. Chen, CX; Zhu, SB; Wang, S; Zhang, WQ; Cheng, Y; Yan, XM*, Multiparameter Quantification of Liposomal Nanomedicines at the Single-particle Level by High Sensitivity Flow Cytometry, ACS Appl. Mater. Interfaces 2017, 9, 13913-13919.
12. Yan, Y; Meng, LY; Zhang, WQ; Zheng, Y; Wang, S; Ren, B; Yang, ZL*; Yan, XM*, High-Throughput Single-Particle Analysis of Metal-Enhanced Fluorescence in Free Solution Using Ag@SiO2 Core-Shell Nanoparticles, ACS Sensors 2017, 2, 1369-1376.
13. Ma, L; Zhu, SB; Tian, Y; Zhang, WQ; Wang, S; Chen, CX; Wu, LN; Yan, XM*, A Label-Free Analysis of Single Viruses with a Resolution Comparable to That of Electron Microscopy and the Throughput of Flow Cytometry, Angew. Chem. Int. Ed. 2016, 55, 10239 –10243. (Hot Paper)
14. Wu, LN; Song, YY; Luan, T; Ma, L; Su, LQ; Wang, S; Yan XM*, Specific Detection of Live Escherichia coli O157:H7 Using Tetracysteine-Tagged PP01 Bacteriophage, Biosens. Bioelectron. 2016, 86, 102-108.
15. Huang, TX; Zheng, Y; Yan, Y; Yang, LL; Yao, YH; Zheng, JX; Wu, LN; Wang, X; Chen, YQ; Xing, JC; Yan, XM*, Probing Minority Population of Antibiotic-Resistant Bacteria, Biosens. Bioelectron. 2016, 80, 323-330.
16. Wu, LN; Wang, S; Song, YY; Wang, X; Yan, XM*. Applications and Challenges for Single-Bacteria Analysis by Flow Cytometry, Sci. China Chem. 2016, 59, 30-39.
17. Chen, CX; Zhang, X; Zhang, SY; Zhu, SB; Xu, JY, Zheng, Y; Han, JY, Zeng, JZ; Yan, XM*, Quantification of protein copy number in single mitochondria: the Bcl-2 family proteins, Biosens. Bioelectron. 2015, 74, 476-482.
18. Zhu, SB; Ma, L; Wang, S; Chen, CX; Zhang, WQ; Yang, LL; Hang, W; Nolan, J. P.; Wu, LN; Yan, XM*, Light-Scattering Detection below the Level of Single Fluorescent Molecules for High-Resolution Characterization of Functional Nanoparticles. ACS Nano 2014, 8, 10998-11006.
19. Zhang, X; Zhang, SY; Zhu, SB; Chen, S; Han, JY; Gao, KM; Zeng, JZ; Yan, XM*, Rapid identification of mitochondria-targeting anticancer compounds by an in vitro strategy, Anal. Chem. 2014, 86, 5232-5237.
20. Wu, LN; Luan, T; Yang, XT; Wang, S; Zheng, Y; Huang, TX; Zhu, SB; Yan, XM*, Trace detection of specific viable bacteria using tetracysteine-tagged bacteriophages, Anal. Chem. 2014, 86, 907-912.


纳米流式检测技术的研发与应用