教授、博士生导师
电话：（0592）**（实验室）
　　　（0592）**（办公室）
传真：（0592）**
电子邮箱：yfzhao@xmu.edu.cn
实验室主页 (Prof. Yufen Zhao Group Website)
个人简历：
博士（美国纽约州立大学石溪分校，1975）学士（台湾清华大学）
博士后（美国纽约州立大学石溪分校）
中国科学院院士
先后获得国际阿布佐夫奖，中科院科技进步二、三等奖，教育部科技进步二、三等奖，中国青年科学家奖，第二届新世纪巾帼发明家等。
研究兴趣：
生命有机化学，有机磷化学，生命起源，药物化学，化学生物学
近期主要代表论著：

“A universal and multiplex kinase assay using γ-[18O4]-ATP”，Fu, Chuan; Zheng, Xueyun; Jiang, Yao; Liu, Yan; Xu, Pengxiang; Zeng, Zhiping; Liu, Rihe; Zhao, Yufen，Chemical Communications (2013), 49(27), 2795-2797.
“Copper-Catalyzed Synthesis of α-Hydroxy Phosphonates from H-Phosphonates and Alcohols or Ethers”，Zhao, Zengxiang; Xue, Wanhua; Gao, Yuxing; Tang, Guo; Zhao, Yufen，Chemistry--An Asian Journal (2013), 8(4), 713-716.
“Nickel(II)-magnesium-catalyzed cross-coupling of 1,1-dibromo-1-alkenes with diphenylphosphine oxide: one-pot synthesis of (E)-1-alkenylphosphine oxides or bisphosphine oxides”，Liu, Liu; Wang, Yulei; Zeng, Zhiping; Xu, Pengxiang; Gao, Yuxing; Yin, Yingwu; Zhao, Yufen，Advanced Synthesis & Catalysis (2013), 355(4), 659-666.
“Stable Isotope N-Phosphorylation Labeling for Peptide de Novo Sequencing and Protein Quantification Based on Organic Phosphorus Chemistry”，Gao, Xiang; Wu, Hanzhi; Lee, Kim-Chung; Liu, Hongxia; Zhao, Yufen; Cai, Zongwei; Jiang, Yuyang，Analytical Chemistry (2012), 84(23), 10236-10244.
“Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry”，Gao, Xiang; Tang, Zhi; Lu, Minghua; Liu, Hongxia; Jiang, Yuyang; Zhao, Yufen; Cai, Zongwei，Chemical Communications (2012), 48(82), 10198-10200.
“An isotope (18O, 15N, and 2H) technique to investigate the metal ion interactions between the phosphoryl group and amino acid side chains by electrospray ionization mass spectrometry”，Gao, Xiang; Hu, Xiaomei; Zhu, Jun; Zeng, Zhiping; Han, Daxiong; Tang, Guo; Huang, Xiantong; Xu, Pengxiang; Zhao, Yufen，Journal of the American Society for Mass Spectrometry (2011), 22(4), 689-702.
“Fast separation of antiviral nucleoside phosphoramidate and H-phosphonate diastereoisomers by reversed-phase liquid chromatography”，Gao, Xiang; Chen, Weizhu; Zhu, Gangtian; Yi, Ruizao; Wu, Zhen; Xu, Pengxiang; Zhao, Yufen，Journal of Chromatography, A (2011), 1218(10), 1416-1422.
“Intermolecular phosphoryl transfer of N-phosphoryl amino acids”，Gao, Xiang; Deng, Honggui; Tang, Guo; Liu, Yan; Xu, Pengxiang; Zhao, Yufen，European Journal of Organic Chemistry (2011), (17), 3220-3228
“Stereospecific Coupling of H-Phosphinates and Secondary Phosphine Oxides with Amines and Alcohols: A General Method for the Preparation of Optically Active Organophosphorus Acid Derivatives”, G. Wang, R.-W. Shen, Q. Xu, Goto Midori, Y.-F. Zhao and L.-B. Han, J. Org. Chem. 2010, 75, 3890–3892
“Selective P-P and P-O-P Bond Formations through Copper-Catalyzed Aerobic Oxidative Dehydrogenative Couplings of H-Phosphonates”, Y.-B. Zhou, S.-F. Yin, Y.-X. Gao, Y.-F. Zhao, Midori Goto, and L.-B. Han, Angew. Chem. Int. Ed,., 2010, 49, 6852 –6855
“Genome wide exploration of the origin and evolution of amino acids”, X.-X. Liu, J.-X. Zhang, F. Ni, X. Dong, B.-C. Han, D.-X. Han, Z.-L. Ji, Y.-F. Zhao, BMC Evolutionary Biology, 2010, 10:77
“Copper-Catalyzed Aerobic Oxidative Coupling of Terminal Alkynes with H-Phosphonates Leading to Alkynylphosphonates”, Y.-X. Gao, G. Wang, L. Chen, P.-X. Xu, Y.-F. Zhao, Y.-B. Zhou, and L.-B. Han, J. Am. Chem. Soc., 2009, 131, 7956–7957
“N-phosphorylation of amino acids by trimetaphosphate in aqueous solution—learning from prebiotic synthesis”, F. Ni, S.-T. Sun, C. Huang and Y.-F. Zhao, Green Chemistry, 2009, 11, 569 – 573
“On the Electrophilicity of cyclic acylphosphoramidates (CAPAs) postulated as intermediates”, F. Ni, X. Gao, Z.-X. Zhao, C. Huang, and Y.-F. Zhao, Eur. J. Org. Chem., 2009, 3026–3035.
“Chirality at phosphorus in pentacoordinate spirophosphoranes: stereochemistry by X-ray structure and spectroscopic analysis”, J.-B. Hou, H. Zhang, J.-N. Guo, Y. Liu, P.-X. Xu, Y.-F. Zhao and G. M. Blackburn, Org. Biomol. Chem., 2009, 7, 3020–3023.
“Negative ion electrospray ionization mass spectrometry of nucleoside phosphoramidate monoesters: elucidation of novel rearrangement mechanisms by multistage mass spectrometry incorporating in-source deuterium labeling”, P.-X. Xu, A.-F. Hu, D. Hu, X. Gao, Y.-F. Zhao, Rapid Communications in Mass Spectrometry, 2008, 2 :19, 2977-2983
“Alpha-amino acid behaves differently from beta- or gamma-amino acids as treated by trimetaphosphate”, X. Gao, Y. Liu, P.-X. Xu, Y.-F. Zhao. Amino Acids., 2008, 34, 47-53.
“DNA cleavage function of seryl-histidine dipeptide and its application”, Y. Ma, X. Chen, M. Sun, R. Wan, C.-J. Zhu, Y.-M. Li, Y.-F. Zhao, Amino Acids., 2008, 35, 251-256.
“Analysis of the phosphoryl transfer mechanism of c-amp dependent protein kinase (pka) by penta-coodinate phosphoric transition state theory”, F. Ni, W. Li, Y. Li, Y.-F. Zhao, Current Protein & Peptide Science, 2005, 6, 437-442.
Selected Targets of Current Interest