杨献文 研究员
招生资格： 博士生导师
邮 箱： yangxianwen@tio.org.cn
招生专业： 海洋生物学/微生物学
研究方向： 海洋天然药物化学


个人简介：
杨献文研究员多年来一直从事天然产物活性成分研究，已分离鉴定3000多个化合物，其中新结构300多个，活性成分50多个；已发表SCI学术论文150多篇，其中以第一作者或通讯作者在Chemical Communications等国际著名刊物上发表SCI论文56篇；平均影响因子>3；先后主持20多项国家或省部级等科研项目，包括国家自然科学基金5项；已授权或申请国内及国际专利20多项，包括国际专利（美国）1项；在国际上具有广泛的学术影响，现为Frontiers in Chemistry的客座副主编，同时也是Organic Letters, Journalof Natural Products, Journal of Agriculture and Food Chemistry等多个国际著名期刊审稿人。
发表文章：
1. Fan, S. Q.; Xie, C. L.; Xia, J. M.; Xing, C. P.; Luo, Z. H.; Shao, Z.; Yan, X. J.; He, S.; Yang, X. W.*, Sarocladione, a unique 5,10:8,9-diseco-steroid from the deep-sea-derived fungus Sarocladium kiliense. Org. Biomol. Chem. 2019, 17, (24), 5925?5928.
2. Zhang, X. W.; Fan, S. Q.; Xia, F.; Ye, Y. S.; Yang, X. W.*; Yang, X. W.*; Xu, G.*, Prenylated acylphloroglucinols from Hypericum faberi. J. Nat. Prod. 2019, 82, (5), 1367–1371.
3. Xie, C. L.; Zhang, D.; Xia, J. M.; Hu, C. C.; Lin, T.; Lin, Y. K.; Wang, G. H.; Tian, W. J.; Li, Z. P.; Zhang, X. K.*; Yang, X. W.*; Chen, H. F.*, Steroids from the deep-sea-derived fungus Penicillium granulatumMCCC 3A00475 induced apoptosis via retinoid X receptor (RXR)-α pathway. Mar. Drugs 2019, 17, (3), 178.
4. Li, Y. L.; Xue, L. J.; Li, J.; Chen, L. M.; Wu, J. J.; Xu, Z. N.; Chen, Y.; Tian, Y. P.; Yang, X. W.*, Abinukitrine A, a unique 17,18-cyclolanostane triterpenoid from Abies nukiangensis. Org. Biomol. Chem. 2019, 17, (8), 2107?2109.
5. Niu, S.; Tang, X. X.; Fan, Z.; Xia, J. M.; Xie, C. L.; Yang, X. W.*, Fusarisolins A–E, polyketides from the marine-derived fungus Fusarium solani H918. Mar. Drugs 2019, 17, (2), 125.
6. Lin, Y. K.; Xie, C. L.; Xing, C. P.; Wang, B. Q.; Tian, X. X.; Xia, J. M.; Jia, L. Y.; Pan, Y. N.*; Yang, X. W.*, Cytotoxic p-terphenyls from the deep-sea-derived Aspergillus candidus. Nat. Prod. Res. 2019, doi: 10.1080/**.2019.**
7. Xing, C. P.; Wu, J.; Xia, J. M.; Fan, S. Q.; Yang, X. W.*, Steroids and anthraquinones from the deep-sea-derived fungus Aspergillus nidulansMCCC 3A00050. Biochem. Syst. Ecol. 2019, 83, 103–105.
8. Li, Y. L.*; Zhang, Q.; Wu, J. J.; Xue, L. J.; Chen, L. M.; Tian, J. M.; Xu, Z. N.; Chen, Y.; Yang, X. W.*; Hao, X. J.; Li, J.*, Nukiangendines A and B, two novel 13,14-seco-abietanes from Abies nukiangensis. Tetrahedron Lett. 2019, 60, (10), 751?753.
9. Xie, C. L.; Xia, J. M.; Wang, J. S.*; Lin, D. H.*; Yang, X. W.*, Metabolomic investigations on Nesterenkonia flavarevealed significant differences between marine and terrestrial actinomycetes. Mar. Drugs 2018, 16, (10), 356.
10. Lin, W. X.; Xie, C. L.; Zhou, M.; Xia, M. L.; Zhou, T. T.; Chen, H. F.; Yang, X. W.*; Yang, Q.*, Chemical constituents from the deep sea-derived Streptomyces xiamenensis MCCC 1A01570 and their effects on RXRα transcriptional regulation. Nat. Prod. Res. 2018, 32, doi: 10.1080/**.2018.**.
11. Niu, S.; Wang, N.; Xie, C. L.; Fan, Z.; Luo, Z.; Chen, H. F.; Yang, X. W.*, Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatumMCCC 3A00475. J. Antibiot. 2018, 71, (7), 658?661.
12. Niu, S.; Xie, C. L.; Xia, J. M.; Luo, Z. H.; Shao, Z.; Yang, X. W.*, New anti-inflammatory guaianes from the Atlantic hydrotherm-derived fungus Graphostroma sp. MCCC 3A00421. Sci. Rep. 2018, 8, (1), 530.
13. Xie, C. L.; Niu, S.; Xia, J. M.; Peng, K.; Zhang, G. Y.; Yang, X. W.*, Saccharopolytide A, a new cyclic tetrapeptide with rare 4-hydroxy-proline moieties from the deep-sea derived actinomycete Saccharopolyspora cebuensis MCCC 1A09850. Nat. Prod. Res. 2018, 32, (14), 1627?1631.
14. Xie, C. L.; Xia, J. M.; Su, R. Q.; Li, J.; Liu, Y.; Yang, X. W.*; Yang, Q.*, Bacilsubteramide A, a new indole alkaloid, from the deep-sea-derived Bacillus subterraneus 11593. Nat. Prod. Res. 2018, 32, (21), 2553?2557.
15. Niu, S.; Liu, Q.; Xia, J. M.; Xie, C. L.; Luo, Z. H.; Shao, Z.; Liu, G. M.; Yang, X. W.*, Polyketides from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421 showed potent antifood allergic activities. J. Agric. Food Chem. 2018, 66, (6), 1369–1376.
16. Niu, S.; Fan, Z.; Tang, X.; Liu, Q.; Shao, Z.; Liu, G.; Yang, X. W.*, Cyclopiane-type diterpenes from the deep-sea-derived fungus Penicillium communeMCCC 3A00940. Tetrahedron Lett. 2018, 59, (4), 375?378.
17. Liu, Q. M.; Xie, C. L.; Gao, Y. Y.; Liu, B.; Lin, W. X.; Liu, H.; Cao, M. J.; Su, W. J.; Yang, X. W.*; Liu, G. M.*, Deep-sea-derived butyrolactone I suppresses ovalbumin-induced anaphylaxis by regulating mast cell function in a murine model. J. Agric. Food Chem. 2018, 66, (22), 5581?5592.
18. Niu, S.; Zhou, T. T.; Xie, C. L.; Zhang, G. Y.; Yang, X. W.*, Microindolinone A, a novel 4,5,6,7-tetrahydroindole, from the deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207. Mar. Drugs 2017, 15, (7), 230.
19. Xie, C. L.; Liu, Q.; Xia, J. M.; Gao, Y.; Yang, Q.; Shao, Z. Z.; Liu, G.; Yang, X. W.*, Anti-allergic compounds from the deep-sea-derived actinomycete Nesterenkonia flava MCCC 1K00610. Mar. Drugs 2017, 15, (3), 71.
20. Niu, S.; Xie, C. L.; Zhong, T.; Xu, W.; Luo, Z. H.; Shao, Z.; Yang, X. W., Sesquiterpenes from a deep-sea-derived fungus Graphostroma sp. MCCC 3A00421. Tetrahedron 2017, 73, (52), 7267?7273.
21. Niu, S.; Fan, Z. W.; Xie, C. L.; Liu, Q.; Luo, Z. H.; Liu, G.; Yang, X. W., Spirograterpene A, a tetracyclic spiro-diterpene with a fused 5/5/5/5 ring system from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475. J. Nat. Prod. 2017, 80, (7), 2174?2177.
22. Ma, X. N.; Xie, C. L.; Miao, Z.; Yang, Q.; Yang, X. W.*, An overview of chemical constituents from Alpinia species in the last six decades. RSC Adv. 2017, 7, (23), 14114?14144.
23. Xie, C. L.; Niu, S. W.; Zhou, T. T.; Zhang, G. Y.; Yang, Q.; Yang, X. W.*, Chemical constituents and chemotaxonomic study on the marine actinomycete Williamsia sp. MCCC 1A11233. Biochem. Syst. Ecol. 2016, 67, 129–133.
主持项目：
1)中国大洋矿产资源研究开发协会课题：深海微生物天然药物新资源获取与活性评价；项目编号：DY135-B2-08；起止年限：2018.6–2020.12。
2)国家自然科学基金面上项目：三株深海微生物中抗食物过敏活性的物质基础及其作用机制研究；项目编号：**；起止年限：2019.1–2022.12。
3)国家自然科学基金面上项目：基于“shock and kill”策略研究两株深海链霉菌中HIV潜伏激活的活性成分；项目编号：**；起止年限：2017.1–2020.12。
4)国家自然科学基金面上项目：三株南海放线菌中作用于PPAR-LXR-ABCA1通路的抗动脉粥样硬化活性次生代谢产物的发现；项目编号：**；起止年限：2014.1–2017.12。
5)国家自然科学基金面上项目：两株南海珊瑚共附生放线菌的PTK活性成分及其机理研究；项目编号：**；起止年限：2012.1–2015.12。
6)国家自然科学基金青年基金：三株南海北部深海放线菌抗植物病原菌的活性成分研究；项目编号：**；起止年限：2011.1–2013.12。
7)厦门市海洋与渔业局海洋产业技术瓶颈和关键难题攻关项目：基于PDX的新型海洋抗癌活性先导化合物的筛选；项目编号：17GYY026NF05；起止年限：2017.8–2020.6。
8)厦门恩成制药有限公司横向项目：海洋新型抗肿瘤活性化合物研发；项目编号：HT**；起止年限：2016.10–2019.9。