姓名:
申河清性别:
男
电话:
**职称:
研究员
通讯地址:
厦门市集美大道1799号
邮政编码:
361021电子邮件:
hqshen@iue.ac.cn


简历：
博士，研究员，博士生导师，中国科学院“百人计划”入选者，厦门大学公共卫生学院兼职教授，国际暴露科学学会会员。1991年6月本科毕业于太原理工大学应用化学系；1997年7月硕士毕业于中科院大连化学物理研究所；2005年3月博士毕业于德国慕尼黑技术大学(TechnicalUniversityMunich)；2005年3月–2006年3月在亥姆霍兹慕尼黑研究中心-德国环境卫生研究中心的生态化学研究所(InstituteofEcologyChemistry,HelmholtzZentrumMünchen-GermanResearchCenterforEnvironmentalHealth)作博士后研究；2006年4月–2009年3月在丹麦哥本哈根大学医院作研究学者(SeniorStaffCand.Sci.,Dept.GrowthandReproduction,CopenhagenUniversity,Rigshospitalets)。
研究领域：
环境污染物的暴露科学和健康效应，即多学科交叉的暴露科学（exposurescience）、毒理学、环境流行病学研究，涉及环境中化学微污染物（micro-pollutants）的监测、人群暴露监测（humanbio-monitoring）、暴露组学（exposomics）和暴露标志物（exposurebiomarkers），污染物的效应标志物（responsebiomarkers）和系统生物学技术筛选（systemsbiology）、环境-表观基因相互作用（environmentepigenetic），环境流行病学（environmentalepidemiology）。

社会任职：

获奖及荣誉：

代表论著：
1.ZhangJ,LiuF,ChenR,FengT,DongS,ShenH*,LevelsofPolychlorinatedBiphenylsandOrganochlorinePesticidesinEdibleShellfishfromXiamen(China)andEstimationofHumanDietaryIntake.FoodChem.Toxicol.2012,50,4285–42912.XuW,BaoH,LiuF,LiuL,ZhuY-G,SheJ,DongS,CaiM,LiL,LiC,ShenH*.Environmentalexposuretoarsenicmayreducehumansemenquality:associationsderivedfromaChinesecross-sectionalstudy.Environ.Health2012,11:463.PengS,ZhangJ*,TianM,WangZ,ShenH*.DeterminationofGlobalDNAMethylationinBiologicalSamplesbyLiquidChromatography-TandemMassSpectrometer(液相色谱-串联质谱法测定生物样本全基因组DNA甲基化).Ch.J.Anal.Chem.2012,40(8),1201-12064.ZhangJ,YanL,TianM,HuangQ,PengS,DongS,ShenH*.Themetabonomicsofcombineddietaryexposuretophthalatesandpolychlorinatedbiphenylsinmice.J.Pharm.Biomed.Anal.2012,66,287-2975.Krysiak-BaltynK,Skakkeb?kNE,ToppariJ,JensenT,VirtanenH,SchrammK-W,ShenH,VartiainenT,KivirantaH,TaboureauO,BrunakS,MainK.Associationbetweenchemicalpatterninbreastmilkandcongenitalcryptorchidism:modelingofcomplexhumanexposure.Int.J.Androl.2012,35(3),294-3026.LiuL,XiaT,GuoL,CaoL,ZhaoB,ZhangJ,DongS,ShenH*.Expressingurinefromageldisposablediaperforbiomonitoringusingphthalatesasanexample.J.Expo.Sci.Environ.Epidemiol.,2012,22,625-6317.PengS,YanL,Zhang*J,ShenH*.Hepatotoxicityofperfluorooctanoicacidinhumanhepatocytesusingmetabonomics(利用代谢组学技术研究全氟辛酸的人肝脏毒性机制).Ch.J.Chromatogr.2012,30(02):123-1278.TianM,PengS,MartinFL,ZhangJ,LiuL,WangZ,DongS,ShenH*.Perfluorooctanoicacidinducesgenepromoterhypermethylationofglutathione-S-transferasePiinhumanliverL02cells.Toxicology.2012,296(1-3)48-559.LiaoY,WangJ,HuangQ,FangC,KiyamaR,ShenH*,DongS*.Evaluationofcellularresponsetoperfluorooctanesulfonateinhumanumbilicalveinendothelialcells.Toxicol.inVitro2012,26(3):421-42810.ShenH,HenkelmannB,RambeckWA,MayerR,WehrU,SchrammK-W.Physiologicallybasedpersistentorganicpollutantaccumulationinpigtissuesandtheirediblesafetydifferences:Aninvivostudy.FoodChem.2012,132(4)1830-183511.FangC,WuX,HuangQ,LiaoY,LiuL,QiuL,ShenH*,DongS*.PFOSelicitstranscriptionalresponsesoftheER,AHRandPPARpathwaysinOryziasmelastigmainastage-specificmanner.AquaticToxicol.2011,106-107,9-1912.ShenH,HenkelmannB,RambeckWA,MayerR,WehrU,SchrammK-W.Thepredictivepoweroftheeliminationofdioxin-likepollutantsfrompigs:Aninvivostudy.Environ.Int.2012,3873-7813.LiuF,NiH-G,ChenF,LuoZ-X,ShenH*,LiuL,WuP.Metalaccumulationinthetissuesofgrasscarps(Ctenopharyngodonidellus)fromfreshwateraroundacoppermineinSoutheastChina.Environ.Monit.Assess.2012,184(7),4289-429914.WangX,SuoY,YinR,ShenH*,WangH*.Ultra-performanceliquidchromatography/tandemmassspectrometryforaccuratequantificationofglobalDNAmethylationinhumansperms.J.Chromatogr.B.2011,879,1647-165215.ZhaoB,ShenH*,LiuF,LiuS,NiuJ,GuoF,SunX.Exposuretoorganochlorinepesticidesisindependentriskfactorofhepatocellularcarcinoma:Acase-controlstudy,J.Expo.Sci.Environ.Epidemiol.2012,22,541-54816.LiuL,BaoH,LiuF,ZhangJ,ShenH*.PhthalatesexposureoftheChinesereproductiveagecouplesandtheireffectonmalesemenquality,aprimarystudy.Environ.Int.2012,42,78-8317.ZhaoB,LiuF,LiuS,NiuJ,GuoF,SunX,ShenH*.Acase-controlstudyoftheassociationbetweenhumanexposuretoselectedchlorinatedpesticidesandprimaryhepatocellularcarcinoma.Epidemiology2011,22,S145Before2010
18.KristinaVoigt,RainerBrueggemann,HagenScherb,HeqingShen,Karl-WernerSchramm.2010.EvaluatingtherelationshipbetweenchemicalexposureandcryptorchidismbydiscretemathematicalmethodusingPyHassesoftware.Environ.Model.Softw.25:1801-1812.19.?smet?ok,MenekseKeskiDonmez,MineUner,ErkanDemirkaya,BernhardHenkelmann,HeqingShen,JarmilaKotalik,Karl-WernerSchramm.2009.Polychlorinateddibenzo-p-dioxins,dibenzofuransandpolychlorinatedbiphenylslevelsinhumanbreastmilkfromdifferentregionsofTurkey.Chemosphere76:1563-1571.20.KonradKrysiak-Baltyn,NielsErikSkakkeb?k,JormaToppari,ThomasJensen,HelenaVirtanen,Karl-WernerSchramm,HeqingShen,TerttuVartiainen,HannuKiviranta,OlivierTaboureau,S?renBrunak,KatharinaMain.2009.Country-specificchemicalsignaturesofpersistentenvironmentalcompoundsinbreastmilk.Int.J.Androl.32:1-9.21.HeqingShen,BernhardHenkelmann,WalkiriaLevy,AdamZsolnay,PeterWeiss,GertJakobi,ManfredKirchner,WolfgangMoche,KatharinaBraunandKarl-WernerSchramm.2009.Altitudinalandchiralsignatureofpersistentorganochlorinepesticidesinair,soil,andspruceneedles(Piceaabies)oftheAlps.Environ.Sci.Technol.43:2450-2455.22.?smet?ok,MenekseKeskiDonmez,M.HakanSat?ro?lu,BatuAyd?nuraz,BernhardHenkelmann,HeqingShen,JarmilaKotalik,Karl-WernerSchramm.2008.Concentrationsofpolychlorinateddibenzo-p-dioxins(PCDDs),polychlorinateddibenzofurans(PCDFs)anddioxin-likePCBsinadiposetissueofinfertilemen.Arch.Environ.Contam.Toxicol.55:143-152.23.HeqingShen,KatharinaM.Main,Anna-MariaAndersson,IdaN.Damgaard,HelenaE.Virtanen,NielsE.Skakkebaek,JormaToppari,andKarl-WernerSchramm.2008.ConcentrationsofpersistentorganochlorinecompoundsinhumanmilkandplacentaarehigherinDenmarkthaninFinland.Hum.Reprod.23:201-210.24.HeqingShen,KatharinaMMain,HelenaEVirtanen,IdaNDamggard,Anne-MaaritHaavisto,MKaleva,KABoisen,IdaMSchmidt,MarlaChellakooty,NielsESkakkebaek,JormaToppari,Karl-WernerSchramm.2007.Frommothertochild:Investigationofprenatalandpostnatalexposuretopersistentbioaccumulatingtoxicantsusingbreastmilkandplacentabiomonitoring.Chemosphere67:256-262.25.MartSimm,OttRoots,JonneKotta,AinLankov,BernhardHenkelmann,HeqingShen,Karl-WernerSchramm.2006.PCDD/Fsinsprat(Sprattussprattusbalticus)fromthegulfofFinland,theBalticSea.Chemosphere65:1570-1575.26.IdaNDamgaard,NielsESkakkeb?k,JormaToppari,HelenaEVirtanen,HeqingShen,Karl-WernerSchramm,J?rgenHPetersen,TinaKJensen,KatharinaMMainandtheNordicCryptorchidism.2006.Studygroup,PersistentpesticidesinhumanbreastmilkandCryptorchidism.Environ.HealthPersp.114:1133-1138.27.HeqingShen,H.E.Virtanen,KatharinaM.Main,M.Kaleva,A.M.Andersson,NielsE.Skakkeb?k,JormaToppariandKarl-WernerSchramm.2006.Enantiomericratiosasanindicatorofexposureprocessesforpersistentpollutantsinhumanplacentas.Chemosphere62:390-395.28.H.Shen,K.M.Main,M.Kaleva,H.Virtanen,A.-M.Haavisto,N.E.Skakkebaek,J.ToppariandK.-W.Schramm.2005.PrenatalorganochlorinepesticidesinplacentasfromFinland:Exposureofmaleinfantsbornduring1997–2001.Placenta26:512-514.29.LiangmoZhou,MengyanNie,QinghaiWang,DaoqianZhu,HeqingShen.1999.Enthalpy-entropycompensationeffectingaschromatographicenantiomericseparation.Ch.J.Chem.17:363-376.30.HeqingShen,QinghaiWang,DaoqingZhu,LiangmoZhou.1999.Astudyofamolecularmechanicsfieldusedinsimulatingenantiorecognition.Ch.Chem.Letters10:415-418.31.DuanZhang,Zhanguolu,HeqingShen,LiangmoZhou,WenshenGuo.1997.Theasymmetricalreductionof1-4’-hydroxyphenyl-1-butanonecomplexedwithsolidl-cedrol,Ch.J.SyntheticChem,A5:559.32.HeqingShen,QinghaiWang,DaoqingZhu,LiangmoZhou.1998.Studyoffourpentylatedα-,β-cyclodextrinchiralstationaryphasesoncapillarygaschromatography.Ch.J.Anal.Chem.26:211-214.33.HeqingShen,QinghaiWang,DaoqingZhu,LiangmoZhou.1998.Studyon2,6-Dipentyl-β-cyclodextrinasastationaryphaseincapillarygaschromatographicseparationofenantiomers.J.Inst.Anal.17:45-46.HeqingShen,QinghaiWang,DaoqingZhu,LiangmoZhou.1997.Molecularmodelingmethodanditsapplicationsinchiralrecognitionmechanism.Ch.J.Anal.Chem.25:110-114.

承担科研项目情况：
育龄男性全氟烷烃类化合物暴露和精子DNA甲基化关系研究2012.1-2015.12
用胶质纸尿片采集尿液作为婴幼儿易代谢内分泌干扰物测定的可行性研究2010.11-2012.11
环境污染物的人群暴露与健康2009.04-2012.04