许瑞安教授
发布时间:2012-05-04 浏览次数:
NameRuian(Ray)Xu(PhDOtago)许瑞安
MailingAddress:
ProfessorandDirector
EngineeringResearchCenterofMolecularMedicine
MinistryofEducation
518/519ShengjunBuilding
HuaqiaoUniversityMainCampus
Fujian,CHINA362021
Tel：0086-**/**952
Fax:**535
Email:ruianxu@hqu.edu.cn
国家教育部分子药物工程研究中心主任、国际癌细胞与基因疗法学会常务理事、国际口服基因疗法主要奠基人和发明人之一、国家科技部科技发展战略专家/国际科技合作管理专家、国家教育部学位中心评审专家、福建省生物医药工程研究生培养基地负责人、华侨大学分子药物所所长、厦门海洋与基因工程重点实验室主任、厦门市国际科技合作分子药物基地负责人、教授、博士生导师、瑞典卡罗琳医学院国际学术刊物Islet编委，美国InternationalPanelofMedicalScienceMonitor,我国WorldJournalofGastroenterologyPharmacologyandTreatment编委、美、英、德、日、瑞典等国际18家Hepatology，GeneTherapy等SCI学术刊物审稿人、“行政院”台北荣民总院荣誉教授、爱尔兰国家自然基金评审专家、新西兰食品科学技术研究院专业委员、北京协和医学院荣誉教授、《中国临床药理学和治疗学》编委、顾问，《中国海洋资源》特邀编委、中国海洋大学海洋药物客座教授，山东大学兼职教授、国家863“十五”肺癌基因疗法课题组组长、首席科学家、肝癌基因疗法课题组副组长、国家863“十一五”肺癌基因疗法课题组首席科学家。
1983年录取教育部出国公派留学，1989年获得Otago大学博士学位，在加拿大完成博士后，一直在国外多家著名国际大学、科研机构从事科研教学工作，先后出任过大学载体研究中心、神经载体研究室主任。其分子药学研究工作发表于NatureMedicine[文章发表于1998年第5期封面]、Science、PNAS等国际一流学术刊物。从1983年起至今已发表学术论文100余篇，其中SCI论文70余篇；并申报/获得专利发明16项。2005年发表在美国的?医学科学检测?杂志的“StabilityofInfectiousrAAVvectorstock”一文被联合国科教文机构下属世界卫生组织定为分子疗法临床应用的主要参考文献之一。
合编《TrendsinGeneTherapyResearch》NOVASciencePublisher,NewYork,USA(2005)。主编《分子基因药物学》北京大学出版社&北京大学医学出版社110万字（被选为我国2008年最佳科技图书），《细胞工程与分子生物技术》化学工业出版社70万字，2007年入选美国Marquis科学工程版Whoiswho。2008年入选美国Marquis国际版Whoiswho。2010年获中国侨界双百奖（创新人才奖）。2010年第二届国际定量药理学与新药评价会议主席。
研究方向：分子药物、分子医学、海洋与基因工程药物
Education:PhD,OtagoUniversity,NZ（1989-05-06）
PATENTAPPLICATIONS:(16)
No.
NameofInventors
ApplicationNumber
TitleofPatent
1
RAXu,X.,Ma
**0.2
Transductingintestinecellsbyoralgenedelivery
2
RAXu，Y.,Diao，K.,Cai
**4.5
Vasostatinforinhibitinglungcancermetstasis
3
RAXu;G.,Wang,Y.Diao
**5.1
Productionandapplicationofrecombinantcytoglobin
4
DZheng;RAXu,HMa,YLiu,XKung
03138357.2
Arecombinantsolubletumornecrosisfactor-relatedapoptosis-inducingligandsequenceandapplication
5
RAXu,XSun,STFang,XKung,G·Kressen
**7.9
Synergizingwithangiostatinadeno-associatedvirus-mediatedB7.1vaccinationtoeradicatethespreadofmetastatictumor
6
RAXu,XL,PFung
**0.6
Adrugforpreventionandtreatmentoflivercirrhosis
7
RAXu,LTse,YDiao
**9.2
TwokindsofnovelangiogenesisinhibitordrugsandtheirapplicationtoCombatCancer
8
RAXu,PFung,JZhu
**4.9
MethodologyandapplicationofAanti-coloncancergenemediecine
9
YDiao;RAXu
**4.X
Ofananti-cardiovascularandcerebrovasculardiseases,traditionalChinesemedicinecompositionanditspreparationmethod
10
QZeng;RAXu
**0.3
AMethodforpreparationofethylcinnamatederivatives
11
RAXu,WXiao,HLu
**4.5
Anewtypeofcell-specificmicroRNAbindinggenesequencecontainingHAAVmirforgenetherapy
12
黄晓平;李招发;刁勇;许瑞安
**4.0
一种分泌表达人Kallistatin的重组酵母菌株及生产工艺
13
许瑞安，张亭亭、李招发、刁勇
**9.8
重组细胞球蛋白在延缓皮肤衰老中的应用
14
许瑞安，吴龙火
**0.9
一种(±)-Murracarpin的合成方法及其抗炎作用
15
许瑞安，施伟杰
**9.0
融合Tat人源细胞球蛋白及其在治疗肝癌中的应用
16
许瑞安、王晓
**7.9
鳄鱼鳞的提取及其临床应用
PUBLICATIONS
I.TotalChaptersofBooks:15
1.1ChapterXuRA*etal.Oralviralgenedelivery（33pages）,In:TrendsinGeneTherapyResearch（2006）NOVASCIENCE，Publisher,NewYork,USA（AninvitationtoXuRAfromNOVASciencePublisher,NewYork,USA）
2.9ChaptersIn:MolecularGeneMedicine。XuRA*,ChenL,XiaoWD
(Es),PekingUniversityPress&PekingUniversityMedicalPress,2008.2
《分子基因药物学》许瑞安*、陈凌、肖卫东主编110万字北京大学出版社&北京大学医学出版社联合出版，2008年，北京。
①Chapter3Moleculedrugdeliverychannelsandintestinalabsorptionofnano-particlesRAXu*pp68-90
②Chapter4AptamerMolecularPharmacologyJLin、RAXupp91-104
②Chapter7MoleculartherapyofParkinson'sdiseaseandProspectsJiaL,RAXupp175-205
④Chapter8MoleculartherapyofhepatitisBLiH、RAXu*pp206-245
⑤Chapter10MoleculartreatmentofthelivercirrhosisLi,X,YLv,RAXu*pp272-301
⑥Chapter13DiabetesgenedrugR&DLiuQ.,CaiS,RAXu*pp346-390
⑦Chapter14CranialmandibulardefectrepairofmodernmedicineDiaoY.,RAXu*pp391-432
⑧Chapter15MolecularpathogenesisandtherapyoflungcancerWangQ,YDiao,RAXu*pp433-525
⑨Chapter16NewtreatmentforlivercancerSun,X.,RAXu*pp525-565
⑩Chapter17MoleculartherapyofcoloncancerLvY.,WangQ.,RAXu*pp566-627
⑾Chapter18StemcellsandcancerstemcellsWangQ,YLv,RAXu*pp628-678
3.5ChaptersIn:CellEngineeringandBiotechnologyDiaoY,XuRA(Es)
ChemicalIndustryPress,Peking,2008
《细胞工程与生物技术实验指南》刁勇许瑞安*主编70万字化学工业出版社
2008年，北京。
①Chapter1InfrastructureofCellsandbiotechnologyXWangX,WShi,RAXupp1-9
②Chapter6InductionofcelldifferentiationtechnologyWTang,RAXu*pp167-197
③Chapter9MammaliancellsRNAiQWang、RAXu*pp221-258
③Chapter13CellsandrecombinantvirusvectortechnologyF.Wang,RAXu*pp306-337
⑤Chapter16ApplicationofCellularBiotechnologyLiuJ,YDiao,RAXu*pp379-415
4.1chapterIn:
Chapter6BiologicsR&Dandpharmacodynamicevaluationofrouteofadministrationofdrugs---GenedrugrouteofadministrationandefficacyevaluationofEfficacyRAXu*HLuo
2.TotalPeerReviewArticles(>100)
ListofRecent12-yearPeerReviewArticles
1ZhangG,WangQ,XuRA*TherapeuticsBasedonmicroRNA:AnNewApproachforLiverCancer.CurrentGenomics,11(5),311-325,2010PubMedID(20)DOI:10.2174/**1616671
2LuH,Qu,G,DingQ,WangX,XuRA,XiaoWAnewtypeofcell-specificmicroRNAbindinggenesequencecontainingHAAVmirforgenetherapyHumanGeneTherapy(2011)PubMedID:(18500941)
3LijuanXie,JingnanCui,XuhongQian,YufangXu,JianwenLiu,R.A.Xu.5-Non-aminoaromaticsubstitutednaphthalimidesaspotentialantitumoragents:SynthesisviaSuzukireaction,antiproliferativeactivity,andDNA-bindingbehavior.Bioorganic&MedicinalChemistry2011;19(2):961-967.
4DiaoYong,ZhaoXiaofeng,LinJunsheng,WangQizhao,R.A.Xu*.ProtectionoftheliveragainstCCl4-inducedinjurybyintramuscularelectrotransferofakallistatin-encodingplasmidWorldJGastroenterol2011Jan;17(1):111-117.
5WuLonghuo,LiPei,WangXiao,ZhuangZhenjing,FarzanehFarzin,R.A.Xu*.Evaluationofanti-inflammatoryandantinociceptiveactivitiesofMurrayaexotica.Pharmaceuticalbiology2010;48(12):1344-53.PubMedID(20738224)
6WilliamXu,QiZhaoWang,QiCui,R.A.Xu**.MicroRNApolymorphisms,MicroRNAPharmacogenomicsandCancerSusceptibility.CurrentPharmacogenomicsandPersonalizedMedicine.2010Dec;8(4):289-305(17).
7TangMqTangM,XuW,WangQ,XuRA*.DNMTanditsrelatedepigeneticregulationinlungtumorigenesis.CurrentGenomics,2009;10(5):336-52PubMedID(20119531)SCI
8WuL,WangX,XuW,FarzanehF,XuRA*.TheStructureandpharmacoligicalfunctionsofcoumarinandtheirdeveritivesCurrentMedicinalChemistry2009;16(32):4236-60.PubMedID(19754420)
9SunX,JiangH,JiangX,TanH,MengQ,SunB,XuRA,KrissansenGWAntisensehypoxia-induciblefactor-1alphaaugmentstranscatheterarterialembolizationinthetreatmentofhepatocellularcarcinomasinrats.HumGeneTher.200920(4):314-24.PubMedID(19327024).
10WangQ,XuW,HabibN,XuRA*.PotentialusesofmicroRNAinlungcancerdiagnosis,prognosisandtherapy.CurrentCancerDrugTargets,2009,9（4）:572-594PubMedID(19754420)
11JiangX,LiH,QiaoH,JiangH,XuR,SunXCombiningkallistatingenetherapyandmeloxicamtotreathepatocellularcarcinomainmice.CancerSci.2009;100(11):2226-33.PubMedID(19709125).
12LvY,WangQ,DiaoY,XuRA*.Cytoglobin:NovelPotentialGeneMedicineforFibrosisandCancerTherapy.CurrentGeneTherapy,2008，8，287-294PubMedID:(18691024)
13LvY,WangQ,XiaoW,DiaoY,XuRA*Trendsindevelopmentofself-complementaryadeno-associatedvirusvectorShengwugongchengxuebao=Chinesejournalofbiotechnology2009,25(5):658~66PubMedID:(19670632)
14JiangH,MengQ,TanH,PanS,SunB,XuR,SunXDown-regulatinghypoxia-induciblefactor1alphaaugmentstranscatheterarterialembolizationtotreathepatocellularcarcinomasinrats.HumanGeneTherapy(2008)(Epub22Dec2008),PubMedID:(19102662)
15DiaoY,MaJ,LiX,SunX,XuR.Constructionandactivityofrecombinantadeno-associatedvirusexpressingvasostatin.Shengwugongchengxuebao=Chinesejournalofbiotechnology24(11),1949-54(2008)PubMedID:(19256344)
16WangQ,LvY,XuRA*.ThedesignofvectorsforRNAideliverysystem.CurrPharmDesign200814（13）：1327-1340.(AninvitationfromEditor-in-chieftoXuRA)PubMedID:(18537656)
17LuH,ChenL,WangJ,HuackB,SarkarR,ZhouS,XuR,DingQ,WangX,WangH,XiaoW.CompletecorrectionofhemophiliaAwithadeno-associatedviralvectorscontainingafull-sizeexpressioncassette.HumanGeneTherapy19(6),648-54(2008)PubMedID:(18500941)
18TseLY，SunX*,JiangH,DongX,FungPWC,FarzanehF,XuR*.Adeno-associatedvirus-mediatedexpressionofkallistatinsuppresseslocalandremotehepatocellularvarcinomas.JGeneMed2008,10(5),508-17PubMedID:(18338836)?
19LiH,LiXY,Lam,KS,CheungT,XuRA*Adeno-associatedvirus-mediatedpancreaticandduodenalmhomeoboxgene-1expressionenhanceddifferentiationofhepaticovalstemcellstoinsulin-producingcellsindiabeticrats.JMedSci,200815,487-497PubMedID:(18253862)
20Cai,K,TamP,XuRA,ShanMH.Suppressionoflungtumormetastasisinmicebyrecombinantadeno-associatedvirus-mediatedexpressionofvasostatinClinCancerRes2008,14(3),939-49PubMedID:(18245558)
21RabieAB,DaiJ,XuRA.Recombinantadeno-associatedvirusmediatedvascularendothelialgrowthfactorgenetherapyinducesmandibularcondylargrowth.GeneTher2007,14,972–980PubMedID:(17460722)
22JiangH,MengQ,TanH,PanS,SunB,XuRA,SunX.Antiangiogenictherapyenhancestheefficacyoftranscatheterarterialembolizationforhepatocellularcarcinomas.IntJCancer2007,121(2):416-24PubMedID:(17330237)
23WangD,LiuW,HanB,XuR.BiochemicalandenzymaticpropertiesofanovelmarinefibrinolyticenzymefromUrechisunicinctus.ApplBiochemBiotech2007136(3):251-64.PubMedID:(17625232)
24XuRA,Harrison,PM,Chen,M,Li,XY,TsuiT-Y,FungPCW,CheungP-T,GuangjiWangG,LiH,DiaoY,XuS,KrissansenGW,FarzanehF.Cytoglobinprotectsagainstdamage-inducedliverfibrosis.MolTher2006,13(6):1093-100PubMedID:(16581302)
25XuRA,ZhaoB,FungP,LiXY.Histologyandhistopathology2006，21：587-92(AninvitationfromEditor-in-chief,ProfessorHernz-calvotoXuRA)PubMedID:(16691539)
26BerndH,XuRA,XieJ,DingQ,SiplerM,WangH,Chen,L,XiaoWD.AnefficientAAV1/AAV2hybridvectorforgenetherapyofHemophilia.HumanGeneTherapy2006,17(1):46-54.PubMedID:(16409124)
27MaH,LiuY,LiuS,XuRA*,ZhengD*.Oraladeno-associatedvirus-sTRAILgenetherapysuppresseshumanhepatocellularcarcinomagrowthinmice.Hepatology2005,42(6):1355-63.PubMedID:(15800912)
28ShiJ,LiuY,GuoJ,ZhangD,ZhengD,LiX,CheungP-t,FarzanehF,XuRA*. Expressionofananti-DR5singlechainantibodyinmusclesofnudemicepreventslungcancergrowth.CancerRes2006,66(24):11946-53.PubMedID:(15753363)
29LeeTK,ManK,HoJW,WangHX,PoonRT,SunKW,NgKT,NgIO,XuRA,FanST.FTY720:apromisingagentfortreatmentofmetastatichepatocellularcarcinoma.ClinCancerRes2005,11(23):8458-66.PubMedID:(16322309)
30TsuiTY,LauCK,WuX,WangYQ,SiuYT,XuRA,SchlittHJ,FanSTHemooxygnase-1genetherapyattenuatesmicronodularLivercirrhosisinrat.Hepatology2005,42(2):335-42.PubMedID:(16025519)
31MaH,ZhengD*,LiuY,LiuS,KungHF,SunX,XuRA*.AAV-MediatedTRAILgenetherapysuppresseslivermetastatictumors.InternationalJournalofCancer2005,116(2):314-21.PubMedID:(15800912)
32ChenM,WangGJ,DiaoY,XieH,LiX,SunJ,XuRA.AAV-mediatedinterferon-gammaamelioratesthehepaticfibrosisinvitroandinvivo.WorldJGastroenterology2005,11(26):4045-51.PubMedID:(12883531)
33WangDL,HuQ,XuRA*.Thebioreactor:apowerfultoolforlarge-scalepreparationforanimalcells.CurrPharmBiotech2005,6(5):397-403.
34ShiJ,ZhengD,LiuY,ShamMH,TamP,FarzanehF,XuRA*.Over-expressionofsolubletumornecrosisfactor-relatedapoptosis-inducingligandinducesapoptosisinhumanlungadenocarcinomaandinhibitsgrowthoftumorxenograftsinnudemice.CancerRes2005,65:1687-92.PubMedID:(15753363)
35SunX,QiaoH,JiangH,ZhiX,LiuF,WangJ,LiuM,DongD,KanwarJR,XuRA,KrissansenGW.Intramusculardeliveryofanti-angiogenicgenessuppressessecondarymetastasesafterremovalofprimarytumors.CancerGeneTher2005,12(1)35-45.PubMedID:(16211089)
36XuRA*,MaH,FungPCW,ChangQ,XuS,DuringMJStabilityofinfectiousrecombinantAAVvector.MedicalScienceMonitor2005,11(9)BR305-308PubMedID:(16127351)
37DaiJ,RabieAB,Hagg,EUO,XuRA*.Anovelstrategyforrepairofcraniofacialbonedefects.CurrGeneTher2004,4(4):469-85;PubMedID:(15578995)
38LeeTK,ManK,HoJW,WangHX,PoonRT,SunKW,NgKT,NgIO,XuRA,FanST.ThesignificanceofRAC-signalingpathwayinHCCcellmotility:Implicationforanewtherapeutictarget.Carcinogenesis2005,26(3):681-7PubMedID:(15604094)
39LeeTK,ManK,HoJW,SunCK,NgKT,WangXH,WongYC,NgIO,XuRA,FanST.FTY720induceapoptosisofhumanhepatomacelllinesthroughPI3-KmediatedAktdephosphorylation.Carcinogenesis2004,25(12)2397-405.PubMedID:(15297371)
40MaH,LiuYX,LiuSL,XuRA,ZhengDX.ExpressionofTRAIL(114-281)mediatedbyadeno-associatedvirusanditstumoricidalactivity.ZhonghuaYiXueZaZhi2004,84(19):1635-41.PubMedID:(15569460)
41TuSP,CuiJT,ListonP,JiangXH,XuRA,LinMCM,ZhuYB,ZouB,SamuelSMNg,XiaHX,WongWM,ChanOO,YuenMF,LamSK,KungHF,WongBCY.Genetherapyforcoloncancerbyadeno-associatedvirus-mediatedtransferofsurvivingCys84Alamutant.Gastroenterology2005,128(2):361-75.PubMedID:(15685548)
42SunX,KrissansenGW,FungPWC,XuS,ShiJ,ManK,FanST,XuRA*.Anti-angiogenictherapysubsequenttoadno-associatedvirusmediatedimmunotherapyeradicateslymphomasthatdisseminatetotheliver.IntJCancer2005,113(4)670-7.PubMedID:(15472906)
43TsuiTY,LauCK,MaJ,WuX,WangYQ,FarkasS,XuR,SchlittHJ,FanST.rAAV-mediatedstableexpressionofhemeoxygenase-1instellatecells:Anewapproachtoattenuateliverfibrosisinrats.Hepatology2005:335-42PubMedID:(16025519)
44SunX,QiaoH,JiangH,ZhiX,LiuF,WangJ,LiuM,DongD,KanwarJR,XuR,KrissansenGW.Intramusculardeliveryofantiangiogenicgenessuppressessecondarymetastasesafterremovalofprimarytumors.ancerGeneTher.2005Jan;12(1):35-45.PubMedID:(15486558)
45XuRA*,SunX,TseLY,LiH,ChanPC,XuS,XiaoW,KungHF,KrissansenGW,FanST.Long-termexpressionofangiostatinandsuppressionoflivermetastaticcancer.Hepatology2003,37:1451-61.PubMedID:(12774025)
46LiXY,XuRA,WangGJ,XieHT,ZhaoXC,ChenM.EffectsofrAAV/rSTAPonmRNALeverofinterstitialcollagenaseinratstellatecell.ChinJClinPharmacolTher2004,9(11):1236-8.
47CaiKX,ShamMH,ZhengDX,XuRA*.Anti-HBVmedicineandtreatment.ChineseJournalofInternalMedicine2003,50:744-6.
48ChenY,LukKDK,CheungKMC,XuRA*,LinM,LuWW,LeongJCY,KungHF.Genetherapyfornewboneformationusinganadeno-associatedviralbonemorphogenticprotein-2.GeneTherapy2003,10:1345-53.PubMedID:(12883531)
49XuRA*,CaiKX,ZhengD,MaH,XuS,FanST.MoleculartherapeuticsofHBV.CurrGeneTher2003,3(4):341-55.PubMedID:(12871021)
50ShiJ,ZhengDX,ManK,FanST,XURA*.TRAIL:Apotentialagentforcancertherapy.CurrMolMed2003,3:727-736.PubMedID:(14682494)
51MaH,XuRA,ChengH,KuoHS,DuringMJ,FangRH.Genetransferintohumankeloidtissuewithadeno-associatedvirusvector.JTrauma2003,54(3):569-573.PubMedID:(12634540)
52Cai,KX,ShamMH,TamP,LamWK,XuRA*.Lungcancergenetherapy.GeneTherMolBiol2003,7:255-72.
53XuRA*,LiH,TseL,KungHF,LuH,LamKSL.Diabetesgenetherapy:potentialandchallenges.CurrGeneTher2003,3(1):65-83.PubMedID:(12553537)
54DiaoY,XuRA,WangGJ,ZhaoXC.Adeno-associatedvirusmediatedexpressionofhumanerythropoietininvitro.ActaPharmacolSin2002,23(1):55-58.PubMedID:(1186073)
55JungSC,HanIP,LimayeA,XuRA,GeldermanMP,ZerfasP,TirumalaiK,MurrayGJ,DuringMJ,BradyRO,QasbaP.Adeno-associatedviralvector-mediatedgenetransferresultsinlog-termenzymaticandfunctionalcorrectioninmultipleorgansoffabricmice.ProcNatlAcadSciUSA2001,98:2676-81.PubMedID:(11226298)(IF10.5)
56MastakovM,BaerC,XuRA,FitzsimonsH,DuringMJ.CombinedinjectionofAAVwithmanitolintoratbrain.MolTher2001,3:225-32.PubMedID:(11237679)
57XuRA,JansonCG,MastakovM,LawlorP,YoungD,MouravlevA,FitzsimonsJ,ChoiKL,MaH,DragunowM,LeoneP,ChenQ,DickerBandDuringMJ.Quantitativecomparisonofexpressionwithadeno-associatedvirus(AAV-2)brain-specificgenecassettes.GeneTher2001,8:1323-32.PubMedID:(11571569)
58DuringMJ,SymesCW,LawlorPA,LinJ,DunningJ,FitzsimonsH,PoulsenD,LeoneP,XuRA,etalAnoralvaccineagainstNMDAR1withefficacyinexperimentalstrokeandepilepsy.Science2000,287:1453-60.PubMedID:(10688787)(IF29.6)
59DragunowM,XuR,WaltonM,WoodgateA,LawlorP,MacGibbonGA,YoungD,GibbonsH,LipskiJ,MuravlevA,PearsonA,DuringM.c-JunpromotesneuriteoutgrowthandsurvivalinPC12cells.MolBrainRes2000,83(1-2):20-33.PubMedID:(11072092)
60WaltonM,WoodgateA,MuravlevA,XuR,DuringM,DragunowM.CREBphosphorylationpromotesnervecellsurvival.Journalofneurochemistry73(5),1836-42(1999)PubMedID:(10537041)
61DuringMJ,XuRA,YoungD,KaplittM,SherwinR,LeonePPeroralgenetherapyoflactoseintoleranceusinganadeno-associatedvirusvector.NatMed1998,4:1131-6.PubMedID:(9771745)
62WangQ，LvY,XuRA*.Dose-responseandcontrolofadeno-associatedviralvectorsbasedpreclinicalandclinicalgenetherapy.ChineseJournalofClinicalPharmacologyandTherapeutics.2008,1:1182-1194.
63LvY,Q,Wang,YDiao,RAXu*OptimizationoftheTransfectionEfficiencyofHumanHepaticStellateCellandHepatocyteUsingLiposome.JournalofHuaqiaoUniversity(NaturalScience).2010,31(1):49-52.
64WangQ,LvY,XiaoW,DiaoY,XuR*.Theclinicalresearchesofrecombinantadeno-associatedvectorr.Chinabiotechnology,2010,31(1):73-79
65WangQ,DiaoY,LvY,LiZ,XuR.MutantK-ras-specificsiRNAinhibitsproliferation,migrationandinducesapoptosisoflungcancerA549cells.ChinJCancerBiotherapy,2009,16(6):564-9.
66DiaoY,WangQ,LvY,XuR.Hurdlesandsolutionstononinvasivepulmonarydeliverygenemedicine.ChineseJournalofNewDrugsandClinicalRemedies,2009,08:571-575
67HuangX,WangX,DongH,ZhaoX,LiZ,WangQ,XuR,DiaoY.HighlevelexpressionofrecombinanthumankallistatininPichiapastorisanditsbioactivity.ChinJBiotech,2010,26(2):249~255
68XURA*ExploringoraldeliveryofmedicalnanoparticleandgenemedicineChineseJournalofClinicalPharmacologyandTherapeutics2007,12:1092-1097.54.
69WangF,DiaoY,XuRA*Largescaleproductionofadeno-associatedviralvectorsforclinicaltrialsChinabiotechnology2010
70DiaoY,XuROraldeviveryofadeno-associatedviralvectorsYaoXueXueBao.2009Jul;44(7):703-9.PubMedID:(19806906)
71吴龙火,许瑞安*.九里香中香豆素Paniculal的化学合成途径.海峡药学,2010,22(1):168-169.
72王启钊,吕颖慧，李招发，刁勇，许瑞安*.腺相关病毒的衣壳装配和DNA衣壳化机制生物工程学报inpress.
73王启钊，李招发，江楠，刁勇，许瑞安*.铁过载氧化应激模型的构建、检测与分析.中国临床药理学与治疗学.Inpress.
74龚玉华,王启钊,许瑞安*.非组蛋白HMGA2:抗肿瘤药物的新靶标．中国药物杂志.2010Nov;45(2):1694-1700.
75王启钊,吕颖慧,肖卫东,刁 勇,许瑞安*.重组腺相关病毒载体临床实验研究.中国生物工程杂志,2010,30(1):73-79.
76卢 超,王启钊,许瑞安*.重组腺相关病毒载体的整合性研究进展生命科学,2010,22(5):459-465.
77卢超,万江波,唐明清,肖卫东,许瑞安*.重组腺相关病毒载体的免疫性研究及其解决策略.中国临床药理学与治疗学,2010May;15(5):577-583.
78刁 勇*，许瑞安.重组腺相关病毒基因药物的细胞免疫毒性及对策.药学学报.2010,45(9):1071?1077.
79黄晓平,王 晓,董 浩,赵小峰,李招发,王启钊,许瑞安,刁 勇*.重组人可溶性TRAIL在毕赤酵母中表达与纯化及其抗肿瘤细胞活性.中国生化药物杂志.2010,31(2):73-77.
80黄晓平，王晓，董浩，赵小峰，李招发，王启钊，许瑞安，刁勇*.重组人kallistatin蛋白在毕赤酵母中的高效表达及生物活性分析.生物工程学报.2010Feb;26(2):249-255.
81吕颖慧，王启钊，刁勇，许瑞安*.脂质体转染人肝星状细胞和肝细胞条件优化.华侨大学学报(自然科学版),2010,Jan;31(1):49-52.
82梁丽英，张国海，许瑞安*.脂肪酸合成酶抑制剂研究热点及其开发.中国现代应用药学.2010April;27(4):300-303.
83熊亚楠,李招发,许瑞安*.纤溶酶系统与阿尔茨海默症.生命的化学.2010;30(1):76-80.
84王启钊,吕颖慧,江 楠,刁 勇,许瑞安*.干细胞不均匀分裂与肿瘤发生.癌症.2010;29(3):265-271.
85刘建福,范燕萍,许瑞安*.福建泉州地区珍稀野生药用植物资源与保护.热带作物学报.2010Feb;31(2):284-291.
86ZHAOYong-Gang,LIHua,XUWilliam2,LUOJia,XURui-An*.AnOverviewoftheFibrinolyticEnzymefromEarth-worm.中国天然药物.2010Jul;8(4):301-308.
87施伟杰,毕丽伟,许瑞安*.联合细胞穿膜肽的肿瘤靶向载体.中国肿瘤生物治疗杂志.2010Feb;17(1):104-114.
88李 培,邱 飞,吴龙火,许瑞安.多功能信封式纳米载体研究进展.中国生物工程杂志.2010;30(6):139-143.
89吴龙火,许瑞安*.简单香豆素药理作用与构效关系研究进展.医药导报.2010Apr;29(14):498-501.
90毕丽伟,施伟杰,许瑞安*.细胞衰老与慢性肝病及对肝纤维化的调节作用.江苏预防医学.2010Mar;21(12):67-69.
91唐明青,王启钊,许瑞安*.癌基因成瘾-肿瘤分子靶向药物研发的一种新思路.中国肿瘤生物治疗杂志.2010Apr;17(2):213-220.
92曾庆友,许瑞安.阿魏酸乙酯的一锅法合成.中国医药工业杂志.2010;41(4):255-256.
93张国海,梁丽英,许瑞安*.RNA干扰抗丙型肝炎病毒的研究进展.重庆医学,2010Jul;39(14):1914-1917.
94张国海,王启钊,张景红,许瑞安*.microRNA调控的靶向性病毒载体在基因治疗中的应用.生物工程学报.2010Jun;26(6):707-714.
95王启钊,刁勇,吕颖慧,李招发,许瑞安*.突变型K-rassiRNA对肺癌细胞的影响.中国肿瘤生物治疗杂志.2009,Accepted.
96王峰、刁勇、许瑞安*重组腺相关病毒规模化生物包装技术.生物工程学报2009,November25;25(11):1608-1613
97王启钊,吕颖慧,许瑞安*肿瘤基因治疗的一点思路.中国肿瘤临床,2009,Accepted.
98罗海涛许瑞安肿瘤干细胞研发热点生命科学，中国上海2009Accepted.
99张亭亭，李招发，许瑞安*重组可溶性细胞球蛋白的制备、纯化与抗氧化活性检测.华侨大学学报，2009
100徐韬,许瑞安*不同作用途径抗肿瘤中药的筛选与前瞻.华侨大学学报,2009，108（33），359-365
101吕颖慧，王启钊，肖卫东,刁勇，许瑞安*.自身互补型腺相关病毒载体研究进展.生物工程学报,2009,25(5):658~66.
102刁勇,许瑞安口服重组腺相关病毒基因药物.药学学报,2009,44(7):703-709.
103吴龙火;王晓;许瑞安*九里香叶总黄酮提取工艺的研究.广西轻工业,2009,1:1-4.
104唐明青;刁勇;许瑞安*以壳聚糖为载体的口服基因药物.中国生化药物杂志,2009,30(2):139-140.
105王峰;刁勇;许瑞安*重组腺相关病毒载体在肺癌治疗中的应用.海峡药学,2009,21(3):8-11.
106张红;曾庆友;林建明;许瑞安*白藜芦醇化学合成研究进.精细化工中间体,2009,39(2):7-11.
107曾庆友，曾明荣,许瑞安*对氧甲基肉桂酸乙酯一锅式绿色合成法精细化工2008,28(2)：192-4.
108WangQ，LvY,XuRA*.Dose-responseandcontrolofadeno-associatedviralvectorsbasedpreclinicalandclinicalgenetherapy.ChineseJournalofClinicalPharmacologyandTherapeutics.2008,1:1182-1194.
109舒静波，刁勇，许瑞安*腺病毒-腺相关病毒嵌合纳米载体研究进展.华大学报2008，29(2):172-176.
110曾庆友，张红，许瑞安,3，4-二甲氧基肉桂酸乙酯的一锅式合成.青岛科技大学学报,2008,(6)
111李华;陈陵霞;许瑞安*纤溶活性的药学测定方法研究.中国临床药理学与治疗学.2008,13(9):1066-1070
112曾庆友，曾明荣,许瑞安*对氧甲基肉桂酸甲酯一锅式绿色合成法.精细化工,2008,25(2)：192-194.
113曾庆友;张红;许瑞安;3,4-二甲氧基肉桂酸乙酯的一锅式合成.青岛科技大学学报,2008,29(6):490-492.
114刁勇，局海亮,许瑞安.单环刺螠抗血栓组分的分离纯化和药效学研究.中国生化药物学杂志,2007；3：199-200.
115吴龙火,许瑞安.小胶质细胞及P38、MAPK在圣经病理性疼痛中的作用.科学研究,38（2）:16-18,2008.
116许瑞安.医用纳米与基因药物口服化的探索.中国药理学与药物治疗学.2007,12:1092-1097.54.
117曾庆友;曾明荣;许瑞安;对甲氧基肉桂酸甲酯的一锅式绿色合成.化学合成，2007,15(5):663-664.
118史娟,刘彦信,刘士廉,许瑞安,郑德先.腺相关病毒介导Smac和DR5单链抗体表达对抑制肿瘤细胞生长的作用；中华医学杂志2006,86(26):1857-9.(SCI)
119许瑞安*,刁勇,谢海棠.基因药物在临床上的最新应用与研发.中国药理学与药物治疗学2006,11:1092-7.
120王佃亮;刘万顺;韩宝芹;许瑞安;张海智;刘学英.一种新型海洋纤溶酶体外抗凝与溶栓作用研究.中国海洋药物,2006,25(4):37-41
4.ABSTRACTSFORINTERNATIONALCONFERENCESANDGUESTSPEAERS：(2005.12—2011.1,total﹥50，partiallylistasbelow)
1许瑞安Cytoglubin抗肝纤维化的机理及其在临床应用前景中国科学院广州生物健康研究院专题讲座（特邀嘉宾）2008年4月20日
2许瑞安*口服基因治疗天津滨海高科技园(邀请报告)2010年9月26日
3许瑞安*FunctionofCytoglubinonanti-agingandapplicationonskinprotection.TheAnit-agingSymposiumAnnualMeeing,June29,2008（Invitedspeaker）台北，台湾
4RAXu*DoublestrandedmicroRNAs,akindofpotentialanti-canceragents,actsimilarlytosiRNAsbutwithmulti-targetsBIT3rdWorldCancerCongress2010Singapore（Invitedspeaker）
5RAXu*,WShiTherecombinantTat-CYGBprotein,ananti-canceragentforliverdease.AGST.2010,May15-19,Seattle,USA
6LuC,WangQ,RAXuDouble-strandedLet-7Mimics,aKindofPotentialAnti-cancerAgentsAGST.2010,May15-19,Seattle,USA
7曾庆友张红，许瑞安固体光气法合成3，4，5-三甲氧基苯甲酸酐，全国第15届有机和精细化工中间体学术交流会2009.9.11-14天津
8Xu,RA*.PotentialandChallengesofDiabetesgnenetherapyBIT’S1stAnnualWorldCongressofEndobolism-2011,Xiamen,China()
9J.Shi,YLiu,YGuo,JZhang,XLi,P-tCheung,FFarzaneh,DXZheng,RAXu*.ExpressionofanAnti-DR5SingleChainAntibodyinMusclesofNudeMicePreventsCancerGrowth.The2ndInternationalCancerMeeting,HongKong,2006
10王峰许瑞安rAAV制备技术福建省2010年药理学年福州,2010年12月22日
11XURA*.Anti-angiogenicinhibitorsoncancergenetherapy.ISCGT.2005,December9-11,Shenzhen,China
12XU,RA*,RahimiM,MaH,FungP,FarzanehF,DuringMJ.Stabilityofinfectiousrecombinantadeno-associatedviralvectoringenedelivery.ISCGT.2005,December9-11,Shenzhen,China
13TseL-Y.XuRA*.SuppressionofHepatocellularcarcinomagrowthbykallistatinandvasostatin.ISCGT.2005,December9-11,Shenzhen,China
14LiuY,GuoY,TaoX,ChnC,LiuS,XURA*,ZhengDX.Anovelanti-humanDR5monoclonicalantibodywithtumor–therapeuticpotential.ISCGT.2005,December9-11,Shenzhen,China
15ShiJ,ZhengDX,LiuY,FarzanehF,ShamMH,XURA*.TRAILgenetherapyoflungcancer.ISCGT.2005,December9-11,Shenzhen,China
16CaiKX,ShamMH,XiaoW,TamP,XURA*.Angiogenicinhibitorssuppresseslungcancergrowthinspontaneouspulmonarymetastasismousemodel.ISCGT.2005,December9-11,Shenzhen,China
17SunX,XURA*,FarzanehF,KrissensanGW.Over-expressionofonHippel-LindautumorsuppressorproteinandantisenseHIF-1αeradicatesgliomas.ISCGT.2005,December9-11,Shenzhen,China
18XuRA,PMHarrison,P-TCheung,SXu,FFarzaneh.Expressionofcytoglobininhibitshepaticstellatecellactivationandliverfibrosisintoxicandcholestaticmodelsofliverinjury.The41thESLSAnnualMeeting.2006,Vienna,Austria
19XuRA*,TseL-Y.SuppressionofHCCgrowthbyangiogenicinhibitors.The41thESLSAnnualMeeting.2006.Vienna,Austria
20DaiJ,RabieAB,XuRA.AAVmediatedVEGFgenetherapytocontrolmandibularcondylargrowth.20thIADR-SEAtravelawardposterpresentation.2006,Malacca,Malaysia
21DaiJ,RabieAB,XuRA.TransductioncharacteristicsofrAAVhybridsinchondrocytesandosteoblasts.IADR/UnileverHattonAwardcompetitionBrisbane,2006,February22,Australia
22XuRA*.Anti-angiogenicagentsforcancertherapy.The4thCongressofInternationalDrugScienceandTechnology.2006,May26-Jun1,Dalian,China
23XuRA*,PMHarrison,MChen,XLi,PTCheung,WXiao,FFarzaneh.InhibitionofhepaticstellatecellactivationandliverfibrosisbyexpressionofCytoglobininvivo.The9thAmericanSocietyofGeneTherapyMeeting.2006,May31-June4.Baltimore,USA
24XuRA*,JMa,PeterCWFung,KWChu,NHabib,FFarzaneh.Twonewanti-angiogenicinhibitorsfortreatmentofcoloncancer.ISCGT.2006,Japan
25Xu,RA*,KexiaCai,PaulTam,QizhaoWang,MaiHarShamSuppressionofLungTumorMetastasisinMicebyRecombinantAdeno-AssociatedVirus-mediatedExpressionofVasostatin.ISCGT2007,Nov18-20.India.(Invitedspeaker)
26RAXu,XLi,YDiao,PHarrison,WXiao,NHabib,FFarzaneh.Long-termeffectandbiosafetyofrAAV-ratCygbexpressionAGST.2007June1,Seattle,USA
27Xu,RA,QizhaoWang,YinghuiLv.Dose-ResponseandControlinViralVectorsBasedPreclinicalandClinicalTherapy.InternationalQuantitativePharmacologyConference2007,October28-31,Nanijng,China(Invitedspeaker)
28Xu,RA,QizhaoWang,YinghuiLv.miRNAinlungcancer.InternationalSocietyforcellandgenetherapyofCancer(ISCGT)conference,2008,Sep.,Shijiazhuang,China(Invitedspeaker)（第五届中国肿瘤学术大会）
29QizhaoWang,Xu,RAmicroRNAinlungcancer.第四届南北肺癌高峰论坛,2008,12,29-20.广州,中国.
30王晓;许瑞安.第二届中草药提取关键技术与提取物产业应用研讨会.厦门2009
31王启钊、吕颖慧、许瑞安肿瘤基因治疗的思路与出路.肿瘤病因学研究与中西医结合肿瘤综合整流交流研讨会论文集.2009,5,7-9.,厦门.
32MingqingTang,QizhaoWang,RuianXu.DNMTsanditsrelatedepigeneticregulationinlungtumorigenesis.肿瘤病因学研究与中西医结合肿瘤综合整流交流研讨会论文集.2009,5,7-9.厦门
33许瑞安.Cytoglubin抗肝纤维化机理(特邀嘉宾),福建省2008年药理学年福州,2008年12月16日
34许瑞安生命科学的活力与分子药物学的张力(特邀嘉宾)泉州市药学年会讲座,2008年11月3日
35WangQZ,HabibN,XiaoW,XuRA.PotentialusesofmicroRNAinlungcancerdiagnosis,prognosis,andtherapyAGST2009May30-June2,Boston,USA
36TangM,WangQ,XiaoW.,XuRA*DNMTsanditsrelatedepigeneticregulationinlungtumorigenesisAGST.2009May27-30,Santiago,USA
37ZhangTingting,LiZ,MengC,XuRA*MechanismofAnti-agingandTrendsinApplicationsofSkinAnti-agingPharmaceuticals第十二届全国数学药理学术大会,西宁,8-10,8,2009(邀请嘉宾)
38吴龙火、许瑞安九里香中香豆素paniculal的化学合成途径2009年全国药物化学学术会议2009.10武汉中国
39XuRA*.ReducingdenovocapsidsynthesisfromreplicationcompetentAAVcontaminationinthetargetingtissueITLifeSciences’3rdAnnualWorldCongressofGene2009(invitedspeaker)
OTHERACEDMICACTIVITIES:
1.CouncilExcutiveMemberofInternationalSocietyofCell&CancerGeneTherapy
2.MemberofEditorialBoardofIslet(Swenden)；
3.InternationalPanelofMedicalScienceMonitor（USA）；
4.MemberofEditorialBoardofWorldJournalofGastroenterologyPharmacologyandTreatment；
5.MemberofEditorialBoardofWorldJournalofHepatology；
6.MemberofEditorialBoardofWorldJournalofClinicalOncology；
7.ReviewerofHepatology（USA）；
8.ReviewerofGeneTherapy(USA)；
9.ReviewerofJournalofAppliedPolymerSciences；
10.ReviewerofInternationalJournalofCancer(Germany)；
11.ReviewerofApoptosis(USA)；
12.ReviewerofAppliedBiochemistryandBiotechnology(USA)；
13.ReviewerofJournalofPharmacyandPharmacology(UK)；
14.ReviewerofJounralBiomedicalScience；
15.ReviewerofTumorBiology(Swenden)；
16.ReviewerofJPP(USA)
17.ReviewerofJournalofCellularPhysiology(USA)
18.ReviewerofCancerImmunologyImmunotherapy
19.ReviewerofCancerLetter
20.ReviewerofIrishNationalHealthResearchGrant
21.ScientificCommitteememberof2006CancerGeneTherapy,Japan.
22.Chairmanof2ndInternationalConferenceofClinicalQuantitativePharmacologyandNewDrugEvaluation,October29-31,2010.
23.BIT’S1stAnnualWorldCongressofEndobolism-2011(大会主持人)
24.丰泽区政府社会经济顾问；
25.晋江市人民政府顾问团顾问；
26.泉州（永春）生物医药产业顾问团顾问；
27.泉州市抗癌协会顾问；
28.泉州市中药现代化工程中心主任；
29.泉州医药同业会高级顾问；
30.泉州市人民政府技术创新工程专家顾问；
31.厦门市科技局评审专家；
32.福建省药物化学重点实验室副主任；
33.安徽省临床药物评价中心顾问；
34.《中国临床药理学和治疗学》编委、顾问；
35.《中国海洋资源》特邀编委；
36.科技部科技发展战略专家；
37.科技部国际合作管理专家；
38.科技部企业技术专家；
39.国家自然科学基金网上评审专家。
SUPERVISONOFPHDSTUDENTS:Total:21（16graduated）
SUPERVISONOFMSCSTUDENTSTotal:39（29graduated）
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