崔秀灵教授
发布时间:2012-05-04　　浏览次数:

崔秀灵
福建省闽江特聘教授，2010
FullProfessor,ChemistryDepartment,ZhengzhouUniversity,2008
AssociateProfessor,ChemistryDepartment,ZhengzhouUniversity,2002
Contact:
Prof.Dr.XiulingCui
MinjiangScholarshipProfessor
ViceofSchoolofMedicalSciencesandDeputyDirectorofInstituteofMolecularMedicine,HuaqiaoUniversity,Xiamen,P.RChina
Email:cuixl@hqu.edu.cn;Tel.&Fax86-**

Researchinterest:
　　主要从事有机合成、药物合成和海洋药物研发等方面的研究，现已研发出用于Suzuki、Heck、Borylation等系列偶联反应的高效、绿色、低残留催化剂和催化体系；利用研发成果合成了数百个药物分子和医药中间体；从海洋生物中分离提纯出高效抗乙肝病毒和抗肝纤维化药物。研究多有创新，获得国内外同行专家的好评，内置氧化剂的偶联反应被称为崔（秀灵）-吴（养洁）偶联反应，已经在JACS，AngewChem,ChemSci等国际著名杂志上发表SCI论文60余篇，拥有7项发明专利。现主持国家自然科学基金、“863”计划、“闽江学者”人才项目和国家海洋局公益项目。
EducationandTraining:
PostdoctoralResearchAssociate:
09/2000-08/2006InstitutodeTecnologiaQuimicaeBiologica,UniversityNovadeLisboa,PortugalwithPostdoctoralfellowshipgrandfromPortugueseMinistryofScientificandTechnologicalwithProfessorRitaDelgado
Preparationandstudyofnewmoleculesworkingasredoxsensorfortransitionmetalions,bio-anionsorbio-neutralmolecules
Ph.D.:
(09/1996-07/1999)DepartmentofChemistry,ZhengzhouUniversity,P.R.China
Supervisor:Professor,Academician,YangjieWu
Studyonthecyclometallationofferrocenyliminesandrelativestereochemistryaspect
M.Sc
(09/1993-07/1996)DepartmentofChemistry,ZhengzhouUniversity,P.R.China
Supervisor:Professor,Academician,YangjieWu
Studyonthecyclometallationofferrocenylimines
B.S.
(09/89-07/93)DepartmentofChemistry,ZhengzhouUniversity,P.R.China

Teaching:
OrganicChemistry,OrganicSynthesisExperiment,ChemistrySpecialtyEnglish
SelectedPublications

2014
1.Copper-catalyzedDirectAminationofQuinolineN-OxidesviaC-HBondActivationunderMildConditions,ChongweiZhu,MeilingYi,DonghuiWei,XuanChen,YangjieWu*,XiulingCui*OrgLett,2014，DOI:10.1021/ol500183w
2.Palladium(II)-catalyzedDirectRegioselectivelyOxidativeAcylationofAzobenzeneswithTolueneDerivatives,HongyuSong,DongChen,ChaoPi,XiulingCui,*YangjieWu,*JOrgChem2014，DOI:10.1021/jo5000219
3.Acatalyst-free,facileandefficientapproachtocyclicester:synthesisof4H-benzo[d][1,3]dioxin-4-ones,FengLin,QiulingSong,YuyuGao,XiulingCui*,RSCAdv.,2014,DOI:10.1039/C4RA01651C
4.KI-catalyzedarylationofbenzothiazolesfromthecouplingofarylaldehydeswithbenzothiazolesinneatwater，YuyuGao,QiulingSong,GuolinChengandXiulingCui*Org.Biomol.Chem.,2014,1044-1048InvitedManuscriptDOI:10.1039/C3OB42318B
5.Copper(I)-catalyzedhomo-couplingofterminalalkynesatroomtemperatureundersolventandbasefreeconditionsusingO2asanoxidantGuolinCheng,HongZhangandXiulingCui*RSCAdv.,2014,4,1849-1852DOI:10.1039/C3RA43873B,Communication
6.Tandemsynthesisof3-allyl-chromonesfromalkynonesandallylicalcoholsundermetal-freeconditionsXuesongWang,GuolinChengandXiulingCui*Chem.Commun.2014,50,652-654DOI:10.1039/C3CC48259F,Communication
7.Benzoquinone-catalyzedAerobicOxidativeHydroxylationofArylboronicAcidsinWater,GuolinCheng,XiaobaoZeng,XiulingCui*,Synthesis,2014295-300
2013
1.AMetal-freeMulticomponentCascadeReactionfortheRegiospecificSynthesisof1,5-Disubstituted1,2,3-Triazoles,GuolinCheng,XiaobaoZeng,JinhaiSheng,XuesongWang,andXiulingCui*,Angew.Chem.Int.Ed.2013，52,13265–13268.
2.“Onepot”regiospecificsynthesisofpolysubstitutedpyrrolesfrombenzylaminesandynonesundermetalfreeconditionsJinhaiShen,GuolinCheng,XiulingCui*,Chem.Comm.2013,49(90),10641–10643.
3.Direct2-acetoxylationofQuinolineN-oxidesviaCopperCatalyzedC-HbondActivation,XuanChen,ChongweiZhu,XiulingCui*andYangjieWu*,Chem.Comm.2013,6900-6902.
4.Palladium-CatalyzedOxidativeCross-CouplingofN-TosylhydrazoneswithIndoles:SynthesisofN-Vinylindoles,Xiaobao,Zeng,GuolinCheng;Jinhai,Shen,XiulingCui*,Org.Lett.2013,3022-3025.
5.RedoxofferrocenecontrolledasymmetricdehydrogenativeHeckreactionviapalladium-catalyzeddualC-Hbondsactivation，ChaoPi,YingLi,XiulingCui*,HaoZhang,YanbingHanandYangjieWu*，ChemSci.,20132675-2679.
6.Sulfonylationofquinoline-N-oxideswitharylsulfonylchloridesviacopper-catalyzedC-Hbondsactivation,ZhiyongWu,HongyuSong,XiulingCui*,ChaoPi,WeiweiDu,YangjieWu*,Org.Lett.,2013,1270-1273
7.EfficientApproachto4-SulfonamidoquinolinesviaCopper(I)-catalyzedCascadeReactionofSulfonylAzideswithAlkynylImines,GuolinCheng,XiulingCui*,Org.Lett.,2013,15(7),1480-1483.
8.DirectC2-AlkylationofQuinolineN-oxideswithEthersviaPalladium-catalyzedDehydrogenativeCross-couplingReaction,ZhiyongWu,ChaoPi,XiulingCui,*JieBai,andYangjieWu*,AdvSynth&Cat,2013,355,1971–1976
9.Synthesisofestersfromaldehydesorcarboxylicacidswithdichloromethane,dichloroethaneordichloropropaneundermildconditions，FengLin,QiangFeng,XiulingCui*,QiulingSong*,RSCAdv.2013,3(43),20246–20253
10.ProgressinRecentStudyofAnti-HBVNaturalProductsandExtracts，YantaoLi,JianweiHuang,RuianXu*andXiulingCui*，Mini-RevOrg.Chem.2013,10,241-253.
11.SynthesisofcyclopentadienylalkylethersviaPd-catalyzedcyclotrimerizationofdiarylacetylenes，RanranCai,MengmengHuang*,XiulingCui,JianyeZhang,ChenxiaDu,YushengWuandYangjieWu*RSCAdv.,2013,3,13140-13143DOI:10.1039/C3RA41326H
12.AHighlyEfficientSynthesisofOpticallyActiveFerrocenylethylaminesviaHydrideReductionofChiralFerrocenylketimines,HengyuQian,ShihaiYan,XiulingCui,*ChaoPi,ChengLiu,YangjieWu*,ChinJChem,2013,992DOI:10.1002/cjoc.**.
2012
1.易合成、易修饰的诱导基作用下的Pd催化的C-H键功能化反应，王勇，程国林，崔秀灵*,有机化学，2012,32,2018-2039.封面
2.天然药物抗HBV作用机制的研究进展，李沿涛,许瑞安,崔秀灵*，中国药理学与毒理学杂志，201226(5),702-705
3.基于钯催化C-H键活化的多米诺反应,沈金海，程国林，崔秀灵*,化学进展，2012，96-108
4.DirectlyFuseHighlySubstitutedNaphthalenesviaPd-CatalyzedDehydrogenativeAnnulationofN,N-DimethylaminomethylFerroceneUsingRedoxProcessofSubstrate"HaoZhang,XiulingCui,*XiangnaYao,HuiWang,JianyeZhang,YangjieWu,*Org.Lett.2012,3012-3015.
5.Syntheses,structuresofN-(substituted)-2-aza-[3]-ferrocenophanesandtheirapplicationasredoxsensorforCu2+ion，LianmeiChen,XiulingCui*,HaitaoCheng,MaopingSong,MingshengTang,DonghuiWei,YangjieWu*，AppliedOrganometChem,2012,449-454.
6.SynthesisofBiarylsvia“One-pot”TandemBorylation/Suzuki-MiyauraCrossCouplingCatalyzedbyPalladacycle,LianhuiWang,XiulingCui*,JingyaLi,YushengWu,ZhiwuZhu,andYangjieWu*Euro.JOrg.Chem.2012595-603.
7.Facilesynthesisofaryl(het)cyclopropanecatalyzedbypalladacycle,MinZhang,XiulingCui*,XiaopeiChen,LianhuiWang,JingyaLi,YushengWu,LifenHouandYangjieWu*,Tetrahedron,2012900-905.
8.Palladacycle-catalyzedcross-couplingreactionsofarylboronicacidswithcarboxylicanhydridesoracylchlorides,AjuanYu,LeiShen,XiulingCui,DongpoPeng,YangjieWu,*Tetrahedron,2012,2283--2288

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