肖卫东教授
发布时间:2012-05-03 浏览次数:
M.SUniversityofSci.andTec.ofChina,Hefei,China
Ph.D.UniversityofNorthCarolina,ChapelHill,NC
工作简历：
1996-1999PostdoctoralFellow,InstituteforHumanGeneTherapyUniversityofPennsylvania,Philadelphia
1999-2000AssistantProfessor,ThomasJeffersonUniversity,Philadelphia,PA
2000-AssistantProfessorofPediatrics,UniversityofPennsylvania,Children’sHospitalofPhiladelphia,Philadelphia,PA
2006-Professor,InstituteofMolecularMedicine,HuaqiaoUniiversity,China
专利申报:
1.Wilson;JM.;Xiao;W.Adeno-associatedvirusserotype1nucleicacidsequences,vectorsandhostcellscontainingsame6,759,237July6,2004
2.Rabinowitz;JE.;Samulski;RJ;Xiao;WRecombinantparvovirusvectorsandmethodofmaking6,491,907December10,2002
3.Wilson;JM.;Xiao;W.MethodsandvectorconstructsusefulforproductionofrecombinantAAV6,482,634November19,2002
4.Xiao;W;During;MJ.;Cao;LHelperfunctionsforrecombinantvectorproduction6,329,181December11,2001
论文发表情况：
1、Xiao,X.,Xiao,W.,Li,J.,Samulski,R.J.:ANovel165-Base-PairTerminalRepeatSequenceIstheSolecisRequirementfortheAdeno-AssociatedVirusLifeCycle.JournalofVirology71:941-948,1997.
2、Xiao,W.,Berta,S.C.,Lu,M.,Tazelaar,J.,Moscioni,D.,WilsonJ.M.:Adeno-AssociatedVirusasAVectorforLiverDirectedGeneTherapy.JournalofVirology72:10222-10226,1998.
3、Xiao,W.,Narendra,C.,Berta,S.C.,Mccullough,B.,Gao,G.,Wilson,J.M.:GeneTherapyVectorsBasedonAdeno-AssociatedVirusTypeI.JournalofVirology73:3994-4003,1999.
4、Xiao,W*,Bals,R.*,Sang,N.,Weiner,D.J.,Meegalla,R.L.,Wilson,J.M.:TransductionofWell-DifferentiatedAirwayEpitheliumbyRecombinantAdeno-AssociatedVirusIsLimitedByVectorEntry.JournalofVirology73:6085-6088,1999.
5、Rabinowitz,J.E.,Xiao,W.,Samulski,R.J.:InsertionalMutagenesisofAAV2CapsidandtheProductionofRecombinantVirus.Virology265:274-285,1999.
6、Gavin,D.K.,Young,S.M.Jr.,Xiao,W.,Temple,B.,Abernathy,C.R.,Pereira,D.J.,Muzyczka,N.,Samulski,R.J.:Charge-to-AlanineMutagenesisoftheAdeno-AssociatedVirusType2Rep78/68ProteinsYieldsTemperature-SensitiveandMagnesium-DependentVariants.JournalofVirology73(11):9433-45,1999.
7、Gao,G.,Qu,G.,Faust,L.Z.,Engdahl,R.K.,Xiao,W.,Hughes,J.V.,Zoltick,P.W.,Wilson,J.M.:HighTiterAdeno-AssociatedViralVectorsfromaRep/CapCellLineandHybridShuttleVirus.GeneTherapy9:2353-2362,1998.
8、Cao,L.,Liu,Y.,During,M.J.,Xiao,W.:High-titer,wild-typefreerecombinantadeno-associatedvirusvectorproductionusingintron-containinghelperplasmids.JournalofVirology74:11456-63,2000
9、Xiao,W.*,Narendra,C.*,Truneh,A.,Schnell,M.A.,Hughes,J.V.,Zoltick,P.,Wilson,J.M.:HumoralImmunitytoAAV2VectorsFollowingAdministrationtoMurineandNon-HumanPrimateMuscle.JournalofVirology74:2420-2425,2000
10、Xiao,W.*,Narendra,C.*,Schnell,M.A.,Tazelaar,J.,Hughes,J.V.,Wilson,J.M.:RouteofAdministrationDeterminesInductionofTcellIndependentHumoralResponsestoAdeno-associatedVirusVectors.(*EqualContribution)MolecularTherapy1:323-329,2000.
11、Mingozzi,F.,Schuttrumpf,J.,Arruda,V.R.,Liu,Y.,Liu,Y.L.,High,K.A.,Xiao,W.,Herzog,R.W.:Improvedhepaticgenetransferbyusinganadeno-associatedvirusserotype5vector.JournalofVirology76:10497-10502,2002.
12、Cao,L.,During,M.,Xiao,W.:ReplicationcompetenthelperfunctionsforrecombinantAAVvectorgeneration.GeneTherapy9:1199-1206,2002.
13、Rabinowitz,J.E.,Rolling,F.,Li,C,Conrath,H.,Xiao,W.,Xiao,X.,Samulski,R.J.:Cross-packagingofasingleadeno-associatedvirus(AAV)type2vectorgenomeintomultipleAAVserotypesenablestransductionwithbroadspecificity.JournalofVirology76:791-801,2002.
14、Xu,R.,Sun,X.,Tse,L.Y,Li,H.,Chan,P.C.,Xu,S.,Xiao,W.,Kung,H.F.,Krissansen,G.W.,Fan,S.T.:Long-termexpressionofangiostatinsuppressesmetastaticlivercancerinmice.Hepatology.37:1451-1460,2003.
15、Hauck,B.,Chen,L.,Xiao,W.:GenerationandCharacterizationofChimericRecombinantAAVvectors.MolecularTherapy7:419-425,2003.
16、Sarkar,R.*,XiaoW*,Kazazian,H.H.:ASingleAAV-MurineFactorVIIIVectorforCorrectingtheHemophiliaAPhenotype.JournalofThrombosisandHaemostasis.1:220-226,2003(Commentary:Genetherapyforhemophilia:areviralvectorsreallyfeasibleC.Walsh1:218-9).
17、Hauck,B.,Xiao,W.:Characterizationoftissuetropismdeterminantsofadeno-associatedvirustype1.JournalofVirology77:2768-2274,2003.
18、Liu,Y.L.,Wagner,K.,Robinson,N.,Sabatino,D.,Margaritis,P.,Xiao,W.,Herzog,R.W.:Optimizedproductionofhigh-titerrecombinantadeno-associatedvirusinrollerbottles.Biotechniques34:184-189,2003.
19、Gao,G.,Zhou,X.,Alvira,M.R.,Tran,P.,Marsh,J.,Lynd,K.,Xiao,W.,Wilson,J.M.:Highthroughputcreationofrecombinantadenovirusvectorsbydirectcloning,green-whiteselectionandI-SceI-mediatedrescueofcircularadenovirusplasmidsin293cells.GeneTherapy.10:1926-1930,2003.
20、Li,Y.,Zhang,T.,Douglas,S.D.,Lai,J.P.,Xiao,W.D.,Pleasure,D.E.,Ho,W.Z.:MorphineenhanceshepatitisCvirus(HCV)repliconexpression.AmericanJournalofPathology.163:1167-1175,2003.
21、Arruda,V.R.,Schuettrumpf,J.,Herzog,R.W.,Nichols,T.C.,Robinson,N.,Lotfi,Y.,Mingozzi,F.,Xiao,W.,Couto,L.B.,High,K.A.:SafetyandefficacyoffactorIXgenetransfertoskeletalmuscleinmurineandcaninehemophiliaBmodelsbyadeno-associatedviralvectorserotype1.Blood.103:85-92,2004
22、HauckB,ZhaoW,HighK,XiaoW.Intracellularviralprocessing,notsinglestrandedDNAaccumulationiscrucialforrAAVtransduction.JournalofVirology.78:13678-13686,2004(*EqualContribution).
版权所有?华侨大学生物医学学院
