Name: Zhaowei Chen (陈兆委)
Title: Professor (闽江********)
Degree: Ph.D. (理学博士)
Position: Supervisor (博士生导师)
QQ:
Email: chenzw@fzu.edu.cn
Research: ChemicalBiology (化学生物学), Artificial cells (人工细胞), Biocatalysis (生物催化), Nanomedicine (纳米医药)
考研系统报名专业：
分析化学 (学硕、博士)、生物与医药工程 (专硕)

Education and Work Experience (教育工作经历)




2021.04 – now: College of Pharmaceutical Sciences, Zhejiang University, Adjunct Professor(浙江大学，药学学院，兼职教授)
2020.03 – now: Collge of Chemistry, Fuzhou University, Professor (福州大学，化学学院，教授)
2019.03–2020.03: University of California-Los Angeles，Postdoc (Supervisor：ZhenGu)
2017.06–2019.03: Argonne National Lab，Postdoc (Supervisor：Elena A. Rozhkova)
2016.04–2017.06: North Carolina Sate University，Postdoc (Supervisor：ZhenGu)
2010.09–2016.01: Changchun Insitute of Applied Chemistry, Ph.D. (Supervisors: 任劲松&曲晓刚)
2006.09–2010.07: Northwestern Polytechnical University(西北工业大学)，B.E.


Courses (教学简介)

Biochemistry (《生物化学》助教)

Group Members (组内成员)

Junduan Dai
(Co-supervised by Prof Yang)
Chen Chen
(Co-supervised by Prof Yang)
Yuheng Guo
(Co-supervised by Prof Li)
Xiao Xu


Hao Lian
(Co-supervised by Prof Yang)
Zheng Liu
(Co-supervised by Prof Yang)
Sijie Song
(Co-supervised by Prof He)
Baoliu Chen


Mengnan Wu

Ting Wu
Dilan Ouyang

Hao Chen





Qi Wang




Reserach Overview (科研简介)
Our group research interests focus on design and synthesis of bioinspired and biomimetic materials for theranostics, biocatalytic, and bioenergy conversion applications. We have pulished around 80 high-impact papers, with citationsnear 4300 and an H-index of 38.

主要从事生命分析化学及化学生物学相关的基础研究与应用。在仿生材料的构建（如仿生人工细胞、人工金属酶、微型反应器、仿生矿化等）及其应用于药物载体、生物催化、抗菌抗生物被膜、生物能源转换等方面进行探索。近年来已在相关领域发表SCI论文80余篇，其中第一作者/通讯作者论文23篇，包括：Nat. Nanotechnol. (2篇), Nat. Chem. Biol., Sci. China Life Sci.,J. Am. Chem. Soc. (2篇), Angew. Chem. Int. Ed. (3篇), Adv. Mater., Adv. Funct. Mater., Chem. Soc. Rev., Acc. Chem. Res. (4篇), Biomaterials (2篇), Biosens. Bioelectron., Chem. Commun., Chem. Eur. J.。总引用次数4300余次，H-因子38。工作多次被NatureNanotechnology, Nature Methods, JAMA等亮点报道。
Research and Publications (研究方向及代表性论文）
Google Scholar:https://scholar.google.com/citations?user=3SyRXJAAAAAJ&hl=en
(I) Artificial synthetic cells and protocells builtuponchemistry, synthetic biology and micro-/nanomaterials for theranostic, biosensing, bioenergy conversion and life-of-origin researches.

1. Z. Chen, J. Wang, W. Sun, E. Archibong, A. R. Kahkoska, X. Zhang, Y. Lu, F. S. Ligler, J. B. Buse and Z. Gu (2018). "Synthetic beta cells for fusion-mediated dynamic insulin secretion." Nature Chemical Biology 14: 86. (Highlighted by NIH blog and JAMA.)
2. Z. Chen, G. De Queiros Silveira, X. Ma, Y. Xie, Y. A. Wu, E. Barry, T. Tajh, H. C. Fry, P. D. Laible, E. A. Rozhkova (2019) “Light-Gated Synthetic Protocells for Plasmon-Enhanced Chemiosmotic Gradient Generation and ATP Synthesis.” Angewandte Chemie International Edition, 58, 4896. (Highlighted by Nature Nanotechnology)
3. Z. Chen, H. Zhang, P. Guo, J. Zhang, G. Tira, Y. J. Kim, Y. A. Wu, Y. Liu, J. Wen, T. Rajh, J. Niklas, O. G. Poluektov, P. D. Laible and E. A. Rozhkova (2019). “Semi-artificial Photosynthetic CO2 Reduction through Purple Membrane Re-engineering with Semiconductor.” Journal of the American Chemical Society 141, 11811.
4. Z. Chen*, D. Wen, & Z. Gu * (2020). “Cargo-encapsulated cells for drug delivery.” Science China Life Sciences 63, 599.
5. X. Han, H. Li, D. Zhou, Z. Chen* and Z. Gu* (2020). “Local and Targeted Delivery of Immune Checkpoint Blockade Therapeutics.” Accounts of Chemical Research 53, 2521.
6. Z. Chen, Z. Wang, Z. Gu (2019) “Bioinspired and Biomimetic Nanomedicines” Accounts of Chemical Research, 52, 1255.
7. Z. Chen, Q. Hu, and Z. Gu (2018). “Leveraging Engineering of Cells for Drug Delivery.” Accounts of Chemical Research 51, 668.


(II) Inspired by the nature of metalloenzyme-catalyzed reactions, metal complex (artificial enzymes) or metal nanoparticles (bioorthogonal catalysts) can be synthesized and utilized as abiotic catalysts for deploying artificial chemistry in biological environments.

1. Z. Chen, H. Li, Y. Bian, Z. Wang, G. Chen, X. Zhang, Y. Miao, D. Wen, J., G. Wan, Y. Zeng, P. Abdou, J. Fang, S. Li, C. and Z. Gu* (2021). “Bioorthogonal Catalytic Patch.” Nature Nanotechnology, DOI: 10.1038/s41565-021-00910-7.
2. Z. Chen, H. Ji, C. Liu, W. Bing, Z. Wang and X. Qu (2016). "A Multinuclear Metal Complex Based DNase-Mimetic Artificial Enzyme: Matrix Cleavage for Combating Bacterial Biofilms." Angewandte Chemie International Edition 55(36): 10732.
3. Z. Chen, Z. Wang, J. Ren and X. Qu (2018). “Enzyme Mimicry for Combating Bacterial and Biofilms.” Accounts of Chemical Research 51, 789.


(III) The high spatiotemporal resolution of light makes optical nanomaterials promising for therapeutic/bioimaging studies, and developing optogenetic light delivery devices.

1. Z. Chen, V. Tsytsarev, Y. Zou Finfrock, O. A. Antipova, Z. Cai, H. Arakawa, F. W. Lischka, B. M. Hooks, R. Wilton, D. Wang, Y. Liu, B. Gaitan, Y. Tao, Y. Chen, R. S. Erzurumlu, H. Yang, and E. A. Rozhkova (2021). "Wireless optogenetic modulation of cortical neurons enabled by radioluminescent nanoparticles."ACS Nano 15(3), 5201.
2. Z. Chen, Z. Li, J. Wang, E. Ju, L. Zhou, J. Ren and X. Qu (2014). "A Multi-synergistic Platform for Sequential Irradiation-Activated High-Performance Apoptotic Cancer Therapy." Advanced Functional Materials 24(4): 522.
3. Z. Chen, Z. Liu, Z. Li, E. Ju, N. Gao, L. Zhou, J. Ren and X. Qu (2015). "Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis." Biomaterials 39: 15.


(IV) Bioinspired microreactors made of Pickering emulsions, colloidal particle-stabilized droplets, or functional nanomaterial-integrated living cells, for biocatalytic conversion applications and beyond.

1. Z. Chen, E. A. Rozhkova (2018) “Intracellular gold nanoclusters boost energy conversion.” Nature Nanotechnology, 13, 880.
2. Z. Chen, C. Zhao, E. Ju, H. Ji, J. Ren, B. P. Binks, X. Qu (2016). “Design of Surface-active Artificial Enzyme Particles to Stabilize Pickering Emulsions for High-Performance Biphasic Biocatalysis.” Advanced Materials 28(8): 1682.
3. Z. Chen, H. Ji, C. Zhao, E. Ju, J. Ren and X. Qu (2015). "Individual Surface-Engineered Microorganisms as Robust Pickering Interfacial Biocatalysts for Resistance-Minimized Phase-Transfer Bioconversion." Angewandte Chemie International Edition 54(16): 4904.
4. Z. Chen, L. Zhou, W. Bing, Z. Zhang, Z. Li, J. Ren and X. Qu (2014). "Light Controlled Reversible Inversion of Nanophosphor-Stabilized Pickering Emulsions for Biphasic Enantioselective Biocatalysis." Journal of the American Chemical Society 136(20): 7498.
(V) The rich chemical characters of biomolecules, like DNA, protein, and polysaccharides, confer on them good templates for directing the growth of inorganic materials, which is known as biomineralization.

1. Z. Chen, C. Liu, F. Cao, J. Ren and X. Qu (2018). “DNA Metallization: Principles, Methods, Structures and Applications.” Chemical Society Reviews 47, 4017.
2. Z. Chen, Z. Li, Y. Lin, M. Yin, J. Ren and X. Qu (2013). "Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery." Biomaterials 34(4): 1364.
3. Z. Chen, L. Zhou, A. Zhao, Z. Zhang, Z. Wang, Y. Lin, J. Ren and X. Qu (2014). "Coupling exonuclease III with DNA metallization for amplified detection of biothiols at picomolar concentration." Biosensors & Bioelectronics 58: 214.
4. Z. Chen, Z. Li, Y. Lin, M. Yin, J. Ren and X. Qu (2013). "Bioresponsive Hyaluronic Acid-Capped Mesoporous Silica Nanoparticles for Targeted Drug Delivery." Chemistry-a European Journal 19(5): 1778.
5. Z. Chen, Y. Lin, C. Zhao, J. Ren and X. Qu (2012). "Silver metallization engineered conformational switch of G-quadruplex for fluorescence turn-on detection of biothiols." Chemical Communications 48(93): 11428.
Major Position in Influential Institutions (社会兼职)
1. Independent Reviewer for JACS, Angew. Chem.,Advanced Mateirals, Science Advances, Nature Communications, Advanced Functional Mateirals, ACS Nano, Nano Letters, ACS Applied Materials and Interface, Nanoscale, NanoResearch, etc.

2. Guest Editor for Molecules (MDPI), Chemistry(MDPI), etc.
Fundings (科研项目）
1. 福州大学“闽江****”****科研启动基金 (2020-2023)。
2. 国家重点研发计划纳米科技重点专项“靶向肿瘤转移节点分子的多模块可编程纳米药物”项目，承担其中课题二的子课题 (2021-2026)。
Awards(获得奖项)
“四青项目”获得者
“闽江****”****
中科院优秀博士学位论文
中科院朱李月华优秀博士生奖
博士研究生国家奖学金
OpenPositions (职位信息)
课题组常年招收具有化学、分子生物学、材料学等背景相关专业的硕士、博士、博士后，待遇优厚。有意向者请发送简历至邮箱：chenzw@fzu.edu.cn或chenzw@zju.edu.cn。实验室位置：福州大学国家大学科技园，阳光科技大厦，北509。
Lab location: Fuzhou University, University National Science Park, Yangguang Blgd, Room North 509.


News (组内动态）
2021
May 10 - Dr. Zhaowei Chen's work on Bioorthogonal Catalysis has been published in Nature Nanotechonlogy. Read more...
Apr. 2 - Welcome Miss Dilan, Hao, and Qi to join the Group!!

Feb. 24 - Dr. Zhaowei Chen's work on X-ray Optogenetics has been published in ACS Nano. Read more...