姓 名： 刘见永
性 别： 男

职 称： 研究员（硕导、博导）
学 历： 博士
职 务：
电 话：
专 业： 有机化学
电子邮件： liujianyong82@163.com
研究方向： 有机共轭大环化合物的合成及性能研究

教育工作经历
2011 - 福州大学 副研究员、研究员
2008－2010 香港中文大学化学系 博士后
2005－2008 香港中文大学化学系 博士

教学简介
承担本科生课程：《有机化学》《综合化学实验》《有机化学实验》
承担研究生课程：《实验室安全讲座》《有机化学研究方法与实验》

科研简介
研究兴趣：
氟硼二吡咯、酞菁类抗癌光敏药物的设计与药效研究；
有机染料分子荧光探针的设计及其在细胞、活体肿瘤中的成像研究；
染料敏化太阳能电池材料的设计及其光电转换性能研究；
酞菁和氟硼二吡咯的超分子化学。

社会兼职
中国抗癌协会光动力治疗专业委员会委员
中国化学会应用化学学科委员会卟啉与酞菁专业委员会秘书
担任Chemical Communications, Journal of Medicinal Chemistry, Green Chemistry, Chemistry A European Journal, Organic Letters, RSC Advances, ChemMedChem, Current Medicinal Chemistry等期刊的通讯审稿人。

科研项目
1.国家自然科学基金：生物素介导靶向光动力治疗-化疗联用抗癌药物的合成及构效关系研究 (No.**)
2.国家自然科学基金：叶酸-酞菁共轭物抗癌光敏剂的合成及其靶向光动力活性 (No.**)
3.福建省科技厅重大项目：抗癌光敏剂福大赛因临床2期人体药代动力学研究（No. 2015Y0086）
4.福建省自然科学基金：Cu（I）催化“点击化学”合成靶向抗癌光敏剂 (No.2012J05021)
5.福州大学海外引进人才项目：功能配合物 (No.022382)
6.福州大学科研启动项目：靶向抗癌光敏剂的研究 (No.600366)
7.福州大学科技发展基金：分子靶点抗癌光敏剂 (N0.2011-XY-6)

代表性论文
1. Chen, Y.; Liu, J.; Song, M.; Jiang, L.; Liu, L; Liu, Y.; Fu, G.; Xue, J.; Liu, J.-Y.*; Huang, M.*; Li,J*. “Insights into the binding mechanism of BODIPY-based photosensitizers to human serum albumin: A combined experimental and computational study”,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2018,203, 158–165.
2. Lin, H.; Chen, J.; Zhang, Y.; Ullab, A.; Liu, J.-Y.; Lin, F.; Jiang, L.; Huang, M*. “Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine”,J. Inorg. Biochem.,2018,189, 192–198.
3. Liu J.-Y*; Zhou, P.-Z.; Ma, J.-L. “Trifluoromethyl Boron Dipyrromethene Derivativesas Potential Photosensitizers for Photodynamic Therapy”,Molecules2018,23, 458-471.
4.Zhang,F.-L.;Song,M.-R.;Yuan,G.-K.;Ye,H.-N.;Tian,Y.;Huang,M.-D.;Xue,J.-P.;Zhang,Z.-H.*;Liu,J.-Y.*“A Molecular Combo of Zinc(II) Phthalocyanine and Tamoxifen Derivative for Dual Targeting Photodynamic Therapy and Hormone Therapy”J. Med. Chem.,2017,60, 6693-6703.
5. Liu J.-Y*; Wang, C.; Zhu, C.-H.; Zhang, Z.-H.*; Xue,J.-P. “Preparation and In Vitro Photodynamic Activity of Glucosylated Zinc(II) Phthalocyanines as Underlying Targeting Photosensitizers”,Molecules2017,22, 845-857.
6. Liu, J.-Y.*; Hou, X.-N.; Tian, Y.; Jiang, L.*; Deng, S.; R?der, B.; Ermilov, E. A.* “Photoinduced energy and charge transfer in a bis(triphenylamine)–BODIPY–C₆₀artificial photosynthetic system”,RSC Advances,2016,6, 57293-57305.
7. Liu, J.-Y.;Li, J.; Yuan, X.; Wang, W.-M.; Xue,J.-P.* “In vitro photodynamic activities of zinc(II) phthalocyanines substituted with pyridine moieties”,Photodiagnosis and Photodynamic Therapy,2016,13, 341-343.
8. Chen, J.; Ye, H.; Zhang, M.; Li, J.; Liu, J.-Y.*;Xue,J.-P.* “Erlotinib Analogue-substituted Zinc(II) Phthalocyanines for Small Molecular Target-based Photodynamic Cancer Therapy”,Chin. J. Chem.,2016,34, 983-988.
9. Ermilov, E. A. *; Liu, J.-Y.; Menting, R.; Huang, Y.-S.; R?der, B.; Ng, D. K. P.*“An artificial photosynthetic model based on a molecular triad of boron dipyrromethene and phthalocyanine”Phys. Chem. Chem. Phys.,2016,18, 10964-10975.
10. Zhang, F.-L.; Huang, Q.; Liu, J.-Y.; Huang, M.-D.; Xue,J.-P.*“Molecular-Target-Based Anticancer Photosensitizer: Synthesis and in vitro Photodynamic Activity of Erlotinib–Zinc(II)Phthalocyanine Conjugates”ChemMedChem,2015,10(2), 312-320.
11. Ermilov, E. A.*;Schlak, M.; Steffen, R.; Liu, X.-Q.; Liu, J.-Y.;R?der, B.“Energy transfer properties of a novel boron dipyrromethene–perylenediimide donor–acceptor dyad”RSC Adv.,2015,5, 67141-67148.
12. Zhou, X.-Q.; Meng, L.-B.; Huang, Q.; Li, J.; Zheng, K.; Zhang, F.-L.;Liu, J.-Y.; Xue, J.-P.*“Synthesis and in vitro Anticancer Activity of Zinc(II) Phthalocyanines Conjugated with Coumarin Derivatives for Dual Photodynamic and Chemotherapy”ChemMedChem,2015,10, 304-311.
13. Lin, J.; Zhu, C.; Liu, X.; Chen, B.; Zhang, Y.; Xue, J.;Liu, J.-Y.*“A Highly Selective and turn-on fluorescence probe for Fe³⁺ion based on perylene tetracarboxylic diimide”Chin. J. Chem.,2014,32, 1116-1120.
14. Jia, X.; Yue, F.; Chen, X.; Pan, H.-B.; Liu, W.-G.*; Liu, J.-Y.*“One-pot controlled synthesis of single-crystal a-Fe₂O₃hollow nanostructure and its gas sensing properties”RSC Adv.,2014,4, 42899-42904.
15. Liu, J.-Y.; Huang, Y.-S.; Menting, R.; R?der, B.; Ermilov, E. A.; Ng, D. K. P.* “A boron dipyrromethene-phthalocyanine pentad as an artificial photosynthetic model”Chem. Commun.2013,49, 2998-3000.
16. Liu, J.-Y.; Ermilov, E. A.; R?der, B.; Ng, D. K. P.* “A light-harvesting porphyrin-boron dipyrromethene conjugate”J. Porphyrins Phthalocyanines2013,17, 831-835.
17. Menting, R.;Liu, J.-Y.;Huang, Y.-S.;Ng, D. K. P.;R?der, B.;Ermilov, E. A.*“Photoinduced energy and charge transfer in ap-phenylene-linked dyad of boron dipyrromethene and monostyryl boron dipyrromethene”Phys. Chem. Chem. Phys.2013,15, 6912-6919.
18. Zhang, F.-L.; Huang, Q.; Zheng, K.; Li, J.;Liu, J.-Y.*; Xue, J.-P.* “A novel strategy for targeting photodynamic therapy. Molecular combo of photodynamic agent zinc(II) phthalocyanine and small molecule target-based anticancer drug erlotinib”Chem. Commun.2013,49, 9570-9572.
19. Jia, X.; Yang, F.-F.; Li, J.;Liu, J.-Y.;Xue, J.-P.*“Synthesis and in Vitro Photodynamic Activity of Oligomeric Ethylene Glycol?Quinoline Substituted Zinc(II) Phthalocyanine Derivatives”J. Med.Chem.2013,56, 5797-5805.
20. He, H.;Liu, J.-Y.;andNg, D. K. P.*“A Phthalocyanine-Based Fluorescent Sensor for Zn²⁺Ion”,J. Porphyrins Phthalocyanines”2013,17, 99-103.
21. Liu, J.-Y.;El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Ferrocene-Distyryl BODIPY Dyad and a Ferrocene-Distyryl BODIPY-C₆₀Triad”ChemPhysChem,2012,13, 2030-2036.
22. Shi, W.-J.; Liu, J.-Y.; Ng, D. K. P.* “A Highly Selective Colorimetric and Fluorescent Probe for Cu²⁺and Hg²⁺Ions Based on a Distyryl BODIPY with Two Bis(1,2,3-triazole)amino Receptors”Chem.Asian.J.2012,7(1), 196-200.
23. Liu, J.-Y.;El-Khouly, M. E.; Fukuzmi, S.*; Ng, D. K. P.* “Mimicking the Photosynthetic Antenna-Reaction Center Complexes with a (Boron Dipyrromethene)₃-Porphyrin-C₆₀Pentad”Chem. Eur.J.2011,17, 1605-1613.
24. Liu, J.-Y.;El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* “Photoinduced Electron Transfer in a Distyryl BODIPY-Fullerene Dyad”Chem. Asian.J.2011,6, 174-179.
25. Liu, J.-Y.;Lo, P.-C.; Ng, D. K. P.* “Phthalocyanine-Containing Supramolecular Arrays”Struct. Bond.2010,135, 169-210.
26. Liu, J.-Y.; Ermilov, E. A.; R?der, B.; Ng, D. K. P.* “Switching the photo-induced energy and electron-transfer processes in BODIPY-phthalocyanine conjugates”Chem. Commun.2009,45, 1517-1519.
27. Liu, J.-Y.; Lo, P.-C.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis and in vitro photodynamic activities of di-?-substituted zinc(II) phthalocyanine derivatives”Dalton Trans.2009,38, 4129-4135.
28. Liu, J.-Y.; Lo, P.-C.; Fong, W.-P.; Ng, D. K. P.* “Effects of the number and position of the substituents on the in vitro photodynamic activities of glucosylatedzinc(II) phthalocyanines”Org. Biomol. Chem.2009,7, 1583-1591.
29. Ermilov, E. A.*; Liu, J.-Y.; Ng, D. K. P.*; R?der, B. “Spectroscopic study of electron and energy transfer in novel silicon phthalocyanine-boron dipyrromethene triads”Phys. Chem. Chem. Phys.2009,11, 6430-6440.
30. Liu, J.-Y.; Yeung, H.-S.; Xu, W.; Li, X.;Ng, D. K. P.* “Highly Efficient Energy Transfer in Subphthalocyanine-BODIPY Conjugates”Org. Lett.2008,10(23), 5421-5424.
31. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Highly photocytotoxic 1,4-dipegylated zinc(II) phthalocyanines. Effects of the chain length on the in vitro photodynamic activities”Org. Biomol. Chem.2008,6, 4560-4566.
32. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* “Synthesis, Characterization, and in vitro Photodynamic Activities of Novel AmphiphilicZinc(II) Phthalocyanines Bearing Oxyethylene-rich Substituents”Metal Based Drugs2008, Article ID: 284691.
33. Lo, P.-C.; Chan, C. M. H.;Liu, J.-Y.; Fong, W.-P.; Ng, D. K.-P.*“Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties”J. Med.Chem.2007,50(9), 2100-2107.



其他
申请发明专利18项，已授权11项