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博士生导师，福建省闽江********，美国西雅图华盛顿大学博士后。主要从事病原微生物蛋白耐药机制与抑菌策略研究。多项相关研究成果已在Journal of Proteome Research、Journal Proteomics、Proteomics、Science Translational Medicine、Molecular & Cellular Proteomics等知名期刊上发表。目前在国际期刊上发表第一作者或通讯作者SCI 论文17篇（其中二区SCI论文12篇），总影响因子100左右，被引用总次数近700余次。先后主持三项国家自然科学基金及福建农林大学****基金与IFS国际基金各一项，曾获2012年广东省科学进步奖一等奖（排名第四），应邀参加多项国际国内会议。自2013年以来共指导本科生获得省级和国家级别创新实验计划、挑战杯赞助多项，接纳10余名本科生进行毕业论文设计, 并培养多名硕士生和博士生。



个人信息
行政职务：
技术职称： 教授
最后学位： 博士学位
邮编： 350002
电话： **
电子邮箱： xiangmin@fafu.edu.cn
办公地点： 海峡生态环境工程学院五楼
通讯地址： 福建农林大学生命科学学院


教育经历
2000年苏州大学生命科学学院生物技术系学士
2005年厦门大学生命科学学院生物系硕士
2009年中山大学生命科学学院生物系博士


工作经历

2009/12-2013/04， 美国华盛顿大学医学院，博士后
2013年至今-福建农林大学


荣誉及奖励
1. 广东省人民政府, 广东省科技进步奖, 一等奖, 2012，排名第四
2. 福建省人民政府，福建省教学成果奖， 特等奖，2014，排名十三
3. 福建农林大学五四青年奖章，2015
4. 福建农林大学“严家显”最高奖教金，2016






研究领域
多种鱼类病原菌例如嗜水气单胞菌(Aeromonas hydrophila)、副溶血弧菌（Vibrio Parahaemolyticus）等细菌是多种水生动物的原发性致病菌,也是典型的人-鱼共患病病原菌，每年由该菌导致的鱼类暴发性流行病给水产养殖业造成了严重的经济损失。由于养殖业中抗生素的普遍使用，该菌的耐药问题已经十分严重。目前已知细菌的生物膜对细菌产生耐药性至关重要，但是对生物膜导致细菌耐药的机理还有待进一步的深入研究。本方向主要利用定量蛋白质组学与分子生物学方法，系统研究植物或水产致病菌的耐药机制，寻找新的耐药功能蛋白与靶点，并对其耐药功能和调控机制进行深入研究。此外，还利用文库筛选策略，筛选细菌群体感应抑制物，为新型抑菌药物的研发提供理论依据。




开授课程
本科教程：《生物信息学》，《生物专业英语》
研究生教程：《生态学专业英语》



科研项目
国家自然科学基金面上项目，**，蛋白修饰影响嗜水气单胞菌耐药功能及其作用机理研究，2017-2020；
国家自然科学基金面上项目，**，外膜蛋白LamB介导的细菌负调控耐药机制研究，2015-2018；
国家自然科学青年基金项目，**，致病性嗜水气单胞菌在生物膜状态下的耐药机制研究，2013-2015;
福建农林大学校****科研人才培养专项基金项目，zjq201201，利用磷酸化蛋白质组学技术研究磷酸化蛋白在嗜水气单胞菌耐药中的功能，2013-2015




论文著作
[1] Guibin Wang#, Yuqian Wang#, Lishan Zhang, Qilan Cai, Yuexu Lin, Ling Lin, Lin XM (林向民)*. Proteomics analysis reveals the effect of Aeromonas hydrophila sirtuin CobB on biological functions.Journal of Proteomics, 2020, 225,103848.
[2] Lishan Zhang, Wanxin Li, Lina Sun, Yuqian Wang, Yuexu Lin, Lin XM (林向民)*. Quantitative proteomics reveals the molecular mechanism of Aeromonas hydrophila in enoxacin stress. Journal of Proteomics, 2020, 211, 103561.
[3] Huanying Pang^#, Wanxin Li^#, Weijie Zhang, Shihui Zhou, Rowena Hoare, Sean J. Monaghan, Jichan Jian, Lin XM (林向民)*. Acetylome profiling of Vibrio alginolyticus reveals its role in bacterial virulence. Journal of Proteomics, 2020, 211,103543.
[4] Lina Sun^#, Zujie Yao^#, Zhuang Guo, Lishan Zhang, Yuqian Wang, Ranran Mao, Yuexu Lin, Yuying Fu, Lin XM(林向民)*. Comprehensive analysis of the lysine acetylome in Aeromonas hydrophila reveals cross-talk between lysine acetylation and succinylation in LuxS. Emerging Microbes & Infections, 2019,8:1229-1239.
[5] Yuexu Lin^#, Wanxin Li^#, Lina Sun, Zhenping Lin, Yuhang Jiang, Yueming Ling*, Lin XM(林向民)*. Comparative metabolomics shows the metabolic profiles fluctuate in multi-drug resistant Escherichia coli strains. Journal of Proteomics, 2019, 207, 103468.
[6] Zeqi Li^#, Yuqian Wang^#, Xiaoyan Li, Zhenping Lin, Yuexu Lin, Srinivasan Ramanathan, Lin XM(林向民)*.The characteristics of antibiotic resistance and phenotypes in 29 outer membrane protein mutant strains in Aeromonas hydrophila.Environmental Microbiology,2019, 21(12): 4614–4628.
[7] Yuying Fu, Qilan Cai, Yuqian Wang, Wanxin Li, Jing Yu, Guidi Yang, Wenxiong Lin* Lin XM(林向民)*.Four LysR-type transcriptional regulator family proteins (LTTRs) involved in antibiotic resistance in Aeromonas hydrophila. World J Microbiol Biotechnol,2019, 35:127.
[8] Wang YQ^#, Wang XY^#, Ali F, Li ZQ, Fu YY, Yang XJ, Lin WX, Lin XM(林向民)*. Comparative extracellular proteomics of Aeromonas hydrophila reveals iron-regulated secreted proteins as potential vaccine candidates. Frontiers in Immunology, 2019, 10:256
[9] Cai QL^#, Wang GB^#, Li ZQ, Zhang LS, Fu YY, Yang XJ, Lin WX, Lin XM(林向民)*. SWATH based quantitative proteomics analysis reveals Hfq2 play an important role on pleiotropic physiological functions in Aeromonas hydrophila. Journal of Proteomics, 2019, 195, 1-10.
[10] Li WX^#, Wang GB^#, Zhang S, Fu YY, Jiang YH, Yang XJ, Lin XM(林向民)*. An integrated quantitative proteomic and metabolomics approach to reveal the negative regulation mechanism of LamB in antibiotics resistance. Journal of Proteomics, 2019, 194,148-159.
[11] Yao ZJ^#, Guo Z^#, Wang YQ, Li WX, Fu YY, Lin YX, Lin WX, Lin XM(林向民)*. Integrated succinylome and metabolomics profiling reveals crucial role of S-ribosylhomocysteine lyase in quorum sensing and metabolism of Aeromonas hydrophila. Molecular & Cellular Proteomics, 2019, 18 (2) 200-215.
[12] Yao ZJ^#, Sun LN^#, Wang YQ, Lin L, Guo Z, Li D, Lin WX, Lin XM(林向民)*. Quantitative proteomics reveals antibiotics resistance function of outer membrane proteins in Aeromonas hydrophila.Frontiers in Cellular and Infection Microbiology, 2018, 8, 390.
[13] Ali F, Yao ZJ, Li WX, Sun LN, Lin WX*, Lin XM(林向民)*In-silico prediction and modeling of the quorum sensing LuxS protein and inhibition of AI-2 biosynthesis in Aeromonas hydrophila. Molecules, 2018, 23(10), 2627, e1-22.
[14] Guo Z, Lin YX, Wang XY, Fu YY, Lin WX, Lin XM(林向民)*. The protective efficacy of four iron-related recombinant proteins and their single-walled carbon nanotube encapsulated counterparts against Aeromonas hydrophila infection in zebrafish. Fish & Shellfish Immunology, 2018, 82, 50-59.
[15] Ye JZ^#, Lin XM(林向民)^#, Cheng ZX, Su YB, Li WX, Ali F, Zheng J, Peng B*. Identification and efficacy of glycine, serine and threonine metabolism in potentiating kanamycin-mediated killing of Edwardsiella piscicida. Journal of Proteomics, 2018,183,34-44.
[16] Cheng ZX, Yang MJ, Peng Bo, Peng XX, Lin XM(林向民)*, Li Hui*. The depressed central carbon and energy metabolisms is associated to the acquisition of levofloxacin resistance in Vibrio alginolyticus.Journal of Proteomics, 2018, 181, 83-91.
[17] Li WX, Zhang S, Wang XY, Yu J, Li ZQ, Lin WX, Lin XM(林向民)*. Systematically integrated metabonomic-proteomic studies of Escherichia coli under ciprofloxacin stress.Journal of Proteomics, 2018, 179, 61-70.
[18] Lin L^#, Sun LN^#, Ali F, Guo Z, Zhang L, Lin WX*, Lin XM(林向民)*. Proteomic analysis of alterations in Aeromonas hydrophila outer membrane proteins in response to oxytetracycline stress. Microbial Drug Resistance, 2018,24(8), 1067-1074.
[19] Li WX^#, Ali F^#, Yao ZJ, Cai QL, Sun LN, Lin WX, Lin XM(林向民)*.Quantitative proteomic analysis reveals that chemotaxis is involved in chlortetracycline resistance in Aeromonas hydrophila. Journal of Proteomics, 2018, 172, 143–151.
[20] Wang YQ, Chen HR, Guo Z, Sun LN, Fu YY, Li T, Lin WX, Lin XM(林向民)*.Quantitative proteomic analysis of iron-regulated outer membrane proteins in Aeromonas hydrophila as potential vaccine candidates. Fish & Shellfish Immunology, 2017, 68, 1-9.
[21] Li WX, Yao ZJ, Zhang XY, Huang F, Lin WX*, Lin XM(林向民)*. Global protein expression profile response of planktonic Aeromonas hydrophila exposed to Chlortetracycline. World J Microbiol Biotechnol, 2017, 33:68, 1-11.
[22] Sun LN, Chen HR, Lin WX*, Lin XM(林向民)*.Quantitative proteomic analysis of Edwardsiella tarda in response to oxytetracycline stress in biofilm. Journal of Proteomics, 2017, 6:150,141-148.
[23] Yao ZJ, Li WX, Lin Y, Wu Q, Yu FF, Lin WX*, Lin XM(林向民)*. Proteomic analysis reveals that metabolic flows affect the susceptibility of Aeromonas hydrophila to antibiotics. Scientific Report, 2016, 6:39413, e1-10.
[24] Li WX^#, Yao ZJ^#, Sun LN, Hu WJ, Cao JJ, Lin WX*, Lin XM(林向民)*. Proteomics analysis reveals a potential antibiotic cocktail therapy strategy for Aeromonas hydrophila infection in biofilm. Journal of Proteome Research, 2016, 15 (6), 1810–1820.
[25] Yao ZJ, Wang ZH, Sun LN, Li WX, Shi Y, Lin L, Lin WX*, Lin XM(林向民)*. Quantitative proteomic analysis of cell envelope preparations under iron starvation stress in Aeromonas hydrophila. BMC Microbiology, 2016, 16:161,1-13.
[26] Lin XM(林向民)*^#, Lin L^#, Yao ZJ, Li WX, Sun LN, Zhang DF, Luo J, Lin WX*. An integrated quantitative and targeted proteomics reveals fitness mechanisms of Aeromonas hydrophila under oxytetracycline stress. Journal of Proteome Research，2015, 14(3):1515-1525.
[27] Lin XM(林向民), Shi M, Masilamoni JG, Dator R, Movius J, Aro P, Smith Y, Zhang J*. Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery. Biochimica et Biophysica Acta- Proteins and Proteomics, 2015, 1854(7):779-787.
[28] Lin R^#, Lin XM(林向民)^#,Guo TT, Wu LK, Zhang WJ, Lin WX*. Metaproteomic analysis of bacterial communities in marine mudflat aquaculture sediment. World J Microbiol Biotechnol, 2015 ,31(9):1397-1408.
[29] Lin XM(林向民),Kan LQ, Hui L, Peng XX*. Fluctuation of multiple metabolic pathways is required for Escherichia coli in response to chlortetracycline stress. Molecular BioSystems, 2014, 10(4), 901-908.
[30] Lin XM(林向民),Hui L, Wang C, Peng XX*. Decrease of LamB and Odp1 complex is crucial for antibiotic resistance in Escherichia coli. Journal of Proteomics.2014, 98, 244-253.
[31] Lin XM(林向民),Wang C, Guo C, Tian Y, Li H, Peng XX*. Differential regulation of OmpC and OmpF by AtpB in Escherichia coli exposed to nalidixic acid and chlortetracycline. Journal of Proteomics. 2012, 18, 5898-5910.
[32] Lin XM(林向民),Cook TJ, Zabetian CP, Leverenz JB, Peskind ER, Hu SC, Cain KC, Pan C, Edgar JS, Goodlett DR, Racette BA, Checkoway H, Montine TJ, Shi M, Zhang J*. DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease.Scientific Reports. 2012, 954, e1-10.
[33] Lin XM(林向民), Yang JN, Peng XX, Li H*. A novel negative regulation mechanism of bacterial outer membrane proteins in response to antibiotic resistance. J Proteome Res, 2010, 9, 5952– 5959.
[34] Lin XM(林向民), Li H, Wang C, Peng XX*. Proteomic analysis of Nalidixic acid resistance in Escherichia coli: identification and functional characterization of OM proteins. J Proteome Res. 2008, 7, 2399-2405.
[35] Lin XM(林向民), Wu LN, Li H, Peng XX*. Down-regulated Tsx and OmpW and up-regulated OmpX are required for iron homeostasis in Escherichia coli. J Proteome Res. 2008, 7, 1235-1243.
[36] Li H^#, Lin XM(林向民)^#, Wang SY, Peng XX*. Identification and antibody-therapeutic targeting of Chloramphenicol resistant outer membrane proteins in Escherichia coli. J Proteome Res. 2007, 6:3628-3646.
[37] Huang CZ^#, Lin XM(林向民)^#, Wu LN, Zhang DF, Liu D, Wang SY, Peng XX*. Systematic identification of the sub-proteome of Escherichia coli cell envelope reveals the interaction network of membrane proteins and membrane-associated peripheral proteins. J Proteome Res. 2006, 5: 3268-3276.
[38 ]姜倩雯，张丽珊，李小艳，武瑶，赵怡扬，徐慧铭，林向民*.单壁碳纳米管载嗜水气单胞菌外膜蛋白亚单位疫苗的研制及免疫效果评价.水产学报,2020.
[39]李小艳，李泽琦，汪玉倩，于晶，林镇平，林向民*. 嗜水气单胞菌acrA缺失菌株的构建及其生理功能的测定. 生物技术通报, 2020
[40]张丽珊，孙莉娜，林镇平，林向民*. 嗜水气单胞菌非核糖体肽合成酶基因功能研究.生物技术通报,2020, 36(4):93-99
[41] 王贵宾, 蔡奇岚, 李泽琦, 赵怡扬, 林镇平, 林向民*.定量蛋白质组学揭示嗜水气单胞菌hfq2基因对生物被膜形成的影响.科学通报, 2019, 64: 1–9. (权威期刊)
[42] 张良，陈小青，宋佳宇，毛然然，姜倩雯，林向民*.巴洛沙星胁迫下大肠杆菌的比较蛋白质组学研究. 生物技术通报, 2019, 35(3):1-6
[43] 毛然然,李小艳,武瑶，林向民. 嗜水气单胞菌OprM 蛋白的克隆表达与免疫保护作用评价.生物技术通报, 2019, 35(9): 244-248
[44] 黄放, 林向民*.嗜水气单胞菌bamA、bamB、bamD突变株的构建及其对外膜蛋白转运的影响.生物技术通报.2018, 34(5):1-6
[45] 胡文杰, 张香玉, 吴倩, 林梅贵, 黄小芳, 林向民*. 嗜水气单胞菌脂肪酸生物合成途径相关蛋白的耐药性. 福建农业学报, 2017, 32(1): 1-6.
[46] 谭礼宁，王娟英，欧阳家和，余小岚，孙莉娜，林向民*. 嗜水气单胞菌低分子质量蛋白的相关研究. 福建农林大学学报(自然科学版), 2015,44(1):74-82
[47] 李碗芯，孙莉娜，林向民*.革兰氏阴性细菌外膜蛋白耐药功能及其抑菌策略研究进展. 福建农林大学学报(自然科学版), 2015, 44(06):561-566
[48] 孙莉娜, 姚祖杰, 谭礼宁, 李碗芯, 胡文杰, 林玲, 林向民*.嗜水气单胞菌外膜囊泡组分及功能分析. 基因组学与应用生物学, 2015,34(12):2617-2623
[49]吴林坤^#, 林向民^#, 林文雄*. 根系分泌物介导下植物-土壤-微生物互作关系研究进展与展望. 植物生态学报2014, 38 (3): 298-310.



科技成果
专利:
[1]一种利用自杀基因快速筛选细菌群体感应抑制剂的方法。 林向民，姚祖杰，林文雄。授权专利号：ZL9.2;B，授权日期：2018-11-06
[2]一种筛选N-酰基高丝氨酸内酯类模拟物的方法。 林向民，姚祖杰，林文雄。 授权专利号：ZL 8.4;B，授权日期：2019-4-18
[3]一种利用发光法快速筛选细菌群体感应抑制剂的方法。 林向民，姚祖杰，林文雄。授权专利号：ZL0.1;B，授权日期：2019-5-16







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