聂代邦
学术学位硕士生导师


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niedaibang@cqmu.edu.cn

基础医学院





学科信息


个人简介
聂代邦，博士，重庆医科大学特聘副教授，硕士生导师。重庆斯德姆生物技术有限公司顾问。
2010年毕业于吉林大学生物化学与分子生物学系，获理学博士学位。2007年获国家建设高水平大学公派研究生项目资助在美国匹兹堡大学医学院进行博士课题研究。主要研究方向：AAV基因治疗、RNA编辑酶 ADAR1在T细胞发育过程中的作用研究以及Omega-3 多不饱和脂肪酸对前列腺癌的影响研究。2010-2015年任长春大成生化科技集团基因工程实验室主任。主要从事发酵法生产蛋氨酸，赖氨酸及苏氨酸基因工程菌的开发。主持课题“发酵法生产蛋氨酸技术的开发”、“发酵生产蛋氨酸关键技术的开发”，并参与课题“高产赖氨酸基因工程菌的构建”以及“新型赖氨酸产品的开发及产业化示范”。研究成果获中华农业科技奖一等奖及吉林省科技进步奖。2015-2018年在美国匹兹堡大学医学院进行博士后课题研究。主要研究方向：肌腱干细胞生物学与运动生物学、衰老引起肌腱退化的细胞和分子机制研究以及mTOR信号通路与肌腱干细胞衰老的机制研究，发表SCI论文10余篇。




成果奖励
中华农业科技奖一等奖
吉林省科技进步奖

论文情况
1.Zhang C, Gu X,Nie D.et al.Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues. Ther Adv Chronic Dis. 2020.
2. Xufeng R,Nie D, Yang Q.et al. RNA editing enzyme ADAR1 is required for early T cell development. Blood Science. 2020.

3. Zhao G, Zhang J,Nie D.et al. HMGB1 Induces Tendinopathy Due to Mechanical Overloading.PLoS one.2019.
4.Zhang J,Nie D, Williamson K.et al. Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing. J Tissue Eng. 2019.
5. Chen B, Zhang J,Nie D.et al. Characterization of the structure of rabbit anterior cruciate ligament and its stem/progenitor cells. J Cell Biochem. 2018.
6. Zhang J,Nie D, Rocha JL.et al.Characterization of the structure, cells, and cellular mechanobiological response of human plantar fascia. J Tissue Eng. 2018.
7.Wang S,Nie D.et al. Lymphatic Endothelial Cells under Mechanical Stress: Altered Expression of Inflammatory Cytokines and Fibrosis.Lymphat Res Biol.2017.
8.Nie D, Wang Z, Zhang Y.et al.Fat-1 gene inhibits human oral squamous carcinoma cells proliferation through down-regulation of β-catenin signaling pathways. Exp Ther Med. 2015.
9. Yu S, Sharma R,Nie D.et al. ADAR1 ablation decreases bone mass by impairing osteoblast function in mice.Gene.2013.
10.Wu X,Ouyang H,Nie D.et al. Production of cloned transgenic cow expressing omega-3 fatty acids.Transgenic Res.2012.


11.Nie D, Wang B.et al. Muscle Specific Gene Transfer of the PEPCK-C Improves Physical Activity in Mice. 56th Annual Meeting of the Orthopaedic Research Society. 2010.
12. Li L, Pang D,Nie D.et al. Production of a reporter transgenic pig for monitoring Cre recombinase activity. Biochem Biophys Res Commun. 2009.
13. Li L, Pang D, Nie D.et al. Establishment of a transgenic pig fetal fibroblast reporter cell line for monitoring Cre recombinase activity. DNA Cell Biol. 2009.


14. Lu Y,Nie D, Zhang J.et al. Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 beta phosphorylation. Mol Cancer Thera. 2008.







研究方向
肌腱干细胞运动生物学，异种器官移植