陈诚
学术学位硕士生导师

教授



cclljjff@163.com

医学信息学院





学科信息


个人简介

担任国际华人骨研学会终身会员，重庆市健康促进与健康教育学会关节健康专业委员会委员，ACSAppliedMaterials&Interface，StemCellResearch&Therapy，StemCellsInternational，BioscienceReport，InternationalWoundJournal等杂志审稿人。自2012年开始从事骨科组织工程与再生医学研究，先后经历了中国人民解放军第三军医大学（现陆军军医大学）博士后（2012-2014）、哈佛大学访问****（2013-2014）、西南医院青年引进人才（2014-2019）、重庆医科大学****（2020至今），近5年发表SCI论文38篇（其中第一作者/通讯作者论文17篇，累计影响因子>80分，IF>5论文6篇）；主持并完成国家自然科学基金青年项目1项，国家及地方博士后基金2项，参与国家自然科学基金项目3项。研究致力于解决关节软骨损伤以及骨关节炎等疾病的病理生物力学，从生物力学，生物材料的角度出发，并选择间充质干细胞作为种子细胞，利用组织工程和再生医学策略对软骨乃至整个关节进行修复。有2项研究发表在JCR分区骨科排名第一的杂志TheAmericanJournalofSportsMedicine，表现出较好的临床参考价值和应用前景。


科研项目

波形蛋白破损对软骨细胞力学生物学的影响及其与骨关节炎发生的关系 ** 201401 201612 国家自然科学基金青年项目 20 主持
Col-I/PVA复合材料诱导自体BMSCs再生形成ACL机制研究 ** 201601 201912 国家自然科学基金面上项目 58 参与
自体软骨微粒复合COLII-HA-CS仿生基质溶胶修复局灶性关节软骨缺损再生机制研究 ** 201301 201612 国家自然科学基金面上项目 70 参与
T-VSCC钙离子通道参与介导力学过载诱发软骨细胞病理性肥大化的机制研究 ** 201901 202112 国家自然科学基金青年项目 26 参与
Annexin 5过度表达致关节软骨细胞终末分化机制研究 ** 201401 201612 国家自然科学基金青年项目 23 参与


论文情况
Natural Ingredients-Derived Antioxidants Attenuate H2O2-induced Oxidative Stress and Have Chondroprotective Effects on Human Osteoarthritic Chondrocytes via Keap1/Nrf2 Pathway Junjun Yang; Xiongbo Song; Yong Feng; Na Liu; Zhenlan Fu; Jiangyi Wu; Tao Li; Hao Chen; Jiajia Chen; Cheng Chen*; Liu Yang* Free Radical Biology & Medicine 2020 152 854-864 SCI 5.657
Asiatic Acid Attenuates Hypertrophic and Fibrotic Differentiation of Articular Chondrocytes via AMPK/PI3K/AKT Signaling Pathway Na Liu, Dejie Fu, Junjun Yang, Pingju Liu, Xiongbo Song 2, Xin Wang 2, Rui Li 2, Zhenlan Fu, Jiajia Chen, Xiaoyuan Gong, Cheng Chen*, Liu Yang* Arthritis Research & Therapy 2020 22(1) 112 SCI 4.148
Effects of Conditioned Medium From Osteoarthritic Cartilage Fragments on Donor-Matched Infrapatellar Fat Pad-Derived Mesenchymal Stromal Cells Zhenlan Fu, Xiongbo Song, Lin Guo, Liu Yang*, Cheng Chen* The American Journal of Sports Medicine 2019 47(12) 2927-2936 SCI 6.093
Aptamer-Functionalized Bioscaffold Enhances Cartilage Repair by Improving Stem Cell Recruitment in Osteochondral Defects of Rabbit Knees Xin Wang, Xiongbo Song, Tao Li, Jiajia Chen, Guotao Cheng, Liu Yang*, Cheng Chen* The American Journal of Sports Medicine 2019 47(10) 2316-2326 SCI 6.093
Silk Fibroin/Carboxymethyl Chitosan Hydrogel With Tunable Biomechanical Properties Has Application Potential as Cartilage Scaffold Tao Li, Xiongbo Song, Changmei Weng 2, Xin Wang 1, Liling Gu 3, Xiaoyuan Gong 1, Quanfang Wei, Xiaojun Duan, Liu Yang, Cheng Chen International Journal of Biological Macromolecules 2019 137 382-391 SCI 4.784
Zyxin-involved Actin Regulation Is Essential in the Maintenance of Vinculin Focal Adhesion and Chondrocyte Differentiation Status Gaoming Li, Xiongbo Song, Rui Li, Li Sun, Xiaoyuan Gong, Cheng Chen*, Liu Yang* Cell Proliferation 2018 52(1) e12532 SCI 5.039
Enzymatically Crosslinked and Mechanically Tunable Silk Fibroin/Pullulan Hydrogels for Mesenchymal Stem Cells Delivery Tao Li, Xiongbo Song, Changmei Weng, Xin Wang, Jiangyi Wu 1, Li Sun 3, Xiaoyuan Gong, Wei-Nan Zeng, Liu Yang*, Cheng Chen* International Journal of Biological Macromolecules 2018 115 300-307 SCI 4.784
Self-crosslinking and injectable chondroitin sulfate/pullulan hydrogel for cartilage tissue engineering Tao Li, Xiongbo Song, Changmei Weng, Xin Wang, Li Sun, Xiaoyuan Gong, Liu Yang*, Cheng Chen* Applied Materials Today 2018 10 173-183 SCI 8.013
Pellet Coculture of Osteoarthritic Chondrocytes and Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells With Chitosan/Hyaluronic Acid Nanoparticles Promotes Chondrogenic Differentiation Shu Huang, Xiongbo Song, Tao Li, Jingfang Xiao, Yemiao Chen 2, Xiaoyuan Gong, Weinan Zeng, Liu Yang*, Cheng Chen* Stem Cell Research & Therapy 2017 8(1) 264 SCI 4.963
Substrate Stiffness Together With Soluble Factors Affects Chondrocyte Mechanoresponses Cheng Chen*, Jing Xie, Linhong Deng, Liu Yang* ACS Applied Materials & Interfaces 2014 6(18) 16106-16116 SCI 6.723


论文情况
Natural Ingredients-Derived Antioxidants Attenuate H2O2-induced Oxidative Stress and Have Chondroprotective Effects on Human Osteoarthritic Chondrocytes via Keap1/Nrf2 Pathway Junjun Yang; Xiongbo Song; Yong Feng; Na Liu; Zhenlan Fu; Jiangyi Wu; Tao Li; Hao Chen; Jiajia Chen; Cheng Chen*; Liu Yang* Free Radical Biology & Medicine 2020 152 854-864 SCI 5.657
Asiatic Acid Attenuates Hypertrophic and Fibrotic Differentiation of Articular Chondrocytes via AMPK/PI3K/AKT Signaling Pathway Na Liu, Dejie Fu, Junjun Yang, Pingju Liu, Xiongbo Song 2, Xin Wang 2, Rui Li 2, Zhenlan Fu, Jiajia Chen, Xiaoyuan Gong, Cheng Chen*, Liu Yang* Arthritis Research & Therapy 2020 22(1) 112 SCI 4.148
Effects of Conditioned Medium From Osteoarthritic Cartilage Fragments on Donor-Matched Infrapatellar Fat Pad-Derived Mesenchymal Stromal Cells Zhenlan Fu, Xiongbo Song, Lin Guo, Liu Yang*, Cheng Chen* The American Journal of Sports Medicine 2019 47(12) 2927-2936 SCI 6.093
Aptamer-Functionalized Bioscaffold Enhances Cartilage Repair by Improving Stem Cell Recruitment in Osteochondral Defects of Rabbit Knees Xin Wang, Xiongbo Song, Tao Li, Jiajia Chen, Guotao Cheng, Liu Yang*, Cheng Chen* The American Journal of Sports Medicine 2019 47(10) 2316-2326 SCI 6.093
Silk Fibroin/Carboxymethyl Chitosan Hydrogel With Tunable Biomechanical Properties Has Application Potential as Cartilage Scaffold Tao Li, Xiongbo Song, Changmei Weng 2, Xin Wang 1, Liling Gu 3, Xiaoyuan Gong 1, Quanfang Wei, Xiaojun Duan, Liu Yang, Cheng Chen International Journal of Biological Macromolecules 2019 137 382-391 SCI 4.784
Zyxin-involved Actin Regulation Is Essential in the Maintenance of Vinculin Focal Adhesion and Chondrocyte Differentiation Status Gaoming Li, Xiongbo Song, Rui Li, Li Sun, Xiaoyuan Gong, Cheng Chen*, Liu Yang* Cell Proliferation 2018 52(1) e12532 SCI 5.039
Enzymatically Crosslinked and Mechanically Tunable Silk Fibroin/Pullulan Hydrogels for Mesenchymal Stem Cells Delivery Tao Li, Xiongbo Song, Changmei Weng, Xin Wang, Jiangyi Wu 1, Li Sun 3, Xiaoyuan Gong, Wei-Nan Zeng, Liu Yang*, Cheng Chen* International Journal of Biological Macromolecules 2018 115 300-307 SCI 4.784
Self-crosslinking and injectable chondroitin sulfate/pullulan hydrogel for cartilage tissue engineering Tao Li, Xiongbo Song, Changmei Weng, Xin Wang, Li Sun, Xiaoyuan Gong, Liu Yang*, Cheng Chen* Applied Materials Today 2018 10 173-183 SCI 8.013
Pellet Coculture of Osteoarthritic Chondrocytes and Infrapatellar Fat Pad-Derived Mesenchymal Stem Cells With Chitosan/Hyaluronic Acid Nanoparticles Promotes Chondrogenic Differentiation Shu Huang, Xiongbo Song, Tao Li, Jingfang Xiao, Yemiao Chen 2, Xiaoyuan Gong, Weinan Zeng, Liu Yang*, Cheng Chen* Stem Cell Research & Therapy 2017 8(1) 264 SCI 4.963
Substrate Stiffness Together With Soluble Factors Affects Chondrocyte Mechanoresponses Cheng Chen*, Jing Xie, Linhong Deng, Liu Yang* ACS Applied Materials & Interfaces 2014 6(18) 16106-16116 SCI 6.723






研究方向
组织工程；再生医学；智慧医学