章述军
学术学位硕士生导师

副教授
**


sjzhang@hospital.cqmu.edu.cn

第一临床学院





学科信息


个人简介
2010年毕业于华中科技大学同济医学院，获内科学博士学位，同年就职于重庆医科大学附属第一医院感染科至今。2015年-2017年赴美国堪萨斯大学肝脏中心进行肝脏炎症免疫调控的相关机制研究，2019年赴上海仁济医院进修肝脏病理和自身免疫性肝病。Journal of Medical Virology 审稿人；作为负责人主持国家自然科学基金项目1项，重庆市自然科学基金1项，重庆市科卫联合医学项目2项，参与6项；发表SCI 论文16篇，中文论文十余篇。 擅长脂肪肝、自身免疫性肝病、病毒性肝炎等各种肝病的诊断和治疗。


科研项目
重庆市中青年医学高端人才，重庆医科大学附属第一医院学术带头人储备人才。
以负责人身份承担国家自然科学基金项目1项，重庆市科卫联合医学研究项目2项，重庆市自然科学基金项目1项，目前在研经费50万元。

论文情况

1.Zhao J, Huang W, Zhang S, Xu J, Xue W, He B, Zhang Y. Efficacy of Glutathione for Patients With Cystic Fibrosis: A Meta-analysis of Randomized-Controlled Studies. American journal of rhinology & allergy 2020;34(1): 115-21.
2.Xiao Q, Zhang S, Ren H, Du R, Li J, Zhao J, Gao Y, Zhu Y, Huang W. Ginsenoside Rg1 alleviates ANIT-induced intrahepatic cholestasis in rats via activating farnesoid X receptor and regulating transporters and metabolic enzymes. Chemico-biological interactions 2020;324: 109062.
3.Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W. Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid. Biosci Biotechnol Biochem 2020;84(11): 2228-40.
4.Xiao Q, Zhang S, Yang C, Du R, Zhao J, Li J, Xu Y, Qin Y, Gao Y, Huang W. Ginsenoside Rg1 Ameliorates Palmitic Acid-Induced Hepatic Steatosis and Inflammation in HepG2 Cells via the AMPK/NF-kappaB Pathway. International journal of endocrinology 2019;2019: **.
5.Lei Q, Li L, Huang W, Qin B, Zhang S（通讯作者）. HEV ORF3 downregulates CD14 and CD64 to impair macrophages phagocytosis through inhibiting JAK/STAT pathway. J Med Virol. 2019 Jan 13.
6. 章述军（第一作者）, 肖晴, 黄文祥, LPS联合z-VAD-FMK对IFNg预处理巨噬细胞发生程序性坏死, 中国病理生理杂志, 2018, 34 (9):1653-1659.
7. Zhao J, Zhang S, Li X, He B, Ou Y, Jiang D. Comparison of Minimally Invasive and Open Transforaminal Lumbar Interbody Fusion for Lumbar Disc Herniation: A Retrospective Cohort Study. Med Sci Monit 2018;24: 8693-98.
8. Zhang S（第一作者）, Li Z, Huang W, Interleukin-4 Enhances the Sensitivity of Human Monocytes to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Through Upregulation of Death Receptor 4. J Interferon Cytokine Res. 2018 Apr; 38(4): 186- 194.
9. Xu Y, Yang C, Zhang S, Li J, Xiao Q, Huang W. Ginsenoside Rg1 Protects against Non-alcoholic Fatty Liver Disease by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation. Biol Pharm Bull 2018;41(11): 1638-44.
10. Lei Q, Li L, Zhang S, Li T, Zhang X, Ding X, Qin B. HEV ORF3 down-regulates TLR7 to inhibit the generation of type I interferon via impairment of multiple signaling pathways. Sci Rep. 2018 Jun 5; 8(1):8585.11. 章述军（通讯作者），雷青松，李麟，秦波，黄文祥，两种PMA诱导方案对THP-1巨噬细胞M1和 M2亚型相关基因表达的影响， 中国细胞生物学学报，2017, 39(6):765-771.
12. Li L, Lei QS, Kong LN, Zhang SJ, Qin B. Gene expression profile after knockdown of USP18 in Hepg2.2.15 cells. Journal of medical virology 2017;89(11): 1920-30.
13. Li L, Lei Q, Zhang S, Kong L, Qin B. Screening and identification of key biomarkers in hepatocellular carcinoma: Evidence from bioinformatic analysis. Oncol Rep 2017;38(5): 2607-18.
14. Li L, Lei QS, , Kong LN, Qin B. Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling. PloS one 2016;11(5): e**.
15. Lei Q, Li L, Cai J, Huang W, Qin B, Zhang S（通讯作者）. ORF3 of Hepatitis E Virus Inhibits the Expression of Proinflammatory Cytokines and Chemotactic Factors in LPS-Stimulated Human PMA-THP1 Cells by Inhibiting NF-κB Pathway. Viral Immunol. 2016 Mar;29(2):105-115.
16. Cai J, Zhang S, Huang W. Association between nonalcoholic fatty liver disease and carotid atherosclerosis: a meta-analysis. Int J Clin Exp Med 2015;8(5): 7673-8.
17. Cai J, Yuan Z, Zhang S. Abdominal pain, diarrhea, constipation--which symptom is more indispensable to have a colonoscopy? Int J Clin Exp Pathol 2015;8(1): 938-42.
18. Jian L, Zhao Q, Zhang S, Huang W, Xiong Y, Zhou X, Jia B. The prevalence of neutralising antibodies to chimpanzee adenovirus type 6 and type 7 in healthy adult volunteers, patients with chronic hepatitis B and patients with primary hepatocellular carcinoma in China. Archives of virology 2014;159(3): 465-70.
19. Zhang S(第一作者), Huang W, Zhou X, Zhao Q, Wang Q, Jia B. Seroprevalence of neutralizing antibodies to human adenoviruses type-5 and type-26 and chimpanzee adenovirus type-68 in healthy Chinese adults. Journal of medical virology 2013;85(6): 1077-84.
20. Zhang S(第一作者), Wang J, Yuan Q, Ge S, Zhang J, Xia N, Tian D. Clinical characteristics and risk factors of sporadic Hepatitis E in central China. Virology journal 2011;8: 152.
21. 章述军(第一作者)，田德英，陈淼，周健，王坤，贾昱娴. 188例散发性急性戊型肝炎临床分析. 内科急危重症杂志 2009;15(5): 3.
22. Zhang S(第一作者), Tian D, Zhang Z, Xiong J, Yuan Q, Ge S, Zhang J, Xia N. Clinical significance of anti-HEV IgA in diagnosis of acute genotype 4 hepatitis E virus infection negative for anti-HEV IgM. Digestive diseases and sciences 2009;54(11): 2512-8.










研究方向
肝脏疾病（病毒性肝炎，肝硬化，肝衰竭，脂肪肝，自身免疫性肝病），肝脏炎症的免疫调控，肝纤维化的发病机制