吕洋
学术学位博士生导师

教授



yanglyu@hospital.cqmu.edu.cn

第一临床学院





学科信息


个人简介
教授/主任医师，医学博士（德国/中国），博士研究生导师，重庆医科大学附属第一医院老年病科副主任。中华医学会老年医学分会青年委员，中华医学会肠外肠内营养学分会青年委员，中华预防医学会老年病预防专业委员会委员，中华医学会老年医学分会老年神经病学组委员，中国医师协会神经内科医师分会认知障碍疾病专业委员会委员，中国医师协会神经内科医师分会神经遗传专业委员会委员，中华医学会心身医学专委会老年心身医学协作学组组员、中国老年保健医学研究会抗衰老研究分会常委，中国康复医学会阿尔茨海默病与认知康复专委会常委，中国老年学和老年医学学会脑认知与健康分会常委，中国老年保健学会阿尔茨海默病分会（ADC）委员，中国老年医学学会认知障碍分会委员，西部老年医学中心联盟副主席，重庆市老年痴呆防治协会副会长，重庆市老年学和老年医学学会副会长，重庆市医师协会老年医学科医师分会副会长，重庆市老年学和老年医学学会老年保健康复分会主任委员，重庆市中西医结合学会慢病与健康管理委员会副主任委员，重庆市医学会老年医学专委会委员，国家自然科学基金一审专家，《中华老年医学杂志》通讯编委。
1992年9月进入重庆医科大学临床医学系本科学习，1997年7月获得医学学士学位，并推荐免试攻读重庆医科大学神经病学硕士学位，2000年7月获得医学硕士学位。于2004年获得国家留学基金委公派出国，从2006年3月至2007年2月赴德国基尔大学(Christian-Albrechts -Universitaet zu Kiel) 做访问****，期间在基尔大学和吕贝克大学从事神经疾病遗传学的科学研究工作，2007年3月获得德国医学博士学位；2008年7月获得重庆医科大学博士学位。2013年8-10月美国贝勒医学院访问****，2015年6-7月法国图卢兹大学医院访问****。
致力于癫痫和难治性癫痫的发病机制和遗传学研究，痴呆和认知障碍的临床和基础研究，神经系统衰老研究，人工智能研究。主持包括国家自然科学基金、教育部科学技术研究重点项目、重庆市科委重点项目在内的各级科研课题18项，教学课题3项，累计科研经费超过500万。以第一完成人获得重庆市科技进步二等奖2项、重庆市卫生局科技成果二等奖1项；参与获得省部级、厅局级科技进步奖8项。以第一完成人获得计算机软件著作权2项。主（参）编著作15部；在国内外发表论文105篇，其中以第一或通讯作者发表SCI期刊论文37篇；参与痴呆相关指南共识撰写6篇。
开设老年记忆障碍门诊十年，在诊断治疗、科学研究、康复训练和健康教育四位一体的道路上不断探索，已经建设成为西南地区最具特色的记忆障碍门诊，开创MDT诊治平台，影响力辐射重庆及云、贵、川、桂等地区，国内知名。开展新药临床试验、认知训练技术、早期集群诊断技术、基于组学的精准全程管理技术、人工智能诊断系统研发等临床研究。



成果奖励
以第一完成人获得重庆市科技进步二等奖2项、重庆市卫生局科技成果二等奖1项；参与获得省部级、厅局级科技进步奖8项。

科研项目
承担国家自然科学基金面上项目2项、参与国家重点研发计划2项、主持教育部科学技术研究重点项目、重庆市科委重点项目、重庆市教委教育教学改革重点项目、重庆市卫计委重点项目等省厅级项目17项；研究经费超过500万。

论文情况
在国内外发表论文105篇，其中以第一或通讯作者发表SCI期刊收录论文37篇：
1.Yuan S, Zhang W, Lü W, Yu W, Zhong F, Xiong L, Wan T, Hu C, Yang W, Chen C, Luo D, Tan B, Huang C, Yu W, Lü Y(通讯作者). The psychological impact on patients with memory disorders and their caregivers during COVID-19. Aging Clinical and Experimental Research 2021;
2. Yu X, Yu W, Wu L, Yang W, Lü Y (通讯作者). Chitotriosidase attenuates microglia-associated inflammation via HDAC3/NF-κB pathway in D-galactose and aluminum-induced rat model with cognitive impairments. Neuroscience Research 2021;
3.Yu W, Yu W, Yang Y, Lü Y (通讯作者). Exploring the key genes and identification of potential diagnosis biomarkers in Alzheimer’s disease using bioinformatics analysis. Frontiers in Aging Neuroscience 2021; 13: 602781. doi: 10.3389/fnagi.2021.602781
4.Fu X, Yu W, Ke M,Wang X, Zhang J, Luo T, Massman PJ, Doody RS, Lü Y (通讯作者).Chinese version of the Baylor rofound Mental Status Examination: a brief staging measure for patients with severe Alzheimer’s disease.The Journal of Prevention of Alzheimer's Disease 2021; 8(2): 175-180.
5.Yu W, Yu W, Liu X, Wan T, Chen C, Xiong L, Zhang W, Lü Y (通讯作者). Associations between malnutrition and cognitive impairment in an elderly Chinese population: an analysis based on a 7-year database. Psychogeriatrics2021; 21(1): 80-88.
6.Yu X, Yu W, Yang W, Lü Y (通讯作者). Usage and adherence of antidementia drugs in a memory clinic cohort in Chongqing, Southwest China. Psychogeriatrics2020; 20(5): 706-712.
7.Zou Y, Chen Y, Yu W, Chen T, Tian Q, Tu Q, Deng Y, Duan J, Xiao M, Lü Y (通讯作者). The prevalence and clinical risk factors of insomnia in the Chinese elderly based on comprehensive geriatric assessment in Chongqing population. Psychogeriatrics 2019; 19(4): 384-390.
8. Zhou J, Yu W, Zhang M, Tian X, Li Y, Lü Y (通讯作者). Imbalance of microglial TLR4/TREM2 in LPS-treated APP/PS1 transgenic mice: a potential link between Alzheimer's disease and systemic inflammation. Neurochemical Research 2019; 44(5), 1138-1151.
9.Hou Q, Guan Y, Yu W, Liu X, Wu L, Xiao M, Lü Y (通讯作者). Associations between obesity and cognitive impairment in the Chinese elderly: an observational study. Clinical Intervention in Aging 2019; 14: 367-373.
10.Wang X, Yu W, Fu X, Ke M, Xiao Q, Lü Y (通讯作者). Chitotriosidase enhances TGFβ-Smad signaling and uptake of β-amyloid in N9 microglia. Neuroscience Letters 2018; 687: 99-103.
11. Fu X, Ke M, Yu W, Wang X, Xiao Q, Gu M, Lü Y (通讯作者). Periodic variation of AAK1 in an Aβ_1-42-induced mouse model of Alzheimer's disease. Journal of Molecular Neuroscience 2018; 65(2): 179-189.
12. Xiao Q, Yu W, Tian Q, Fu X, Wang X, Gu M, Lü Y (通讯作者). Chitinase1 contributed to a potential protection via microglia polarization and Aβ oligomer reduction in D-galactose and aluminium induced rat model with cognitive impairments. Neuroscience 2017; 355: 61-70.
13.Yu W, Du Y, Zou Y, Wang X, Stephani U, Lü Y (通讯作者). Smad anchor for receptor activation contributes to seizures in temporal lobe epilepsy. Synapse 2017; 71(3): e21957.
14. Tian Q, Zhang M, Deng Y, Duan J, Tu Q, Cao Y, Zhu Q, Yu W, Lü Y (通讯作者). Does gait speed replace comprehensive geriatric assessment in the elderly? International Journal of Gerontology 2016; 10: 232-236.
15. Giri M, Chen T, Yu W, Lü Y (通讯作者). Prevalence and correlates of cognitive impairment and depression among elderly people in the world's fastest growing city, Chongqing, China. Clinical Intervention in Aging 2016; 11: 1091-1098.
16. Liu S, Yu W, Lü Y (通讯作者). The causes of new-onset epilepsy and seizures in the elderly. Neuropsychiatric Disease and Treatment 2016; 12: 1425-1434.
17. Xiao Q, Shi R, Yang W, Zou Y, Du Y, Zhang M, Yu W, Lü Y (通讯作者). Time-dependent increase of Chitinase1 in APP/PS1 double transgenic mice. Neurochemical Research 2016; 41(7), 1604-1611.
18. Giri M, Zhang M, Lü Y (通讯作者). Genes associated with Alzheimer's disease: an overview and current status. Clinical Intervention in Aging 2016; 11: 665-681.
19. Tian Q, Xiao Q, Yu W, Gu M, Zhao N, Lü Y (通讯作者). The inhibition of transforming growth factor beta activated kinase 1 contributed to neuroprotection via inflammatory reaction in pilocarpine induced rats with epilepsy. Neuroscience 2016; 325: 111-123.
20. Shi R, Duan J, Deng Y, Tu Q, Cao Y, Zhang M, Zhu Q, Lü Y (通讯作者). Nutritional status of an elderly population in Southwest China: a cross-sectional study based on comprehensive geriatric assessment. The Journal of Nutrition, Health & Aging 2015; 19(1): 26-32.
21. Yu W, Zou Y, Du Y, Luo J, Zhang M, Yang W, Wang X, Lü Y (通讯作者). Altered cerebrospinal fluid concentrations of TGFβ1 in patients with drug-resistant epilepsy. Neurochemical Research 2014; 39(11): 2211-2217.
22. Zou Y, Zhu Q, Deng Y, Duan J, Pan L, Tu Q, Dai R, Zhang X, Chu LW, Lü Y (通讯作者). Vascular risk factors and mild cognitive impairment in the elderly population in Southwest China. American Journal of Alzheimer's Disease and Other Dementias 2014; 29(3): 242-247.
23. Zou Y, Li Y, Yu W, Du Y, Shi R, Zhang M, Duan J, Deng Y, Tu Q, Dai R,Lü Y (通讯作者). Hypoxia-up-regulated mitochondrial movement regulator does not contribute to APP/PS1 double transgenic mouse model of Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 2013; 36(3-4): 137-145.
24. Du Y, Zou Y, Yu W, Shi R, Zhang M, Yang W, Duan J, Deng Y, Wang X, Lü Y (通讯作者). Expression pattern of sorting nexin 25 in temporal lobe epilepsy: a study on patients and pilocarpine-induced rats. Brain Research 2013; 1509: 79-85.
25. Lu Y, Xiao Z, Yu W, Xiao F, Xiao Z, Hu Y, Chen Y, Wang X. Efficacy and safety of adjunctive zonisamide in adult patients with refractory partial-onset epilepsy: a randomized, double-blind, placebo-controlled trial. Clinical Drug Investigation 2011; 31(4): 221-229.
26. Lu Y, Yu W, Xi Z, Xiao Z, Kou X, Wang XF. Mutational analysis of SCN2B, SCN3B and SCN4B in a large Chinese Han family with generalized tonic-clonic seizure. Neurological Sciences 2010; 31(5): 675-677.
27. Lu Y, Xue T, Yuan J, Li X, Wu Y, Xi Z, Xiao Z, Chen Y, Wang X. Increased expression of TGFbeta type I receptor in brain tissues of patients with temporal lobe epilepsy. Clinical Science (London) 2009; 117(1): 17-22.
28. Lu Y, Yu W, Wang X. Efficacy of topiramate in adult patients with symptomatic epilepsy: an open-label, long-term, retrospective observation. CNS Drugs 2009; 23(4): 351-359.
29. Lu Y, Wang X. Genes associated with idiopathic epilepsies: a current overview. Neurological Research 2009; 31(2): 135-143.
30. Lu Y, Yu W, Shen D, Wang X. Three new forms of familial epilepsy syndromes in the proposed diagnostic scheme of the ILAE (2001): a clinical experience in southwest China. Epilepsia 2008; 49(6): 1103.
31. Lu Y, Waltz S, Stenzel K, Muhle H, Stephani U. Photosensitivity in epileptic syndromes of childhood and adolescence. Epileptic Disorders 2008; 10(2): 136-143.
32. Lu Y, Wang X, Yan Y, Xiao Z, Stephani U. Nongenetic cause of epileptic seizures in 2 otherwise healthy Chinese families: tetramine. –case presentation and literature survey. Clinical Neuropharmacology 2008; 31(1): 57-61.
33. Lu Y, Wang X, Li Q, Li J, Yan Y. Tolerability and safety of topiramate in Chinese patients with epilepsy: an open-label, long-tem, prospective study. Clinical Drug Investigation 2007; 27(10): 683-690.
34. Lü Y (通讯作者), Yan Y, Wang XF. Antiepileptic drug-induced multidrug resistance P-glycoprotein overexpression in astrocytes from rat brain. Chinese Medical Journal (Engl) 2004; 117(11): 1682-1686.
35. Chen D, Lu Y (共同第一), Yu W, Luo J, Xiao Z, Xiao F, Wang X. Clinical value of decreased superoxide dismutase 1 in patients with epilepsy. Seizure 2012; 21(7): 508-511.
36. Hu Y, Lu Y (共同第一), Yu W, Xiao Z, Xi Z, Wang X. Long-term retention rate of topiramate as initial monotherapy in Chinese patients with newly diagnosed epilepsy: A prospective, observational study. Epilepsy Research 2010; 90(3): 278-284.
37. Wang X, Lu Y (共同第一). Genetic etiology of new forms of familial epilepsy. Frontiers in Bioscience 2008; 13(8): 3159-3167.






指导研究生情况(近五年)
近10年指导博士生5名，硕士生49名，指导研究生获得重庆市研究生科研创新项目6项，庆医科大学优秀硕士毕业论文7篇，国家奖学金获得者2人，国内优秀会议论文5篇，参加国内会议40人次。

知识产权
以第一发明人获得国家发明专利1项、软件著作权2项，参与获得国家发明专利1项，公开受理国家发明专利3项。

著作教材
主编《老年期痴呆》、《与失智老人快乐相处》（重庆市优秀科普图书）、参编老年医学、神经病学、全科医学教材编著作12部。





研究方向
癫痫和认知障碍，神经系统衰老