陈国俊
学术学位博士生导师

研究员



woodchen2015@163.com

第一临床学院





学科信息


个人简介
陈国俊教授，重庆市神经精神疾病重点实验室主任。重庆市********、巴渝********和学术技术带头人。分别在重庆医科大学和上海医科大学获得神经病学硕士和博士学位；并在中山医科大学附一院神经科完成博士后训练。先后在扬州市第二人民医院神经科、重庆医科大学附属第一医院神经科和中山医科大学一院神经科工作。现专职从事基础研究已达20余年。赴美国研修10年并于2011年回国。
主要方向是阿尔茨海默病。研究兴趣包括：（1）利用化学生物学原理，在高通量扫描的基础上，开展小分子化合物的作用靶点、机制和动物疗效研究。（2）RNA致病机制，包括探索RNA结合蛋白的翻译调控及其致病原理。（3）细胞内关键蛋白的转运机制和调控。获得多项NSFC重点和面上项目资助，并获得一项国家发明专利。代表性文章：PNAS, Brain, Aging Cell, J Neurosci., Mol Neurodegen等。


科研项目
国家自然科学基金项目：Furin通过内体转运途径调节APP降解并参与阿尔茨海默病（**），55万，2020-2023
科技部重点研发计划项目，基于医体结合的记忆和运动障碍三级全程化诊疗模式研究(2018YFC**)。子课题负责，230万（共880万），2019-2020
重庆市科委面上项目：MMP13对BACE1的调控机制及其对阿尔茨海默病治疗价值的实验研究(Cstc2018jcyjAX0067)， 10万，2019-2020
重庆市教委重点项目：基于ADAM10蛋白水平调控的阿尔茨海默病天然小分子药调控 （KJZD-K）， 10万，2019-10-30到2022-10-30
国家自然科学基金国际合作重大项目，钙通道调节异常的分子机制与阿尔茨海默病(），290万，2013-2017.
国家自然科学基金，A-beta在中间神经元损害nAChR介导兴奋性机制研究(**)。55万，2012-2015.
重庆市卫生局重点基金，中间神经元功能障碍在阿尔茨海默病中的作用机制(2011-1-018)。10万，2012-2014


论文情况
研究论文（第一/通讯）


1. Zhong, B., Zhou, G., Song, L., Wen, Q., Deng, X., Ma, Y., Hu, L., and Chen, G. (2021) TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35, e21445
2. Li, K. Y., Xiang, X. J., Song, L., Chen, J., Luo, B., Wen, Q. X., Zhong, B. R., Zhou, G. F., Deng, X. J., Ma, Y. L., Hu, L. T., and Chen, G. J. (2021) Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression. J Neurochem 157, 1351-1365
3. Tang, J., Sun, F., Deng, X. J., Ma, Y. L., Li, K. Y., Tang, Y., and Chen, G. J. (2020) Ubiquitination status does not affect Vps34 degradation. Genes Dis 7, 401-407
4. Chen, J., Luo, B., Zhong, B.-R., Li, K.-Y., Wen, Q.-X., Song, L., Xiang, X.-J., Zhou, G.-F., Hu, L.-T., Deng, X.-J., Ma, Y.-L., and Chen, G.-J. (2020) Sulfuretin exerts diversified functions in the processing of amyloid precursor protein. Genes & Diseases (DOI https://doi.org/10.1016/j.gendis.2020.11.008)
5. Zhu, B. L., Long, Y., Luo, W., Yan, Z., Lai, Y. J., Zhao, L. G., Zhou, W. H., Wang, Y. J., Shen, L. L., Liu, L., Deng, X. J., Wang, X. F., Sun, F., and Chen, G. J. (2019) MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation. Brain 142, 176-192
6. Yang, J., Long, Y., Xu, D. M., Zhu, B. L., Deng, X. J., Yan, Z., Sun, F., and Chen, G. J. (2019) Age- and Nicotine-Associated Gene Expression Changes in the Hippocampus of APP/PS1 Mice. J Mol Neurosci (epub ahead of print)
7. Xiang, X. J., Song, L., Deng, X. J., Tang, Y., Min, Z., Luo, B., Wen, Q. X., Li, K. Y., Chen, J., Ma, Y. L., Zhu, B. L., Yan, Z., and Chen, G. J. (2019) Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology. Exp Neurol 318, 145-156
8. Lai, Y. J., Zhu, B. L., Sun, F., Luo, D., Ma, Y. L., Luo, B., Tang, J., Xiong, M. J., Liu, L., Long, Y., Hu, X. T., He, L., Deng, X. J., Zhang, J. H., Yang, J., Yan, Z., and Chen, G. J. (2019) Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging Cell, 18(4):e12961
9. Zhu, B., Zhao, L., Luo, D., Xu, D., Tan, T., Dong, Z., Tang, Y., Min, Z., Deng, X., Sun, F., Yan, Z., and Chen, G. (2018) Furin promotes dendritic morphogenesis and learning and memory in transgenic mice. Cellular and molecular life sciences : CMLS 75, 2473-2488
10. Tang, Y., Min, Z., Xiang, X. J., Liu, L., Ma, Y. L., Zhu, B. L., Song, L., Tang, J., Deng, X. J., Yan, Z., and Chen, G. J. (2018) Estrogen-related receptor alpha is involved in Alzheimer's disease-like pathology. Exp Neurol 305, 89-96
11. Min, Z., Tang, Y., Hu, X. T., Zhu, B. L., Ma, Y. L., Zha, J. S., Deng, X. J., Yan, Z., and Chen, G. J. (2018) Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5'UTR and PI3K Signaling. Front Mol Neurosci 11, 198
12. Zha, J. S., Zhu, B. L., Liu, L., Lai, Y. J., Long, Y., Hu, X. T., Deng, X. J., Wang, X. F., Yan, Z., and Chen, G. J. (2017) Phorbol esters dPPA/dPA promote furin expression involving transcription factor CEBPβ in neuronal cells. Oncotarget 8, 60159-60172
13. Xu, X. Y., Deng, C. Q., Wang, J., Deng, X. J., Xiao, Q., Li, Y., He, Q., Fan, W. H., Quan, F. Y., Zhu, Y. P., Cheng, P., and Chen, G. J. (2017) Plasma levels of soluble receptor for advanced glycation end products in Alzheimer's disease. Int J Neurosci 127, 454-458
14. Liu, L., Lai, Y. J., Zhao, L. G., and Chen, G. J. (2017) Increased expression of Myc-interacting zinc finger protein 1 in APP/PS1 mice. Exp Ther Med 14, 5751-5756
15. Lai, Y. J., Yu, D., Zhang, J. H., and Chen, G. J. (2017) Cooperation of Genomic and Rapid Nongenomic Actions of Estrogens in Synaptic Plasticity. Mol Neurobiol 54, 4113-4126
16. Lai, Y. J., Liu, L., Hu, X. T., He, L., and Chen, G. J. (2017) Estrogen Modulates ubc9 Expression and Synaptic Redistribution in the Brain of APP/PS1 Mice and Cortical Neurons. J Mol Neurosci 61, 436-448
17. Hu, X. T., Zhu, B. L., Zhao, L. G., Wang, J. W., Liu, L., Lai, Y. J., He, L., Deng, X. J., and Chen, G. J. (2017) Histone deacetylase inhibitor apicidin increases expression of the α-secretase ADAM10 through transcription factor USF1-mediated mechanisms. Faseb j 31, 1482-1493
18. Hu, L. T., Zhu, B. L., Lai, Y. J., Long, Y., Zha, J. S., Hu, X. T., Zhang, J. H., and Chen, G. J. (2017) HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms. Biochem Biophys Res Commun 486, 492-498
19. Wang, J., and Chen, G. J. (2016) Mitochondria as a therapeutic target in Alzheimer's disease. Genes Dis 3, 220-227
20. He, L., Hu, X. T., Lai, Y. J., Long, Y., Liu, L., Zhu, B. L., and Chen, G. J. (2016) Regulation and the Mechanism of Estrogen on Cav1.2 Gene in Rat-Cultured Cortical Astrocytes. J Mol Neurosci 60, 205-213
21. Fan, W., Long, Y., Lai, Y., Wang, X., Chen, G., and Zhu, B. (2016) NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons. J Mol Neurosci 58, 401-410
22. Cao, Q., Wang, W., Gu, J., Jiang, G., Wang, K., Xu, Z., Li, J., Chen, G., and Wang, X. (2016) Elevated Expression of Acid-Sensing Ion Channel 3 Inhibits Epilepsy via Activation of Interneurons. Mol Neurobiol 53, 485-498
23. Xu, Z., Xu, P., Chen, Y., Liu, J., Zhang, Y., Lv, Y., Luo, J., Fang, M., Zhang, J., Wang, J., Wang, K., Wang, X., and Chen, G. (2015) ENT1 inhibition attenuates epileptic seizure severity via regulation of glutamatergic neurotransmission. Neuromolecular Med 17, 1-11
24. Tang, B., Luo, D., Yang, J., Xu, X. Y., Zhu, B. L., Wang, X. F., Yan, Z., and Chen, G. J. (2015) Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Sci Rep 5, 14099
25. Shi, H. B., Tang, B., Liu, Y. W., Wang, X. F., and Chen, G. J. (2015) Alzheimer disease and cancer risk: a meta-analysis. J Cancer Res Clin Oncol 141, 485-494
26. Luo, D., Long, Y., and Chen, G. J. (2015) Cyclooxygenase-2 gene polymorphisms and risk of Alzheimer's disease: A meta-analysis. J Neurol Sci 359, 100-105
27. Jiang, G., Wang, W., Cao, Q., Gu, J., Mi, X., Wang, K., Chen, G., and Wang, X. (2015) Insulin growth factor-1 (IGF-1) enhances hippocampal excitatory and seizure activity through IGF-1 receptor-mediated mechanisms in the epileptic brain. Clin Sci (Lond) 129, 1047-1060
28. Hu, L. T., Sun, F., and Chen, G. J. (2015) Multiple targets for multiple sclerosis. Genes Dis 2, 222-223
29. Zhang, X., Chen, G., Lu, Y., Liu, J., Fang, M., Luo, J., Cao, Q., and Wang, X. (2014) Association of mitochondrial letm1 with epileptic seizures. Cereb Cortex 24, 2533-2540
30. Chen, G. J., Xiong, Z., and Yan, Z. (2013) Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex. Mol Neurodegener 8, 3
31. Xu, Y., Zeng, K., Han, Y., Wang, L., Chen, D., Xi, Z., Wang, H., Wang, X., and Chen, G. (2012) Altered expression of CX3CL1 in patients with epilepsy and in a rat model. Am J Pathol 180, 1950-1962
32. Xu, Y., Luo, J., Yue, Z., Wu, L., Zhang, X., Zhou, C., Zhao, F., Wang, X., and Chen, G. (2012) Increased expression of placental growth factor in patients with temporal lobe epilepsy and a rat model. Brain Res 1429, 124-133
33. Luo, J., Zeng, K., Zhang, C., Fang, M., Zhang, X., Zhu, Q., Wang, L., Wang, W., Wang, X., and Chen, G. (2012) Down-regulation of CRMP-1 in patients with epilepsy and a rat model. Neurochem Res 37, 1381-1391
34. Hu, Y., Huang, X., Shen, D., Ding, M., Sun, H., Peng, B., Hu, X., Li, H., Zeng, K., Xi, Z., Zhang, Y., Cao, Q., Liu, J., Zhou, Y., Wu, M., Lu, Y., Chen, G., and Wang, X. (2012) Outcomes of sustained-release formulation of valproate and topiramate monotherapy in patients with epilepsy: a multi-centre, cohort study. PLoS One 7, e47982
35. Han, Y., Yin, H., Xu, Y., Zhu, Q., Luo, J., Wang, X., and Chen, G. (2012) Increased expression of calponin-3 in epileptic patients and experimental rats. Exp Neurol 233, 430-437
36. Chen, G., Chen, P., Tan, H., Ma, D., Dou, F., Feng, J., and Yan, Z. (2008) Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease. Neurobiol Aging 29, 1795-1804
37. Chen, G., Kittler, J. T., Moss, S. J., and Yan, Z. (2006) Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci 26, 2513-2521
38. Chen, G., Greengard, P., and Yan, Z. (2004) Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex. Proc Natl Acad Sci U S A 101, 2596-2600
39. Chen, G. J., Xu, J., Lahousse, S. A., Caggiano, N. L., and de la Monte, S. M. (2003) Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. J Alzheimers Dis 5, 209-228



成果奖励
1. 1994年四川省科技进步一等奖，参与者，抗癫痫药的基础和临床研究。
2. 2003年广东省科技进步二等奖，参与者，Duchenne 肌营养不良症的机制和实验治疗。
3. 2014中华医学科技二等奖， 参与者，癫痫防治新技术开发及相关研究。





研究方向
阿尔茨海默病