关国良
学术学位博士生导师

教授
***


Patrick.kwan@unimelb.edu.au

第一临床学院





学科信息


个人简介
重庆高校神经病学重点实验室主任，国际抗癫痫联盟内科治疗委员会的主席、药物基因组学课题组组长、皇家墨尔本医院神经病学教授和癫痫病顾问，研究专注于癫痫流行病学、药理学、遗传学和抗癫痫药物耐药机制等领域。首次发现抗癫痫药物的皮肤反应与HLA1502.B基因突变有关，促使美国FDA重新定义了抗癫痫药物的概念定义和使用指南，其提出的耐药性癫痫防治方案被国际抗癫痫联盟作为行业标准向全球推广。研究论文发表在新英格兰医学、自然、柳叶刀、柳叶刀神经病学、英国医学等众多著名杂志，其中影响因子大于20分的有11篇，总共被引用12632次，科研成果曾获得过国内外众多奖项。


论文情况
发表论文100多篇，代表性论文10篇。
Kwan P, Brodie MJ: Early identification of refractory epilepsy.The New England journal of medicine2000;342:314-319.(IF=72.40)
Kwan P, Schachter SC, Brodie MJ: Drug-resistant epilepsy.The New England journal of medicine2011;365:919-926.(IF=72.40)
Kwan P, Brodie MJ: Neuropsychological effects of epilepsy and antiepileptic drugs.Lancet2001;357:216-222.(IF=47.83)
Wong EH, Hui AC, Mok VC, Leung H, Chan RC, Wong KS,Kwan PK: A young man who kept falling over.Lancet2008;372:418.(IF=47.83)
Brodie MJ, Elder AT,Kwan P: Epilepsy in later life.The Lancet Neurology2009;8:1019-1030.(IF=26.28)
Kwan P, Brodie MJ, Kalviainen R, Yurkewicz L, Weaver J, Knapp LE: Efficacy and safety of pregabalin versus lamotrigine in patients with newly diagnosed partial seizures: A phase 3, double-blind, randomised, parallel-
group trial.The Lancet Neurology2011;10:881-890.(IF=26.28)
Kwan P, Brodie MJ: Definition of refractory epilepsy: Defining the indefinable?The Lancet Neurology2010;9:27-29.(IF=26.28)
Brodie MJ,Kwan P: Newer drugs for focal epilepsyin adults.BMJ2012;344:e345.(IF=20.78)
Kwan P, Sills GJ, Brodie MJ: The mechanisms of action of commonly used antiepileptic drugs.Pharmacology & therapeutics2001;90:21-34.(IF=11.12)
Chen Z, Lusicic A, O'Brien TJ, Velakoulis D, Adams SJ,Kwan P: Psychotic disorders induced by antiepileptic drugs in people with epilepsy.Brain2016;139:2668-2678.(IF=10.29)。





科研项目
领导（参与）过的主要项目
National Institute of Health, USA 5R21NS069223-02) Kwan (PI) 01/07/2010 – 31/12/2012 Validation of clinical assessment tools for population genetic studies of epilepsy in rural China The goal of this study was to develop and apply phenotyping tools to establish a DNA bank of epilepsy patients in rural China. Role: Contact PD/PI
Health and Health Services Research Fund, Hong Kong **Kwan (PI) 01/03/2010 – 30/09/2011 Association between HLA–B*1502 allele and antiepileptic drugs-induced severe cutaneous reactions in Han Chinese: a Hong Kong-wide population based study The goal of this study was to identify HLA-B alleles associated with antiepileptic drugs-induced severe cutaneous reactions. Role: PI
Research Grants Council, Hong Kong 7630/12 Cherny (PI) 01/01/2009-31/12/2010 Genome-wide association mapping of susceptibility loci for symptomatic epilepsy. The goal of this study was to identify common genetic variants associated with symptomatic epilepsy. Role: Co-I
Innovation and Technology Fund, Hong Kong ITS/079/08 Kwan (PI) 01/09/2008 – 31/08/2009 Development and validation of a rapid and inexpensive pharmacogenetic test of HLA-B*1502 allele for widespread clinical application. The goal of this study was to develop a novel genetic testing method to detect HLA-B*15:02. Role: PI
Research Grants Council, Hong Kong CUHK4466/06M Kwan (PI) 01/06/2007 – 31/06/2009 Genetics and expression of P-glycoprotein and other drug transporters in pharmacoresistant epilepsy. The goal of this study was to investigate the role of efflux drug transporters in pharmacoresistance in epilepsy. Role: PI
NHMRC, Australia APP** Kwan (PI) 01/01/2016 – 31/12/2018 Genomics of antiepileptic drug-induced Stevens Johnson syndrome. The goal of this study is to discovery genetic variants that modify the development of SJS/TEN to carbamazepine in HLA-B*15:02 carriers, and to understand the effects of the genetic variants on drug specific T cell responses. Role: CIA
NHMRC, Australia APP** Hildebrand (PI) 01/01/2015 – 31/12/2017 Exploring somatic mutation in focal epilepsies. The goal of this study is to identify somatic mutations in brain tissues of focal epilepsies. Role: CIC
Australia Research Council DP Kwan (PI) 01/02/2014 – 31/01/2017 Rapid point-of-care detection of genomic variations for personalised medicine. The goal of this study is to develop a point-of-care diagnostic device for detecting genetic variants predictive of drug response. Role: CIA
Health and Medical Research Fund, Hong Kong ** Kwan (PI) 01/02/2014 – 30/06/2016 Next generation sequencing to identify rare variants associated with antiepileptic drug-induced severe cutaneous adverse drug reactions. The goal of this study is to identify genetic variants associated with antiepileptic drug-induced severe cutaneous reactions. Role: PI






研究方向
研究专注于癫痫流行病学、药理学、遗传学和抗癫痫药物耐药机制等领域。