董志芳
学术学位博士生导师

研究员



zfdong@cqmu.edu.cn

儿科学院





学科信息


个人简介
现任重庆医科大学附属儿童医院儿科研究所所长助理、认知发育与学习记忆障碍转化医学重庆市重点实验室副主任、研究员、博士生导师，国家“优青”获得者，中国医疗保健国际交流促进会认知障碍分会常委，中国神经科学学会离子通道与受体分会委员，中国卒中学会脑健康分会委员，重庆市青年科技领军人才协会理事和重庆医师协会康复分会委员等。课题组主要利用行为学、神经电生理和分子生物学等技术，致力于认知障碍相关神经系统疾病的发病机制研究，如阿尔茨海默病（AD）、癫痫（Epilepsy）、脑卒中（Stroke）、缺氧缺血性脑损伤（HIBD）等。系列研究成果在J Clin Invest，PNAS，Cell Death Differ，J Neurosci等期刊发表SCI论文50余篇，并多次受邀在国际和国内学术会议上做学术报告。先后主持国家自然科学基金6项，重庆市重点项目等多项。于2014年入选首批“重庆市青年拔尖人才”培养计划和第八届“重庆市青年科技奖”，2015年获首届“重庆十佳科技青年奖”，2016年获得国家“优青”，2020年获“重庆英才·创新领军人才”等称号。研究项目获得重庆市自然科学奖二等奖（第一完成人），重庆市科技进步一等奖和教育部科技进步二等奖等。


成果奖励
2020：重庆英才-创新领军人才
2017：阿尔茨海默病的发病机制与调控研究，2017-Z-2-06-R01，重庆市自然科学奖二等奖（第1完成人）
2016：国家自然科学基金优秀青年科学基金
2015：首届重庆市十佳科技青年奖
2014：第八届重庆青年科技奖
2013：首批“重庆市青年拔尖人才”支撑计划
2012：维生素A影响儿童健康的基础研究与临床应用，2012-J-1-12-R09，重庆市科技进步奖一等奖
2011：维生素A及相关因素对儿童早期生长发育的影响和干预研究，2011-275，教育部高等学校科技进步奖二等奖
2011：维生素A及相关因素对儿童早期生长发育的影响和干预研究，2011-2-10，重庆市卫生局医学科技成果一等奖


科研项目
2021.1-2024.12，NLRP3炎症小体通过p97介导AMPA受体内吞在新生鼠缺氧缺血性脑损伤中的作用及其机制研究（**），国家自然科学基金面上项目，55万（主持）
2021.1-2023.12，重庆英才计划创新领军人才，40万（主持）
2020.10.30-2023.10.28，抑制NLRP3炎症体/caspase-1/IL-1β通路调控的AMPA受体内吞在新生儿缺血缺氧性脑病修复中的作用及其机制研究（cstc2020jcyj-zdxmX0004），重庆市自然科学基金重点项目，80万（主持）
2019.10.30-2022.10.30，抑制细胞焦亡在新生儿缺血缺氧性脑病修复中的作用及相关机制研究（KJZD-K），重庆市教委科学技术研究项目重点项目，10万（主持）
2019.7-2022.6，认知障碍相关疾病发病机制研究（CXQTP19034），重庆市高校创新研究群体，50万（群体负责人）
2018.1-2020.12，MKP-1抑制MAPK活化在阿尔兹海默病引起的神经退行性病变中的作用（**），国家自然科学基金重大研究计划“器官衰老与器官退行性变化的机制”培育项目，60万（主持）
2017.7-2022.6，基于蛋白质机器的抑郁障碍脑分子网络图谱构建及应用（2017YFA**），国家重点研发计划“蛋白质机器与生命过程调控”重点专项，95万（学术骨干）
2017.1-2019.12，阿尔茨海默症发病机理（**），国家自然科学基金优秀青年科学基金，130万（主持）
2016. 1-2019.121，抑制Nedd4-1介导的PTEN核转移在新生鼠缺氧缺血性脑损伤修复中的作用及相关机制研究（**），国家自然科学基金面上项目，57万（主持）
2014.1-2016.12，首批“重庆市青年拔尖人才”支持计划，45万（主持）
2014.1-2018.12，表观遗传调控的中央杏仁核GABA神经环路与慢性神经痛（2014CB548100），科技部“青年973项目”，129万（学术骨干）
2014.1-2014.12，慢性锂处理对母婴隔离诱导的孤独症样行为的改善作用及分子机制（第八届重庆青年科技奖），重庆市科协，1万（主持）
2013.1-2016.12，老年性痴呆症发病初期认知功能障碍的突触可塑性机制研究（**），国家自然科学基金面上项目，70万（主持）
2012.1-2016.12，儿童孤独症的遗传基础及其致病的机制研究（2012CB517900），科技部“973项目”，50万（学术骨干）
2011.1-2012.12，新环境适应过程中海马突触可塑性变化及其分子机制研究（cstc），重庆市科委国际科技合作项目，20万（主持）
2011.1-2012.12，新环境适应的海马突触可塑性机制（**），国家自然科学基金科学部主任基金，19万（主持）
2010.8-2015.7，新环境适应过程中海马突触可塑性变化及其分子机制研究，重庆医科大学附属儿童医院引进人才启动经费，100万（主持）


著作教材

Zhifang Dong and Zhong Chen, Refractory Status Epilepticus (Chapter 2: Pathogenesis of Refractory Status Epilepticus), Springer Nature Singapore Pte Ltd. 2017
董志芳，曹军，王永富，杨雅，韩会丽，徐林（2006）现代神经科学研究技术 (第五章: 活体动物中神经元电活动：细胞外和细胞内记录)，科学出版社


论文情况



1. Dai C, Wu B, Chen Y, Li X, Bai Y, Du Y, Pang Y, Wang YT, Dong Z^#. Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage. Cell Death Differ. 2021; doi: 10.1038/s41418-021-00757-4.
2. Jin JW*, Fan X*, Del Cid-Pellitero E*, Liu XX, Zhou L, Dai C, Gibbs E, He W, Li H, Wu X, Hill A, Leavitt BR, Cashman N, Liu L, Lu J, Durcan TM, Dong Z^#, Fon EA^#, Wang YT^#. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Commun Biol. 2021 Feb 19;4(1):232.
3. He W, Tu M, Du Y, Li J, Pang Y, Dong Z^#. Nicotine Promotes AβPP Nonamyloidogenic Processing via RACK1- Dependent Activation of PKC in SH-SY5Y-AβPP695 Cells. J Alzheimers Dis. 2020;75(2):451-460.
4. Zhang Y, Dong Z^#, Song W^#. NLRP3 inflammasome as a novel therapeutic target for Alzheimer’s disease. Signal Transduct Target Ther. 2020 April 1;5:37.
5. Zhang L^#, Dong Z^#, Zhang J. Immunomodulatory role of mesenchymal stem cells in Alzheimer's disease. Life Sci. 2020 Apr 1;246:117405.
6. Du Y*, Fu M*, Huang Z, Tian X, Li J, Pang Y, Song W, Wang YT, Dong Z^#. TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer’s disease. Aging Cell. 2020 Mar;19(3):e13113.
7. Du Y, Du Y, Zhang Y, Huang Z, Fu M, Li J, Pang Y, Lei P, Wang TY, Song W^#, He G^#, Dong Z^#. MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models. Signal Transduct Target Ther. 2019 Dec 6;4:58.
8. Xu K*, He Y*, Chen X*, Tian Y*, Cheng K*, Zhang L*, Wang Y, Yang D, Wang H, Wu Z, Li Y, Lan T, Dong Z^#, Xie P^#. Validation of the Targeted Metabolomic Pathway in the Hippocampus and Comparative Analysis with the Prefrontal Cortex of Social Defeat Model Mice. J Neurochem. 2019 Jun;149(6):799-810.
9. Zhou L, Chen L, Li X, Li T, Dong Z^#, Wang YT^#. Food allergy induces alteration in brain inflammatory status and cognitive impairments.Behav Brain Res. 2019 May 17;364:374-382.
10. Du Y*, Fu M*, Wang YT, Dong Z^#. Neuroprotective effects of ginsenoside Rf on Aβ-induced neurotoxicity in vitro and in vivo. J Alzheimers Dis. 2018;64(1):309-322.
11. Tan T*, Wang W*, Xu H, Huang Z, Wang YT, Dong Z^#. Low-Frequency rTMS Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation Through Regulating the Synaptic GABA Transmission. Front Cell Neurosci. 2018 Feb 28;12:46.
12. Yu Y, Huang Z, Dai C, Du Y, Han H, Wang YT^#, Dong Z^#. Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats. Neuropharmacology. 2018 Jan 29;133:155-162.
13. Wang W*, Tan T*, Yu Y*, Huang Z, Du Y, Han H, Dong Z^#. Inhibition of AMPAR endocytosis alleviates pentobarbital-induced spatial memory deficits and synaptic depression . Behav Brain Res. 2018 Feb 26;339:66-72.
14. Guo H*, Huang ZL*, Wang W*, Zhang SX*, Li J*, Cheng K*, Xu K, He Y, Gui SW, Li PF, Wang HY, Dong ZF^#, Xie P^#. iTRAQ-Based Proteomics Suggests Ephb6 as a Potential Regulator of the ERK Pathway in the Prefrontal Cortex of Chronic Social Defeat Stress Model Mice. Proteomics Clin Appl. 2017 Dec;11(11-12).
15. Dai C, Liu Y, Dong Z^#. Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage. Mol Brain. 2017 Nov 14;10(1):52.
16. Huang Z*, Tan T*, Du Y, Chen L, Fu M, Yu Y, Zhang L, Song W, Dong Z^#. Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Cognitive Function and Synaptic Plasticity in APP23/PS45 Mouse Model of Alzheimer’s Disease. Front Aging Neurosci. 2017 Sep 12;9:292.
17. Chen L, Huang Z, Du Y, Fu M, Han H, Wang Y, Dong Z^#. Capsaicin Attenuates Amyloid-β-Induced Synapse Loss and Cognitive Impairments in Mice. J Alzheimers Dis. 2017;59(2):683-694.
18. Li Y*, Chen L*, Du Y*, Huang D, Han H, Dong Z^#. Fluoxetine Ameliorates Atopic Dermatitis-Like Skin Lesions in BALB/c Mice through Reducing Psychological Stress and Inflammatory Response. Front Pharmacol. 2016 Sep 13;7:318.
19. Li X, Dai C, Chen L, Zhou W, Han H, Dong Z^#. 7,8-dihydroxyflavone ameliorates motor deficits via suppressing a-synuclein expression and oxidative stress in the MPTP-induced mouse model of parkinson’s disease. CNS Neurosci Ther. 2016 Jul;22(7):617-24.
20. Chen L, Wang W, Tan T, Han H, Dong Z^#. GABAA receptors in the central nucleus of amygdala are involved in pain- and itch-related responses. J Pain. 2016 Feb;17(2):181-9.
21. Zhou L*, Bai Y*, Li Y, Liu X, Tan T, Meng S, He W, Wu X^#, Dong Z^#. Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cells. Oncol Lett. 2016 Jan;11(1):365-372.
22. Dong Z^#, Han H, Li H, Bai Y, Wang W, Tu M, Peng Y, Zhou L, He W, Wu X, Tan T, Liu M, Wu X, Zhou W, Jin W, Zhang S, Sacktor TC, Li T^#, Song W^#, Wang YT^#. Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis. J Clin Invest. 2015;125(1):234–247.
23. Han H, Dai C, Dong Z^#. Single fluoxetine treatment before but not after stress prevents stress-induced hippocampal long-term depression and spatial memory retrieval impairment in rats. Sci Rep. 2015 Jul 28;5:12667.
24. Han H, Peng Y, Dong Z^#. D-serine rescues the deficits of hippocampal long-term potentiation and learning and memory induced by sodium fluoroacetate. Pharmacol Biochem Behav. 2015 Jun;133 (2015) 51–56.
25. Wu X, Bai Y, Tan T, Li H, Xia S, Chang X, Zhou Z, Zhou W, Li T, Wang YT, Dong Z^#. Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats. Front Behav Neurosci. 2014 Jun 26;8:234.
26. Bai Y, Zhou L, Wu X, Dong Z^#. D-Serine enhances fear extinction by increasing GluA2-containing AMPA receptor endocytosis. Behav Brain Res. 2014 May 23;270C:223-227.
27. Dong Z^#, Bai Y, Wu X, Li H, Gong B, Howland JG, Huang Y, He W, Li T, Wang YT^#. Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze. Neuropharmacology. 2013 Jan;64:65-73.
28. Dong Z^#, Gong B, Li H, Bai Y, Wu X, Huang Y, He W, Li T, Wang YT^#. Mechanisms of Hippocampal Long-Term Depression Are Required for Memory Enhancement by Novelty Exploration. J Neurosci. 2012 Aug 29; 32(35):11980-90.
29. Li H, Wu X, Bai Y, Huang Y, He W, Dong Z^#. Unilateral lesion of dorsal hippocampus in adult rats impairs contralateral long-term potentiation in vivo and spatial memory in the early postoperative phase. Behav Brain Res. 2012 May 1;230(2):428-32.
30. Ge Y*, Dong Z*, Bagot R, Howland J, Phillips A, Wong TP^#, Wang YT^#. Hippocampal long-term depression is required for the consolidation of spatial memory. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16697-702.
31. Dong Z, Han H, Cao J, Xu L. Opioid withdrawal for 4 days prevents synaptic depression induced by low dose of morphine or naloxone in rat hippocampal CA1 area in vivo. Hippocampus. 2010 Feb;20(2):335-43.
32. Dong Z*, Han H*, Cao J, Zhang X, Xu L. Coincident activity of converging pathways enables simultaneous long-term potentiation and long-term depression in hippocampal CA1 network in vivo. PLoS ONE. 2008 Aug 6;3(8):e2848.
33. Dong Z*, Zhong W*, Tian M, Han H, Mao R, Cao J, Sui N, Xu T, Luo J, Xu L. Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio. Brain Res. 2008 May 1;1207:164-73.
34. Dong Z, Cao J, Xu L. Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo. Neuroscience. 2007 Feb 9;144(3):845-54.
35. Dong Z*, Zhong W*, Tian M, Han H, Cao J, Xu T, Luo J, Xu L. Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo. Hippocampus. 2006;16(12):1017-25.
36. Dong Z, Han H, Wang M, Xu L, Hao W, Cao J. Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens. Hippocampus. 2006;16(10):809-13.
37. Dong Z, Mao R, Han H, Cao J, Xu L. Morphine withdrawal modifies antinociceptive effects of acute morphine in rats. Biochem Biophys Res Commun. 2006 Jul 28;346(2):578-82.
38. Zhong W*, Dong Z*, Tian M, Cao J, Xu T, Xu L, Luo J. Opiate withdrawal induces dynamic expressions of AMPA receptors and its regulatory molecule CaMKIIalpha in hippocampal synapses. Life Sci. 2006 Jul 24;79(9):861-9.
39. Zhong WX*, Dong Z*, Tian M, Cao J, Xu L, Luo JH. N-methyl-d-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate creceptor subunits and associated proteins in the whole hippocampus. Neuroscience. 2006 Sep 1;141(3):1399-413.
40. Yu C, Li A, Li X, Chen Z, Wang P, Dong Z, Daskalakis ZJ, Zhou D. Impaired LTD-like motor cortical plasticity in female patients with major depression disorder. Neuropharmacology. 2020 Nov 15;179:108268.
41. Zhang H, Tian X, Lu X, Xu D, Guo Y, Dong Z, Li Y, Ma Y, Chen C, Yang Y, Yang M, Yang Y, Liu F, Zhou R, He M, Xiao F, Wang X. TMEM25 modulates neuronal excitability and NMDA receptor subunit NR2B degradation. J Clin Invest. 2019 Sep 3;129(9):3864-3876.
42. Zhang L, Li B, Liu B, Dong Z. Co-transplantation of Epidermal Neural Crest Stem Cells and Olfactory Ensheathing Cells Repairs Sciatic Nerve Defects in Rats. Front Cell Neurosci. 2019 Jun 12;13:253.
43. Wang J, Jin WS, Bu XL, Zeng F, Huang ZL, Li WW, Shen LL, Zhuang ZQ, Fang Y, Sun BL, Zhu J, Yao XQ, Zeng GH, Dong ZF, Yu JT, Hu Z, Song W, Zhou HD, Jiang JX, Liu YH, Wang YJ. Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies. Acta Neuropathol. 2018 Oct;136(4):525-536.
44. Bu XL, Xiang Y, Jin WS, Wang J, Shen LL, Huang ZL, Zhang K, Liu YH, Zeng F, Liu JH, Sun HL, Zhuang ZQ, Chen SH, Yao XQ1, Giunta B, Shan YC, Tan J, Chen XW, Dong ZF, Zhou HD, Zhou XF, Song W, Wang YJ. Blood-derived amyloid-β protein induces Alzheimer's disease pathologies. Mol Psychiatry. 2018 Sep;23(9):1-9
45. Zhu B, Zhao L, Luo D, Xu D, Tan T, Dong Z, Tang Y, Min Z, Deng X, Sun F, Yan Z, Chen G. Furin promotes dendritic morphogenesis and learning and memory in transgenic mice. Cell Mol Life Sci. Cell Mol Life Sci. 2018 Jul;75(13):2473-2488.
46. Lai X, Wu X, Hou N, Liu S, Li Q, Yang T, Miao J, Dong Z, Chen J, Li T. Vitamin A Deficiency Induces Autistic-Like Behaviors in Rats by Regulating the RARβ-CD38-Oxytocin Axis in the Hypothalamus. Mol Nutr Food Res. 2018 Mar;62(5).
47. Jin WS, Shen LL, Bu XL, Zhang WW, Chen SH, Huang ZL, Xiong JX, Gao CY, Dong Z, He YN, Hu ZA, Zhou HD, Song W, Zhou XF, Wang YZ, Wang YJ. Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model. Acta Neuropathol. 2017 Aug;134(2):207-220.
48. Peng Y, Wang W, Tan T, He W, Dong Z, Wang YT, Han H. Maternal sleep deprivation at different stages of pregnancy impairs the emotional and cognitive functions, and suppresses hippocampal long-term potentiation in the offspring rats. Mol Brain. 2016 Feb 15;9(1):17.
49. Wang W, Tan T, Tu M, He W, Dong Z, Han H. Acute pentobarbital treatment impairs spatial learning and memory and hippocampal long-term potentiation in rats. Physiol Behav. 2015 Jun 5;149:169-173.
50. Han H, Dong Z, Jia Y, Mao R, Zhou Q, Yang Y, Wang L, Xu L, Cao J. Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus. Sci Rep. 2015 May 5;5:9666.
51. Hou N, Ren L, Gong M, Bi Y, Gu Y, Dong Z, Liu Y, Chen J, Li T. Vitamin A Deficiency Impairs Spatial Learning and Memory: The Mechanism of Abnormal CBP-Dependent Histone Acetylation Regulated by Retinoic Acid Receptor Alpha. Mol Neurobiol. 2015 Apr;51(2):633-47.
52. Zhang S, Taghibiglou C, Girling K, Dong Z, Lin SZ, Lee W, Shyu WC, Wang YT. Critical Role of Increased PTEN Nuclear Translocation in Excitotoxic and Ischemic Neuronal Injuries. J Neurosci. 2013 May 1;33(18):7997-8008.
53. Zhu S, Tai C, Petkau TL, Zhang S, Liao C, Dong Z, Wen W, Chang Q, Tian Wang Y, Macvicar BA, Leavitt BR, Jia W, Cynader MS. Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. Brain Res. 2013 Sep 12;1530:54-65.
54. Wang M, Yang Y, Dong Z, Cao J, Xu L. NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo. Neuroreport. 2006 Aug 21;17(12):1343-6.
55. Li H, Han H, Ma W, Dong Z, Xu L. Enhancement of GABAA Receptor-Mediated Inhibitory Postsynaptic Currents Induced by “Partial Oxygen-Glucose Deprivation”. Zoological Research. 2007 Oct. 28 (5): 491-496.
56. Wang M, Dong Z, Cao J, Xu L. Repeated morphine treatment influences operant and spatial learning differentially. Neurosci Bull. 2006 May;22(3):137-43.
57. Li Z, Zhou Q, Li L, Mao R, Wang M, Peng W, Dong Z, Xu L, Cao J. Effects of unconditioned and conditioned aversive stimuli in an intense fear conditioning paradigm on synaptic plasticity in the hippocampal CA1 area in vivo. Hippocampus. 2005;15(6):815-24.
58. Yang Y, Zheng X, Wang Y, Cao J, Dong Z, Cai J, Sui N, Xu L. Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: possible mechanisms for corticosterone on opiate addiction. J Neurosci. 2004 Mar 10;24(10):2412-20.
59. Xiong W, Wei H, Xiang X, Cao J, Dong Z, Wang Y, Xu T, Xu L. The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages. Brain Res. 2004 Apr 16;1005(1-2):187-92.








研究方向
认知障碍相关疾病的发病机制研究