毛华伟
学术学位博士生导师

教授



maohwei@qq.com

儿科学院





学科信息


个人简介

毛华伟，教授、博士生导师，首批重庆英才青年拔尖人才、重庆市中青年医学高端人才，亚太免疫缺陷学会（APSID）临床委员会主席、中华儿科学会免疫学组青委副组长、美国临床免疫学会员、广东省罕见病学会免疫学组副组长、中国药师协会罕见病用药工作委员会委员、香港过敏医学会委员、深圳市海外高层次人才“孔雀计划”人才，兼香港大学儿童与青少年医学系助理教授、深圳市原发性免疫缺陷病重点实验室副主任等。临床工作主要从事儿童风湿性疾病、原发性免疫缺陷病（PID）、造血干细胞移植、以及PID遗传咨询与产前基因诊断等。开展PID与自身炎症性疾病临床转化研究，是最先采用下一代高通量测序技术研究PID新致病基因与发病机制的研究人员之一，全球首次鉴定了一种全新的PID致病基因，实现了中国在该领域零的突破。主持国家自然科学基金面上项目、香港研究资助局RGC、香港食物卫生署、深圳市发改委以及科创委等研究课题，担任Frontiers in Immunology编委、European Journal of Immunology、Journal of Immunology Research、Genes & Diseases、BMC Infectious Diseases等期刊审稿人等。近五年在J Allergy Clin Immunol, Front Immunol, J Virol等专业领域权威期刊发表20多篇SCI论文，总影响因子100多，总引用率1000多次。申请国家发明专利两项。获中国原发性免疫缺陷病年度贡献奖、深圳市医管五四“****”、产业发展与创新人才奖等多项奖励。






成果奖励


1. 中国原发性免疫缺陷病年度贡献奖，2019
2. 首批重庆英才青年拔尖人才，2019
3. 重庆市中青年医学高端人才，2019
4. 重庆市医学会风湿病学术年会优秀论文，2019
5. 深圳市医管中心五四“****”，2017
6. 深圳市产业发展与创新人才奖，2015、2016、2017
7. 深圳市海外高层次人才“孔雀计划”B类人才，2014
8. First Prize for Best Poster Presentation, 5thAnnual Scientific Meeting, Hong Kong Society for PIID. 2012
9. Best Poster Award, 17thAnnual Scientific Meeting, Hong Kong Society of Flow Cytometry. 2012
10. Best Oral Presentation Award, 2010 Scientific Meeting of Hong Kong Society for Immunology. 2010
11. Travel Award. Hong Kong Society for Immunology. 2010



科研项目
1. 国家自然科学基金面上项目：重症联合免疫缺陷病新型致病基因鉴定. 2020 -2023，55万，主持
2. 国家自然科学基金面上项目：全外显子组测序鉴定自身免疫淋巴细胞增生综合征致病基因及其机制研究，2017-2020，58万，主持
3. 深圳市发改委未来产业发展专项，2015-2017，500万，共同主持
4. 深圳市科创委项目：外显子组测序鉴定多重感染免疫缺陷患儿基因突变，2014-2016，10万，主持
5. 香港研究资助局RGC项目：The effects of BTK mutation on TLR3- mediated type I IFN response against poliovirus infection in X-linked agammaglobulinemia. 2014-2016, 68.4万，共同主持
6. 香港食物卫生署RFCID项目：Immune evasion of Natural Killer Cells by Influenza Virus in Vivo. 2011-2013, 98.9万，共同主持



论文情况


1. Yang L, Xue X, Wu J, Yang X, Xu L, Tang X, Wang M, Mao H#, Zhao X#. Abatacept is effective in Chinese patients with LRBA and CTLA4 deficiency. Genes & Diseases, 2020, DOI: 10.1016/j.gendis.2020.03.001.
2. Luk ADW, Ni K, Wu Y, Lam KT, Chan KW, Lee PP, Tu W, Mao H#, Lau YL#. Type I and III interferon Productions are impaired in X-linked agammaglobulinemia Patients Toward Poliovirus but not influenza Virus. Frontiers in Immunology. 2018. doi: 10.3389/ mmu.2018.01826
3. Mao H#, Yang W, Latour S, Yang J, Winter S, Zheng J, Ni K, Lv M, Liu C, Huang H, Chan, KW, Lee PPW, Tu W, Fischer A, Lau YL#. RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease. J Allergy Clin Immunol. 2018,142(2):595-604.e16
4. Mao H#, Liu Y, Sia SF, Peiris JSM, Lau YL, Tu W#. Avian influenza virus directly infects human natural killer cells and inhibits cell activity. Virologica Sinica. 2017; 32(2):122-9
5. Lee PPW*, Mao H*, Yang W, Chan, KW, Ho MHK, Lee TL, Chan JFW, Woo PCY, Tu W, Lau YL. Penicillium marneffei infection and Impaired Interferon-gamma Immunity in humans with Autosomal Dominant Gain-of-phosphorylation STAT1 mutations. J Allergy Clin Immunol. 2014;133(3): 894-896.e5.
6. Mao H, Yen HL, Liu Y, Lau YL, Peiris JSM, Tu W. Conservation of T cell epitopes between seasonal influenza viruses and the novel influenza A H7N9 virus. Virologica Sinica. 2014; 29(3):170-5
7. Li J*, Li H*, Mao H*, Yu M, Yang F, Feng T, Fan Y, Lu Q, Shen C, Yin Z, Mao M, Tu W. Impaired NK cell antiviral cytokine response against influenza virus in small-for-gestational-age neonates. Cell Mol Immunol. 2013;10(5):437-43.
8. Li J*, Li H*, Mao H*, Yu M, Feng T, Yang F, Fan Y, Lu Q, Shen C, Yin Z, Tu W, Mao M. Vγ9Vδ2-T lymphocytes have impaired antiviral function in small-for-gestational-age and preterm neonates. Cell Mol Immunol. 2013;10(3):253-60.
9. Mao H, Yang W, Lee PW, Ho HK, Yang J, Zeng S, Chong CY, Lee TL, Tu W, Lau YL. Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease. Genes Immun. 2012;13(5):437-42.
10. Mao H, Tu W, Liu Y, Qin G, Zheng J, Chan PL, Lam KT, Peiris M, Lau YL. Inhibition of primary human natural killer cell activity by influenza virion and hemagglutinin. J Virol. 2010;84(9):4148-57.
11. Mao H, Tu W, Qin G, Law HK, Sia SF, Chan PL, Liu Y, Lam KT, Zheng J, Peiris M, Lau YL. Influenza virus directly infects human natural killer cells and induces cell apoptosis. J Virol. 2009;83(18):9215-22.
12. Mao HW, Yang XQ, Zhao XD. Characterization of human metapneumoviruses isolated in Chongqing, China. Chin Med J. 2008;121(22):2254-7.
13. Lee PP, Lao-araya M, Yang J, Chan KW, Ma H, Pei LC, Kui L, Mao H, Yang W, Zhao X, Trakultivakorn M and Lau YL. Application of Flow Cytometry in the Diagnostics Pipeline of Primary Immunodeficiencies Underlying Disseminated Talaromyces marneffei Infection in HIV-Negative Children. Front. Immunol. 10:2189. doi: 10.3389/fimmu.2019.02189
14. Luk ADW, Lee PP, Mao H, Chan KW, Chen XY, Chen TX, He JX, Kechout N, Suri D, Tao YB, Xu YB, Jiang LP, Liew WK, Jirapongsananuruk O, Daengsuwan T, Gupta A, Singh S, Rawat A, Abdul Latiff AH, Lee ACW, Shek LP, Nguyen TVA, Chin TJ, Chien YH, Latiff ZA, Le TMH, Le NNQ, Lee BW, Li Q, Raj D, Barbouche MR, Thong MK, Ang MCD, Wang XC, Xu CG, Yu HG, Yu HH, Lee TL, Yau FYS, Wong WH, Tu W, Yang W, Chong PCY, Ho MHK, Lau YL. Family history of early infant death correlates with earlier age at diagnosis but not shorter time to diagnosis for severe combined immunodeficiency. Front Immunol. 2017;8:808. doi: 10.3389/fimmu.2017.00808
15. Liu Y, Zheng J, Liu Y, Wen L, Huang L, Xiang Z, Lam KT, Lv A, Mao H, Lau YL, Tu W. Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection. Cell Mol Immunol. 2018;15(9):827-37.
16. Han Y, Ling MT, Mao H, Zheng J, Liu M, Lam KT, Liu Y, Tu W, Lau YL. Influenza virus-induced lung inflammation was modulated by cigarette smoke exposure in mice. PLoS One. 2014; 21;9(1):e86166.
17. Chan PL, Zheng J, Liu Y, Lam KT, Xiang Z, Mao H, Liu Y, Qin G, Lau YL, Tu W. TLR5 Signaling Enhances the Proliferation of Human Allogeneic CD40-Activated B Cell Induced CD4(hi)CD25(+) Regulatory T Cells. PLoS One. 2013;8(7):e67969.
18. Dou Y, Zhao Y, Zhang ZY, Mao HW, Tu WW, Zhao XD. Respiratory syncytial virus infection induces higher Toll-like receptor-3 expression and TNF-α production than human metapneumovirus infection. PLoS One. 2013;8(9):e73488.
19. Ling MT, Tu W, Han Y, Mao H, Chong WP, Guan J, Lam KT, Law HKW, Peiris JSM, Takahashi K, Lau YL. Mannose binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection. J Infect Dis. 2012;205(1):44-53
20. Wu Y, Mao H, Ling MT, Chow KH, Ho PL, Tu W, Lau YL. Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function. BMC Infect Dis. 2011;11:201
21. Hui KP, Lee SM, Cheung CY, Mao H, Lai AK, Chan RW, Chan MC, Tu W, Guan Y, Lau YL, Peiris JS. H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades. J Infect Dis. 2011;204(12):1866-78.
22. Qin G, Liu Y, Zheng J, Ng IH, Xiang Z, Lam KT, Mao H, Li H, Peiris JS, Lau YL, Tu W. Type-1 responses of human Vgamma9Vdelta2 T cells to influenza A viruses. J Virol. 2011;85(19):10109-16
23. Tu W, Mao H, Zheng J, Liu Y, Chiu SS, Qin G, Chan PL, Lam KT, Guan J, Zhang L, Guan Y, Yuen KY, Peiris JSM, Lau YL. Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus. J Virol. 2010;84(13):6527-35.
24. Qin G, Mao H, Zheng J, Sia SF, Liu Y, Chan PL, Lam KT, Peiris JS, Lau YL, Tu W. Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses. J Infect Dis. 2009;200(6):858-65.
25. Zheng J, Liu Y, Qin G, Chan PL, Mao H, Lam KT, Lewis DB, Lau YL, Tu W. Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells. J Immunol. 2009;183(6):3742-50.
26. Tu W, Lau YL, Zheng J, Liu Y, Chan PL, Mao H, Dionis K, Schneider P, Lewis DB. Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Blood. 2008;112(6):2554-62.
27. 中华医学会儿科学分会免疫学组，中华儿科杂志编辑委员会. 原发性免疫缺陷病免疫球蛋白G替代治疗专家共识. 中华儿科杂志, 2019,57(12):909-912
28. 毛华伟. 原发性免疫缺陷病分子诊断及新发原发性免疫缺陷病. 中国实用儿科杂志, 2017, 32(7): 491-6.
29. 毛华伟，赵晓东. 进一步加强免疫球蛋白G替代治疗原发性免疫缺陷病. 中华儿儿科杂志. 2017,55(1):1-3












研究方向
原发性免疫缺陷病与自身炎症性疾病的精准医学研究