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重庆医科大学导师教师师资介绍简介-蔡志刚

本站小编 Free考研考试/2021-10-06


蔡志刚
学术学位博士生导师

教授



US36zcai@126.com

基础医学院





学科信息


个人简介
教育经历(从大学本科开始,按时间倒序排序;请列出攻读研究生学位阶段导师姓名):
2001-07至2006-12, 中国科学院, 遗传学, 博士(硕博连读)
1997-09至2001-07, 云南大学, 生物学, 学士
科研与学术工作经历(按时间倒序排序;如为在站博士后研究人员或曾有博士后研究经历,请列出合作导师姓名):


2019-04至2020-10, 美国印第安纳大学医学院,儿科系, 研究助理教授
2015-04至2019-04, 美国印第安纳大学医学院, 微生物与免疫学系, NIH-T32资助研究员
2013-01至2015-04, 美国印第安纳大学医学院, 眼科系, 助理研究员

2013-01至2015-04, 美国印第安纳大学医学院, 医学遗传与分子遗传系, 博士后研究人员



科研方向:


克隆性造血的驱动因素以及对髓系血液肿瘤的影响


代表性论著(包括论文与专著)
论文:
1. Cai, Z.*; Kotzin, J. J.; Ramdas, B.; Chen, S.; Nelanuthala, S; Palam, L.R.; Pandey, R.; Mali, R.S.; Liu, Y.; Kelley, M.R.; Sandusky, G.; Mohseni, M.; Williams, A.; Henao-Mejia, J.; Kapur, R.* Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis. Cell Stem Cell, 2018, 23(6): 833-49 (通讯作者)
2. Cai, Z.*; Nelanuthala, S.; Lu, X.; Aguilera, F.; Hadley, A.; Ramdas, B.; Kotzin, J.J.; Fang, F.; Nephew, K.; Zhang, C.; Jenao-Mejia, J.; Kapur, R.* Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by pro-inflammatory cytokine induced lncRNA Morrbid. Journal of Clinical Investigation. 2020 (通讯作者) (In Press)
3. Cai, Z.*; Zhang, C.; Kotzin, J.J.; Williams, A.; Henao-Mejia, J.; Kapur, R. Role of lncRNA Morrbid in PTPN11 (Shp2)E76K Driven Juvenile Myelomonocytic Leukemia. Blood Advances. 2020 Jul 28; 4(14): 3246–3251. (通讯作者)
4. Cai, Z.*; Aguilera, F.; Ramdas, B.; Daulatabad, S.V.; Kotzin, J.J.; Carroll, M.; Wertherim, G.; Williams, A.; Janga, S. C.; Zhang, C.; Jenao-Mejia, J.; Kapur, R.* Targeting Bim via a LncRNA Morrbid regulates the survival of preleukemic and leukemic cells Cell Reports. (通讯作者) 2020 Jun 23;31(12):107816.

5. Ramdas, B.*; Cai, Z.; Kapur, R. Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell Autonomous and Niche Modulation. Stem Cell Report. 2020 Jul 14;15(1):95-109.
6. Chen, S.; Wang, Q.; Yu, H.; Capitano, M.; Vemula, S.; Nabinger, S.; Gao, R.; Yao, C.; Kobayashi, M.; Geng, Z.; Fahey, A.; Henley, D; Liu, S.; Barajas, S.; Cai, W.; Wolf, E.; Ramdas, B.; Cai, Z; Gao, H.; Luo, N.; Sun, Y.; Wong, T.; Link, D.; Liu, Y.; Boswell, H.; Mayo, L.; Huang, G.; Kapur, R.; Yoder, M.; Broxmeyer, H.; Gao, Z.*; Liu, Y.* Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway. Nature Communications, 2019, 10(1): 1-14
7. Cai, Z.; Grobe K.; Zhang, X.* Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis. Developmental Dynamics, 2014, 243(10): 1310-6
8. Cai, Z.; Tao, C.; Ladher, R.; Gotoh, H.; Feng, G.S.; Wang, F.; Zhang, Z.* Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development, 2013, 140(13): 2711-23
9. Cai, Z; Simons, DL; Fu, X-Y; Feng, G-S; Wu, SM; Zhang, X* Loss of Shp2-mediated Mitogen-Activated Protein Kinase Signaling in Muller Glial Cells Results in Retinal Degeneration Molecular Cellular Biology, 2011, 26(6): 2973-83
10.Cai, Z.; Feng, G.S.; Zhang, X.* Temporal Requirement of the Protein TyrosinePhosphatase Shp2 in Establishing the Neuronal Fatein Early Retinal Development. Journal of Neuroscience. Journal of Neuroscience, 2010, 30(11): 4110-9
11. Li, H.; Tao, C.; Cai, Z.; Hertzler-Schaefer, K.; Collins, T.N.; Wang, F.; Feng, G.S.; Gotoh, N.; Zhang, X.* Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development. Journal of Cell Science, 2014, 127(3): 571-82
12. Carbe, C.; Garg, A.; Cai, Z.; Li, H.; Powers, A.; Zhang, X. An allelic series at the paired box gene 6 (Pax6) locus reveals the functional specificity of Pax genes. Journal of Biological Chemistry. , 2013, 288(17): 12130-41


专著:
1. 蔡志刚*, 章节综述贡献者。章节名:《白血病分子细胞水平的病理学概论和近期进展综述》(10千字),专著名:《肿瘤靶向治疗和免疫治疗的进展》 中国科学出版社 , 2020 (在印)











研究方向
尚未录入;







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