王玉田
学术学位博士生导师

教授



ytwang@brain.ubc.ca

儿科学院





学科信息


个人简介

王玉田，加拿大皇家科学院院士，Howard Hughes研究员，UBC大学脑研究中心终生讲座教授，重庆医科大学附属儿童医院兼职教授，兼职博士生导师。1992年获得加拿大纽芬兰纪念大学医学院神经科学博士。1992-1994年在加拿大多伦多大学生理学系从事博士后研究；1994-2000年在多伦多大学实验医学病理系担任助理教授和儿童医院研究员；2000-2001年在多伦多大学实验医学病理系担任副教授和儿童医院资深研究员；2001年之今任加拿大哥伦比亚大学医学系教授，加拿大BC和YUKON省中风研究协会研究首席，霍华德医学研究所国际研究员；2010-今任重庆医科大学客座教授，荣誉学术委员会主任，教育部省部共建儿童发育疾病研究重点实验室 重庆医科大学附属儿童医院。
自1985年以来，王玉田院士所在的课题组一直致力于脑、神经疾病研究。课题组主要研究离子通道性神经递质受体在神经细胞内转运及膜表面动态表达和调节的分子机制、及其在脑功能和及神经系统疾病发生和发展中的作用。不仅致力于基础理论研究，还尽力将理论研究的突破应用于临床医疗实践过程中，尤其在学习、认知与记忆的分子机制研究，以及中风、癫痫、药物成瘾等中枢神经系统疾病的特异性药物研发中取得一系列国际领先的成果，已经在高影响力学术杂志Science、Nature、Cell等上发表研究论文数篇，并已申请并获得发明专利两项。自2002年起多次应邀回国讲学和进行学术交流，被中国国家自然科学基金委员聘任为特邀海外评审专家，****海外评审专家。




论文情况


1.Du Y, Fu M, Huang Z, Tian X, Li J, Pang Y, Song W, Wang YT ,Dong Z#. TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer's disease. Aging Cell. Aging Cell. 2020 Mar;19(3):e13113
2.Du Y, Du Y, Zhang Y, Huang Z, Fu M, Li J, Pang Y, Lei P, Wang YT, Song W, He G, Dong Z. MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer's disease models. Signal Transduct Target Ther. 2019;4:58.
3.Zhou L, Chen L, Li X, Li T, Dong Z#, Wang YT#.Food allergy induces alteration in brain inflammatory status and cognitive impairments. Behav Brain Res. 2019 May 17;364:374-382.
4.Du Y, Fu M, Wang YT, Dong Z#. Neuroprotective effects of ginsenoside Rf on Aβ-induced neurotoxicity in vitro and in vivo. J Alzheimers Dis. 2018;64(1):309-322.
5.Tan T, Wang W, Xu H, Huang Z, Wang YT,Dong Z#. Low-Frequency rTMS Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation Through Regulating the Synaptic GABA Transmission. Front Cell Neurosci. 2018 Feb 28;12:46
6.Yu Y, Huang Z, Dai C, Du Y, Han H, Wang YT#, Dong Z#. Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats. Neuropharmacology. 2018 Jan 29;133:155-162.
7.Dong Z#, Han H, Li H, Bai Y, Wang W, Tu M, Peng Y, Zhou L, He W, Wu X, Tan T, Liu M, Wu X, Zhou W, Jin W, Zhang S, Sacktor TC, Li T#, Song W#, Wang YT#. Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis. J Clin Invest. 2015;125(1):234–247.
8.Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, Wang YT, Fischer A, Dean C. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2019 Jan 4;363(6422):eaav1483.
9.Ge Y, Chen W, Axerio-Cilies P, Wang YT. NMDARs in Cell Survival and Death: Implications in Stroke Pathogenesis and Treatment. Trends Mol Med. 2020 Jun;26(6):533-551.
10.Aleksandrova LR, Phillips AG, Wang YT. Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism. J Psychiatry Neurosci. 2017 Jun;42(4):222-229.
11.Wang YQ, Huang YH, Balakrishnan S, Liu L, Wang YT, Nestler EJ, Schlüter OM, Dong Y. AMPA and NMDA Receptor Trafficking at Cocaine-Generated Synapses. J Neurosci. 2021 Mar 3;41(9):1996-2011.
12.Jin JW, Fan X, Del Cid-Pellitero E, Liu XX, Zhou L, Dai C, Gibbs E, He W, Li H, Wu X, Hill A, Leavitt BR, Cashman N, Liu L, Lu J, Durcan TM, Dong Z, Fon EA, Wang YT. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Commun Biol. 2021 Feb 19;4(1):232.
13.Ashby DM, Floresco SB, Phillips AG, McGirr A, Seamans JK, Wang YT. LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields. Nat Commun. 2021 Jan 4;12(1):100.

成果奖励
2006
2001-present
2005
2004
2002
2002-2007
2001-2006
2000-2002
1996-2001
1996-2001
1996-1997
1992-1995
Fellow of the Royal Society of Canada (the Academy of Sciences of Canada)
Howard Hughes Medical Institute International Scholar
Killam Professor, UBC
The J.A.F. Stevenson Lecturer of the Canadian Physiological Society
UBC Distinguished University Scholar
Michael Smith Foundation for Health Research Senior Scholar
CIHR (Canadian Institutes of Health Research) Investigator
EJLB Foundation Research Scholar
HSFC (Heart and Stroke Foundation of Canada) Research Scholarship
Canadian MRC Scholarship, declined
The MacDonald Scholar Award, awarded to the highest-rated HSFC Research Scholar of the year
Canadian MRC Fellowship










研究方向
脑、神经系统疾病研究