朱涛
专业学位硕士生导师

副主任医师



***

第二临床学院





学科信息


个人简介
加州大学博士后，四川大学华西医院博士后，呼吸内科副主任医师，硕士研究生导师。主要从事支气管哮喘、慢性阻塞性肺疾病和急性呼吸窘 迫综合征和的基础与临床研究。目前参与发表论文 50 余篇，其中以第一作者/通讯作者发表 SCI 论著 20 余篇(最高 IF 为 13.146，包括中科院 1 区 1 篇，中科院 2 区 4 篇)，CSCD 论著4 篇，目前 H-index 为 16，引用超过1000 次，单篇最高引用超过 200 次。主持课题省部级课 题 6 项，国家级项目 1 项(中国博士后科学基金)。参与 3 项国家自然基金研究项目研究。 Mediators of inflammation、Oxidative Medicine and Cellular Longevity、Chinese Medical Journal (CMJ)等十余个 SCI 期刊审稿人。




论文情况
【科研论文】
[1]. Sun W, Luo Y, Zhang F, Tang S, Zhu T (corresponding author). (2021) Involvement of TRP Channels in Adipocyte Thermogenesis: An Update. Front. Cell Dev. Biol. 9:686173. doi: 10.3389/fcell.2021.686173. (综述) (IF: 6.684) 中科院二区，JCR 1区
[2]. Min Z, Zeng Y, Zhu T (co-author), Cui B, Mao R, Jin M, Chen Z. Lipopolysaccharide-Activated Bone Marrow-Derived Dendritic Cells Suppress Allergic Airway Inflammation by Ameliorating the Immune Microenvironment. Front Immunol. 2021 May 19;12:595369. doi: 10.3389/fimmu.2021.595369. PMID: **; PMCID: PMC**. (IF: 7.561) 中科院二区，JCR 1区
[3]. Zhu T, Zhang X, Chen X, Brown AP, Weirauch MT, Guilbert TW, Khurana Hershey GK, Biagini JM, Ji H. Nasal DNA methylation differentiates severe from non-severe asthma in African-American children. Allergy. 2021 Jun;76(6):1836-1845. doi: 10.1111/all.14655. Epub 2020 Nov 25. PMID: **; PMCID: PMC**. (IF: 13.146) 中科院一区，JCR 1区
[4]. Zhu T, Li S, Wang J, Liu C, Gao L, Zeng Y, Mao R, Cui B, Ji H, Chen Z. Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine. EPMA J. 2020 Nov 4;11(4):645-659. doi: 10.1007/s13167-020-00227-w. PMID: **; PMCID: PMC**. (IF:6.543) 中科院二区，JCR 1区
[5]. Sun W, Yu Z, Yang S, Jiang C, Kou Y, Xiao L, Tang S, Zhu T (corresponding author). A Transcriptomic Analysis Reveals Novel Patterns of Gene Expression During 3T3-L1 Adipocyte Differentiation. Front Mol Biosci. 2020 Sep 16;7:564339. doi: 10.3389/fmolb.2020.564339. PMID: **; PMCID: PMC**. (IF:5.246) 中科院二区，JCR 2区
[6]. Guangming Dai, Yajuan Ran, Jiajia Wang, Xingru Chen, Junnan Peng, Xinglong Li, Huojin Deng, Min Xiao, Zhu T (corresponding author). Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study. Mediators Inflamm. 2020 Nov 12;2020:**. doi: 10.1155/2020/**. PMID: **; PMCID: PMC**. (IF:4.711) 中科院三区，JCR 2区
[7]. Dai GM, Wang JJ, Chen ZH, Ran YJ, Deng HJ, Mao RL, Zhu T (corresponding author). Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro. Chin Med J (Engl). 2020 Sep 30;134(1):88-97. doi: 10.1097/CM9.1154. PMID: **. (IF: 2.628)
[8]. Zhu T, Brown AP, Ji H. The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures. Epigenet Insights. 2020; 13:25**155. Published 2020 Mar 3. doi:10.1177/25**155. (Review)
[9]. Zhu T, Chen Z, Chen G, Wang D, Tang S, Deng H, Wang J, Li S, Lan J, Tong J, Li H, Deng X, Zhang W, Sun J, Tu Y, Luo W, Li C. Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro. Mediators Inflamm. 2019 Apr 3; 2019:**. (IF: 3.549)
[10]. Zhu T, Chen ZH, Tang S, Yang XJ, Fang S, Deng HJ. Primary pulmonary lymphoepithelioma-like carcinoma combined with situs inversus totalis. Chin Med J (Engl). 2019 Jan 20; 132(2):223-226. (IF: 1.596)
[11]. Tang S, Jin S, Liao X, Huang K, Luo J, Zhu T (corresponding author). Transforaminal Percutaneous Endoscopic Lumbar Decompression by Using Rigid Bendable Burr for Lumbar Lateral Recess Stenosis: Technique and Clinical Outcome. Biomed Res Int. 2018 Nov 26; 2018: **. (IF: 2.58)
[12]. Zhu T, Luo WT, Chen GH, Tu YS, Tang S, Deng HJ, Xu W, Zhang W, Qi D, Wang DX, Li CY, Li H, Wu YQ, Li SJ. Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis. Chin Med J (Engl). 2018 Sep 20;131(18):2210-2215. (IF: 1.596)
[13]. Zhu T, Li C, Zhang X, Ye C, Tang S, Zhang W, Sun J, Huang N, Wen F, Wang D, Deng H, He J, Qi D, Deng W, Yang T. GLP-1 Enhances SP-A Expression in LPS-induced Acute Lung Injury through the TTF-1 Signaling Pathway. Mediators Inflamm. 2018; 2018: **. (IF: 3.549)
[14]. Zhu T, Zhang W, Feng SJ, Yu HP. Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPARγ-dependent pathway. Int Immunopharmacol. 2016 May;34:16-24. (IF: 2.956)
[15]. Zhu T, Wu XL, Zhang W, Xiao M. Glucagon Like Peptide-1 (GLP-1) Modulates OVA-Induced Airway Inflammation and Mucus Secretion Involving a Protein Kinase A (PKA)-Dependent Nuclear Factor-κB (NF-κB) Signaling Pathway in Mice. Int J Mol Sci. 2015; 16(9): 20195-20211. (IF: 3.257)
[16]. Zhu T, Wang DX, Zhang W, Liao XQ, Guan X, Bo H, Sun JY, Huang NW, He J, Zhang YK, Tong J, Li CY. Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB. PLoS One. 2013;8(2):e56407. doi: 10.1371/journal.pone.**. Epub 2013 Feb 21. PMID: **; PMCID: PMC**. (IF: 3.534) 2013. 2. 21
[17]. Zhu T, Zhang W, Xiao M, Chen H, Jin H. Protective Role of Andrographolide in Bleomycin-Induced Pulmonary Fibrosis in Mice. Int J Mol Sci. 2013; 14(12):23581-23596. (IF: 2.339)
[18]. Zhu T, Zhang W, Wang DX. Insulin up-regulates epithelial sodium channel in LPS-induced acute lung injury model in rats by SGK1 activation. Injury. 2012; 43(8): 1277–1283. (IF: 1.931)
[19]. Zhu T, Zhang W, Wang DX, Huang NW, Bo H, Deng W, Deng J. Rosuvastatin attenuates mucus secretion in a murine model of chronic asthma by inhibiting the gamma-aminobutyric acid type A receptor. Chin Med J (Engl) 2012; 125(8): 1457-1464. (IF: 0.901)
[20]. Xiao M, Zhu T (co-author), Zhang W, Wang T, Shen YC, Wan QF, Wen FQ. Emodin Ameliorates LPS-Induced Acute Lung Injury, Involving the Inactivation of NF-κB in Mice. Int J Mol Sci. 2014; 15(11):19355-19368. (IF: 2.862)
[21]. 朱涛, 施婵妹, 李鹤, 何婧, 杨艳丽, 王勤, 邓欣雨, 吴砚樵, 王静, 赵燕, 邓火金. 姜黄素通过调控PPARγ/NF-κB信号通路减轻CSE诱导的人气道上皮细胞氧化应激反应.南方医科大学学报, 2018, (10):1209.
[22]. 朱涛, 管弦, 张维, 王导新. 脱氢穿心莲内酯琥珀酸半酯通过抑制iNOS减轻LPS诱导的急性肺损伤导致的氧化应激. 南方医科大学学报 2012; 32(9): 1238-1241. (Medline)
[23]. 朱涛, 任旭斌, 朱静, 薄红, 刘春涛. γ-氨基丁酸 A 型受体调节哮喘动物模型气道重构的实验研究. 南方医科大学学报, 2010, 30(4): 842-846. (Medline)
[24]. Gou S, Zhu T, Wang W, Xiao M, Wang XC, Chen ZH. Glucagon like peptide-1 attenuates bleomycin-induced pulmonary fibrosis, involving the inactivation of NF-κB in mice. Int Immunopharmacol. 2014; 22(2):498-504. (IF: 2.711)
[25]. Xiao M, Zhu T, Wang T, Wen FQ. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma. Eur Rev Med Pharmacol Sci. 2013; 17(8): 1033-1043. (IF: 0.988)
[26]. Bi J, Min Z, Yuan H, Jiang Z, Mao R, Zhu T, Liu C, Zeng Y, Song J, Du C, Chen Z. PI3K Inhibitor Treatment Ameliorates the Glucocorticoid Insensitivity of PBMCs in Severe Asthma. Clin Transl Med . 2020 Feb 28;9(1):22.
[27]. He J, Qi D, Wang DX, Deng W, Ye Y, Feng LH, Zhu T, Zhao Y, Zhang CR. Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: role of mTORC2/SGK1 pathway. Exp Cell Res. 2015 Feb 1; 331(1):164-75. (IF: 3.246)
[28]. Huang K, Shi C, Min J, Li L, Zhu T, Yu H, Deng H. Study on the Mechanism of Curcumin Regulating Lung Injury Induced by Outdoor Fine Particulate Matter (PM2.5). Mediators Inflamm. 2019 Aug 21; 2019:**. (IF: 3.549)
[29]. Xu K, Wu N, Min Z, Li Z, Zhu T, Liu C, Zeng Y, Song J, Mao R, Ji H, Jiang Z, Chen Z. Adoptive transfer of bone marrow-derived dendritic cells (BMDCs) alleviates OVA-induced allergic airway inflammation in asthmatic mice. Sci Rep. 2020;10(1):13915. Published 2020 Aug 17. doi:10.1038/s41598-020-70467-3. (IF: 3.998)
[30]. 肖敏, 朱涛, 汪涛, 等. 甘草酸二胺通过上调水通道蛋白5减轻小鼠急性肺损伤肺水肿的实验研究. 四川大学学报（医学版）, 2014; 45(3):376-379. (Medline)
[31]. 肖敏, 朱涛, 汪涛, 等. 甘草酸二铵抑制慢性哮喘模型小鼠气道平滑肌增生. 南方医科大学学报, 2013, 33(10): 1416-1420. (Medline)
[32]. 任旭斌, 刘春涛, 朱涛. 荷包牡丹碱对哮喘小鼠肺组织α-SMA及气道重构的影响. 四川大学学报（医学版）, 2010, 41(4): 626-626. (Medline)
[33]. 张玉坤, 王导新, 朱涛, 等. 染料木黄酮通过上调血红素氧合酶-1 表达减缓野百合碱诱导的大鼠肺动脉高压. 南方医科大学学报, 2012, 32(2): 151-154. (Medline)
[34]. 朱涛, 叶春燕, 文富强, 张维. 瑞舒伐他汀对支气管哮喘患者Th2免疫异常的调控作用. 西部医学, 2015, 27(11): 1634-1637. 2015.11
[35]. 朱涛, 肖敏, 文富强, 汪涛. 脱氢穿心莲内酯琥珀酸半酯上调水通道蛋白5减轻LPS诱导的急性肺损伤肺水肿的实验研究. 西部医学, 2014, 26(01): 16-18, 22. 2014.01

【教学文章】
[1] 王勤, 江德鹏, 朱涛 (通讯作者). 智能化病例教学系统在呼吸内科见习中的应用研究. 西部素质教育. 2019(9): 134-135, 148.
[2] 王勤, 江德鹏, 朱涛 (通讯作者). “CBL+ PBL” 教学法在呼吸病学教学中的应用. 西部素质教育. 2019(8): 151-153.



科研项目
【主持课题】
[1] 重庆市科卫联合医学科研项目(面上项目) (基金号：2020MSXM112)，时间2020.09-2023.08，题目：咳嗽变异性哮喘与典型哮喘鼻粘膜上皮DNA甲基化和转录组学差异研究。经费：10.0万
[2] 广州市科技计划项目(一般项目专题) (基金号：2)，时间2017.05-2020.04，题目：单核细胞趋化蛋白诱导蛋白1通过γ-氨基丁酸A型受体负性调控支气管哮喘气道上皮粘液高分泌的机制研究。经费：20.0万
[3] 广东省自然科学基金(博士科研启动纵向协同管理试点项目) (基金号：2017A)，时间 2017.01.01 至 2020.01.01，题目：胰高血糖素样肽-1通过甲状腺转录因子-1对II型肺泡上皮细胞SP-A的调控作用及其对急性肺损伤的影响。经费：10.0万
[4] 中国博士后科学基金(基金号：2014M552369)，时间2014.05-2015.05，题目：GLP-1对SP-B的调控机制及其对ARDS的影响。经费：5.0万
[5] 四川省医学科研青年创新课题计划(基金号：Q15002)，时间2015.01-2016.12，题目：GLP-1在TTF-1调控SP-B中的作用及其对急性呼吸窘迫综合症的影响。经费：1.0万
[6] 四川省卫生和计划生育委员会科研课题(基金号：150123)，时间2015.01-2016.12，题目： GLP-1信号通路对SP-B的调控作用及其对急性呼吸窘迫综合症的影响。经费：1.5万
[7] 四川省医学会科研课题院内项目(基金号：)，时间2015.01-2016.06，题目：瑞舒伐他汀对轻到中度成年支气管哮喘患者Th2免疫异常的调控作用及随机、安慰剂对照临床研究。经费：2.0万
[8] 四川大学博士后专项基金特别资助，时间2015.01-2016.01，题目：GLP-1通过TTF-1对SP-B的调控机制及其对急性呼吸窘迫综合症的影响。经费：3.0万



成果奖励
获奖情况：
[1]中华医学会呼吸病学分会，高影响力呼吸学术论文奖，2019
Zhu T, Wang DX, Zhang W, Liao XQ, Guan X, Bo H, Sun JY, Huang NW, He J, Zhang YK, Tong J, Li CY. Andrographolide Protects Against LPS-induced Acute Lung Injury by Inactivation of NF-κB. PLOS ONE. 2013; 8(2): e56407.
[2]朱涛(6/10)，急性呼吸窘迫综合征(ARDS)发生发展新机制与临床研究，重庆市科学技术委员会，重庆市科技进步奖，二等奖，2017
(获奖人员：王导新、邓旺、何婧、赵燕、戚迪、朱涛、邓嘉、李长毅、唐琳、童瑾)







研究方向
慢性气道炎症性疾病的基础与临床