神经智能研究中心主任/国家****、兼聘研究生导师、教授



学习经历
1. 2007/09 – 2011/06, 德国慕尼黑工业大学医学院，博士（PhD）
2. 2004/09 – 2007/06，第三军医大学，医学硕士
3. 1999/09 – 2004/06，第三军医大学，临床医学学士


工作经历
1. 2019 - 至今，重庆大学医学院兼聘研究生导师
2. 2014 - 至今，中国科学院脑科学与智能技术卓越创新中心，年轻骨干
3. 2013/01 - 至今，陆军军医大学脑科学研究室，主任、教授
4. 2011/09 - 2013/01，德国慕尼黑工业大学神经科学研究所，博士后


研究方向、教学课程
谌小维博士主要从事大脑皮层感觉信息处理机制研究，近年来在信息记忆、运动输出、等发生机制，以及光学成像技术的研发等方面取得了突出成绩。
1、阐明空间长期记忆和时间瞬时记忆的神经回路机制。
2、解析排尿运动控制的皮层机制。
3、建立脑活动图谱绘制工具。
研究兴趣：
大脑皮层感觉信息处理机制、光学成像技术、类脑计算。
成果：1.文章2.专利3.项目4.获奖
谌小维博士在Nature、Science、Nature Neuroscience、Neuron、PNAS等杂志发表论文50篇，单篇最高引用超过350次，总引用率超过2000次。


代表性论文
1.Jin W, Qin H, Zhang K,Chen X. (2020) Spatial Navigation.Adv Exp Med Biol1284:63-90.
2.Wang M, Liao X*, Li R, Liang S, Ding R, Li J, Zhang JX, He W, Liu K, Pan J, Zhao Z, Li T, Zhang K,Li X, Lyu J, Zhou Z, Varga Z, Mi Y, Zhou Y, Yan J, Zeng S, Liu J, Konnerth A, Nelken I, Jia H*,Chen X*. (2020) Single-neuron representation of learned complex sounds in the auditory cortex.Nature Communications11:4361.
3.Sun HL, Chen SH, Yu ZY, Cheng Y, Tian DY, Fan DY, He CY, Wang J, Sun PY, Chen Y, Tan CR, Wang JP, Song W, Zhou HD,Chen XW, Hu ZA, Bu XL, Wang YJ.(2020)Blood cell-produced amyloid-β induces cerebral Alzheimer-type pathologies and behavioral deficits.Mol PsychiatryJul 17.
4.Wang J, Sun BL, Xiang Y, Tian DY, Zhu C, Li WW, Liu YH, Bu XL, Shen LL, Jin WS, Wang Z, Zeng GH, Xu W, Chen LY,Chen XW, Hu Z, Zhu ZM, Song W, Zhou HD, Yu JT, Wang YJ. (2020) Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice.Transl Psychiatry10:230.
5.Yang M, Zhou Z, Zhang J, Jia S, Li T, Guan J, Liao X, Leng B, Lyu J, Zhang K, Li Min, Gong Y, Zhu Z, Yan J, Zhou Y, Liu J,Varga Z, Konnerth A, Tang Y, Gao J,Chen X, Jia H. (2019) MATRIEX Imaging: Multiarea Two-photon Real-time In-vivo Explorer.Light Sci Appl8:109.
6.Qin H, Lu J, Jin W,Chen X, Fu L. (2019) Multichannel fiber photometry for mapping axonal terminal activity in a restricted brain region in freely moving mice.Neurophotonics6:035011.
7.Cui Y, Wu H, Li Q, Liao J, Gao P, Sun F, Zhang H, Lu Z, Wei X, He C, Ma T, Wei X,Chen X, Zheng H, Yang G, Liu D, Zhu Z. (2019) Impairment of Bitter Taste Sensor Transient Receptor Potential Channel M5-Mediated Aversion Aggravates High-Salt Intake and Hypertension.Hypertension74:1021-1032.
8.Li M, Xu H, Chen G, Sun S, Wang Q, Liu B, Wu X, Zhou L, Chai Z, Sun X, Lu Y, Younus M, Zheng L, Zhu F, Jia H,Chen X, Wang C, Zhou Z. (2019) Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson's disease.Brain142:3099-3115.
9.Yao J, Li Q, Li X, Qin H, Liang S, Liao X,Chen X*, Li W*, Yan J*.(2019) Simultaneous Measurement of Neuronal Activity in the Pontine Micturition Center and Cystometry in Freely Moving Mice.Front Neurosci13:663.
10.Wu W, Yang Y, Yang Y, Yang Y, Zhang K, Guo L, Ge H,Chen X*, Liu J*, Feng H*. (2019) Molecular Engineering of an Organic NIR-II Fluorophore with Aggregation-Induced Emission Characteristics for In Vivo Imaging.Small15:e**.
11.Ren S, Wang YL, Yue F, Cheng X, Dang R, Qiao Q, Sun X, Li X, Jiang Q, Yao J, Qin H, Wang G, Liao X, Gao D, Xia J, Zhang J, Hu B, Yan JA, Wang YJ, Xu M, Han Y, Tang X,Chen X*,He C*, Hu Z*. (2018) The paraventricular thalamus is a critical thalamic area for wakefulness.Science362:429-434
12.Yao J, Zhang Q, Liao X, Li Q, Liang S, Li X, Zhang Y, Li XN, Wang H, Qin H, Wang M, Li J, Zhang J, He W, Zhang W, Li T, Xu F, Gong H, Jia H, Xu X*, Yan J*,Chen X*. (2018)A corticopontine circuit for initiation of urination.Nature Neuroscience21:1541-1550.
13.Qin H, Fu L*, Hu B, Liao X, Lu J, He W, Liang S, Zhang K, Li R, Yao J, Yan J-A, Chen H, Jia H, Zott B, Konnerth A*,Chen X*. (2018) A visual cue-dependent memory circuit for place navigation.Neuron99:47-55.
14.Li R, Wang M, Yao J, Liang SS, Liao X, Yang M, Zhang J, Yan JA, Jia H,Chen X*, Li X*.(2018) Two-Photon Functional Imaging of the Auditory Cortex in Behaving Mice: From Neural Networks to Single Spines.Front Neural Circuits12:33.
15.Wang M, Li R, Li J, Zhang J,Chen X*, Zeng S*, Liao X*.(2018) Frequency selectivity of echo responses in the mouse primary auditory cortex.Sci Rep8:49.
16.Guan J, Li J, Liang S, Li R, Li X, Shi X, Huang C, Zhang J, Pan J, Jia H, Zhang L,Chen X*, Liao X*. (2018) NeuroSeg: automated cell detection and segmentation for in vivo two-photon Ca²⁺imaging data.Brain Struct Funct223:519-533.
17.Bu XL, Xiang Y, Jin WS, Wang J, Shen LL, Huang ZL, Zhang K, Liu YH, Zeng F, Liu JH, Sun HL, Zhuang ZQ, Chen SH, Yao XQ, Giunta B, Shan YC, Tan J,Chen XW, Dong ZF, Zhou HD, Zhou XF, Song W, Wang YJ. (2018) Blood-derived amyloid-β protein induces Alzheimer's disease pathologies.Mol Psychiatry23:1948-1956.
18.Li Q, Cui Y, Jin R, Lang H, Yu H, Sun F, He C, Ma T, Li Y, Zhou X, Liu D, Jia H,Chen X, Zhu Z. (2017) Enjoyment of Spicy Flavor Enhances Central Salty-Taste Perception and Reduces Salt Intake and Blood Pressure.Hypertension70:1291-1299.
19.Zhang K,Chen X*.(2017) Sensory response in host and engrafted astrocytes of adult brain in vivo.Glia65:1867-1884. (Cover Review)
20.Ding R, Liao X, Li J, Zhang J, Wang M, Guang Y, Qin H, Li X, Zhang K, Liang S, Guan JH, Lou J, Jia H, Chen B*, Shen H*,Chen X*. (2017) Targeted Patching and Dendritic Ca²⁺Imaging in Nonhuman Primate Brain in vivo.Sci Rep7:2873.
21.Li J, Zhang J, Wang M, Pan J,Chen X*, Liao X*. Functional imaging of neuronal activity of auditory cortex by using Cal-520 in anesthetized and awake mice. (2017)Biomed Opt Express8:2599-2610.
22.Zhang QC^#, Yao JW^#, Guang Y^#, Liang SS, Guan JH, Qin H, Liao X, Jin WJ, Zhang JX, Pan JX, Jia HB, Yan JA, Feng ZZ*, Li WB*,Chen X*. (2017) Locomotion-related population cortical Ca²⁺transients in freely behaving mice.Front Neural Circuits11:24.
23.Li J, Liao X, Zhang J, Wang M, Yang N, Zhang J, Lv G, Li H, Lu J, Ding R, Li X, Guang Y, Yang Z, Qin H, Jin W, Zhang K, He C, Jia H, Zeng S, Hu Z, Nelken I,Chen X*. (2017) Primary auditory cortex is required for anticipatory motor response.Cereb Cortex27:3254-3271.
24.Zhang K, Chen C, Yang Z, He W, Liao X, Ma Q, Deng P, Lu J, Li J, Wang M, Li M, Zheng L, Zhou Z, Sun W, Wang L, Jia H, Yu Z, Zhou Z*,Chen X*. (2016) Sensory response of transplanted astrocytes in adult mammalian cortex in vivo.Cereb Cortex26:3690-704 (Cover paper).
25.Grienberger C,Chen X, Konnerth A. (2015) Dendritic function in vivo.Trends Neurosci38:45-54.
26.Dao Duc K, Parutto P,Chen X, Epsztein J, Konnerth A, Holcman D*. (2015) Synaptic dynamics and neuronal network connectivity are reflected in the distribution of times in Up states.Front Comput Neurosci9:96.
27.Hao Z, Wei L, Feng Y,Chen X, Du W, Ma J, Zhou Z, Chen L, Li W*.(2015) Impaired maturation of large dense-core vesicles in muted-deficient adrenal chromaffin cells.J Cell Sci128:1365-74.
28.Grienberger C,Chen X, Konnerth A*.(2014) NMDA receptor-dependent multidendrite calcium spikes required for hippocampal burst firing in vivo.Neuron81:1274-81.
29.Chen X*,Rochefort NL, Sakmann B,KonnerthA*.(2013) Reactivation of the same synapses during spontaneous up states and sensory stimuli.Cell Reports4:31-9.
30.Busche MA,ChenX, Henning HA, Reichwald J, Staufenbiel M, Sakmann B,KonnerthA*.(2012) Critical role of soluble amyloid-βfor early hippocampal hyperactivity in a mouse model of Alzheimer's disease.Proc Natl Acad Sci USA109:8740-5.
31.Chen X^#, Leischner U^#, Varga Z, Jia H, Deca D, Rochefort NL, Konnerth A*.(2012) LOTOS-based two-photon calcium imaging of dendritic spines in vivo.Nat Protoc7:1818-29.
32.Chen X^#, Leischner U^#, Rochefort NL, Nelken I, Konnerth A*.(2011) Functional mapping of single spines in cortical neurons in vivo.Nature475:501-5.
33.Jia H, Rochefort NL,Chen X, Konnerth A*.(2011)In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons.Nat Protoc6:28-35.
34.Chen XW,KovalchukY,AdelsbergerH,HenningHA,SausbierM,WietzorrekG,RuthP,YaromY,KonnerthA*. (2010) Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels.Proc Natl Acad Sci USA107:12323-8.
35.Jia HB, Rochefort NL,Chen XW, Konnerth A*. (2010) Dendritic organization of sensory input to cortical neurons in vivo.Nature464:1307-12.
36.Li B, Chen F, Ye J,Chen X, Yan J, Li Y, Xiong Y, Zhou Z, Xia J & Hu Z*. (2009) The Modulation of Orexin A on HCN Currents of Pyramidal Neurons in Mouse Prelimbic Cortex.Cereb Cortex20:1756-67.
37.Chen XW^#, Feng YQ^#, Hao CJ, Guo XL, He X, Zhou ZY, Guo N, Huang HP, Xiong W, Zheng H, Zuo PL, Zhang CX, Li W & Zhou Z*. (2008) DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release.J Cell Biol181:791-801.
38.Chen XW, Mu Y, Huang HP, Guo N, Zhang B, Fan SY, Xiong JX, Wang SR, Xiong W, Huang W, Liu T, Zheng LH, Zhang CX, Li LH, Yu ZP, Hu ZA & Zhou Z*. (2008) Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons.J Neurosci28:3202-3208.
39.Huang HP, Wang SR, Yao W, Zhang C, Zhou Y,Chen XW, Zhang B, Xiong W, Wang LY, Zheng LH, Landry M, Hokfelt T, Xu ZQ & Zhou Z*. (2007) Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices.Proc Natl Acad Sci USA104:1401-1406.
40.Yu X^#,Chen XW^#, Zhou P, Yao L, Liu T, Zhang B, Li Y, Zheng H, Zheng LH, Zhang CX, Bruce I, Ge JB, Wang SQ, Hu ZA, Yu HG & Zhou Z*. (2007) Calcium influx through If channels in rat ventricular myocytes.Am J Physiol Cell Physiol292:C1147-1155.


代表性项目
2012年入选 国家高层次引进人才青年项目
2015年获得 国家科技部青年973项目（首席科学家）
2019年获得 国家****科学基金



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