李梢 教授
清华信息科技国家实验室(筹)生物信息学部 副主任
通讯地址：清华大学FIT楼1-107室 邮政编码：100084
电话： Fax：
Email：shaoli@mail.tsinghua.edu.cn

展开




教育背景

北京中医药大学 医学博士（1998.9－2001.7）
皖南医学院 医学硕士（继承家族医学-国家非物质文化遗产）（1995.9－1998.7）
北京中医药大学 医学学士（1990.9－1995.7）

工作履历

清华大学 教授 （2009.12至今）
清华大学 博士生导师 （2008.9至今）
清华信息科技国家实验室（筹）生物信息学研究部 副主任 （2006.2至今）
清华大学自动化系、生物信息学教育部重点实验室 副研究员 （2004.12－2009.11）
清华大学自动化系、生物信息学教育部重点实验室 讲师 （2003.8－2004.12）
清华大学自动化系、生物信息学教育部重点实验室 博士后 （2001.9－2003.8）

学术兼职

世界中医药学会联合会网络药理学专业委员会 会长
中国药理学会网络药理学专业委员会 副主任委员
Scientific Reports等刊物 编委
中国研究型医院学会 生物标志物专业委员会 副主任委员

研究领域

本课题组致力于从生物信息学、系统生物学、大数据、人工智能与中西医药交叉的角度，提出“网络靶标”新概念，建立网络药理学新方法，从网络与系统的角度研究消化道炎症和肿瘤的生物机制、中医个体化诊疗机理和防治药物，推动建立新一代中西医智慧医疗。主要方向包括：
1. 利用中西医学生物大数据，以信息与系统的观点，分析炎症和肿瘤等疾病和中医证候的复杂生物网络
2. 以炎症和肿瘤的生物网络为干预靶标，分析药物、中医药的作用机制，发展系统控制复杂疾病的新方法
3. 网络药理学、生物信息学中的信息处理和复杂网络分析方法


奖励与荣誉

国家“”科技创新领军人才（2019）
国家科学基金（2012）
科技部中青年科技创新领军人才（2018）
世界中医药十大新闻（2014）
大挑战2015？青年科学家（美国盖茨基金会、中国科技部联合颁发）（2015）
国家教学成果二等奖（2009）
国家科技进步二等奖（2004）
全国优秀博士学位论文（2003）
中华中医药学会中青年创新人才（2018）
茅以升北京青年科技奖（2009）
教育部新世纪优秀人才支持计划（2007）
清华大学先进工作者（2008）

学术成果

主要论文（*：通讯作者）
1.Zhang P, Yang M, Zhang Y, Xiao S, Tai X, Tan A, Du S, Li S*. Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer. Cell Reports 2019
2.Guo Y, Bao C, Ma D, Cao Y, Li Y, Xie Z*, Li S*. Network-based combinatorial CRISPR-Cas9 screens identify synergistic modules in human cells. ACS Synthetic Biology 2019;8:482？490 (封面论文)
3.Cui J, Cui H, Yang M, Du S, Li J, Li Y, Liu L, Zhang X*, Li S*. Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade. Protein & Cell 2019
4.Zheng J, Wu M, Wang H, Li SS, Wang X, Li Y, Wang D, Li S*. Network pharmacology to unveil the biological basis of health strengthening herb medicine in cancer treatment. Cancers 2018;10(11):461:1-23
5.Zhang T, Xue R, Wang X, Zhao S, An L, Li Y, Zhang Y*, Li S*. Network-based drug repositioning: a novel strategy for discovering potential antidepressants and their mode of action. European Neuropsychopharmacology 2018;28:1137-1150
6.Zhang B, Wang X, Li Y, Wu M, Wang S, Li S*. Matrine is identified as a novel macropinocytosis inducer by a network target approach. Frontiers in Pharmacology 2018
7.Guo Y, Nie Q, MacLean A, Li Y, Lei J*, Li S*. Multiscale modeling of inflammation-induced tumorigenesis reveals competing oncogenic and onco-protective roles for inflammation. Cancer Research 2017;77(22):6429-6441
8.Li S*. Exploring traditional Chinese medicine by a novel therapeutic concept of network target. Chinese Journal of Integrative Medicine 2016;22(9):647-652 (Feature Article)
9.Qi Q, Li R, Li H, Cao Y, Bai M, Fan X, Wang S, Zhang B*, Li S*. Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach. Acta Pharmacologica Sinica 2016;37:963-972
10.Li S*. Mapping ancient remedies: applying a network approach to traditional Chinese medicine. Science 2015;350(6262 Supplement):S72-S74 (传统医学增刊)
11.Zu S, Chen T, Li S*. Global optimization-based inference of chemogenomic features from drug-target interactions. Bioinformatics 2015;31(15):2523-2529
12.Zhang B, Lu C, Bai M, He X, Tan Y, Bian Y, Xiao C, Zhang G, Lu A*, Li S*. Tetramethylpyrazine identified by a network pharmacology approach ameliorates methotrexate-induced oxidative organ injury. Journal of Ethnopharmacology 2015;175:638-647
13.Li Y, Li R, Ouyang Z, Li S*. Herb network analysis for a famous TCM doctor’s prescriptions on treatment of rheumatoid arthritis. Evidence-Based Complementary and Alternative Medicine 2015: 451319
14.Liang X, Li H, Li S*. A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-wei-di-huang Pill as a case study. Molecular BioSystems 2014,10(5):1014-1022 (封面论文)
15.Wang L, Wang Y, Hu Q, Li S*. Systematic analysis of new drug indications by drug-gene-disease coherent subnetworks. CPT: Pharmacometrics and Systems Pharmacology 2014;3:e146
16.Li R, Ma T, Gu J, Liang X, Li S*. Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients. Scientific Reports 2013;3:1543
17.Li S*, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chinese Journal of Natural Medicines 2013;11(2):110-120
18.Zhang B, Wang X, Li S*. An integrative platform of TCM network pharmacology and its application on an herbal formula, Qing-Luo-Yin. Evidence-based Complementary and Alternative Medicine 2013:456747
19.Wang T, Gu J, Yuan J, Tao R, Li Y, Li S*. Inferring pathway crosstalk networks using gene set co-expression signatures. Molecular BioSystems 2013;9(7):1822-1828
20.Jiang B, Liang X, Chen Y, Ma T, Liu L, Li J, Jiang R, Chen T, Zhang X*, Li S*. Integrating next-generation sequencing and traditional tongue diagnosis to determine tongue coating microbiome. Scientific Reports 2012;2:936
21.Zhao S, Li S*. A co-module approach for elucidating drug-disease associations and revealing their molecular basis. Bioinformatics 2012;28(7):955-961
22.Chen Y, Gu J, Li D, Li S*. Time-course network analysis reveals TNF-alpha can promote G1/S transition of cell cycle in vascular endothelial cells. Bioinformatics 2012;28(1):1-4
23.Li S*, Zhang B, Zhang NB. Network target for screening synergistic drug combinations with application to traditional Chinese medicine. BMC Systems Biology 2011;5(S1):S10 (Faculty of 1000 推荐)
24.Yao X, Hao H, Li Y, Li S*. Modularity-based credible prediction of disease genes and detection of disease subtypes on the phenotype-gene heterogeneous network. BMC Systems Biology 2011;5:79
25.李梢. 网络靶标：中药方剂网络药理学研究的一个切入点.中国中药杂志 2011;36:2017-2020
26.Li S*, Zhang B, Jiang D, Wei YY, Zhang NB. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics 2010;11(S11):S6
27.Zhao S, Li S*. Network-based relating pharmacological and genomic spaces for drug target identification. PLoS ONE 2010;5(7):e11764 （Nature China亮点论文）
28.Yan H, Zhang B, Li S*, Zhao Q*. A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway. BMC Systems Biology 2010;4:50
29.Ma T, Tan C, Zhang H, Wang M, Ding W, Li S*. Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network. Molecular BioSystems 2010;6:613-619
30.Gu J, Chen Y, Li S*, Li Y*. Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis. BMC Systems Biology 2010;4:47
31.Huang Y, Li S*. Detection of characteristic sub pathway network for angiogenesis based on the comprehensive pathway network. BMC Bioinformatics 2010;11(S1):S32
32.Wu X, Li S*. Cancer Gene Prediction Using a Network Approach. Chapter 11. Cancer Systems Biology (Ed. Edwin Wang). Series: Chapman & Hall/CRC Mathematical & Computational Biology, USA: CRC Press 2010: 191-212
33.Li S. Network systems underlying traditional Chinese medicine syndrome and herb formula. Current Bioinformatics 2009;4(3):188-196
34.Wu X, Jiang R, Zhang MQ, Li S*. Network-based global inference of human disease genes. Molecular Systems Biology 2008;4:189, pages:1-11 （Nature China亮点论文；美国医学信息学会Translational Bioinformatics2009峰会年度选评论文；国际计算生物学会ISMB2009亮点论文）
35.Zhang J, Ma T, Li YD, Li S*. dbNEI2.0: building multilayer network for drug-NEI-disease. Bioinformatics 2008;24:2409-2411
36.Li S*, Zhang Z, Wu L, Zhang X, Li Y, Wang Y. Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network. IET Systems Biology 2007;1(1):51-60
37.李梢. 基于生物网络调控的方剂研究模式与实践. 中西医结合学报 2007;5(5):1-5
38.Li S*, Wu LJ, Zhang ZQ. Constructing biological networks through combined literature mining and microarray analysis: a LMMA approach. Bioinformatics 2006;22:2143-2150