文献详情
Developing chemically modified redox-responsive proteins as smart therapeutics
文献类型：期刊
通讯作者：Zhang, MN (reprint author), Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China.; Wang, M (reprint author), Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci, Key Lab Analyt Chem Living Biosyst,Inst Chem, Beijing 100190, Peoples R China.; Wang, M (reprint author), Univ Chinese Acad Sci, Beijing 100190, Peoples R China.
期刊名称：CHEMICAL COMMUNICATIONS影响因子和分区
年：2019
卷：55
期：35
页码：5163-5166
ISSN：1359-7345
所属部门：化学系
摘要：The conditional control of protein function in response to the physiological changes of diseased cells is essential to develop smart protein therapeutics. Herein, we report a redox-responsive chemical modification of a protein by conjugating an intracellular glutathione (GSH)-cleavable ligand, NSA, onto a protein residue. We demonstrated that the NSA conjugation of Ribonuclease A (RNase A) enabled the control of the protein function by GSH in an aqueous solution and living cells, with extended a ...More
The conditional control of protein function in response to the physiological changes of diseased cells is essential to develop smart protein therapeutics. Herein, we report a redox-responsive chemical modification of a protein by conjugating an intracellular glutathione (GSH)-cleavable ligand, NSA, onto a protein residue. We demonstrated that the NSA conjugation of Ribonuclease A (RNase A) enabled the control of the protein function by GSH in an aqueous solution and living cells, with extended applications for targeted cancer therapy using a lipid nanoparticle-based intracellular protein delivery strategy. ...Hide

DOI：10.1039/c9cc00519f
百度学术：Developing chemically modified redox-responsive proteins as smart therapeutics
语言：外文
被引频次：3
人气指数：3
浏览次数：3
基金：National Key Research and Development Programof China [2017YFA0208100, 2016YFA0200104]; National Science Foundation of ChinaNational Natural Science Foundation of China [21522509, 21874152, 21778056]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01EB027170-01]
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