文献详情
Recent Progress on Endoplasmic Reticulum-Targetable Small Organic Fluorescent Probes
文献类型：期刊
通讯作者：Xing, GW (reprint author), Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China.
期刊名称：CHINESE JOURNAL OF ORGANIC CHEMISTRY影响因子和分区
年：2019
卷：39
期：4
页码：940-951
ISSN：0253-2786
关键词：endoplasmic reticulum; fluorescent probe; targetable localization; multi-functional probe
摘要：Endoplasmic reticulum (ER) is an important organelle in eukaryotic cells and participates in the synthesis and secretion of various proteins, glycogen, lipids, and cholesterol substances. It is surrounded by a single membrane in the cytoplasm, which is a three-dimensional mesh structure formed by flat cysts, membrane tubes, and bubbles. Research on the physiological morphology of ER can facilitate the resolution of certain metabolic diseases. Due to the good optical properties and outstanding sp ...More
Endoplasmic reticulum (ER) is an important organelle in eukaryotic cells and participates in the synthesis and secretion of various proteins, glycogen, lipids, and cholesterol substances. It is surrounded by a single membrane in the cytoplasm, which is a three-dimensional mesh structure formed by flat cysts, membrane tubes, and bubbles. Research on the physiological morphology of ER can facilitate the resolution of certain metabolic diseases. Due to the good optical properties and outstanding specific localization, fluorescent probe technology has been widely used in structural investigation and activity tracking of organelles. The ER fluorescent probes can be divided into two types, one is a single functional ER localization probe, the other is a multi-functional ER probe, which has multiple functions of locating and detecting active species in ER, the morphology and environment of ER. In this article, the structure, function and biological application of ER fluorescent probes in recent years are summarized and reviewed. Various localization mechanisms of ER fluorescent probes are described. The development trend of ER fluorescent probes in life science research is prospected. ...Hide

DOI：10.6023/cjoc201810021
百度学术：Recent Progress on Endoplasmic Reticulum-Targetable Small Organic Fluorescent Probes
语言：外文
被引频次：1
基金：National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21272027]
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