文献详情
Cobalt-Catalyzed Three-Component Difluoroalkylation-Peroxidation of Alkenes
文献类型：期刊
期刊名称：The Journal of organic chemistry
年：2019
卷：84
期：9
页码：5328-5338
ISSN：1520-6904
所属部门：化学系
摘要：The Co(acac)2-catalyzed three-component difluoroalkylation-peroxidation of alkenes with difluorohaloactates and hydroperoxides has been developed. The protocol provides an efficient and selective access to various β-peroxyl difluoroalkyl derivatives, which can be transformed into α-amino acid and pyrimidine derivatives by the reactions with amines and amidines. The mild reaction conditions, broad substrate scopes, gram-scale synthesis, and synthetic applications exemplified the utility and pract ...More
The Co(acac)2-catalyzed three-component difluoroalkylation-peroxidation of alkenes with difluorohaloactates and hydroperoxides has been developed. The protocol provides an efficient and selective access to various β-peroxyl difluoroalkyl derivatives, which can be transformed into α-amino acid and pyrimidine derivatives by the reactions with amines and amidines. The mild reaction conditions, broad substrate scopes, gram-scale synthesis, and synthetic applications exemplified the utility and practicability of this method. In addition, this methodology can be extended to other halide compounds to give the alkylation-peroxidation products. ...Hide

DOI：10.1021/acs.joc.9b00339
百度学术：Cobalt-Catalyzed Three-Component Difluoroalkylation-Peroxidation of Alkenes
语言：外文
人气指数：1
浏览次数：1
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