杜为红 Weihong Du



专业：物理化学
电话：，传真：
电子邮件：whdu@ruc.edu.cn
教育背景：
1986.9-1990.7,?山西大学化学系,?本科
1990.9-1993.7,?山西大学分子科学研究所,?硕士
1997.9-2000.7,?北京大学化学与分子工程学院,?博士
工作经历：
1993.7-1997.8,?山西大学化学系，教师
2000.9-2001.3,?香港大学化学系，博士后
2001.4-2003.4,?美国加州大学戴维斯分校化学系，博士后
2003.8-2005.5,?北京师范大学化学系,?教师
2005.6-,?中国人民大学化学系，教师
教授课程：
物理化学（本科）；生物物理化学（研究生）
主要研究方向：生物物理与生物无机化学
主要研究内容：
生物大分子与配体相互作用的光谱学、波谱学研究
生物毒素的结构与功能关系
生物大分子与小分子相互作用的热动力学
主要科研项目与课题：
中国人民大学引进人才资助项目?50万元
国家自然科学基金面上项目?26万元
教育部科学技术重点项目?10万元
973?计划子课题?20万元
主要发表论文：
Jia Xu, Gowei Yin,Weihong Du^*.?Distal mutation modulates the heme sliding in mouse neuroglobin investigated by molecular dynamics simulation.?Proteins. Struc. Func. Bioinfo.?2011, 79, 191-202.
Yanli Wang, Jia Xu, Lu Wang, Bingbing Zhang,Weihong Du^*.?Interaction of the human prion protein PrP106-126 with metal complexes: potential therapeutic agents against prion disease.?Chemistry, Eur. J.?2010, 16, 13339-42.
Yanli Wang, Tong Zhang^*, Jia Xu,Weihong Du^*.?Comparison of the binding affinity of chlorogenic acid with two serum albumins.?Int. J. Biol. Macromol.?2010, in press.
4. Jia Xu, Yanli Wang, Binbin Zhang, Baohuai Wang,Weihong Du^*.Stereochemistry of 4-hydroxyproline affects the conformation of conopeptides.? Commun.?2010, 46, 5467-5469.
5. Jia Xu, Guowei Yin, Feijuan Huang, Baohuai Wang,Weihong Du^*. Molecular dynamics simulation of a carboxy murine neuroglobin mutated on the proximal side: heme displacement and concomitant rearrangement in loop regions Mol. Model.?2010, 16, 759-770.
6. Bin Gao, Jia Xu, Maria del Carmen Rodrigues, Humberto Lanz-Mendoza, Rosaura Hernondez -Rivas,Weihong Du^*,Shunyi Zhu^*. Characterization of two linear cationic antimalarial peptides in the scorpion mesobuthus eupeus.Biochimie?2010, 92, 350-359.
7. Jia Xu, Lianzhi Li, Guowei Yin, Haili Li,Weihong Du^*.Ligand orientation of human neuroglobin obtained from solution NMR and molecular dynamics simulation as compared with X-ray crystallography.? Inorg. Biochem.?2009, 103, 1693-1701.
8. Feijuan Huang,Weihong Du^*, Solution Structure of Hyp10Pro variant of conomarphin, a cysteine-free and D-amino-acid containing conopeptide.Toxicon, 2009, 54, 153-160.
9. Yuhong Han, Feijuan Huang, Hui Jiang, Li Liu, Qi Wang, Yanfang Wang, Xiaoxia Shao,Chengwu Chi,Weihong Du^*and Chunguang Wang^*?, Purification and structural characterization of a D-amino acid containing conopeptide, conomarphin, from?conus marmoreus.?FEBS J.?2008, 275, 1976-1987.
10.GuoweiYin,?Yanjie Li,?Juan Li,?Jing Li,?Weihong?Du*,?Qun Wei^*,?Weihai? Solution H-1 NMR study of the active site structure for the double mutant H64Q/V68F cyanide complex from mouse neuroglobin.?Biophys. Chem.?2008, 136, 115-123.
11.Weihong Du,Yuhong Han, Feijuan Huang, Juan Li, Chengwu Chi, Weihai Fang^*. Solution structure of an M-1 Conotoxin mr3e with a novel disulfide linkage.?FEBS J.?2007, 274, 2596-2602.
12. Yiming Li, Guowei Yin, Wei Wei, Hengbin Wang, Shanhao Jiang, Duyuan Zhu^*,Weihong Du^*, Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by¹H NMR relaxation rate,? Chem.?2007, 129, 212-217.
13.Weihong Du, Ling Wang, Baohuai Wang, Zhifen Li, Weihai Fang^*.Actinoimycin D binds to single stranded DNA oligomers? which contains double GTC triplets.?Thermochimica Acta?2007, 452, 31-35.
14.Weihong Du, Ray Syvitski, Sylvia Dewilde, Luc Moens, and Gerd N. La Mar^*. Solution¹H NMR Characterization of Equilibrium Heme Orientational Disorder with Functional Consequence in Mouse Neuroglobin.? Am. Chem. Soc.?2003, 125, 8080-8081.
15.?Weihong Du, Zhicheng Xia, Sylvia Dewilde, Luc Moens, Gerd N. La Mar^*.?¹H NMR? study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O₂-avid globin from trametode Paraphistomum epiclitum.?Eur. J. Biochem.?2003, 270, 2707-2720.?

杜为红 Weihong Du