蒋京呈,
胡俊杰,
王燕飞,
菅小东,
葛海虹
生态环境部固体废物与化学品管理技术中心, 北京 100029
作者简介: 赵静(1984-),女,硕士,工程师,研究方向为化学品环境管理政策研究、国际化学品管理战略谈判技术支持等,E-mail:zhaojing@meescc.cn.
基金项目: 生态环境部化学品污染防治项目（2110304）中图分类号: X171.5
Pollution Status and Control Countermeasures for Pharmaceutical and Personal Care Products in China
Zhao Jing,Jiang Jingcheng,
Hu Junjie,
Wang Yanfei,
Jian Xiaodong,
Ge Haihong
Solid Waste and Chemicals Management Center, Ministry of Ecology and Environment, Beijing 100029, China
CLC number: X171.5
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摘要:药物和个人护理用品（PPCPs）指各种香料、化妆品、遮光剂、染发剂、处方和非处方药（包括人和动物用药）等有机合成化学品的总称，应用非常广泛。化学物质的固有生物毒性决定了其在造福人类的同时也带来环境和健康风险，PPCPs已成为全球广泛关注的新型污染物。在过去的十几年内，国际社会针对PPCPs来源、环境归趋和对人类健康的风险等进行了大量的研究，我国PPCPs的生产和消费量巨大，面临的污染情势更加严峻。本文综述了国内外对PPCPs的研究进展，提出了我国应对PPCPs污染的对策建议。
关键词: PPCPs/
药物/
个人护理用品/
环境污染/
管控对策
Abstract:Pharmaceutical and personal care products (PPCPs) are a general term for a wide range of organic synthetic chemicals such as perfumes, cosmetics, sunscreens, hair dyes, prescription and nonprescription drugs (including human and veterinary drugs). The inherent biological toxicity of chemicals determines their environmental and health risks while benefiting humans, and PPCPs have become the new emerging pollutant garnered extensive attention of the international community. In the past ten years, the international community has conducted a lot of research on the sources, environmental fate, risks to human health of PPCPs. The production and consumption of PPCPs in China is huge, and the pollution situation is even more severe. This paper reviewed the domestic and international research progress of PPCPs, conducted research on the pollution of PPCPs in China, and proposed the countermeasures for PPCPs pollution control.
Key words:PPCPs/
pharmaceutical/
personal care product/
environmental pollution/
control countermeasures.
| Daughton C G, Ternes T A. Pharmaceuticals and personal care products in the environment:Agents of subtle change?[J]. Environmental Health Perspectives, 1999, 107(6):907-938 |
| Liu J, Wong M H. Pharmaceuticals and personal care products (PPCPs):A review on environmental contamination in China[J]. Environment International, 2013, 182(1):208-224 |
| 张芹, 张圣虎, 汪贞, 等. 骆马湖表层水体中32种PPCPs类物质的污染水平、分布特征及风险评估[J]. 环境科学, 2017, 38(1):162-169Zhang Q, Zhang S H, Wang Z, et al. Pollution level, distribution characteristics and risk assessment of 32 PPCPs in surface water of Luomahu Lake[J]. Environmental Science, 2017, 38(1):162-169(in Chinese) |
| 刘印平, 祝凌燕, 李敬光. 药品与个人护理用品的生态与健康影响研究进展[J]. 卫生研究, 2009, 38(2):237-240Liu Y P, Zhu L Y, Li J G. Research process of pharmaceutical and personal care products on ecological and human health[J]. Journal of Hygiene Research, 2009, 38(2):237-240(in Chinese) |
| Kolpin D W, Furlong E T, Meyer M T, et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000:A National Reconnaissance[J]. Environmental Science and Technology, 2002, 36(6):1202-1211 |
| Ramirez A J, Brain R A, Usenko S, et al. Occurrence of pharmaceuticals and personal care products (PPCPs) in fish tissues:Results of a national pilot study in the United States[J]. Environmental Toxicology and Chemistry, 2009, 28:2587-2597 |
| Monteiro S C, Boxall A B A. Factors affecting the degradation of pharmaceuticals in agricultural soils[J]. Environmental Toxicology & Chemistry, 2009, 28(12):2546-2554 |
| Center for Drug Evaluation and Research. Guidance for industry-environmental assessment of human drug and biologics applications[R]. Washington DC:United States Food & Drug Administration, 1998 |
| United States Environmental Protection Agency. Effluent guidelines-Pharmaceutical manufacturing effluent guidance documents[R]. Washington DC:United States Environmental Protection Agency, 1998 |
| 代朝猛, 周雪飞, 张亚雷, 等. 环境介质中药物和个人护理品的潜在风险研究进展[J]. 环境污染与防治, 2009, 31(2):77-80Dai C M, Zhou X F, Zhang Y L, et al. Research advancements in potential risk of PPCPs of environmental media[J]. Environmental Pollution and Control, 2009, 31(2):77-80(in Chinese) |
| 胡洪营, 王超, 郭美婷. 药品和个人护理用品(PPCPs)对环境的污染现状与研究进展[J]. 生态环境, 2005, 14(6):947-952Hu H Y, Wang C, Guo M T. The present status of environmental pollution by pharmaceuticals and personal care products (PPCPs)[J]. Ecology and Environment, 2005, 14(6):947-952(in Chinese) |
| United States Environmental Protection Agency. Method 1694:Pharmaceuticals and personal care products in water, soil, sediment, and biosolids by HPLC/MS/MS[R]. Washington DC:United States Environmental Protection Agency, 2007 |
| United States Environmental Protection Agency. Contaminants of emerging concern (CECs) in fish:Pharmaceuticals and personal care products (PPCPs)[R]. Washington DC:United States Environmental Protection Agency, 2013 |
| European Agency for the Evaluation of Medicinal Products. Guideline on environmental impact assessment for veterinary medicinal products phase Ⅱ. CVMP/VICH/790/03-FINAL[R]. London:Committee for Medicinal Products for Veterinary Use, 2004 |
| European Medicines Agency. Guideline on the environmental risk assessment of medicinal products for human use. EMEA/CHMP/SWP/4447/00 corr 1[R]. London:Committee for Medicinal Products for Human Use, 2006 |
| Australia Department of Health. CTD Module 1 Administrative information and prescribing information for Australia[R]. Canberra:Therapeutic Goods Administration, 2018 |
| World Health Organization. Pharmaceuticals in drinking water[R]. Geneva:World Health Organization, 2011 |
| 胡金龙. 典型PPCPs在污水处理厂中的迁移转化规律研究[D]. 上海:东华大学, 2014:3-6 Hu J L. Occurrence and removal of typical pharmaceuticals and personal care products (PPCPS) in a wastewater treatment plant[D]. Shanghai:Donghua University, 2014:3-6(in Chinese) |
| Khetan S K, Collins T J. Human pharmaceuticals in the aquatic environment:A challenge to Green Chemistry[J]. Chemical Reviews, 2006, 107:2319-2364 |
| 安婧, 周启星. 药品及个人护理用品(PPCPs)的污染来源、环境残留及生态毒性[J]. 生态学杂志, 2009, 28(9):1878-1890An J, Zhou Q X. Pollution sources, environmental residues, and ecological toxicity of pharmaceuticals and personal care products (PPCPs):A review[J]. Chinese Journal of Ecology, 2009, 28(9):1878-1890(in Chinese) |
| 高艳蓬, 李桂英, 马盛韬, 等. 合成麝香的研究新进展与当前挑战:从人体护理、环境污染到人体健康[J]. 化学进展, 2017, 29(9):1082-1092Gao Y P, Li G Y, Ma S T, et al. Research progress and challenge of synthetic musks:From personal care, environment pollution to human health[J]. Progress in Chemistry, 2017, 29(9):1082-1092(in Chinese) |
| Artola-Garicano E, Borkent I, Damen K, et al. Sorption kinetics and microbial biodegradation activity of hydrophobic chemicals in sewage sludge:Model and measurements based on free concentrations[J]. Environmental Science and Technology, 2003, 37(1):116-122 |
| Rimkus G, Rimkus B, Wolf M. Nitro musks in human adipose tissue and breast milk[J]. Chemosphere, 1994, 28(2):421-432 |
| Sanderson H, Dyer S D, Price B B, et al. Occurrence and weight-of-evidence risk assessment of alkyl sulfates, alkyl ethoxysulfates, and linear alkylbenzene sulfonates (LAS) in river water and sediments[J]. Science of the Total Environment, 2006, 368(2):695-712 |
| 萨仁其其格. 内蒙古牧区土壤中链霉素残留的检测及吸附行为的研究[D]. 呼和浩特:内蒙古大学, 2010:2 Sarenqiqige. Study on detection of streptomycin residue and adsorption behavior on soil of Inner Mongolia pastoral[D]. Hohhot:Inner Mongolia University, 2010:2(in Chinese) |
| 万遂如. 关于我国畜牧业生产中限制抗生素的使用问题[J]. 养猪, 2017(1):1-5 |
| 应光国. 中国抗生素使用与流域污染[C]//中国化学会. 中国化学会第30届学术年会摘要集-第二十六分会:环境化学. 大连:中国化学会, 2016:1 |
| 周静. 日用化学品用合成麝香[J]. 日用化学工业, 2016, 46(9):530-538Zhou J. Synthetic musk in daily chemicals[J]. China Surfactant Detergent & Cosmetics, 2016, 46(9):530-538(in Chinese) |
| 赵永杰. 2018年中国化妆品行业运行情况分析[J]. 日用化学品科学, 2019, 42(9):1-5Zhao Y J. Analysis on the operation of China cosmetic industry in 2018[J]. Detergent & Cosmetics, 2019, 42(9):1-5(in Chinese) |
| Kang X, Bhandari A, Das K, et al. Occurrence and fate of pharmaceuticals and personal care products (PPCPs) in biosolids[J]. Journal of Environment Quality, 2005, 34(1):91-104 |
| 刘学娅, 赵亚洲, 冷平生. 城市污泥的土地利用及其环境影响研究进展[J]. 农学学报, 2018, 8(6):21-27Liu X Y, Zhao Y Z, Leng P S. Land use of municipal sludge and its environmental impacts:Research progress[J]. Journal of Agriculture, 2018, 8(6):21-27(in Chinese) |
| 熊云武, 林晓燕, 龚亚龙, 等. 城市污泥安全农用研究进展[J]. 现代农业科技, 2016(3):228-229 Xiong Y W, Lin X Y, Gong Y L, et al. Research advance on safe utilization of municipal sewage sludge as agricultural resource[J]. Modern Agricultural Science and Technology, 2016(3):228-229(in Chinese) |
| 李彦文, 莫测辉, 赵娜, 等. 菜地土壤中磺胺类和四环素类抗生素污染特征研究[J]. 环境科学, 2009, 30(6):1762-1766Li Y W, Mo C H, Zhao N, et al. Investigation of sulfonamides and tetracyclines antibiotics in soil from various vegetable fields[J]. Environmental Science, 2009, 30(6):1762-1766(in Chinese) |
| 田艺心, 王美娥, 陈卫平, 等. 污水和污泥中的人工合成麝香分析方法[J]. 生态学杂志, 2011, 30(2):395-400Tian Y X, Wang M E, Chen W P, et al. Analytical methods for synthetic musk in wastewater and sewage sludge[J]. Chinese Journal of Ecology, 2011, 30(2):395-400(in Chinese) |
| Peng X Z, Yu Y Y, Tang C M, et al. Occurrence of steroid estrogens, endocrine-disrupting phenols, and acid pharmaceutical residues in urban riverine water of the Pearl River Delta, South China[J]. Science of the Total Environment, 2008, 397(1-3):158-166 |
