段晨晖^1,2,
房彦军²,
梁俊^1,,,
高志贤^2,,
1. 天津科技大学省部共建食品营养与安全国家重点实验室, 天津 300457;
2. 军事科学院军事医学研究院环境医学与作业医学研究所, 天津市环境与食品安全风险监控技术重点实验室, 天津 300050

作者简介: 段晨晖(1995-),男,硕士研究生,研究方向为食品接触材料的毒理学效应,E-mail:thomas1103@163.com.

通讯作者: 梁俊,jliang1118@yeah.net ; 高志贤,gaozhx@163.com

基金项目: ”十三五” 国家重点研发计划项目(2018YFC1603001)


中图分类号: X171.5

In Vitro Cytotoxicity Evaluation of Phthalate Plasticizers

Duan Chenhui^1,2,
Fang Yanjun²,
Liang Jun^1,,,
Gao Zhixian^2,,
1. State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China;
2. Tianjin Key Laboratory of Risk Assessment and Control Technology for Environment and Food Safety, Institute of Environmental and Operational Medicine, Academy of Military Medical Science, Academy of Military Science, Tianjin 300050, China

Corresponding authors: Liang Jun,jliang1118@yeah.net ; Gao Zhixian,gaozhx@163.com

CLC number: X171.5

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摘要:邻苯二甲酸酯(Phthalate esters, PAEs)是环境介质中的一类典型的有机污染物。已有研究表明，PAEs具有明显的内分泌干扰毒性，并会对动物和人体的生殖发育与神经系统造成损伤。体外细胞评价模型因具有高通量、测试周期短、成本低和毒性效应易于探明等技术优点，被广泛应用到PAEs毒理学效应的研究中。本文从内分泌干扰毒性、胚胎发育毒性、神经毒性、免疫毒性、遗传毒性以及致癌作用等方面，对PAEs的一些体外细胞毒性评价模型进行了分类和总结，并对其相应的研究进展进行了综述。本文旨在为体外细胞毒性评价模型的有效利用提供借鉴，并对PAEs毒性作用机制的深入研究提供思路和依据。
关键词: 邻苯二甲酸酯类(PAEs)/
毒理学效应/
体外细胞毒性评价

Abstract:Phthalates esters (PAEs) are a group of typical organic compounds in the environment. Studies have shown that PAEs have significant endocrine disrupting toxicity and can cause damage to the reproductive development and nervous system of animals and humans. The in vitro cytotoxicity evaluation model is widely used in the study of toxicological effects of PAEs due to its high throughput, short test period, low cost, and easiness for detecting toxic effects. In this paper, some in vitro cytotoxicity evaluation models of PAEs were classified and summarized from the aspects of endocrine disrupting toxicity, embryonic developmental toxicity, neurotoxicity, immunotoxicity, genotoxicity and carcinogenesis, and the corresponding research progress was reviewed. It is hoped that this paper can provide reference for the effective use of in vitro cytotoxicity evaluation model, and provide ideas and basis for the in-depth study of the toxic mechanism of PAEs.
Key words:phthalates (PAEs)/
toxicological effect/
in vitro cytotoxicity evaluation.