王秀娟^1,2,3,
薛玉英^1,2,3,
唐萌^1,2,3
1. 环境医学工程教育部重点实验室, 南京 210009;
2. 东南大学公共卫生学院&苏州纳米科技协同创新中心, 南京 210009;
3. 江苏省生物材料与器件重点实验室, 南京 210009

作者简介: 王秀娟(1993-),女,硕士研究生,研究方向为纳米毒理学,E-mail:924153949@qq.com.

基金项目: 国家自然科学基金项目(81573186，81473003)


中图分类号: X171.5

Research Progress on Internal Toxicity and the Toxic Mechanism of Silver Nanoparticles

Wang Xiujuan^1,2,3,
Xue Yuying^1,2,3,
Tang Meng^1,2,3
1. Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Nanjing 210009, China;
2. School of Public Health of Southeast University & Collaborative Innovation Center of Suzhou Nanoscience and Technology, Nanjing 210009, China;
3. Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210009, China

CLC number: X171.5

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摘要:很多研究表明纳米银对机体的消化系统、呼吸系统、生殖系统等多个系统均会产生毒作用，且其毒作用受到多种因素的影响。目前关于纳米银的毒作用机制尚未明确，研究发现纳米银的毒作用机制可能与银离子释放、活性氧自由基产生、氧化应激的发生、炎症反应等有关，最新研究指出纳米银的毒性作用还可能与内质网应激和自噬有关，本文将就纳米银的体内毒性及毒作用机制进行了综述。
关键词: 纳米银/
活性氧/
氧化应激/
内质网应激/
自噬

Abstract:Many researches have shown that nanosilver could cause toxic effects on the digestive system, respiratory system, reproductive system and other systems, and the toxic effects are influenced by a variety of factors. At present, the mechanism of the toxic effect of silver nanoparticles is not clear. It has been found that the mechanism of silver nanoparticles might be related to the release of silver ions, ROS production, oxidative stress and inflammatory reaction, etc. The latest research shows that the toxic mechanism of nanosilver is also associated with endoplasmic reticulum stress and autophagy. This paper reviews the toxicity and toxic mechanism of nanosilver.
Key words:silver nanoparticles/
reactive oxygen species/
oxidative stress/
endoplasmic reticulum stress/
autophagy.