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群体感应信号分子存在下磺胺对大肠杆菌生长、突变及R388质粒接合转移的影响

本站小编 Free考研考试/2021-12-30

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王雅娟1,2,3,
马清萍4,
于洋5,
宋春磊1,
程逸飞6,
史珺怡4,
林志芬1,2,3
1. 同济大学环境科学与工程学院, 污染控制与资源化研究国家重点实验室, 上海 200092;
2. 上海市化学品分析、风险评估与控制重点实验室, 上海 200092;
3. 上海污染控制与生态安全研究院, 上海 200092;
4. 上海海洋大学海洋生态与环境学院, 上海 201306;
5. 环境保护部固体废物与化学品管理技术中心, 北京 100029;
6. 桂林理工大学环境科学与工程学院, 桂林 541004
作者简介: 王雅娟(1994-),女,硕士,研究方向为微生物毒理学,E-mail:1631314@tongji.edu.cn.
基金项目: 同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRK16007);国家自然科学面上基金(21577105,21777123);水体污染控制与治理科技重大专项(2018ZX07109-1);上海市科学技术委员会科研计划课题(14DZ2261100,17DZ1200103);环境化学与生态毒理学国家重点实验室开放基金课题(KF2016-11);111工程


中图分类号: X171.5


Effect of Sulfonamides on Growth and Mutation of Escherichia coli and Conjugal Transfer of Plasmid R388 in the Presence of Quorum Sensing Signal Molecules

Wang Yajuan1,2,3,
Ma Qingping4,
Yu Yang5,
Song Chunlei1,
Cheng Yifei6,
Shi Junyi4,
Lin Zhifen1,2,3
1. College of Environmental Science and Engineering, Tongji University, State Key Laboratory of Pollution Control and Resource Reuse, Shanghai 200092, China;
2. Shanghai Key Lab of Chemical Assessment and Sustainability, Shanghai 200092;
3. Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China;
4. College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China;
5. Solid Waste and Chemicals Management Center, Ministry of Environmental Protection, Beijing 100029, China;
6. College of Environmental Science and Engineering, Guilin University of Technology, Guilin 541004, China

CLC number: X171.5

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摘要:抗生素的滥用使细菌耐药性问题日益突出,给许多疾病的预防与控制增加了难度。基因突变和质粒接合转移是细菌获得抗生素抗性基因的主要方式,许多研究围绕抗性基因来展开,但是关于群体感应对于抗性基因产生和传播的影响鲜有报道。本文以大肠杆菌(Escherichia coli)为模式生物,群体感应信号分子N-(β-酮己酰)-L-高丝氨酸内酯(3-oxo-C6-HSL, C6)和3种磺胺类抗生素(磺胺嘧啶、磺胺甲恶唑、磺胺氯哒嗪)为研究对象,测定了其对大肠杆菌生长效应、突变效应及接合转移效应的影响。结果表明:C6不影响磺胺对大肠杆菌的生长抑制率,但能够削弱磺胺对大肠杆菌突变的促进作用,并且能增强磺胺对大肠杆菌R388质粒接合转移的抑制作用。本文为从群体感应角度研究大肠杆菌耐药性的产生与传播提供新思路。
关键词: 群体感应信号分子/
磺胺/
大肠杆菌/
突变/
接合转移

Abstract:Due to the indiscriminate use of antibiotics, bacterial resistance has become increasingly severe, which make the prevention and control of diseases more difficult. Mutation and conjugal transfer of plasmid are two main ways of bacteria getting antibiotic resistance genes. Previous studies have focused on the antibiotics resistance genes, which have frequently neglected the influence of quorum sensing on the formation and the spread of resistance genes. In this study, the effects of three kinds of sulfonamides (SAs, i.e., sulfadiazine, sulfamethoxazole, sulfachloropyridazine) on the growth, mutation and conjugal transfer of plasmid of Escherichia coli (E. coli) were investigated in the presence of N-(beta-ketocaproyl)-dl-homoserine lactone (3-oxo-C6-HSL, C6), a type of quorum sensing signal molecules. The results showed that C6 had no influence on the growth effect of SAs on E. coli, but weakened the stimulatory effect of SAs on mutation and meanwhile enhanced the inhibitory effect of SAs on conjugal transfer of plasmid R388. This work can provide a new reference for the research on the formation and the spread of E.coli resistance from quorum sensing.
Key words:quorum sensing signal molecule/
sulfonamide/
Escherichia coli/
mutation/
conjugal transfer.

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