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环境污染物导致氧化应激的关键信号通路及其检测方法

本站小编 Free考研考试/2021-12-30

袁圣武1,
黄超1,
季晓亚1,
马梅1,2
1. 中国科学院生态环境研究中心中国科学院饮用水科学与技术重点实验室, 北京 100085;
2. 中国科学院大学资源与环境学院, 北京 100190
作者简介: 袁圣武(1991-),男,博士生,研究方向为水生态毒理学,E-mail:swyuan_st@rcees.ac.cn.
基金项目: 水体污染控制与治理重大专项课题(2014ZX07206005-002);国家自然科学基金重点项目(21437006);中国科学院前沿科学重点研究项目(QYZDY-SSW-DQC004)


中图分类号: X171.5


Main Signaling Pathways and Detection Methods of Oxidative Stress Caused by Environmental Pollutants

Yuan Shengwu1,
Huang Chao1,
Ji Xiaoya1,
Ma Mei1,2
1. State Key Laboratory of Drink Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;
2. College of Resources and Environmental Science, University of Chinese Academy of Sciences, Beijing 100190, China

CLC number: X171.5

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摘要:环境污染物能够以多种途径进入生物体内,在体内产生含氧自由基等活性氧物质,并通过多种信号通路及酶反应引起氧化应激,造成生物体内的脂质过氧化、蛋白质损伤、DNA表达改变、酶失活等,从而引发心血管疾病、风湿类疾病、感染及癌症等的发生。本文对环境污染物致氧化应激产生的原因、涉及的信号通路及酶反应、造成的危害,以及常见的基于细胞模型的氧化应激检测方法进行了综述,期望为评价环境污染物和检测氧化损伤提供参考。
关键词: 环境污染物/
氧化应激/
氧化损伤/
信号通路/
监测方法

Abstract:Environmental pollutants can be uptaken by living organism through different ways, and produce some reactive oxygen species like oxygen free radicals in vivo, which arouse oxidative stress by a variety of signaling pathways and enzyme reactions. Some of the reactive oxygen species are associated with human diseases, such as cardiovascular disease, rheumatic diseases, infentions and cancer, which may be resulted by lipid peroxidation, protein denaturation, DNA damage, and enzyme inactivation, etc. This article summarized the reasons and harmful effects of oxidative stress caused by environmental pollutants. It reviewed, the involved signaling pathways and enzymatic reactions during oxidative stress, and the currently used cell-model-based approaches for detecting oxidative stress. The purpose of this review article is to provide information for better understanding the oxidative stress associated-mechanisms and further development of detecting methods for oxidative damages.
Key words:environmental pollutants/
oxidative stress/
oxidative damage/
signaling pathways/
detection methods.

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