季晓亚¹,
李娜¹,
袁圣武¹,
黄超¹,
饶凯锋¹,
马梅^1,2,
王子健¹
1. 中国科学院生态环境研究中心 中国科学院饮用水科学与技术重点实验室, 北京 100085;
2. 中国科学院大学资源与环境学院, 北京 100190

作者简介: 季晓亚(1992-),女,硕士研究生,研究方向为水生态毒理学,E-mail:jxya1992@163.com.

基金项目: 国家自然科学基金重点课题(No.51290283)；国家自然科学基金重点基金(No.21437006)；国家自然科学基金青年基金(No.21107131)


中图分类号: X171.5

Research Progress in the Mechanisms for Biological Effects of Environmental Estrogens

Ji Xiaoya¹,
Li Na¹,
Yuan Shengwu¹,
Huang Chao¹,
Rao Kaifeng¹,
Ma Mei^1,2,
Wang Zijian¹
1. Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;
2. College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100190, China

CLC number: X171.5

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摘要:环境雌激素(environmental estrogens, EEs)种类繁多，来源多样且分布广泛，大量工业添加剂、食品添加剂和农药类物质已被证实具有雌激素活性。EEs对人体生殖、神经、免疫等系统生物毒性，已经引起了公众的普遍关注。近年来的研究表明，EEs不仅结合雌激素核受体(nuclear estrogen receptor, nER)，还可以活化雌激素膜受体(membrane estrogen receptor, mER),干扰正常的雌激素基因组信号通路。本文总结了EEs通过nER、mER介导的多种雌激素基因组和非基因组信号途径及其产生的生物学效应，综述了在其毒理学作用机理基础上发展的环境样品的雌激素活性评估和EEs混合物的联合作用研究，以期为该类污染物的筛查、风险评估和进一步的机制研究提供参考。
关键词: 环境雌激素/
核受体/
膜受体/
基因组/
非基因组/
信号通路

Abstract:Environmental estrogens (EEs) have a variety of types and sources. A great number of industrial additives, food additives and pesticides have been identified to have estrogenic activities. The potential reproductive toxicity, neurotoxicity and immunotoxicity resulted from estrogenic activities have attracted widespread attention. It was found in recent years that EEs disrupt normal estrogen signaling pathways by binding to nuclear estrogen receptor and membrane estrogen receptor. In this review, the biological effects resulted from nER and mER mediated multiple estrogen genomic and non-genomic signaling pathways were summarized. In order to provide better understanding for screening, risk assessment and mechanism studies of EEs, the research progress of the estrogen activity assessment of environmental samples and the combined effects of the EEs mixture were reviewed.
Key words:environmental estrogens/
nuclear receptor/
membrane receptor/
genomic/
non-genomic/
signaling pathways.