方琪^1,2,
马彦博³,
张思远¹,
焦必宁^1,2
1. 西南大学柑桔研究所, 重庆 400712;
2. 农业部柑桔产品质量安全风险评估实验室(重庆), 重庆 400712;
3. 中国科学院重庆绿色智能技术研究院, 重庆 400714

作者简介: 方琪(1987-),女,助理研究员,研究方向为环境毒理学,E-mail:fangqi@cric.cn.

基金项目: 中央高校基本科研业务费专项资金项目(XDJK2015C088,SWU115026)；国家农产品质量安全风险评估重大专项(GJFP2017004，GJFP2016004,GJFP2016014)
国家现代农业(柑橘)产业技术体系建设专项(CARS-27)


中图分类号: X171.5

Research Progress in Endocrine Disrupting Effects of Pesticides

Fang Qi^1,2,
Ma Yanbo³,
Zhang Siyuan¹,
Jiao Bining^1,2
1. Citrus Research Institute, SouthWest University, Chongqing 400712, China;
2. Laboratory of Quality and Safety Risk Assessment for Citrus Products, Ministry of Agriculture, Chongqing 400712, China;
3. Chongqing Institute of Green and Intelligent Technology, Chinese Academy ofSciences, Chongqing 400714, China

CLC number: X171.5

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摘要:农药作为农业生产过程中的一类重要生产资料，主要用作杀虫剂、杀菌剂和除草剂等。由于农药的大量使用，目前在各类农产品及各种环境介质中都能被检测到，对饮食健康和环境安全带来潜在危害。研究发现，许多农药为内分泌干扰物，其能够干扰人类和其他生物体的内分泌系统正常功能。本文在总结国内外相关研究的基础上，对农药内分泌干扰效应的作用机理及筛选模型进行总结，对有机氯、有机磷和拟除虫菊酯等各类农药的内分泌干扰效应研究进展进行综述，并提出深入探究农药致毒作用机制和低剂量下多种农药联合毒性是本领域的重要研究方向。
关键词: 农药/
内分泌干扰效应

Abstract:Pesticides are widely used as insecticides, fungicides and herbicides in the agricultural production, and have been detected in all kinds of agriculture products and environment，which bring potential risk to food safety and environmental health. It is reported that many pesticides have been identified as endocrine disruptors, which could alter the normal functioning of the endocrine system of both wildlife and humans. This paper reviews the potential mechanism and screening models of endocrine disruptors, and makes a summary of the endocrine disrupting effects of major pesticides, such as organochlorine, organophosphorus and pyrethroid, which is important to the future study of pesticides toxicity mechanism and especially to combined toxicological effects of the pesticides mixture under low concentrations.
Key words:pesticides/
endocrine disrupting effects.