侯昌成¹,
赵玲¹,
尹平河²,
陆钢¹
1. 暨南大学环境学院, 广州环境暴露与健康重点实验室, 广东环境污染与健康重点实验室, 广州 510632;
2. 暨南大学生命科学技术学院, 暨南大学分析测试中心, 广州 510632

作者简介: 侯昌成(1991-),男,硕士研究生,助理研究员,研究方向为固体废物处理处置和生态毒理学评价,E-mail:chas_hou@163.com.

基金项目: 国家自然基金项目(51508228，U113303，41676110)；广东省产学研项目(2013B090600009)；广东省科技计划项目(2014A020217007)


中图分类号: X171.5

Cytotoxicity Analysis of Typical Endocrine Disrupting Chemicals (EDCs) in Landfill Leachate

Hou Changcheng¹,
Zhao Ling¹,
Yin Pinghe²,
Lu Gang¹
1. School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China;
2. College of Life Science and Technology, Research Center of Analysis and Test, Jinan University, Guangzhou 510632, China

CLC number: X171.5

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摘要:垃圾渗滤液的人类健康风险评估日益受到人们重视,也成为研究热点。本文采用一种新型高级氧化技术UV-Fenton处理渗滤液,并用人体乳腺癌细胞(MCF-7)评估处理过程中渗滤液原液以及渗滤液中典型内分泌干扰物质(EDCs)的细胞毒性,对垃圾渗滤液中EDCs的细胞毒性和变化规律进行了研究。结果表明渗滤液中的邻苯二甲酸二丁酯(DBP)、双酚A(BPA)、壬基酚(NP)是产生细胞毒性的主要物质,其毒性大小为DBP>BPA>NP。在同样的氧化降解过程中显示出不同毒性变化规律,通过GC-MS分析,结果显示UV-Fenton过程中产生了大量的中间产物,这也是引起毒性变化的主要原因。实验结果也说明垃圾渗滤液细胞毒性可以通过UV-Fenton过程有效去除。
关键词: 垃圾渗滤液/
内分泌干扰物质/
人体乳腺癌细胞/
细胞毒性/
高级氧化过程/
UV-Fenton/
中间产物

Abstract:Recently, the health risk assessment on the landfill leachate has attracted increasing attentions and has become a research focus. In the present study, a novel advanced oxidation technology (UV-Fenton technology) was adopted to treat the leachate, and the cell toxicity of raw leachate and typical EDCs in the leachate in the treatment process has been evaluated by using human breast cancer cells (MCF-7). The results indicated that di-butyl phthalate (DBP), bisphenol A (BPA) and nonylphenol (NP) in the leachate were main substances which have significant cytotoxicity on MCF-7 cells. The toxicity variations of these three chemicals were different in the same oxidative degradation process, and the toxicity order was DBP > BPA > NP. According to the GC-MS analysis results, a great amount of intermediate products have been produced in UV-Fenton process, which may be a major reason that induced toxicity variations. The results implied that UV-Fenton technology is an effective method to reduce toxicity of landfill leachate.
Key words:landfill leachate/
endocrine disrupting chemicals/
MCE-7/
cytotoxicity/
advanced oxidation process/
UV-Fenton/
intermediate product.