潘永正¹,
孙昊宇²,
王大力²,
林志芬²,
印春生¹,
巫晓丹¹
1. 上海海洋大学海洋生态与环境学院, 上海 201306;
2. 污染控制与资源化研究国家重点实验室, 同济大学环境科学与工程学院, 上海 200092

作者简介: 潘永正(1993-),男,硕士,研究方向为微生物毒理学,E-mail:1634671991@qq.com.

基金项目: 同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRK16007)；国家自然科学面上基金(21377096,21577105)；同济大学英才(攀登)计划(0400219287)；上海市科学技术委员会(14DZ2261100)；同济大学污染控制与资源化研究国家重点实验室开放基金(PCRRF14001)；上海市化学品分析、风险评价与控制重点实验室开放基金(SCI2016-1)；中国博士后科学基金(2016M600332)


中图分类号: X171.5

Progress in Researches on Cross Phenomenon between Evaluation Model Curve and Actual Concentration-response Curve of Mixture Pollutants

Pan Yongzheng¹,
Sun Haoyu²,
Wang Dali²,
Lin Zhifen²,
Yin Chunsheng¹,
Wu Xiaodan¹
1. College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China;
2. State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China

CLC number: X171.5

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摘要:许多研究在使用评价模型进行混合物联合作用模式判别时发现,混合污染物的评价模型曲线和浓度效应曲线之间存在交叉的现象,表现为联合作用模式随混合物浓度发生变化。虽然交叉现象不断被报道出来,但是该现象形成机制的研究却非常欠缺。本文系统分析了文献中出现的交叉现象,探讨了交叉现象可能的形成原因和机制,提出了化合物的hormesis效应是导致交叉现象的关键因素:混合组分中某些化合物在低浓度时会对受试生物的某些蛋白、基因等的表达量产生刺激作用,影响其他化合物对机体产生的效应,从而改变混合组分的联合作用模式。该研究不仅为交叉现象形成机制的进一步探索提供了理论依据,还为混合物的生态毒理评估和环境风险评价提供理论指导。
关键词: 混合污染物/
交叉现象/
联合作用模式/
评价模型/
浓度效应曲线/
Hormesis效应

Abstract:Previous studies have found that there is a cross phenomenon between evaluation model curve and concentration-response curve of mixture pollutants when using the evaluation model to judge the joint toxic action of mixtures, which is characterized by the joint toxic action varying with the concentration of mixtures. Although cross phenomenon has been reported in many researches, the mechanistic investigation on this phenomenon is extremely limited. This study systematically analyzed the cross phenomenon reported in studies and discussed the potential mechanism, which found that hormesis might be the key factor resulting in cross phenomenon: some components in mixtures might cause the stimulatory effect on the expression of certain proteins or genes at low concentration that would change the effect of other components on the test organism. This study not only provides a basis for the further mechanistic exploration on cross phenomenon, but also provides theoretical guidance for ecologically toxicological evaluation and environmental risk assessment of mixture pollutants.
Key words:mixture pollutants/
cross phenomenon/
joint toxic action/
evaluation model/
concentration-response curve/
hormesis.