邓桂荣^1,2,3,
梅承芳^1,2,3,
柳燕贞^1,2,3,
张宏涛^1,2,3,4,
陈泽芳^1,2,3,
曾国驱^1,2,3,,
1. 广东省微生物分析检测中心 生态毒理与环境安全实验室, 广州 510070;
2. 广东省微生物研究所 广东省菌种保藏与应用重点实验室, 广州 510070;
3. 省部共建华南应用微生物国家重点实验室, 广州 510070;
4. 佛山市环境健康与安全评价研究中心, 佛山 528000

作者简介: 邓桂荣(1984-),男,工程师,研究方向为生态毒理学,E-mail:deng8818@163.com.

通讯作者: 曾国驱,zenggq@gddcm.com

基金项目: 新材料环境健康安全评价科技创新服务平台(广东省科技计划项目，2013B090800004)


中图分类号: X171.5

Application of Robust Statistic Method in Quality Analysis of Ready Biodegradability Test

Deng Guirong^1,2,3,
Mei Chengfang^1,2,3,
Liu Yanzhen^1,2,3,
Zhang Hongtao^1,2,3,4,
Chen Zefang^1,2,3,
Zeng Guoqu^1,2,3,,
1. Laboratory of Ecotoxicity and Environmental Safety, Guangdong Detection Center of Microbiology, Guangzhou 510070, China;
2. Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, China;
3. State Key Laboratory of Applied Microbiology, Southern China, Guangzhou 510070, China;
4. Foshan Research Center for Environmental Health and Safety Assessment, Foshan 528000, China

Corresponding author: Zeng Guoqu,zenggq@gddcm.com

CLC number: X171.5

-->

摘要
HTML全文
图(0)表(0)
参考文献(0)
相关文章
施引文献
资源附件(0)
访问统计

摘要:快速生物降解性试验在新化学物质的生态毒理测试中占据重要地位,其测试数据的可靠性直接影响后续的测试策略和物质的申报登记、以及新化学物质进入环境后的风险管理。为研究OECD 301系列试验(301B、301D和301F)的质量,选用本机构近5年来积累的标准化物质苯甲酸钠14 d快速生物降解率数据,首次采用稳健统计技术,以稳健总计统计量的Z比分数作为评价指标,对各试验数据和试验系统的质量开展评估。结果显示,当301B、301D和301F试验的苯甲酸钠降解率分别在63.8%~88.0%、63.4%~89.2%和66.0%~99.8%范围内时,表明测试结果满意,该批次试验数据质量良好;若苯甲酸钠降解率不在此范围,则表明测试结果可能存在问题,甚至得到的可能是错误数据,需要进一步验证。据此提出了对实际测试工作具有指导意义的质量分析对照表,以期为测试机构开展新化学物质快速生物降解性试验时的质量分析提供参考。
关键词: 苯甲酸钠/
快速生物降解性试验/
稳健统计/
Z比分数/
质量分析

Abstract:Ready biodegradability test plays an important role in ecotoxicity testing of new chemicals. The reliability of ready biodegradation test results directly determines the subsequent testing strategy and affects the registration and declaration of new chemical substances, as well as the risk management after entering environment. In order to study the data quality of ready biodegradability series tests (OECD 301B, 301D and 301F), Z-score of robust statistics method was firstly used to analyze the 14 d biodegradation data of sodium benzoate which were produced by our laboratory in the past 5 years. The results showed that, when the biodegradation rates of sodium benzoate of 301B, 301D and 301F are within the range of 63.8%-88.0%, 63.4%-89.2% and 66.0%-99.8%, respectively, it indicates that the test results are satisfactory and the data quality are good. Otherwise, it means that there are some problems with the data and further verification is needed. As a result, a comparison table of quality analysis of ready biodegradability test was constructed for providing the references for quality analysis of ready biodegradability test of new chemical substances.
Key words:sodium benzoate/
ready biodegradability/
robust statistic/
Z-score/
quality analysis.